Additional evidence of a variant translocation t(12;22) with EWS/CHOP fusion in myxoid liposarcoma: Clinicopathological features

Journal of Pathology

Volumn 182, Issue 4, 1997, Pages 437-441

  Dal Cin, Paola ^a,e   Sciot, Raf ^b   Panagopoulos, Ioannis ^c   Åman, Pierre ^c   Samson, Ignace ^b   Mandahl, Nils ^c   Mitelman, Felix ^c   Van Den Berghe, Herman ^a   Fletcher, Christopher D M ^d  

^a Flander Interuniv Inst Biotechnol   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c LUND UNIVERSITY HOSPITAL   (Sweden)

^d HARVARD MEDICAL SCHOOL   (United States)

^e CENTER FOR HUMAN GENETICS   (Belgium)

Author keywords

cytogenetics; EWS gene; liposarcoma; RT PCR

Indexed keywords

ADULT; ARTICLE; CASE REPORT; CHROMOSOME 12; CHROMOSOME 22; CHROMOSOME TRANSLOCATION; FEMALE; HISTOLOGY; HUMAN; HUMAN TISSUE; LIPOSARCOMA; MALE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; CCAAT-ENHANCER-BINDING PROTEINS; CLONING, MOLECULAR; DNA-BINDING PROTEINS; FEMALE; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS; HUMANS; KARYOTYPING; LIPOSARCOMA, MYXOID; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; RIBONUCLEOPROTEINS; RNA-BINDING PROTEIN EWS; RNA-BINDING PROTEIN FUS; TRANSCRIPTION FACTOR CHOP; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC;

EID: 0030836659     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(199708)182:4<437::AID-PATH882>3.0.CO;2-X     Document Type: Article

References (24)

1. Sandberg AA, Bridge JA. The Cytogenetics of Bone and Soft Tissue Tumors. Austin, TX: R. G. Landes Company, 1994.
2. Knight JC, Renwick PJ, Dal Cin P, Van den Berghe H, Fletcher CDM. Translocation t(12:16)(q13:p11) in myxoid liposarcoma and round cell liposarcoma: molecular and cytogenetic analysis. Cancer Res 1995; 55: 24-27.
3. Fletcher CMD, Akerman M, Dal Cin P, et al. Correlation between clinicopathologic features and karyotype in lipomatous tumors. A report of 178 cases from the chromosomes and morphology (CHAMP) collaborative study group. Am J Pathol 1996; 148: 623-630.
4. Tallini G, Akerman M, Dal Cin P, et al. Combined morphologic and karyotypic study of 28 myxoid liposarcomas: implications for a revised morphologic typing. Am J Surg Pathol 1996; 20: 1047-1055.
5. Aman P, Ron D, Mandahl N, et al. Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12:16)(q1l3;p11). Genes Chromosom Cancer 1992; 5: 278-285.
6. Crozat A, Åman P, Mandahl N, Ron D, Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. Nature 1993; 363: 640-644.
7. Rabbins T, Forster A, Larson R, Nathan P. Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12:16) in malignant liposarcoma. Nature Genet 1993; 4: 175-280.
8. Mitelman F, Catalog of Chromosome Aberrations in Cancer. 5th edn. New York: Wiley-Liss, 1994.
9. Becher R, Wake N, Gibas Z, Ochi H, Sandberg AA. Chromosome changes in soft tissue sarcomas. JNCI 1984; 71: 823-831.
10. Karakousis CP, Dal Cin P, Turc-Carel C, Limon J, Sandberg AA. Chromosomal changes in soft-tissue sarcomas. A new diagnostic parameter. Arch Surg 1987; 122: 1257-1260.
11. Molenaar WM, DeJong B, Buist J, et al. Chromosomal analysis and the classification of soft tissue sarcomas. Lab Invest 1989; 60: 266-274.
12. Gibas Z, Miettinen M, Limon J, et al. Cytogenetic and immunohistochemical profile of myxoid liposarcoma. Am J Clin Pathol 1995; 103: 20-26.
13. Panagopoulos I, Höglund M, Mertens F, Mandahl N, Mitelman F, Aman P. Fusion of the EWS and CHOP genes in myxoid liposarcoma. Oncogene 1996; 12: 489-494.
14. Limon J, Dal Cin P, Sandberg AA. Application of long-term collagenase disaggregation for the cytogenetic analysis of human solid tumors. Cancer Genet Cytogenet 1986; 23: 305-313.
15. Mitelman F (ed.). ISCN. Guidelines for Cancer Cytogenetics. Supplement to An International System for Human Cytogenetic Nomenclature. Basel: S. Karger, 1995.
16. Kilpatrick SC, Doyon J, Choong PFM, Sim FH, Nascimento AG. The clinicopathologic spectrum of myxoid and round cell liposarcoma. A study of 95 cases. Cancer 1996; 77: 1450-1458.
17. Smith TA, Easley KA, Goldblum JR. Myxoid/round cell liposarcoma of the extremities. A clinicopathologic study of 29 cases with particular attention to extent of round cell liposarcoma. Am J Surg Pathol 1996; 20: 171-180.
18. Sreekantaiah C, Karakousis CP, Leong SPL, Sandberg AA. Cytogenetic findings in liposarcoma correlate with histopathologic subtypes. Cancer 1992; 69: 2484-2495.
19. Delattre O, Zucman J, Plougastel B, et al. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. Nature 1992; 359: 162-165.
20. Ladanyi M. The emerging molecular genetics of sarcoma translocations. Diagn Mul Pathol 1995; 4: 162-173.
21. Kaneko Y, Yoshida K, Handa M, et al. Fusion of an ETS-family gene, EIAF, to EWS by t(17;22)(q12;q12) chromosome translocation in an undifferentiated sarcoma of infancy. Genes Chromosom Cancer 1996; 15: 115-121.
22. Zucman J, Delattre O, Desmaze C, et al. EWS and ATF-1 gene fusion induced by the recurrent t(12;22) translocation in malignant melanoma of soft parts. Nature Genet 1993; 4: 341-345.
23. Gerald WL, Ladanyi M, de Alava E, Rosai J. Desmoplastic small round-cell tumor: a recently recognized tumor type associated with a unique gene fusion. Adv Anat Pathol 1995; 2: 341-345.
24. Labelle YK, Zucman J, Stenman G, et al. Oncogenic conversion of a novel orphan nuclear receptor by chromosome translocation. Hum Mol Genet 1995; 4: 2219-2226.