Rac1 pharmacological inhibition rescues human endothelial dysfunction

Journal of the American Heart Association

Volumn 6, Issue 3, 2017, Pages

  Carrizzo, Albino ^a   Vecchione, Carmine ^a,b   Damato, Antonio ^a   di Nonno, Flavio ^a   Ambrosio, Mariateresa ^a   Pompeo, Franco ^a   Cappello, Enrico ^a   Capocci, Luca ^a   Peruzzi, Mariangela ^c   Valenti, Valentina ^d   Biondi Zoccai, Giuseppe ^a,c   M Marullo, Antonino G ^c   Palmerio, Silvia ^c   Carnevale, Roberto ^c   Spinelli, Chiara C ^e   Puca, Annibale A ^b,e   Rubattu, Speranza ^a,c   Volpe, Massimo ^a,c   Sadoshima, Junichi ^f   Frati, Giacomo ^a,c   Sciarretta, Sebastiano ^a,c   more..

^a IRCCS NEUROMED   (Italy)

^b UNIVERSITY OF SALERNO   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^e IRCCS MULTIMEDICA   (Italy)

^f RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Cardiovascular disease; Endothelial dysfunction; Nitric oxide; Oxidative stress

Indexed keywords

4 AMINO 6 [2 [[4 (DIETHYLAMINO) 1 METHYLBUTYL]AMINO] 6 METHYL 4 PYRIMIDINYL] 2 METHYLQUINOLINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; AMINOQUINOLINE DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NOS3 PROTEIN, HUMAN; PYRIMIDINE DERIVATIVE; RAC1 PROTEIN, HUMAN;

ADULT; ARTICLE; BLOOD VESSEL REACTIVITY; COMPARATIVE STUDY; CONCENTRATION RESPONSE; DRUG MECHANISM; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM DEPENDENT VASORELAXATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EX VIVO STUDY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MIDDLE AGED; MOLECULAR DYNAMICS; OXIDATIVE STRESS; PHARMACOLOGICAL BLOCKING; SAPHENOUS VEIN; VASODILATATION; ADOLESCENT; AGED; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CHRONIC DISEASE; DRUG EFFECTS; FEMALE; IMMUNOBLOTTING; MALE; METABOLISM; PATHOPHYSIOLOGY; VASCULAR ENDOTHELIUM; VEIN INSUFFICIENCY; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AMINOQUINOLINES; CHRONIC DISEASE; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; IMMUNOBLOTTING; MALE; MIDDLE AGED; NADP; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; PYRIMIDINES; RAC1 GTP-BINDING PROTEIN; REACTIVE OXYGEN SPECIES; SAPHENOUS VEIN; VASODILATION; VENOUS INSUFFICIENCY; YOUNG ADULT;

EID: 85015029761     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.116.004746     Document Type: Article

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