NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth

Nature Immunology

Volumn 18, Issue 5, 2017, Pages 541-551

  Chen, Liang ^a,b   Wilson, Justin E ^a,b   Koenigsknecht, Mark J ^c   Chou, Wei Chun ^a   Montgomery, Stephanie A ^a,b   Truax, Agnieszka D ^a,b   Brickey, W June ^a,b   Packey, Christopher D ^d   Maharshak, Nitsan ^e   Matsushima, Glenn K ^a   Plevy, Scott E ^f   Young, Vincent B ^c   Sartor, R Balfour ^a   Ting, Jenny P Y ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d Department of Medicine   (United States)

^e TEL AVIV UNIVERSITY   (Israel)

^f API Large Molecule Pharmaceutical Development and Manufacturing Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INFLAMMASOME; NLRP12 PROTEIN; RNA 16S; UNCLASSIFIED DRUG; DEXTRAN SULFATE; NLRP12 PROTEIN, MOUSE; SIGNAL PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GROWTH; BACTERIAL MICROBIOME; BACTERIUM ISOLATE; BONE MARROW DERIVED MACROPHAGE; COHORT ANALYSIS; COLITIS; COMMENSAL; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE EXACERBATION; DYSBIOSIS; EXPERIMENTAL COLITIS; EXPLANT; FECAL MICROBIOTA TRANSPLANTATION; FECES MICROFLORA; GENE SEQUENCE; GENETIC SUSCEPTIBILITY; HISTOPATHOLOGY; HOMEOSTASIS; HUMAN; IMMUNOBLOTTING; INTESTINE FLORA; LACHNOSPIRACEAE; MACROPHAGE; MICROBIAL DIVERSITY; MONOZYGOTIC TWINS; MOUSE; NONHUMAN; PRIORITY JOURNAL; ULCERATIVE COLITIS; WEIGHT REDUCTION; ANIMAL; BIODIVERSITY; C57BL MOUSE; CHEMICALLY INDUCED; CLOSTRIDIALES; COLON; FECES; FIRMICUTES; GENETICS; GENOTYPE ENVIRONMENT INTERACTION; IMMUNOLOGY; INNATE IMMUNITY; KNOCKOUT MOUSE; METABOLISM; MICROBIOLOGY; MICROFLORA; PHYSIOLOGY; SYMBIOSIS;

ANIMALS; BIODIVERSITY; CLOSTRIDIALES; COLITIS, ULCERATIVE; COLON; DEXTRAN SULFATE; FECES; FIRMICUTES; GENE-ENVIRONMENT INTERACTION; HUMANS; IMMUNITY, INNATE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROBIOTA; RNA, RIBOSOMAL, 16S; SYMBIOSIS; TWINS, MONOZYGOTIC;

EID: 85015041482     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3690     Document Type: Article

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