Synthesis, debugging, and effects of synthetic chromosome consolidation: synVI and beyond

Science

Volumn 355, Issue 6329, 2017, Pages

  Mitchell, Leslie A ^a   Wang, Ann ^b,c   Stracquadanio, Giovanni ^b,d   Kuang, Zheng ^a   Wang, Xuya ^a   Yang, Kun ^b   Richardson, Sarah ^b   Martin, J Andrew ^a   Zhao, Yu ^a   Walker, Roy ^e   Luo, Yisha ^e   Dai, Hongjiu ^f   Dong, Kang ^f   Tang, Zuojian ^a   Yang, Yanling ^a   Cai, Yizhi ^e   Heguy, Adriana ^a   Ueberheide, Beatrix ^a   Fenyö, David ^a   Dai, Junbiao ^c   Bader, Joel S ^b,c   Boeke, Jef D ^a   more..

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c TSINGHUA UNIVERSITY   (China)

^d UNIVERSITY OF ESSEX   (United Kingdom)

^e UNIVERSITY OF EDINBURGH   (United Kingdom)

^f GenScript Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN; PROTEIN PRE4; PROTEOME; TRANSCRIPTOME; TRANSFER RNA; UNCLASSIFIED DRUG; PRE4 PROTEIN, S CEREVISIAE; PROTEASOME; SACCHAROMYCES CEREVISIAE PROTEIN;

CHROMOSOME; EUKARYOTE; GENE EXPRESSION; GENETIC ANALYSIS; GENOME; PHENOTYPE; PROTEOMICS;

ARTICLE; AUXOTROPHY; CHROMOSOME; CODON; CONTROLLED STUDY; ENDOREDUPLICATION; FUNGAL STRAIN; GENE INTERACTION; GENE MUTATION; NONHUMAN; OPEN READING FRAME; PHENOTYPE; PRIORITY JOURNAL; PROTEOMICS; SUPPRESSOR GENE; SYNTHETIC CHROMOSOME VI; TRANSCRIPTION INITIATION; TRANSCRIPTOMICS; YEAST; ARTIFICIAL CELL; CHEMISTRY; CHROMOSOMAL MAPPING; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; PROCEDURES; SACCHAROMYCES CEREVISIAE; SYNTHETIC BIOLOGY; YEAST ARTIFICIAL CHROMOSOME;

EUKARYOTA;

ARTIFICIAL CELLS; CHROMOSOMES, ARTIFICIAL, YEAST; PHYSICAL CHROMOSOME MAPPING; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOMICS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SYNTHETIC BIOLOGY;

EID: 85014834845     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaf4831     Document Type: Article

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