MLKL activation triggers NLRP3-mediated processing and release of il-1β independently of gasdermin-d

Journal of Immunology

Volumn 198, Issue 5, 2017, Pages 2156-2164

  Gutierrez, Kimberley D ^a   Davis, Michael A ^a   Daniels, Brian P ^a   Olsen, Tayla M ^a   Ralli Jain, Pooja ^a   Tait, Stephen W G ^b   Gale, Michael ^a   Oberst, Andrew ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CRYOPYRIN; GASDERMIN D; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MEMBRANE PROTEIN; MIXED LINEAGE KINASE DOMAIN LIKE PROTEIN; POTASSIUM; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG; GSDMD PROTEIN, HUMAN; MLKL PROTEIN, HUMAN; PROTEIN KINASE; TUMOR NECROSIS FACTOR; TUMOR PROTEIN;

ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; EMBRYO; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MEMBRANE DAMAGE; MONOCYTE; NECROPTOSIS; POTASSIUM TRANSPORT; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN PROCESSING; APOPTOSIS; CELL LINE; CELL MEMBRANE; HOMEOSTASIS; METABOLISM; NECROSIS; PHYSIOLOGY; SIGNAL TRANSDUCTION;

APOPTOSIS; CELL LINE; CELL MEMBRANE; HOMEOSTASIS; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; MONOCYTES; NECROSIS; NEOPLASM PROTEINS; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; POTASSIUM; PROTEIN KINASES; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 85014931414     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1601757     Document Type: Article

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