메뉴 건너뛰기




Volumn 54, Issue , 2017, Pages 307-320

Copper sulfide nanoparticle-based localized drug delivery system as an effective cancer synergistic treatment and theranostic platform

Author keywords

Combination therapy; Diffusion molecular retention; Hollow mesoporous CuS; Localized delivery; Tumor targeted

Indexed keywords

CELLS; CONTROLLED DRUG DELIVERY; CYTOLOGY; DIFFUSION; DISEASES; INFRARED DEVICES; MOLECULAR BIOLOGY; NANOPARTICLES; PHOTOACOUSTIC EFFECT; PHOTODYNAMIC THERAPY; SULFUR COMPOUNDS; TARGETED DRUG DELIVERY; TUMORS;

EID: 85014846588     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2017.03.005     Document Type: Article
Times cited : (106)

References (40)
  • 1
    • 84896690540 scopus 로고    scopus 로고
    • Osteosarcoma treatment – Where do we stand? A state of the art review
    • [1] Luetke, A., Meyers, P.A., Lewis, I., Juergens, H., Osteosarcoma treatment – Where do we stand? A state of the art review. Cancer Treat. Rev. 40 (2014), 523–532.
    • (2014) Cancer Treat. Rev. , vol.40 , pp. 523-532
    • Luetke, A.1    Meyers, P.A.2    Lewis, I.3    Juergens, H.4
  • 2
    • 84950157408 scopus 로고    scopus 로고
    • Localized co-delivery of doxorubicin, cisplatin, and methotrexate by thermosensitive hydrogels for enhanced osteosarcoma treatment
    • [2] Ma, H.C., He, C.L., Cheng, Y.L., Yang, Z.M., Zang, J.T., Liu, J.G., Chen, X.S., Localized co-delivery of doxorubicin, cisplatin, and methotrexate by thermosensitive hydrogels for enhanced osteosarcoma treatment. ACS Appl. Mater. Inter. 7 (2015), 27040–27048.
    • (2015) ACS Appl. Mater. Inter. , vol.7 , pp. 27040-27048
    • Ma, H.C.1    He, C.L.2    Cheng, Y.L.3    Yang, Z.M.4    Zang, J.T.5    Liu, J.G.6    Chen, X.S.7
  • 3
    • 84890253473 scopus 로고    scopus 로고
    • Novel thermo-sensitive hydrogel system with paclitaxel nanocrystals: high drug-loading, sustained drug release and extended local retention guaranteeing better efficacy and lower toxicity
    • [3] Lin, Z.Q., Gao, W., Hu, H.X., Ma, K., He, B., Dai, W.B., Wang, X.Q., Wang, J.C., Zhang, X., Zhang, Q., Novel thermo-sensitive hydrogel system with paclitaxel nanocrystals: high drug-loading, sustained drug release and extended local retention guaranteeing better efficacy and lower toxicity. J. Control. Release 174 (2014), 161–170.
    • (2014) J. Control. Release , vol.174 , pp. 161-170
    • Lin, Z.Q.1    Gao, W.2    Hu, H.X.3    Ma, K.4    He, B.5    Dai, W.B.6    Wang, X.Q.7    Wang, J.C.8    Zhang, X.9    Zhang, Q.10
  • 4
    • 79955521271 scopus 로고    scopus 로고
    • In vivo efficacy of an intratumorally injected in situ-forming doxorubicin/poly(ethylene glycol)-b-polycaprolactone diblock copolymer
    • [4] Kang, Y.M., Kim, G.H., Il Kim, J., Kim, D.Y., Lee, B.N., Yoon, S.M., Kim, J.H., Kim, M.S., In vivo efficacy of an intratumorally injected in situ-forming doxorubicin/poly(ethylene glycol)-b-polycaprolactone diblock copolymer. Biomaterials 32 (2011), 4556–4564.
    • (2011) Biomaterials , vol.32 , pp. 4556-4564
    • Kang, Y.M.1    Kim, G.H.2    Il Kim, J.3    Kim, D.Y.4    Lee, B.N.5    Yoon, S.M.6    Kim, J.H.7    Kim, M.S.8
  • 5
    • 84887134441 scopus 로고    scopus 로고
    • Poly(ethylene glycol)–poly(lactic-co-glycolic acid) based thermosensitive injectable hydrogels for biomedical applications
    • [5] Alexander, A., Ajazuddin, Khan, J., Saraf, S., Saraf, S., Poly(ethylene glycol)–poly(lactic-co-glycolic acid) based thermosensitive injectable hydrogels for biomedical applications. J. Control. Release 172 (2013), 715–729.
    • (2013) J. Control. Release , vol.172 , pp. 715-729
    • Alexander, A.1    Ajazuddin2    Khan, J.3    Saraf, S.4    Saraf, S.5
  • 6
    • 84923264006 scopus 로고    scopus 로고
    • An injectable, thermosensitive and multicompartment hydrogel for simultaneous encapsulation and independent release of a drug cocktail as an effective combination therapy platform
    • [6] Wang, W.W., Song, H.J., Zhang, J., Li, P., Li, C., Wang, C., Kong, D.L., Zhang, Q., An injectable, thermosensitive and multicompartment hydrogel for simultaneous encapsulation and independent release of a drug cocktail as an effective combination therapy platform. J. Control. Release 203 (2015), 57–66.
    • (2015) J. Control. Release , vol.203 , pp. 57-66
    • Wang, W.W.1    Song, H.J.2    Zhang, J.3    Li, P.4    Li, C.5    Wang, C.6    Kong, D.L.7    Zhang, Q.8
  • 7
    • 84876515823 scopus 로고    scopus 로고
    • A reconstituted “two into one” thermosensitive hydrogel system assembled by drug-loaded amphiphilic copolymer nanoparticles for the local delivery of paclitaxel
    • [7] Wang, W.W., Deng, L.D., Xu, S.X., Zhao, X.M., Lv, N., Zhang, G.X., Gu, N., Hu, R.J., Zhang, J.H., Liu, J.J., Dong, A.J., A reconstituted “two into one” thermosensitive hydrogel system assembled by drug-loaded amphiphilic copolymer nanoparticles for the local delivery of paclitaxel. J. Mater. Chem. B 1 (2013), 552–563.
    • (2013) J. Mater. Chem. B , vol.1 , pp. 552-563
    • Wang, W.W.1    Deng, L.D.2    Xu, S.X.3    Zhao, X.M.4    Lv, N.5    Zhang, G.X.6    Gu, N.7    Hu, R.J.8    Zhang, J.H.9    Liu, J.J.10    Dong, A.J.11
  • 8
    • 79251483489 scopus 로고    scopus 로고
    • Thermoreversible Pluronic (R) F127-based hydrogel containing liposomes for the controlled delivery of paclitaxel: in vitro drug release, cell cytotoxicity, and uptake studies
    • [8] Nie, S.F., Hsiao, W.L.W., Pan, W.S., Yang, Z.J., Thermoreversible Pluronic (R) F127-based hydrogel containing liposomes for the controlled delivery of paclitaxel: in vitro drug release, cell cytotoxicity, and uptake studies. Int. J. Nanomed. 6 (2011), 151–166.
    • (2011) Int. J. Nanomed. , vol.6 , pp. 151-166
    • Nie, S.F.1    Hsiao, W.L.W.2    Pan, W.S.3    Yang, Z.J.4
  • 12
    • 84882672543 scopus 로고    scopus 로고
    • Hydrophobic anticancer drug delivery by a 980 nm laser-driven photothermal vehicle for efficient synergistic therapy of cancer cells in vivo
    • [12] Dong, K., Liu, Z., Li, Z.H., Ren, J.S., Qu, X.G., Hydrophobic anticancer drug delivery by a 980 nm laser-driven photothermal vehicle for efficient synergistic therapy of cancer cells in vivo. Adv. Mater. 25 (2013), 4452–4458.
    • (2013) Adv. Mater. , vol.25 , pp. 4452-4458
    • Dong, K.1    Liu, Z.2    Li, Z.H.3    Ren, J.S.4    Qu, X.G.5
  • 13
    • 84865586016 scopus 로고    scopus 로고
    • Copper sulfide nanoparticles as a new class of photoacoustic contrast agent for deep tissue imaging at 1064 nm
    • [13] Ku, G., Zhou, M., Song, S.L., Huang, Q., Hazle, J., Li, C., Copper sulfide nanoparticles as a new class of photoacoustic contrast agent for deep tissue imaging at 1064 nm. ACS Nano 6 (2012), 7489–7496.
    • (2012) ACS Nano , vol.6 , pp. 7489-7496
    • Ku, G.1    Zhou, M.2    Song, S.L.3    Huang, Q.4    Hazle, J.5    Li, C.6
  • 14
    • 84964608286 scopus 로고    scopus 로고
    • Tumor-targeted and multi-stimuli responsive drug delivery system for near-infrared light induced chemo-phototherapy and photoacoustic tomography
    • [14] Feng, Q., Zhang, Y., Zhang, W., Shan, X., Yuan, Y., Zhang, H., Hou, L., Zhang, Z., Tumor-targeted and multi-stimuli responsive drug delivery system for near-infrared light induced chemo-phototherapy and photoacoustic tomography. Acta Biomater. 38 (2016), 129–142.
    • (2016) Acta Biomater. , vol.38 , pp. 129-142
    • Feng, Q.1    Zhang, Y.2    Zhang, W.3    Shan, X.4    Yuan, Y.5    Zhang, H.6    Hou, L.7    Zhang, Z.8
  • 15
    • 84923392368 scopus 로고    scopus 로고
    • Plasmonic copper sulfide nanocrystals exhibiting near-infrared photothermal and photodynamic therapeutic effects
    • [15] Wang, S.H., Riedinger, A., Li, H.B., Fu, C.H., Liu, H.Y., Li, L.L., Liu, T.L., Tan, L.F., Barthel, M.J., Pugliese, G., Plasmonic copper sulfide nanocrystals exhibiting near-infrared photothermal and photodynamic therapeutic effects. ACS Nano 9 (2015), 1788–1800.
    • (2015) ACS Nano , vol.9 , pp. 1788-1800
    • Wang, S.H.1    Riedinger, A.2    Li, H.B.3    Fu, C.H.4    Liu, H.Y.5    Li, L.L.6    Liu, T.L.7    Tan, L.F.8    Barthel, M.J.9    Pugliese, G.10
  • 16
    • 84899798970 scopus 로고    scopus 로고
    • New materials for tunable plasmonic colloidal nanocrystals
    • [16] Comin, A., Manna, L., New materials for tunable plasmonic colloidal nanocrystals. Chem. Soc. Rev. 43 (2014), 3957–3975.
    • (2014) Chem. Soc. Rev. , vol.43 , pp. 3957-3975
    • Comin, A.1    Manna, L.2
  • 17
    • 84929469605 scopus 로고    scopus 로고
    • Engineering hollow mesoporous silica nanocontainers with molecular switches for continuous self-healing anticorrosion coating
    • [17] Chen, T., Chen, R.P., Jin, Z., Liu, J., Engineering hollow mesoporous silica nanocontainers with molecular switches for continuous self-healing anticorrosion coating. J. Mater. Chem. A 3 (2015), 9510–9516.
    • (2015) J. Mater. Chem. A , vol.3 , pp. 9510-9516
    • Chen, T.1    Chen, R.P.2    Jin, Z.3    Liu, J.4
  • 18
    • 58149314198 scopus 로고    scopus 로고
    • In vitro cancer cell imaging and therapy using transferrin-conjugated gold nanoparticles
    • [18] Li, J.L., Wang, L., Liu, X.Y., Zhang, Z.P., Guo, H.C., Liu, W.M., Tang, S.H., In vitro cancer cell imaging and therapy using transferrin-conjugated gold nanoparticles. Cancer Lett. 274 (2009), 319–326.
    • (2009) Cancer Lett. , vol.274 , pp. 319-326
    • Li, J.L.1    Wang, L.2    Liu, X.Y.3    Zhang, Z.P.4    Guo, H.C.5    Liu, W.M.6    Tang, S.H.7
  • 19
    • 84899936214 scopus 로고    scopus 로고
    • Enhanced delivery of artemisinin and its analogues to cancer cells by their adducts with human serum transferrin
    • [19] Yang, Y., Zhang, X.M., Wang, X.F., Zhao, X.M., Ren, T.R., Wang, F., Yu, B., Enhanced delivery of artemisinin and its analogues to cancer cells by their adducts with human serum transferrin. Int. J. Pharmaceut. 467 (2014), 113–122.
    • (2014) Int. J. Pharmaceut. , vol.467 , pp. 113-122
    • Yang, Y.1    Zhang, X.M.2    Wang, X.F.3    Zhao, X.M.4    Ren, T.R.5    Wang, F.6    Yu, B.7
  • 20
    • 57749092893 scopus 로고    scopus 로고
    • Synthesis and anti-cancer activity of covalent conjugates of artemisinin and a transferrin-receptor targeting peptide
    • [20] Oh, S., Kim, B.J., Singh, N.P., Lai, H., Sasaki, T., Synthesis and anti-cancer activity of covalent conjugates of artemisinin and a transferrin-receptor targeting peptide. Cancer Lett. 274 (2009), 33–39.
    • (2009) Cancer Lett. , vol.274 , pp. 33-39
    • Oh, S.1    Kim, B.J.2    Singh, N.P.3    Lai, H.4    Sasaki, T.5
  • 21
    • 84922250132 scopus 로고    scopus 로고
    • Transferrin-mediated fullerenes nanoparticles as Fe2+-dependent drug vehicles for synergistic anti-tumor efficacy
    • [21] Zhang, H.J., Hou, L., Jiao, X.J., Ji, Y.D., Zhu, X.L., Zhang, Z.Z., Transferrin-mediated fullerenes nanoparticles as Fe2+-dependent drug vehicles for synergistic anti-tumor efficacy. Biomaterials 37 (2015), 353–366.
    • (2015) Biomaterials , vol.37 , pp. 353-366
    • Zhang, H.J.1    Hou, L.2    Jiao, X.J.3    Ji, Y.D.4    Zhu, X.L.5    Zhang, Z.Z.6
  • 22
    • 84929155744 scopus 로고    scopus 로고
    • Ultrasmall Cu2-xS nanodots for highly efficient photoacoustic imaging-guided photothermal therapy
    • [22] Mou, J., Li, P., Liu, C.B., Xu, H.X., Song, L., Wang, J., Zhang, K., Chen, Y., Shi, J.L., Chen, H.R., Ultrasmall Cu2-xS nanodots for highly efficient photoacoustic imaging-guided photothermal therapy. Small 11 (2015), 2275–2283.
    • (2015) Small , vol.11 , pp. 2275-2283
    • Mou, J.1    Li, P.2    Liu, C.B.3    Xu, H.X.4    Song, L.5    Wang, J.6    Zhang, K.7    Chen, Y.8    Shi, J.L.9    Chen, H.R.10
  • 23
    • 84900440280 scopus 로고    scopus 로고
    • Heavily-doped colloidal semiconductor and metal oxide nanocrystals: an emerging new class of plasmonic nanomaterials
    • [23] Liu, X., Swihart, M.T., Heavily-doped colloidal semiconductor and metal oxide nanocrystals: an emerging new class of plasmonic nanomaterials. Chem. Soc. Rev. 43 (2014), 3908–3920.
    • (2014) Chem. Soc. Rev. , vol.43 , pp. 3908-3920
    • Liu, X.1    Swihart, M.T.2
  • 24
    • 84864697596 scopus 로고    scopus 로고
    • Hyaluronic acid-based hydrogel for regional delivery of paclitaxel to intraperitoneal tumors (vol 158, pg 386, 2012)
    • [24] Bajaj, G., Yeo, Y., Hyaluronic acid-based hydrogel for regional delivery of paclitaxel to intraperitoneal tumors (vol 158, pg 386, 2012). J. Control. Release, 162, 2012, 257.
    • (2012) J. Control. Release , vol.162 , pp. 257
    • Bajaj, G.1    Yeo, Y.2
  • 26
    • 84921512162 scopus 로고    scopus 로고
    • Copper sulfide nanoparticles with phospholipid-PEG coating for in vivo near-infrared photothermal cancer therapy
    • [26] Huang, Y.Z., Lai, Y.L., Shi, S.G., Hao, S.F., Wei, J.P., Chen, X.L., Copper sulfide nanoparticles with phospholipid-PEG coating for in vivo near-infrared photothermal cancer therapy. Chem-Asian J. 10 (2015), 370–376.
    • (2015) Chem-Asian J. , vol.10 , pp. 370-376
    • Huang, Y.Z.1    Lai, Y.L.2    Shi, S.G.3    Hao, S.F.4    Wei, J.P.5    Chen, X.L.6
  • 27
    • 84875260534 scopus 로고    scopus 로고
    • The use of polyethylenimine-modified graphene oxide as a nanocarrier for transferring hydrophobic nanocrystals into water to produce water-dispersible hybrids for use in drug delivery
    • [27] Yan, L., Chang, Y.-N., Zhao, L., Gu, Z., Liu, X., Tian, G., Zhou, L., Ren, W., Jin, S., Yin, W., The use of polyethylenimine-modified graphene oxide as a nanocarrier for transferring hydrophobic nanocrystals into water to produce water-dispersible hybrids for use in drug delivery. Carbon 57 (2013), 120–129.
    • (2013) Carbon , vol.57 , pp. 120-129
    • Yan, L.1    Chang, Y.-N.2    Zhao, L.3    Gu, Z.4    Liu, X.5    Tian, G.6    Zhou, L.7    Ren, W.8    Jin, S.9    Yin, W.10
  • 28
    • 84888428832 scopus 로고    scopus 로고
    • Nanoparticle-directed sub-cellular localization of doxorubicin and the sensitization breast cancer cells by circumventing GST-mediated drug resistance
    • [28] Zeng, X., Morgenstern, R., Nystrom, A.M., Nanoparticle-directed sub-cellular localization of doxorubicin and the sensitization breast cancer cells by circumventing GST-mediated drug resistance. Biomaterials 35 (2014), 1227–1239.
    • (2014) Biomaterials , vol.35 , pp. 1227-1239
    • Zeng, X.1    Morgenstern, R.2    Nystrom, A.M.3
  • 29
    • 84893574648 scopus 로고    scopus 로고
    • Visualization of protease activity in vivo using an activatable photo-acoustic imaging probe based on CuS nanoparticles
    • [29] Yang, K., Zhu, L., Nie, L., Sun, X., Cheng, L., Wu, C., Niu, G., Chen, X., Liu, Z., Visualization of protease activity in vivo using an activatable photo-acoustic imaging probe based on CuS nanoparticles. Theranostics 4 (2014), 134–141.
    • (2014) Theranostics , vol.4 , pp. 134-141
    • Yang, K.1    Zhu, L.2    Nie, L.3    Sun, X.4    Cheng, L.5    Wu, C.6    Niu, G.7    Chen, X.8    Liu, Z.9
  • 30
    • 84855554316 scopus 로고    scopus 로고
    • Antitumor activity of artemisinin and its derivatives: from a well-known antimalarial agent to a potential anticancer drug
    • [30] Crespo-Ortiz, M.P., Wei, M.Q., Antitumor activity of artemisinin and its derivatives: from a well-known antimalarial agent to a potential anticancer drug. J. Biomed. Biotechnol., 2012, 2012, 247597.
    • (2012) J. Biomed. Biotechnol. , vol.2012 , pp. 247597
    • Crespo-Ortiz, M.P.1    Wei, M.Q.2
  • 31
    • 58149316208 scopus 로고    scopus 로고
    • Transferrin receptor-dependent cytotoxicity of artemisinin-transferrin conjugates on prostate cancer cells and induction of apoptosis
    • [31] Nakase, I., Gallis, B., Takatani-Nakase, T., Oh, S., Lacoste, E., Singh, N.P., Goodlett, D.R., Tanaka, S., Futaki, S., Lai, H., Transferrin receptor-dependent cytotoxicity of artemisinin-transferrin conjugates on prostate cancer cells and induction of apoptosis. Cancer Lett. 274 (2009), 290–298.
    • (2009) Cancer Lett. , vol.274 , pp. 290-298
    • Nakase, I.1    Gallis, B.2    Takatani-Nakase, T.3    Oh, S.4    Lacoste, E.5    Singh, N.P.6    Goodlett, D.R.7    Tanaka, S.8    Futaki, S.9    Lai, H.10
  • 32
    • 84865009936 scopus 로고    scopus 로고
    • Dihydroartemisinin exerts its anticancer activity through depleting cellular iron via transferrin receptor-1
    • [32] Ba, Q., Zhou, N., Duan, J., Chen, T., Hao, M., Yang, X., Li, J., Yin, J., Chu, R., Wang, H., Dihydroartemisinin exerts its anticancer activity through depleting cellular iron via transferrin receptor-1. PLoS ONE, 7, 2012, e42703.
    • (2012) PLoS ONE , vol.7 , pp. e42703
    • Ba, Q.1    Zhou, N.2    Duan, J.3    Chen, T.4    Hao, M.5    Yang, X.6    Li, J.7    Yin, J.8    Chu, R.9    Wang, H.10
  • 33
    • 0036180668 scopus 로고    scopus 로고
    • Deoxyartemisinin derivatives from photooxygenation of anhydrodeoxydihydroartemisinin and their cytotoxic evaluation
    • [33] Galal, A.M., Ross, S.A., ElSohly, M.A., ElSohly, H.N., El-Feraly, F.S., Ahmed, M.S., McPhail, A.T., Deoxyartemisinin derivatives from photooxygenation of anhydrodeoxydihydroartemisinin and their cytotoxic evaluation. J. Nat. Prod. 65 (2002), 184–188.
    • (2002) J. Nat. Prod. , vol.65 , pp. 184-188
    • Galal, A.M.1    Ross, S.A.2    ElSohly, M.A.3    ElSohly, H.N.4    El-Feraly, F.S.5    Ahmed, M.S.6    McPhail, A.T.7
  • 34
    • 11844269839 scopus 로고    scopus 로고
    • Effects of artemisinin-tagged holotransferrin on cancer cells
    • [34] Lai, H., Sasaki, T., Singh, N.P., Messay, A., Effects of artemisinin-tagged holotransferrin on cancer cells. Life Sci. 76 (2005), 1267–1279.
    • (2005) Life Sci. , vol.76 , pp. 1267-1279
    • Lai, H.1    Sasaki, T.2    Singh, N.P.3    Messay, A.4
  • 35
    • 79953194472 scopus 로고    scopus 로고
    • Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production
    • [35] Hamacher-Brady, A., Stein, H.A., Turschner, S., Toegel, I., Mora, R., Jennewein, N., Efferth, T., Eils, R., Brady, N.R., Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production. J. Biol. Chem. 286 (2011), 6587–6601.
    • (2011) J. Biol. Chem. , vol.286 , pp. 6587-6601
    • Hamacher-Brady, A.1    Stein, H.A.2    Turschner, S.3    Toegel, I.4    Mora, R.5    Jennewein, N.6    Efferth, T.7    Eils, R.8    Brady, N.R.9
  • 36
    • 78651404852 scopus 로고    scopus 로고
    • The role of heme and the mitochondrion in the chemical and molecular mechanisms of mammalian cell death induced by the artemisinin antimalarials
    • [36] Mercer, A.E., Copple, I.M., Maggs, J.L., O'Neill, P.M., Park, B.K., The role of heme and the mitochondrion in the chemical and molecular mechanisms of mammalian cell death induced by the artemisinin antimalarials. J. Biol. Chem. 286 (2011), 987–996.
    • (2011) J. Biol. Chem. , vol.286 , pp. 987-996
    • Mercer, A.E.1    Copple, I.M.2    Maggs, J.L.3    O'Neill, P.M.4    Park, B.K.5
  • 37
    • 38949108587 scopus 로고    scopus 로고
    • Recent developments in taxane drug delivery
    • [37] Safavy, A., Recent developments in taxane drug delivery. Curr. Drug Deliv. 5 (2008), 42–54.
    • (2008) Curr. Drug Deliv. , vol.5 , pp. 42-54
    • Safavy, A.1
  • 38
    • 79960925147 scopus 로고    scopus 로고
    • Targeted drug delivery to tumors: myths, reality and possibility
    • [38] Bae, Y.H., Park, K., Targeted drug delivery to tumors: myths, reality and possibility. J. Control. Release 153 (2011), 198–205.
    • (2011) J. Control. Release , vol.153 , pp. 198-205
    • Bae, Y.H.1    Park, K.2
  • 40
    • 84860921054 scopus 로고    scopus 로고
    • Pharmacokinetics of a paclitaxel-loaded low molecular weight heparin-all-trans-retinoid acid conjugate ternary nanoparticulate drug delivery system
    • [40] Hou, L., Yao, J., Zhou, J., Zhang, Q., Pharmacokinetics of a paclitaxel-loaded low molecular weight heparin-all-trans-retinoid acid conjugate ternary nanoparticulate drug delivery system. Biomaterials 33 (2012), 5431–5440.
    • (2012) Biomaterials , vol.33 , pp. 5431-5440
    • Hou, L.1    Yao, J.2    Zhou, J.3    Zhang, Q.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.