Thromboelastography in patients with severe sepsis: a prospective cohort study

Intensive Care Medicine

Volumn 41, Issue 1, 2015, Pages 77-85

  Haase, Nicolai ^a   Ostrowski, Sisse Rye ^a   Wetterslev, Jørn ^a   Lange, Theis ^b   Møller, Morten Hylander ^a,c   Tousi, Hamid ^d   Steensen, Morten ^a,e   Pott, Frank ^c   Søe Jensen, Peter ^d   Nielsen, Jonas ^a,e   Hjortrup, Peter Buhl ^a   Johansson, Pär Ingemar ^a,f   Perner, Anders ^a  

^a Rigshospitalet   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c BISPEBJERG HOSPITAL   (Denmark)

^d GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^e HVIDOVRE HOSPITAL   (Denmark)

^f UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Coagulation; Hydroxyethyl starch; Sepsis; Thromboelastography

Indexed keywords

CALCIUM CHLORIDE PLUS POTASSIUM CHLORIDE PLUS SODIUM CHLORIDE; HETASTARCH; HETASTARCH DERIVATIVE; PLASMA SUBSTITUTE;

ADULT; AGED; ARTICLE; BLOOD CLOTTING; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; FLUID RESUSCITATION; HAZARD RATIO; HUMAN; HYPOCOAGULABILITY; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OBSERVATIONAL STUDY; PROSPECTIVE STUDY; SEPSIS; SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE; SEVERE SEPSIS; THROMBOELASTOGRAPHY; BLOOD; BLOOD COAGULATION DISORDERS; CLINICAL TRIAL; COMPLICATION; DISEASE COURSE; FLUID THERAPY; MIDDLE AGED; PROCEDURES; RANDOMIZED CONTROLLED TRIAL; RESUSCITATION;

AGED; BLOOD COAGULATION DISORDERS; DISEASE PROGRESSION; FEMALE; FLUID THERAPY; HUMANS; HYDROXYETHYL STARCH DERIVATIVES; MALE; MIDDLE AGED; PLASMA SUBSTITUTES; PROSPECTIVE STUDIES; RESUSCITATION; SEPSIS; THROMBELASTOGRAPHY;

EID: 84918588764     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-014-3552-9     Document Type: Article

References (30)

1. Angus DC, van der Poll T (2013) Severe sepsis and septic shock. N Engl J Med 369:840–851. doi:10.1056/NEJMra1208623
2. Bakhtiari K, Meijers JCM, de Jonge E, Levi M (2004) Prospective validation of the International Society of Thrombosis and Haemostasis scoring system for disseminated intravascular coagulation. Crit Care Med 32:2416–2421
3. Ostrowski SR, Windeløv NA, Ibsen M et al (2012) Consecutive thrombelastography clot strength profiles in patients with severe sepsis and their association with 28-day mortality: a prospective study. J Crit Care. doi:10.1016/j.jcrc.2012.09.003
4. Johansson PI, Stensballe J, Vindeløv N et al (2010) Hypocoagulability, as evaluated by thrombelastography, at admission to the ICU is associated with increased 30-day mortality. Blood Coagul Fibrinolysis 21:168–174. doi:10.1097/MBC.0b013e3283367882
5. Müller MC, Meijers JC, Vroom MB, Juffermans NP (2014) Utility of thromboelastography and/or thromboelastometry in adults with sepsis: a systematic review. Crit Care 18:R30. doi:10.1186/cc13721
6. Perner A, Haase N, Guttormsen AB et al (2012) Hydroxyethyl starch 130/0.42 versus Ringer’s acetate in severe sepsis. N Engl J Med 367:124–134. doi:10.1056/NEJMoa1204242
7. American College of Chest Physicians/Society of Critical Care Medicine (1992) American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 20:864–874
8. Perner A, Haase N, Wetterslev J et al (2011) Comparing the effect of hydroxyethyl starch 130/0.4 with balanced crystalloid solution on mortality and kidney failure in patients with severe sepsis (6S-Scandinavian starch for severe sepsis/septic shock trial): study protocol, design and rationale fora double-blinded randomised clinical trial. Trials 12:24. doi:10.1186/1745-6215-12-24
9. Haase N, Wetterslev J, Winkel P, Perner A (2013) Bleeding and risk of death with hydroxyethyl starch in severe sepsis: post hoc analyses of a randomized clinical trial. Intensive Care Med 39:2126–2134. doi:10.1007/s00134-013-3111-9
10. Von Elm E, Altman DG, Egger M et al (2008) The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol 61:344–349. doi:10.1016/j.jclinepi.2007.11.008
11. Le Gall JR, Lemeshow S, Saulnier F (1993) A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. JAMA 270:2957–2963
12. Vincent JL, Moreno R, Takala J et al (1996) The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 22:707–710
13. Nates JL, Cárdenas-Turanzas M, Wakefield C et al (2010) Automating and simplifying the SOFA score in critically ill patients with cancer. Health Informatics J 16:35–47. doi:10.1177/1460458209353558
14. Coppell JA, Thalheimer U, Zambruni A et al (2006) The effects of unfractionated heparin, low molecular weight heparin and danaparoid on the thromboelastogram (TEG): an in vitro comparison of standard and heparinase-modified TEGs with conventional coagulation assays. Blood Coagul Fibrinolysis 17:97–104. doi:10.1097/01.mbc.0000203859.62739.25
15. Rizopoulos D (2012) Joint models for longitudinal and time-to-event data, 1st edn. Chapman & Hall/CRC Biostatistics Series, London
16. Gabriel SE, Normand S-LT (2012) Getting the methods right—the foundation of patient-centered outcomes research. N Engl J Med 367:787–790. doi:10.1056/NEJMp1207437
17. Schafer JL (1999) Multiple imputation: a primer. Stat Method Med Res 8:3–15
18. Gonano C, Sitzwohl C, Meitner E et al (2006) Four-day antithrombin therapy does not seem to attenuate hypercoagulability in patients suffering from sepsis. Crit Care 10:R160. doi:10.1186/cc5098
19. Daudel F, Kessler U, Folly H et al (2009) Thromboelastometry for the assessment of coagulation abnormalities in early and established adult sepsis: a prospective cohort study. Crit Care 13:R42. doi:10.1186/cc7765
20. Sivula M, Pettilä V, Niemi TT et al (2009) Thromboelastometry in patients with severe sepsis and disseminated intravascular coagulation. Blood Coagul Fibrinolysis 20:419–426. doi:10.1097/MBC.0b013e32832a76e1
21. Brenner T, Schmidt K, Delang M et al (2012) Viscoelastic and aggregometric point-of-care testing in patients with septic shock—cross-links between inflammation and haemostasis. Acta Anaesthesiol Scand 56:1277–1290. doi:10.1111/j.1399-6576.2012.02750.x
22. Adamzik M, Langemeier T, Frey UH et al (2011) Comparison of thrombelastometry with simplified acute physiology score II and sequential organ failure assessment scores for the prediction of 30-day survival: a cohort study. Shock 35:339–342. doi:10.1097/SHK.0b013e318204bff6
23. Massion PB, Peters P, Ledoux D et al (2012) Persistent hypocoagulability in patients with septic shock predicts greater hospital mortality: impact of impaired thrombin generation. Intensive Care Med 38:1326–1335. doi:10.1007/s00134-012-2620-2
24. Nates JL, Cattano D, Chelly JE, Doursout M-F (2014) Study of acute hemocoagulation changes in a porcine endotoxemic shock model using thrombelastography. Transl Res. doi:10.1016/j.trsl.2014.09.002
25. Hartog CS, Reuter D, Loesche W et al (2011) Influence of hydroxyethyl starch (HES) 130/0.4 on hemostasis as measured by viscoelastic device analysis: a systematic review. Intensive Care Med 37:1725–1737. doi:10.1007/s00134-011-2385-z
26. Mittermayr M, Streif W, Haas T et al (2007) Hemostatic changes after crystalloid or colloid fluid administration during major orthopedic surgery: the role of fibrinogen administration. Anesth Analg 105:905–917. doi:10.1213/01.ane.0000280481.18570.27
27. Fenger-Eriksen C, Jensen TM, Kristensen BS et al (2009) Fibrinogen substitution improves whole blood clot firmness after dilution with hydroxyethyl starch in bleeding patients undergoing radical cystectomy: a randomized, placebo-controlled clinical trial. J Thromb Haemost 7:795–802
28. Gluud C, Gluud LL (2005) Evidence based diagnostics. BMJ 330:724–726
29. Gluud C, Brok J, Gong Y, Koretz R (2007) Hepatology may have problems with putative surrogate outcome measures. J Hepatol 46:734–742
30. Afshari A, Wikkelsø A, Brok J et al (2011) Thrombelastography (TEG) or thromboelastometry (ROTEM) to monitor haemotherapy versus usual care in patients with massive transfusion. Cochrane Database Syst Rev 3:CD007871. doi:10.1002/14651858.CD007871.pub2