Synovial Sarcoma Microvesicles Harbor the SYT-SSX Fusion Gene Transcript: Comparison of Different Methods of Detection and Implications in Biomarker Research

Stem Cells International

Volumn 2016, Issue , 2016, Pages

  Fricke, A ^a   Ullrich, P V ^a   Cimniak, A F V ^a   Follo, M ^a   Nestel, S ^b   Heimrich, B ^b   Nazarenko, I ^c   Stark, G B ^a   Bannasch, H ^a   Braig, D ^a   Eisenhardt, S U ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; NANOPARTICLE; RNA;

ADULT; ARTICLE; BLOOD CELL; CANCER CELL CULTURE; CLINICAL ARTICLE; CONTROLLED STUDY; FUSION GENE; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERMETHOD COMPARISON; MEMBRANE MICROPARTICLE; MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; RNA ANALYSIS; SARCOMA CELL; SENSITIVITY ANALYSIS; SYNOVIAL SARCOMA; SYT SSX2 FUSION GENE TRANSCRIPT; TRANSMISSION ELECTRON MICROSCOPY;

EID: 84971264673     PISSN: None     EISSN: 16879678     Source Type: Journal    
DOI: 10.1155/2016/6146047     Document Type: Article

References (43)

1. C. E. Herzog, "Overview of sarcomas in the adolescent and young adult population, " Journal of Pediatric Hematology/ Oncology, vol. 27, no. 4, pp. 215-218, 2005.
2. F. C. Eilber and S. M. Dry, "Diagnosis and management of synovial sarcoma, " Journal of Surgical Oncology, vol. 97, no. 4, pp. 314-320, 2008.
3. A. J. Crew, J. Clark, C. Fisher et al., "Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma, " The EMBO Journal, vol. 14, no. 10, pp. 2333-2340, 1995.
4. J. Clark, P. J. Rocques, A. J. Crew et al., "Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11. 2;q11. 2) translocation found in human synovial sarcoma, " Nature Genetics, vol. 7, no. 4, pp. 502-508, 1994.
5. B. Skytting, G. Nilsson, B. Brodin et al., "A novel fusion gene, SYT-SSX4, in synovial sarcoma, " Journal of the National Cancer Institute, vol. 91, no. 11, pp. 974-975, 1999.
6. C. Kadoch and G. R. Crabtree, "Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma, " Cell, vol. 153, no. 1, pp. 71-85, 2013.
7. T. O. Nielsen, N. M. Poulin, and M. Ladanyi, "Synovial sarcoma: recent discoveries as a roadmap to new avenues for therapy, " Cancer Discovery, vol. 5, no. 2, pp. 124-134, 2015.
8. M. Haldar, J. D. Hancock, C. M. Coffin, S. L. Lessnick, and M. R. Capecchi, "A conditional mouse model of synovial sarcoma: insights into a myogenic origin, " Cancer Cell, vol. 11, no. 4, pp. 375-388, 2007.
9. M. Ladanyi and J. A. Bridge, "Contributionofmolecular genetic data to the classification of sarcomas, "Human Pathology, vol. 31, no. 5, pp. 532-538, 2000.
10. A. Kawai, J. Woodruff, J. H. Healey, M. F. Brennan, C. R. Antonescu, and M. Ladanyi, "SYT-SSX gene fusion as a determinant ofmorphology and prognosis in synovial sarcoma, " The New England Journal of Medicine, vol. 338, no. 3, pp. 153-160, 1998.
11. T. Kubo, S. Shimose, J. Fujimori, T. Furuta, and M. Ochi, "Prognostic value of SS18-SSX fusion type in synovial sarcoma; systematic review and meta-analysis, " SpringerPlus, vol. 4, article 375, 2015.
12. T. Ren, Q. Lu, W. Guo et al., "The clinical implication of SS18-SSX fusion gene in synovial sarcoma, " British Journal of Cancer, vol. 109, no. 8, pp. 2279-2285, 2013.
13. J. Skog, T. Würdinger, S. van Rijn et al., "Glioblastoma microvesicles transport RNAand proteins that promote tumour growth and provide diagnostic biomarkers, " Nature Cell Biology, vol. 10, no. 12, pp. 1470-1476, 2008.
14. Y. Xie, M. Törnkvist, Y. Aalto et al., "Gene expression profile by blocking the SYT-SSX fusion gene in synovial sarcoma cells. Identification of XRCC4 as a putative SYT-SSX target gene, " Oncogene, vol. 22, no. 48, pp. 7628-7631, 2003.
15. E. Eitan, S. Zhang, K. W. Witwer, and M. P. Mattson, "Extracellular vesicle-depleted fetal bovine and human sera have reduced capacity to support cell growth, " Journal of Extracellular Vesicles, vol. 4, Article ID26373, 2015.
16. H. Valadi, K. Ekström, A. Bossios, M. Sjöstrand, J. J. Lee, and J. O. Lötvall, "Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells, " Nature Cell Biology, vol. 9, no. 6, pp. 654-659, 2007.
17. S. Hellwig, A. Masuch, S. Nestel, N. Katzmarski, M. Meyer-Luehmann, and K. Biber, "Forebrain microglia from wild-type but not adult 5xFAD mice prevent amyloid-plaque formation in organotypic hippocampal slice cultures, " Scientific Reports, vol. 5, Article ID 14624, 2015.
18. D. Ferreira Barreto-Vieira and O. M. Barth, "Negative and positive staining in transmission electron microscopy for virus diagnosis, " in Microbiology in Agriculture and Human Health, M. M. Shah, Ed., InTech, 2015.
19. A. Keller, P. Leidinger, A. Bauer et al., "Toward the blood-borne miRNome of human diseases, " Nature Methods, vol. 8, no. 10, pp. 841-843, 2011.
20. N. Hashimoto, A. Myoui, N. Araki et al., "Detection of SYT-SSX fusion gene in peripheral blood from a patient with synovial sarcoma, " The American Journal of Surgical Pathology, vol. 25, no. 3, pp. 406-410, 2001.
21. A. Fricke, P. V. Ullrich, J. Heinz et al., "Identification of a blood-borne miRNA signature of synovial sarcoma, " Molecular Cancer, vol. 14, article 151, 2015.
22. M. Hisaoka, A. Matsuyama, Y. Nagao et al., "Identification of altered MicroRNA expression patterns in synovial sarcoma, " Genes Chromosomes and Cancer, vol. 50, no. 3, pp. 137-145, 2011.
23. M. Baj-Krzyworzeka, R. Szatanek, K. Wglarczyk et al., "Tumour-derived microvesicles carry several surface determinants and mRNA of tumour cells and transfer some of these determinants to monocytes, " Cancer Immunology, Immunotherapy, vol. 55, no. 7, pp. 808-818, 2006.
24. G. Andreola, L. Rivoltini, C. Castelli et al., "Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles, " Journal of Experimental Medicine, vol. 195, no. 10, pp. 1303-1316, 2002.
25. D. Barz, M. Goppelt, M. Szamel, V. Schirrmacher, and K. Resch, "Characterization of cellular and extracellular plasma membrane vesicles from a non-metastasizing lymphoma (Eb) and its metastasizing variant (ESb), " Biochimica et Biophysica Acta (BBA)-Biomembranes, vol. 814, no. 1, pp. 77-84, 1985.
26. M. F. C. Amary, F. Berisha, F. D. C. Bernardi et al., "Detection of SS18-SSX fusion transcripts in formalin-fixed paraffinembedded neoplasms: Analysis of conventional RT-PCR, qRTPCR and dual color FISH as diagnostic tools for synovial sarcoma, " Modern Pathology, vol. 20, no. 4, pp. 482-496, 2007.
27. D. Drandi, L. Kubiczkova-Besse, S. Ferrero et al., "Minimal residual disease detection by droplet digital pcr in multiple myeloma, mantle cell lymphoma, and follicular lymphoma: A comparison with real-time PCR, " The Journal of Molecular Diagnostics, vol. 17, no. 6, pp. 652-660, 2015.
28. G. Fontanelli, C. Baratè, E. Ciabatti et al., "Real-time PCR and droplet digital PCR: two techniques for detection of the JAK2(V617F) mutation in Philadelphia-negative chronic myeloproliferative neoplasms, " International Journal of Laboratory Hematology, vol. 37, no. 6, pp. 766-773, 2015.
29. R. T. Hayden, Z. Gu, J. Ingersoll et al., "Comparison of droplet digital PCR to real-time PCR for quantitative detection of cytomegalovirus, " Journal of Clinical Microbiology, vol. 51, no. 2, pp. 540-546, 2013.
30. M. Kiselinova, A. O. Pasternak, W. De Spiegelaere, D. Vogelaers, B. Berkhout, and L. Vandekerckhove, "Comparison of droplet digital PCR and seminested real-time PCR for quantification of cell-associated HIV-1 RNA, " PLoS ONE, vol. 9, no. 1, Article ID e85999, 2014.
31. M. Miyachi, K. Tsuchiya, H. Yoshida et al., "Circulatingmusclespecific microRNA, miR-206, as a potential diagnostic marker for rhabdomyosarcoma, " Biochemical and Biophysical Research Communications, vol. 400, no. 1, pp. 89-93, 2010.
32. A. M. Sieuwerts, J. Kraan, J. Bolt et al., "Anti-epithelial cell adhesion molecule antibodies and the detection of circulating normal-like breast tumor cells, " Journal of the National Cancer Institute, vol. 101, no. 1, pp. 61-66, 2009.
33. W. J. Allard, J. Matera, M. C. Miller et al., "Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases, " Clinical Cancer Research, vol. 10, no. 20, pp. 6897-6904, 2004.
34. J.-M. Hou, A. Greystoke, L. Lancashire et al., "Evaluation of circulating tumor cells and serological cell death biomarkers in small cell lung cancer patients undergoing chemotherapy, " The American Journal of Pathology, vol. 175, no. 2, pp. 808-816, 2009.
35. D. F. Hayes, M. Cristofanilli, G. T. Budd et al., "Circulating tumor cells at each follow-up time point during therapy of metastatic breast cancer patients predict progression-free and overall survival, " Clinical Cancer Research, vol. 12, no. 14, part 1, pp. 4218-4224, 2006.
36. A. Satelli, A. Mitra, J. J. Cutrera et al., "Universal marker and detection tool for human sarcoma circulating tumor cells, " Cancer Research, vol. 74, no. 6, pp. 1645-1650, 2014.
37. Y.-H. Kitamura, A. Shirahata, M. Sakata et al., "Frequentmethylation of Vimentin in well-differentiated gastric carcinoma, " Anticancer Research, vol. 29, no. 6, pp. 2227-2229, 2009.
38. M. Li, B. Zhang, X. Wang et al., "A novel function for vimentin: the potential biomarker for predicting melanoma hematogenous metastasis, " Journal of Experimental and Clinical Cancer Research, vol. 29, article 109, 2010.
39. G. Schleiermacher, M. Peter, O. Oberlin et al., "Increased risk of systemic relapses associated with bone marrowmicrometastasis and circulating tumor cells in localized ewing tumor, " Journal of Clinical Oncology, vol. 21, no. 1, pp. 85-91, 2003.
40. D. C. West, H. E. Grier, M. M. Swallow, G. D. Demetri, L. Granowetter, and J. Sklar, "Detection of circulating tumor cells in patients with Ewing's sarcoma and peripheral primitive neuroectodermal tumor, " Journal of Clinical Oncology, vol. 15, no. 2, pp. 583-588, 1997.
41. E. de Alava, M. D. Lozano, A. Patiño, L. Sierrasesúmaga, and F. J. Pardo-Mindán, "Ewing family tumors: Potential prognostic value of reverse-transcriptase polymerase chain reaction detection of minimal residual disease in peripheral blood samples, " Diagnostic Molecular Pathology, vol. 7, no. 3, pp. 152-157, 1998.
42. K. M. Kelly, R. B. Womer, and F. G. Barr, "Minimal disease detection in patients with alveolar rhabdomyosarcoma using a reverse transcriptase-polymerase chain reaction method, " Cancer, vol. 78, no. 6, pp. 1320-1327, 1996.
43. M. Hoshino, A. Ogose, H. Kawashima et al., "Molecular analyses of cell origin and detection of circulating tumor cells in the peripheral blood in alveolar soft part sarcoma, " Cancer Genetics and Cytogenetics, vol. 190, no. 2, pp. 75-80, 2009.