An injectable, thermosensitive and multicompartment hydrogel for simultaneous encapsulation and independent release of a drug cocktail as an effective combination therapy platform

Journal of Controlled Release

Volumn 203, Issue , 2015, Pages 57-66

  Wang, Weiwei ^a   Song, Huijuan ^a   Zhang, Ju ^b   Li, Pan ^a   Li, Chen ^a   Wang, Chun ^a   Kong, Deling ^a   Zhao, Qiang ^b  

^a INSTITUTE OF BIOMEDICAL ENGINEERING   (China)

^b NANKAI UNIVERSITY   (China)

Author keywords

Combination therapy; Doxorubicin; Multicompartment release system; Paclitaxel; Thermosensitive hydrogel

Indexed keywords

BEHAVIORAL RESEARCH; CHEMOTHERAPY; DRUG DOSAGE; DRUG INTERACTIONS; DRUG PRODUCTS; ENERGY TRANSFER; FLUORESCENCE; HYDROGELS; NANOPARTICLES;

COMBINATION THERAPY; DOXORUBICIN; MULTICOMPARTMENT RELEASE SYSTEM; PACLITAXEL; THERMO-SENSITIVE HYDROGEL;

DRUG THERAPY;

2 (PERFLUOROBUTYL) ETHYL METHACRYLATE; DOXORUBICIN; FLUOROCARBON; HYDROCARBON; METHOXY POLY(ETHYLENE GLYCOL); NANOCOATING; NANOPARTICLE; PACLITAXEL; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; DELAYED RELEASE FORMULATION; FLUORINATED HYDROCARBON; HYDROGEL; MACROGOL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST ADENOCARCINOMA; CANCER CELL CULTURE; CANCER COMBINATION CHEMOTHERAPY; CANCER GROWTH; CANCER INHIBITION; CANCER REGRESSION; CANCER SIZE; CANCER SURVIVAL; CHEMICAL STRUCTURE; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CROSS LINKING; DEGRADATION; FEMALE; FLUORESCENCE RESONANCE ENERGY TRANSFER; HEAT SENSITIVITY; HUMAN; HUMAN CELL; HYDROGEL; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; MCF 7 CELL LINE; MOLECULAR WEIGHT; MOUSE; MULTICOMPARTMENT HYDROGEL; NANOENCAPSULATION; NONHUMAN; PARTICLE SIZE; PATIENT COMPLIANCE; PRIORITY JOURNAL; SURFACE PROPERTY; SUSTAINED DRUG RELEASE; TRANSITION TEMPERATURE; TREATMENT OUTCOME; TREATMENT RESPONSE; TUMOR CELL INOCULATION; WEIGHT CHANGE; ANIMAL; BAGG ALBINO MOUSE; BREAST; BREAST NEOPLASMS; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG EFFECTS; INJECTION; NUDE MOUSE; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BREAST; BREAST NEOPLASMS; CELL LINE, TUMOR; DELAYED-ACTION PREPARATIONS; DOXORUBICIN; FEMALE; HUMANS; HYDROCARBONS, FLUORINATED; HYDROGEL; INJECTIONS; MICE, INBRED BALB C; MICE, NUDE; NANOPARTICLES; PACLITAXEL; POLYETHYLENE GLYCOLS;

EID: 84923264006     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.02.015     Document Type: Article

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