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Volumn 10, Issue , 2017, Pages 1155-1164

Update on the role of trabectedin in the treatment of intractable soft tissue sarcomas

Author keywords

Chemotherapy; Histotypes; L sarcomas; Non L sarcomas; Soft tissue sarcoma

Indexed keywords

AMINOTRANSFERASE; ANTHRACYCLINE; DACARBAZINE; DOCETAXEL; DOXORUBICIN; ERIBULIN; GEMCITABINE; IFOSFAMIDE; OLAPARIB; OLARATUMAB; PAZOPANIB; TRABECTEDIN;

EID: 85014789214     PISSN: None     EISSN: 11786930     Source Type: Journal    
DOI: 10.2147/OTT.S127955     Document Type: Review
Times cited : (29)

References (72)
  • 2
    • 84889658911 scopus 로고    scopus 로고
    • The evolving classification of soft tissue tumours – an update based on the new 2013 WHO classification
    • Fletcher CD. The evolving classification of soft tissue tumours – an update based on the new 2013 WHO classification. Histopathology. 2014;64(1):2–11.
    • (2014) Histopathology , vol.64 , Issue.1 , pp. 2-11
    • Fletcher, C.D.1
  • 3
    • 84961160296 scopus 로고    scopus 로고
    • Trabectedin and the L-Sarcomas: A decade-long odyssey
    • Schwartz GK. Trabectedin and the L-Sarcomas: a decade-long odyssey. J Clin Oncol. 2016;34(8):769–771.
    • (2016) J Clin Oncol , vol.34 , Issue.8 , pp. 769-771
    • Schwartz, G.K.1
  • 4
    • 79961076378 scopus 로고    scopus 로고
    • Incidence of sarcoma histotypes and molecular subtypes in a prospective epidemiological study with central pathology review and molecular testing
    • Ducimetière F, Lurkin A, Ranchère-Vince D, et al. Incidence of sarcoma histotypes and molecular subtypes in a prospective epidemiological study with central pathology review and molecular testing. PLoS One. 2011;6(8):e20294.
    • (2011) Plos One , vol.6 , Issue.8
    • Ducimetière, F.1    Lurkin, A.2    Ranchère-Vince, D.3
  • 5
    • 84911472747 scopus 로고    scopus 로고
    • Soft tissue and visceral sarcomas: ESMO clinical practice guidelines for diagnosis, treatment and follow-up
    • The ESMO/European Sarcoma Network Working Group. Soft tissue and visceral sarcomas: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2014;25(Suppl 3):iii102–iii112.
    • (2014) Ann Oncol , vol.25 , pp. iii102-iii112
  • 6
    • 84969256021 scopus 로고    scopus 로고
    • Preoperative or postoperative radiotherapy versus surgery alone for retroperitoneal sarcoma: A case-control, propensity score-matched analysis of a nationwide clinical oncology database
    • Nussbaum DP, Rushing CN, Lane WO, et al. Preoperative or postoperative radiotherapy versus surgery alone for retroperitoneal sarcoma: a case-control, propensity score-matched analysis of a nationwide clinical oncology database. Lancet Oncol. 2016;17(7):966–975.
    • (2016) Lancet Oncol , vol.17 , Issue.7 , pp. 966-975
    • Nussbaum, D.P.1    Rushing, C.N.2    Lane, W.O.3
  • 7
    • 84867850606 scopus 로고    scopus 로고
    • Incidence of soft tissue sarcoma and beyond: A population-based prospective study in 3 European regions
    • Mastrangelo G, Coindre JM, Ducimetière F, et al. Incidence of soft tissue sarcoma and beyond: a population-based prospective study in 3 European regions. Cancer. 2012;118(6):5339–5348.
    • (2012) Cancer , vol.118 , Issue.6 , pp. 5339-5348
    • Mastrangelo, G.1    Coindre, J.M.2    Ducimetière, F.3
  • 8
    • 84897031194 scopus 로고    scopus 로고
    • Doxorubicin alone versus intensified doxorubicin plus ifosfamide for first-line treatment of advanced or metastatic soft-tissue sarcoma: A randomised controlled phase 3 trial
    • Judson I, Verweij J, Gelderblom H, et al. Doxorubicin alone versus intensified doxorubicin plus ifosfamide for first-line treatment of advanced or metastatic soft-tissue sarcoma: a randomised controlled phase 3 trial. Lancet Oncol. 2014;15:415–423.
    • (2014) Lancet Oncol , vol.15 , pp. 415-423
    • Judson, I.1    Verweij, J.2    Gelderblom, H.3
  • 9
    • 79959300987 scopus 로고    scopus 로고
    • Spanish Group for Research on Sarcomas. Randomized phase II study comparing gemcitabine plus dacarbazine versus dacarbazine alone in patients with previously treated soft tissue sarcoma: A Spanish group for research on sarcomas study
    • García-Del-Muro X, López-Pousa A, Maurel J, et al; Spanish Group for Research on Sarcomas. Randomized phase II study comparing gemcitabine plus dacarbazine versus dacarbazine alone in patients with previously treated soft tissue sarcoma: a Spanish group for research on sarcomas study. J Clin Oncol. 2011;29:2528–2533.
    • (2011) J Clin Oncol , vol.29 , pp. 2528-2533
    • García-Del-Muro, X.1    López-Pousa, A.2    Maurel, J.3
  • 10
    • 0029001008 scopus 로고
    • High-dose ifosfamide: Circumvention of resistance to standard-dose ifosfamide in advanced soft tissue sarcomas
    • Le Cesne A, Antoine E, Spielmann M, et al. High-dose ifosfamide: circumvention of resistance to standard-dose ifosfamide in advanced soft tissue sarcomas. J Clin Oncol. 1995;13(7):1600–1608.
    • (1995) J Clin Oncol , vol.13 , Issue.7 , pp. 1600-1608
    • Le Cesne, A.1    Antoine, E.2    Spielmann, M.3
  • 11
    • 84861098484 scopus 로고    scopus 로고
    • Pazopanib for metastatic soft-tissue sarcoma (PALETTE): A randomised, double-blind, placebo-controlled phase 3 trial
    • Van der Graaf WT, Blay JY, Chawla SP, et al. Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet. 2012;379(9829):1879–1886.
    • (2012) Lancet , vol.379 , Issue.9829 , pp. 1879-1886
    • Van Der Graaf, W.T.1    Blay, J.Y.2    Chawla, S.P.3
  • 12
    • 84939792571 scopus 로고    scopus 로고
    • Randomized, open-label, multicenter, phase III study of eribulin versus dacarbazine in patients (Pts) with leiomyosarcoma (LMS) and adipocytic sarcoma (ADI)
    • Schöffski P, Maki R, Italiano A, et al. Randomized, open-label, multicenter, phase III study of eribulin versus dacarbazine in patients (pts) with leiomyosarcoma (LMS) and adipocytic sarcoma (ADI). J Clin Oncol. 2015;33.
    • (2015) J Clin Oncol , pp. 33
    • Schöffski, P.1    Maki, R.2    Italiano, A.3
  • 13
    • 84961127695 scopus 로고    scopus 로고
    • Efficacy and safety of trabectedin or dacarbazine for metastatic liposarcoma or leiomyosarcoma after failure of conventional chemotherapy: Results of a phase III randomized multicenter clinical trial
    • Demetri GD, von Mehren M, Jones RL, et al. Efficacy and safety of trabectedin or dacarbazine for metastatic liposarcoma or leiomyosarcoma after failure of conventional chemotherapy: results of a phase III randomized multicenter clinical trial. J Clin Oncol. 2016;34(8):786–793.
    • (2016) J Clin Oncol , vol.34 , Issue.8 , pp. 786-793
    • Demetri, G.D.1    Von Mehren, M.2    Jones, R.L.3
  • 14
    • 70249101414 scopus 로고    scopus 로고
    • Efficacy and safety of trabectedin in patients with advanced or metastatic liposarcoma or leiomyosarcoma after failure of prior anthracyclines and ifosfamide: Results of a randomized phase II study of two different schedules
    • Demetri GD, Chawla SP, von Mehren M, et al. Efficacy and safety of trabectedin in patients with advanced or metastatic liposarcoma or leiomyosarcoma after failure of prior anthracyclines and ifosfamide: results of a randomized phase II study of two different schedules. J Clin Oncol. 2009;27(25):4188–4196.
    • (2009) J Clin Oncol , vol.27 , Issue.25 , pp. 4188-4196
    • Demetri, G.D.1    Chawla, S.P.2    Von Mehren, M.3
  • 15
    • 84944402876 scopus 로고    scopus 로고
    • Efficacy of trabectedin in malignant solitary fibrous tumors: A retrospective analysis from the French Sarcoma Group
    • Khalifa J, Ouali M, Chaltiel L, et al. Efficacy of trabectedin in malignant solitary fibrous tumors: a retrospective analysis from the French Sarcoma Group. BMC Cancer. 2015;15:700.
    • (2015) BMC Cancer , vol.15 , pp. 700
    • Khalifa, J.1    Ouali, M.2    Chaltiel, L.3
  • 16
    • 84867579960 scopus 로고    scopus 로고
    • A retrospective analysis of antitumour activity with trabectedin in translocation-related sarcomas
    • Le Cesne A, Cresta S, Maki RG, et al. A retrospective analysis of antitumour activity with trabectedin in translocation-related sarcomas. Eur J Cancer. 2012;48(16):3036–3044.
    • (2012) Eur J Cancer , vol.48 , Issue.16 , pp. 3036-3044
    • Le Cesne, A.1    Cresta, S.2    Maki, R.G.3
  • 17
    • 84930590633 scopus 로고    scopus 로고
    • Trabectedin in advanced synovial sarcomas: A multicenter retrospective study from four European institutions and the Italian Rare Cancer Network
    • Sanfilippo R, Dileo P, Blay JY, et al. Trabectedin in advanced synovial sarcomas: a multicenter retrospective study from four European institutions and the Italian Rare Cancer Network. Anticancer Drugs. 2015;26(6):678–681.
    • (2015) Anticancer Drugs , vol.26 , Issue.6 , pp. 678-681
    • Sanfilippo, R.1    Dileo, P.2    Blay, J.Y.3
  • 18
    • 84945967459 scopus 로고    scopus 로고
    • Efficacy of trabectedin in advanced soft tissue sarcoma: Beyond lipo- and leiomyosarcoma
    • De Sanctis R, Marrari A, Marchetti S, et al. Efficacy of trabectedin in advanced soft tissue sarcoma: beyond lipo- and leiomyosarcoma. Drug Des Devel Ther. 2015;27(9):5785–5791.
    • (2015) Drug Des Devel Ther , vol.27 , Issue.9 , pp. 5785-5791
    • De Sanctis, R.1    Marrari, A.2    Marchetti, S.3
  • 19
    • 0141906807 scopus 로고    scopus 로고
    • Histologic subtype and margin of resection predict pattern of recurrence and survival for retroperitoneal liposarcoma
    • Singer S, Antonescu CR, Riedel E, Brennan MF. Histologic subtype and margin of resection predict pattern of recurrence and survival for retroperitoneal liposarcoma. Ann Surg. 2003;238(3):358–370.
    • (2003) Ann Surg , vol.238 , Issue.3 , pp. 358-370
    • Singer, S.1    Antonescu, C.R.2    Riedel, E.3    Brennan, M.F.4
  • 20
    • 79958857301 scopus 로고    scopus 로고
    • Clinical and molecular approaches to well differentiated and dedifferentiated liposarcoma
    • Crago AM, Singer S. Clinical and molecular approaches to well differentiated and dedifferentiated liposarcoma. Curr Opin Oncol. 2011;23(4):373–378.
    • (2011) Curr Opin Oncol , vol.23 , Issue.4 , pp. 373-378
    • Crago, A.M.1    Singer, S.2
  • 21
    • 0034106241 scopus 로고    scopus 로고
    • Coordinated expression and amplification of the MDM2, CDK4 and HMGI-C genes in atypical lipomatous tumours
    • Dei Tos AP, Doglioni C, Piccinin S, et al. Coordinated expression and amplification of the MDM2, CDK4 and HMGI-C genes in atypical lipomatous tumours. J Pathol. 2000;190(5):531–536.
    • (2000) J Pathol , vol.190 , Issue.5 , pp. 531-536
    • Dei Tos, A.P.1    Doglioni, C.2    Piccinin, S.3
  • 22
    • 0034884492 scopus 로고    scopus 로고
    • Cytogenetic and molecular genetic analyses of liposarcoma and its soft tissue simulators: Recognition of new variants and differential diagnosis
    • Meis-Kindblom JM, Sjögren H, Kindblom LG, et al. Cytogenetic and molecular genetic analyses of liposarcoma and its soft tissue simulators: recognition of new variants and differential diagnosis. Virchows Arch. 2001;439(2):141–151.
    • (2001) Virchows Arch , vol.439 , Issue.2 , pp. 141-151
    • Meis-Kindblom, J.M.1    Sjögren, H.2    Kindblom, L.G.3
  • 25
    • 0027227651 scopus 로고
    • Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma
    • Crozat A, Aman P, Mandahl N, Ron D. Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. Nature. 1993;363(6430):640–644.
    • (1993) Nature , vol.363 , Issue.6430 , pp. 640-644
    • Crozat, A.1    Aman, P.2    Mandahl, N.3    Ron, D.4
  • 26
    • 0030836659 scopus 로고    scopus 로고
    • Additional evidence of a variant translocation t(12;22) with EWS/CHOP fusion in myxoid liposarcoma: Clinicopathological features
    • Dal Cin P, Sciot R, Panagopoulos I, et al. Additional evidence of a variant translocation t(12;22) with EWS/CHOP fusion in myxoid liposarcoma: clinicopathological features. J Pathol. 1997;182(4):437–441.
    • (1997) J Pathol , vol.182 , Issue.4 , pp. 437-441
    • Dal Cin, P.1    Sciot, R.2    Panagopoulos, I.3
  • 27
    • 0036227609 scopus 로고    scopus 로고
    • Pleomorphic liposarcoma: Clinicopathologic, immunohistochemical, and follow-up analysis of 63 cases: A study from the French Federation of Cancer Centers Sarcoma Group
    • Gebhard S, Coindre JM, Michels JJ, et al. Pleomorphic liposarcoma: clinicopathologic, immunohistochemical, and follow-up analysis of 63 cases: a study from the French Federation of Cancer Centers Sarcoma Group. Am J Surg Pathol. 2002;26(2):601–616.
    • (2002) Am J Surg Pathol , vol.26 , Issue.2 , pp. 601-616
    • Gebhard, S.1    Coindre, J.M.2    Michels, J.J.3
  • 28
    • 84879888440 scopus 로고    scopus 로고
    • Diagnosis, prognosis, and management of leiomyosarcoma: Recognition of anatomic variants
    • Bathan AJ, Constantinidou A, Pollack SM, Jones RL. Diagnosis, prognosis, and management of leiomyosarcoma: recognition of anatomic variants. Curr Opin Oncol. 2013;25(4):384–389.
    • (2013) Curr Opin Oncol , vol.25 , Issue.4 , pp. 384-389
    • Bathan, A.J.1    Constantinidou, A.2    Pollack, S.M.3    Jones, R.L.4
  • 29
    • 84881021974 scopus 로고    scopus 로고
    • The influence of primary site on outcomes in leiomyosarcoma: A review of clinicopathologic differences between uterine and extrauterine disease
    • Farid M, Ong WS, Tan MH, et al. The influence of primary site on outcomes in leiomyosarcoma: a review of clinicopathologic differences between uterine and extrauterine disease. Am J Clin Oncol. 2013;36(4):368–374.
    • (2013) Am J Clin Oncol , vol.36 , Issue.4 , pp. 368-374
    • Farid, M.1    Ong, W.S.2    Tan, M.H.3
  • 30
    • 84991716151 scopus 로고    scopus 로고
    • Current classification, treatment options, and new perspectives in the management of adipocytic sarcomas
    • De Vita A, Mercatali L, Recine F, et al. Current classification, treatment options, and new perspectives in the management of adipocytic sarcomas. Onco Targets Ther. 2016;9(12):6233–6246.
    • (2016) Onco Targets Ther , vol.9 , Issue.12 , pp. 6233-6246
    • De Vita, A.1    Mercatali, L.2    Recine, F.3
  • 31
    • 34447572873 scopus 로고    scopus 로고
    • Randomized phase II study of gemcitabine and docetaxel compared with gemcitabine alone in patients with metastatic soft tissue sarcomas: Results of sarcoma alliance for research through collaboration study 002
    • Maki RG, Wathen JK, Patel SR, et al. Randomized phase II study of gemcitabine and docetaxel compared with gemcitabine alone in patients with metastatic soft tissue sarcomas: results of sarcoma alliance for research through collaboration study 002. J Clin Oncol. 2007;25(4):2755–2763.
    • (2007) J Clin Oncol , vol.25 , Issue.4 , pp. 2755-2763
    • Maki, R.G.1    Wathen, J.K.2    Patel, S.R.3
  • 32
    • 0033566150 scopus 로고    scopus 로고
    • Ecteinascidin 743: A minor groove alkylator that bends DNA toward the major groove
    • Zewail-Foote M, Hurley LH. Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove. J Med Chem. 1999;42(8):1493–1497.
    • (1999) J Med Chem , vol.42 , Issue.8 , pp. 1493-1497
    • Zewail-Foote, M.1    Hurley, L.H.2
  • 33
    • 0029838307 scopus 로고    scopus 로고
    • DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata
    • Pommier Y, Kohlhagen G, Bailly C, Waring M, Mazumder A, Kohn KW. DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata. Biochemistry. 1996;35(41):13303–13309.
    • (1996) Biochemistry , vol.35 , Issue.41 , pp. 13303-13309
    • Pommier, Y.1    Kohlhagen, G.2    Bailly, C.3    Waring, M.4    Mazumder, A.5    Kohn, K.W.6
  • 34
    • 77955505177 scopus 로고    scopus 로고
    • A review of trabectedin (ET-743): A unique mechanism of action
    • D’Incalci M, Galmarini CM. A review of trabectedin (ET-743): a unique mechanism of action. Mol Cancer Ther. 2010;9(8):2157–2163.
    • (2010) Mol Cancer Ther , vol.9 , Issue.8 , pp. 2157-2163
    • D’Incalci, M.1    Galmarini, C.M.2
  • 35
    • 0037096739 scopus 로고    scopus 로고
    • Ecteinascidin-743 inhibits activated but not constitutive transcription
    • Friedman D, Hu Z, Kolb EA, Gorfajn B, Scotto KW. Ecteinascidin-743 inhibits activated but not constitutive transcription. Cancer Res. 2002;62(12):3377–3381.
    • (2002) Cancer Res , vol.62 , Issue.12 , pp. 3377-3381
    • Friedman, D.1    Hu, Z.2    Kolb, E.A.3    Gorfajn, B.4    Scotto, K.W.5
  • 36
    • 60849129809 scopus 로고    scopus 로고
    • Trabectedin (ET-243) promotes differentiation in myxoid liposarcoma tumors
    • Forni C, Minuzzo M, Virdis E, et al. Trabectedin (ET-243) promotes differentiation in myxoid liposarcoma tumors. Mol Cancer Ther. 2009;8(2):449–457.
    • (2009) Mol Cancer Ther , vol.8 , Issue.2 , pp. 449-457
    • Forni, C.1    Minuzzo, M.2    Virdis, E.3
  • 37
    • 84873597334 scopus 로고    scopus 로고
    • Role of macrophage targeting in the antitumor activity of trabectedin
    • Germano G, Frapolli R, Belgiovine C, et al. Role of macrophage targeting in the antitumor activity of trabectedin. Cancer Cell. 2013;23(2):249–262.
    • (2013) Cancer Cell , vol.23 , Issue.2 , pp. 249-262
    • Germano, G.1    Frapolli, R.2    Belgiovine, C.3
  • 38
    • 34347214071 scopus 로고    scopus 로고
    • Efficacy of trabectedin (Ecteinascidin-743) in advanced pretreated myxoid liposarcomas: A retrospective study
    • Grosso F, Jones RL, Demetri GD, et al. Efficacy of trabectedin (ecteinascidin-743) in advanced pretreated myxoid liposarcomas: a retrospective study. Lancet Oncol. 2007;8(7):595–602.
    • (2007) Lancet Oncol , vol.8 , Issue.7 , pp. 595-602
    • Grosso, F.1    Jones, R.L.2    Demetri, G.D.3
  • 39
    • 0036387382 scopus 로고    scopus 로고
    • Pharmacokinetics of ecteinascidin 743 administered as a 24-h continuous intravenous infusion to adult patients with soft tissue sarcomas: Associations with clinical characteristics, pathophysiological variables and toxicity
    • Puchalski TA, Ryan DP, Garcia-Carbonero R, et al. Pharmacokinetics of ecteinascidin 743 administered as a 24-h continuous intravenous infusion to adult patients with soft tissue sarcomas: associations with clinical characteristics, pathophysiological variables and toxicity. Cancer Chemother Pharmacol. 2002;50(4):309–319.
    • (2002) Cancer Chemother Pharmacol , vol.50 , Issue.4 , pp. 309-319
    • Puchalski, T.A.1    Ryan, D.P.2    Garcia-Carbonero, R.3
  • 40
    • 0035127175 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of ecteinascidin 743 administered as a 72-hour continuous intravenous infusion in patients with solid malignancies
    • Ryan DP, Supko JG, Eder JP, et al. Phase I and pharmacokinetic study of ecteinascidin 743 administered as a 72-hour continuous intravenous infusion in patients with solid malignancies. Clin Cancer Res. 2001;7(2):231–242.
    • (2001) Clin Cancer Res , vol.7 , Issue.2 , pp. 231-242
    • Ryan, D.P.1    Supko, J.G.2    Eder, J.P.3
  • 41
    • 0142121506 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of Yondelis (Ecteinascidin-743; ET-743) administered as an infusion over 1 h or 3 h every 21 days in patients with solid tumours
    • Twelves C, Hoekman K, Bowman A, et al. Phase I and pharmacokinetic study of Yondelis (Ecteinascidin-743; ET-743) administered as an infusion over 1 h or 3 h every 21 days in patients with solid tumours. Eur J Cancer. 2003;39(13):1842–1851.
    • (2003) Eur J Cancer , vol.39 , Issue.13 , pp. 1842-1851
    • Twelves, C.1    Hoekman, K.2    Bowman, A.3
  • 42
    • 0035281641 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of ecteinascidin-743, a new marine compound, administered as a 24-hour continuous infusion in patients with solid tumors
    • Taamma A, Misset JL, Riofrio M, et al. Phase I and pharmacokinetic study of ecteinascidin-743, a new marine compound, administered as a 24-hour continuous infusion in patients with solid tumors. J Clin Oncol. 2001;19(5):1256–1265.
    • (2001) J Clin Oncol , vol.19 , Issue.5 , pp. 1256-1265
    • Taamma, A.1    Misset, J.L.2    Riofrio, M.3
  • 43
    • 1542398698 scopus 로고    scopus 로고
    • Phase II study of ecteinascidin-743 in advanced pretreated soft tissue sarcoma patients
    • Yovine A, Riofrio M, Blay JY, et al. Phase II study of ecteinascidin-743 in advanced pretreated soft tissue sarcoma patients. J Clin Oncol. 2004;22(5):890–899.
    • (2004) J Clin Oncol , vol.22 , Issue.5 , pp. 890-899
    • Yovine, A.1    Riofrio, M.2    Blay, J.Y.3
  • 44
    • 2342461682 scopus 로고    scopus 로고
    • Phase II and pharmacokinetic study of ecteinascidin 743 in patients with progressive sarcomas of soft tissues refractory to chemotherapy
    • Garcia-Carbonero R, Supko JG, Manola J, et al. Phase II and pharmacokinetic study of ecteinascidin 743 in patients with progressive sarcomas of soft tissues refractory to chemotherapy. J Clin Oncol. 2004;22(8):1480–1490.
    • (2004) J Clin Oncol , vol.22 , Issue.8 , pp. 1480-1490
    • Garcia-Carbonero, R.1    Supko, J.G.2    Manola, J.3
  • 45
    • 20044372153 scopus 로고    scopus 로고
    • Phase II study of ET-743 in advanced soft tissue sarcomas: A European Organisation for the Research and Treatment of Cancer (EORTC) soft tissue and bone sarcoma group trial
    • Le Cesne A, Blay JY, Judson I, et al. Phase II study of ET-743 in advanced soft tissue sarcomas: a European Organisation for the Research and Treatment of Cancer (EORTC) soft tissue and bone sarcoma group trial. J Clin Oncol. 2005;23(3):576–584.
    • (2005) J Clin Oncol , vol.23 , Issue.3 , pp. 576-584
    • Le Cesne, A.1    Blay, J.Y.2    Judson, I.3
  • 46
    • 84878445731 scopus 로고    scopus 로고
    • Clinical outcomes and safety with trabectedin therapy in patients with advanced soft tissue sarcomas following failure of prior chemotherapy: Results of a worldwide expanded access program study
    • Samuels BL, Chawla S, Patel S, et al. Clinical outcomes and safety with trabectedin therapy in patients with advanced soft tissue sarcomas following failure of prior chemotherapy: results of a worldwide expanded access program study. Ann Oncol. 2013;24(6):1703–1709.
    • (2013) Ann Oncol , vol.24 , Issue.6 , pp. 1703-1709
    • Samuels, B.L.1    Chawla, S.2    Patel, S.3
  • 47
    • 84873261540 scopus 로고    scopus 로고
    • Long-term outcome and effect of maintenance therapy in patients with advanced sarcoma treated with trabectedin: An analysis of 181 patients of the French ATU compassionate use program
    • Blay JY, Italiano A, Ray-Coquard I, et al. Long-term outcome and effect of maintenance therapy in patients with advanced sarcoma treated with trabectedin: an analysis of 181 patients of the French ATU compassionate use program. BMC Cancer. 2013;13:64.
    • (2013) BMC Cancer , vol.13 , pp. 64
    • Blay, J.Y.1    Italiano, A.2    Ray-Coquard, I.3
  • 48
    • 84857530639 scopus 로고    scopus 로고
    • Phase II clinical trial of neoadjuvant trabectedin in patients with advanced localized myxoid liposarcoma
    • Gronchi A, Bui BN, Bonvalot S, et al. Phase II clinical trial of neoadjuvant trabectedin in patients with advanced localized myxoid liposarcoma. Ann Oncol. 2012;23(3):771–776.
    • (2012) Ann Oncol , vol.23 , Issue.3 , pp. 771-776
    • Gronchi, A.1    Bui, B.N.2    Bonvalot, S.3
  • 50
    • 0035019955 scopus 로고    scopus 로고
    • Genetic and molecular abnormalities in tumors of the bone and soft tissues
    • Letson GD, Muro-Cacho CA. Genetic and molecular abnormalities in tumors of the bone and soft tissues. Cancer Control. 2001;8(3):239–251.
    • (2001) Cancer Control , vol.8 , Issue.3 , pp. 239-251
    • Letson, G.D.1    Muro-Cacho, C.A.2
  • 52
    • 0028862047 scopus 로고
    • EWS-FLI-1 and EWS-ERG chimeric mRNAs in Ewing’s sarcoma and primitive neuroectodermal tumor
    • Ida K, Kobayashi S, Taki T, et al. EWS-FLI-1 and EWS-ERG chimeric mRNAs in Ewing’s sarcoma and primitive neuroectodermal tumor. Int J Cancer. 1995;63(4):500–504.
    • (1995) Int J Cancer , vol.63 , Issue.4 , pp. 500-504
    • Ida, K.1    Kobayashi, S.2    Taki, T.3
  • 53
    • 84990903073 scopus 로고    scopus 로고
    • Dermatofibrosarcoma protuberans: Pathology, genetics, and potential therapeutic strategies
    • Thway K, Noujaim J, Jones RL, Fisher C. Dermatofibrosarcoma protuberans: pathology, genetics, and potential therapeutic strategies. Ann Diagn Pathol. 2016;25:64–71.
    • (2016) Ann Diagn Pathol , vol.25 , pp. 64-71
    • Thway, K.1    Noujaim, J.2    Jones, R.L.3    Fisher, C.4
  • 54
    • 13044279490 scopus 로고    scopus 로고
    • Clinical significance of genetic imbalances revealed by comparative genomic hybridization in chondrosarcomas
    • Larramendy ML, Mandahl N, Mertens F, et al. Clinical significance of genetic imbalances revealed by comparative genomic hybridization in chondrosarcomas. Hum Pathol. 1999;30(10):1247–1253.
    • (1999) Hum Pathol , vol.30 , Issue.10 , pp. 1247-1253
    • Larramendy, M.L.1    Mandahl, N.2    Mertens, F.3
  • 55
    • 84892398882 scopus 로고    scopus 로고
    • Clinicopathological features, diagnosis and treatment of clear cell sarcoma/melanoma of soft parts
    • Mavrogenis AF, Bianchi G, Stavropoulos NA, Papagelopoulos PJ, Ruggieri P. Clinicopathological features, diagnosis and treatment of clear cell sarcoma/melanoma of soft parts. Hippokratia. 2013;17(4):298–302.
    • (2013) Hippokratia , vol.17 , Issue.4 , pp. 298-302
    • Mavrogenis, A.F.1    Bianchi, G.2    Stavropoulos, N.A.3    Papagelopoulos, P.J.4    Ruggieri, P.5
  • 56
    • 42049095890 scopus 로고    scopus 로고
    • Inflammatory myofibroblastic tumours: Where are we now?
    • Gleason BC, Hornick JL. Inflammatory myofibroblastic tumours: where are we now? J Clin Pathol. 2008;61(4):428–437.
    • (2008) J Clin Pathol , vol.61 , Issue.4 , pp. 428-437
    • Gleason, B.C.1    Hornick, J.L.2
  • 57
    • 0032956619 scopus 로고    scopus 로고
    • Solitary fibrous tumor of the pleura: A cytogenetic study
    • Donner LR, Silva MT, Dobin SM, et al. Solitary fibrous tumor of the pleura: a cytogenetic study. Cancer Genet Cytogenet. 1999;111(2):169–171.
    • (1999) Cancer Genet Cytogenet , vol.111 , Issue.2 , pp. 169-171
    • Donner, L.R.1    Silva, M.T.2    Dobin, S.M.3
  • 58
    • 84971264673 scopus 로고    scopus 로고
    • Synovial sarcoma microvesicles harbor the SYT-SSX fusion gene transcript: Comparison of different methods of detection and implications in biomarker research
    • 6146047
    • Fricke A, Ullrich PV, Cimniak AF, et al. Synovial sarcoma microvesicles harbor the SYT-SSX fusion gene transcript: comparison of different methods of detection and implications in biomarker research. Stem Cells Int. 2016;2016:6146047.
    • (2016) Stem Cells Int , vol.2016
    • Fricke, A.1    Ullrich, P.V.2    Cimniak, A.F.3
  • 59
    • 84897074467 scopus 로고    scopus 로고
    • Randomised phase III trial of trabectedin versus doxorubicin-based chemotherapy as first-line therapy in translocation-related sarcomas
    • Blay JY, Leahy MG, Nguyen BB, et al. Randomised phase III trial of trabectedin versus doxorubicin-based chemotherapy as first-line therapy in translocation-related sarcomas. Eur J Cancer. 2014;50(6):1137–1147.
    • (2014) Eur J Cancer , vol.50 , Issue.6 , pp. 1137-1147
    • Blay, J.Y.1    Leahy, M.G.2    Nguyen, B.B.3
  • 60
    • 84930588472 scopus 로고    scopus 로고
    • Trabectedin monotherapy after standard chemotherapy versus best supportive care in patients with advanced, translocation-related sarcoma: A randomized, open-label, phase 2 study
    • Kawai A, Araki N, Sugiura H, et al. Trabectedin monotherapy after standard chemotherapy versus best supportive care in patients with advanced, translocation-related sarcoma: a randomized, open-label, phase 2 study. Lancet Oncol. 2015;16(4):406–416.
    • (2015) Lancet Oncol , vol.16 , Issue.4 , pp. 406-416
    • Kawai, A.1    Araki, N.2    Sugiura, H.3
  • 61
    • 84879659927 scopus 로고    scopus 로고
    • Trabectedin in metastatic soft tissue sarcomas: Role of pretreatment and age
    • Hoiczyk M, Grabellus F, Podleska L, et al. Trabectedin in metastatic soft tissue sarcomas: role of pretreatment and age. Int J Oncol. 2013;43(1):23–28.
    • (2013) Int J Oncol , vol.43 , Issue.1 , pp. 23-28
    • Hoiczyk, M.1    Grabellus, F.2    Podleska, L.3
  • 62
    • 79960983277 scopus 로고    scopus 로고
    • Efficacy of trabectedin in metastatic solitary fibrous tumor
    • Chaigneau L, Kalbacher E, Thiery-Vuillemin A, et al. Efficacy of trabectedin in metastatic solitary fibrous tumor. Rare Tumors. 2011;3(3):e29.
    • (2011) Rare Tumors , vol.3 , Issue.3
    • Chaigneau, L.1    Kalbacher, E.2    Thiery-Vuillemin, A.3
  • 63
    • 84930678267 scopus 로고    scopus 로고
    • European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group (EORTC/STBSG) and the Sarcoma Alliance for Research through Collaboration (SARC). A phase IIb multicentre study comparing the efficacy of trabectedin to doxorubicin in patients with advanced or metastatic untreated soft tissue sarcoma: The TRUSTS trial
    • Bui-Nguyen B, Butrynski JE, Penel N, et al; European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group (EORTC/STBSG) and the Sarcoma Alliance for Research through Collaboration (SARC). A phase IIb multicentre study comparing the efficacy of trabectedin to doxorubicin in patients with advanced or metastatic untreated soft tissue sarcoma: the TRUSTS trial. Eur J Cancer. 2015;51(10):1312–1320.
    • (2015) Eur J Cancer , vol.51 , Issue.10 , pp. 1312-1320
    • Bui-Nguyen, B.1    Butrynski, J.E.2    Penel, N.3
  • 64
    • 84976463182 scopus 로고    scopus 로고
    • Randomized Phase II study of trabectedin and doxorubicin compared with doxorubicin alone as first-line treatment in patients with advanced soft tissue sarcomas: A Spanish group for research on sarcoma study
    • Martin-Broto J, Pousa AL, de Las Peñas R, et al. Randomized Phase II study of trabectedin and doxorubicin compared with doxorubicin alone as first-line treatment in patients with advanced soft tissue sarcomas: a Spanish group for research on sarcoma study. J Clin Oncol. 2016;34(19):2294–2302.
    • (2016) J Clin Oncol , vol.34 , Issue.19 , pp. 2294-2302
    • Martin-Broto, J.1    Pousa, A.L.2    De Las Peñas, R.3
  • 65
    • 85014774665 scopus 로고    scopus 로고
    • Yondelis® summary of product characteristics. Available from: www.ema.europa.eu/docs/en_GB. Accessed March 3, 2016
    • Yondelis® summary of product characteristics. Available from: www.ema.europa.eu/docs/en_GB. Accessed March 3, 2016.
  • 66
    • 33745161449 scopus 로고    scopus 로고
    • Steroid premedication markedly reduces liver and bone marrow toxicity of trabectedin in advanced sarcoma
    • Grosso F, Dileo P, Sanfilippo R, et al. Steroid premedication markedly reduces liver and bone marrow toxicity of trabectedin in advanced sarcoma. Eur J Cancer. 2006;42(10):1484–1490.
    • (2006) Eur J Cancer , vol.42 , Issue.10 , pp. 1484-1490
    • Grosso, F.1    Dileo, P.2    Sanfilippo, R.3
  • 67
    • 84862266455 scopus 로고    scopus 로고
    • Trabectedin in pre-treated patients with advanced or metastatic soft tissue sarcoma: A phase II study evaluating co-treatment with dexamethasone
    • Paz-Ares L, López-Pousa A, Poveda A, et al. Trabectedin in pre-treated patients with advanced or metastatic soft tissue sarcoma: a phase II study evaluating co-treatment with dexamethasone. Invest New Drugs. 2012;30(2):729–740.
    • (2012) Invest New Drugs , vol.30 , Issue.2 , pp. 729-740
    • Paz-Ares, L.1    López-Pousa, A.2    Poveda, A.3
  • 68
    • 84863793434 scopus 로고    scopus 로고
    • A comprehensive safety analysis confirms rhabdomyolysis as an uncommon adverse reaction in patients treated with trabectedin
    • Grosso F, D’Incalci M, Cartoafa M, et al. A comprehensive safety analysis confirms rhabdomyolysis as an uncommon adverse reaction in patients treated with trabectedin. Cancer Chemother Pharmacol. 2012;69(6):1557–1565.
    • (2012) Cancer Chemother Pharmacol , vol.69 , Issue.6 , pp. 1557-1565
    • Grosso, F.1    D’Incalci, M.2    Cartoafa, M.3
  • 69
    • 84925373086 scopus 로고    scopus 로고
    • French Sarcoma Group. French Sarcoma Group. Trabectedin in patients with advanced soft tissue sarcoma: A retrospective national analysis of the French Sarcoma Group
    • Le Cesne A, Ray-Coquard I, Duffaud F, et al; French Sarcoma Group. French Sarcoma Group. Trabectedin in patients with advanced soft tissue sarcoma: a retrospective national analysis of the French Sarcoma Group. Eur J Cancer. 2015;51(6):742–750.
    • (2015) Eur J Cancer , vol.51 , Issue.6 , pp. 742-750
    • Le Cesne, A.1    Ray-Coquard, I.2    Duffaud, F.3
  • 70
    • 84924912711 scopus 로고    scopus 로고
    • Interruption versus continuation of trabectedin in patients with soft-tissue sarcoma (T-DIS): A randomised phase 2 trial
    • Le Cesne A, Blay JY, Domont J, et al. Interruption versus continuation of trabectedin in patients with soft-tissue sarcoma (T-DIS): a randomised phase 2 trial. Lancet Oncol. 2015;16(3):312–319.
    • (2015) Lancet Oncol , vol.16 , Issue.3 , pp. 312-319
    • Le Cesne, A.1    Blay, J.Y.2    Domont, J.3
  • 71
    • 84990844920 scopus 로고    scopus 로고
    • Olaratumab and doxorubicin versus doxorubicin alone for treatment of soft-tissue sarcoma: An open-label phase 1b and randomised phase 2 trial
    • Tap WD, Jones RL, Van Tine BA, et al. Olaratumab and doxorubicin versus doxorubicin alone for treatment of soft-tissue sarcoma: an open-label phase 1b and randomised phase 2 trial. Lancet. 2016;388(10043):488–497.
    • (2016) Lancet , vol.388 , Issue.10043 , pp. 488-497
    • Tap, W.D.1    Jones, R.L.2    Van Tine, B.A.3
  • 72
    • 0032952928 scopus 로고    scopus 로고
    • Prognostic factors for the outcome of chemotherapy in advanced soft tissue sarcoma: An analysis of 2,185 patients treated with anthracycline-containing first-line regimens – a European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Study
    • Van Glabbeke M, van Oosterom AT, Oosterhuis JW, et al. Prognostic factors for the outcome of chemotherapy in advanced soft tissue sarcoma: an analysis of 2,185 patients treated with anthracycline-containing first-line regimens – a European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Study. J Clin Oncol. 1999;17(1):150–157.
    • (1999) J Clin Oncol , vol.17 , Issue.1 , pp. 150-157
    • Van Glabbeke, M.1    Van Oosterom, A.T.2    Oosterhuis, J.W.3


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