Oncogenic retinoic acid receptor γ knockdown reverses multi-drug resistance of human colorectal cancer via Wnt/β-catenin pathway

Cell Cycle

Volumn 16, Issue 7, 2017, Pages 685-692

  Huang, Gui Li ^a   Song, Wei ^b   Zhou, Pan ^a   Fu, Qi Rui ^a   Lin, Chen Lu ^a   Chen, Qing Xi ^a   Shen, Dong Yan ^c  

^a XIAMEN UNIVERSITY   (China)

^b HENAN UNIVERSITY OF URBAN CONSTRUCTION   (China)

^c THE FIRST AFFILIATED HOSPITAL OF XIAMEN UNIVERSITY   (China)

Author keywords

chemoresistance; colorectal cancer; multi drug resistance 1; Retinoic acid receptor ; catenin

Indexed keywords

BETA CATENIN; MULTIDRUG RESISTANCE PROTEIN 1; RETINOIC ACID RECEPTOR GAMMA; WNT PROTEIN; ABCB1 PROTEIN, HUMAN; ANTINEOPLASTIC AGENT; MULTIDRUG RESISTANCE PROTEIN; RETINOIC ACID RECEPTOR;

ADULT; ARTICLE; CANCER RESISTANCE; CELL CYCLE; CELL PROLIFERATION; COLORECTAL CANCER; COLORECTAL CANCER CELL LINE; CONTROLLED STUDY; CYTOPLASM; DOWN REGULATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MULTIDRUG RESISTANCE; TISSUE MICROARRAY; UPREGULATION; WNT SIGNALING PATHWAY; COLORECTAL TUMOR; DRUG EFFECTS; DRUG RESISTANCE; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; METABOLISM; ONCOGENE; PATHOLOGY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; ONCOGENES; P-GLYCOPROTEINS; RECEPTORS, RETINOIC ACID; UP-REGULATION; WNT SIGNALING PATHWAY;

EID: 85014781594     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.1080/15384101.2017.1295180     Document Type: Article

References (31)

1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin 2015; 65:5-29; PMID:25559415; http://dx.doi.org/10.3322/caac.21254
2. Davies JM, Goldberg RM. Treatment of metastatic colorectal cancer. Semin Oncol 2011; 38:552-60; PMID:21810514; http://dx.doi.org/10.1053/j.seminoncol.2011.05.009
3. Dai Y, Wilson G, Huang B, Peng M, Teng G, Zhang D, Zhang R, Ebert MP, Chen J, Wong BC, et al. Silencing of Jagged1 inhibits cell growth and invasion in colorectal cancer. Cell Death Dis 2014; 5:e1170; PMID:24722295; http://dx.doi.org/10.1038/cddis.2014.137
4. Gronemeyer H, Gustafsson J-Å, Laudet V. Principles for modulation of the nuclear receptor superfamily. Nat Rev Drug Discov 2004; 3:950-64; PMID:15520817; http://dx.doi.org/10.1038/nrd1551
5. Purton LE, Dworkin S, Olsen GH, Walkley CR, Fabb SA, Collins SJ, Chambon P. RARgamma is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation. J Exp Med 2006; 203:1283-93; PMID:16682494; http://dx.doi.org/10.1084/jem.20052105
6. Yasuhara R, Yuasa T, Williams JA, Byers SW, Shah S, Pacifici M, Iwamoto M, Enomoto-Iwamoto M. Wnt/beta-catenin and retinoic acid receptor signaling pathways interact to regulate chondrocyte function and matrix turnover. J Biol Chem 2010; 285:317-27; PMID:19858186; http://dx.doi.org/10.1074/jbc.M109.053926
7. Goranov BB, Campbell Hewson QD, Pearson AD, Redfern CP. Overexpression of RARgamma increases death of SH-SY5Y neuroblastoma cells in response to retinoic acid but not fenretinide. Cell Death Differ 2006; 13:676-9; PMID:16341128; http://dx.doi.org/10.1038/sj.cdd.4401824
8. Pettersson F, Dalgleish AG, Bissonnette RP, Colston KW. Retinoids cause apoptosis in pancreatic cancer cells via activation of RAR-gamma and altered expression of Bcl-2/Bax. Br J Cancer 2002; 87:555-61; PMID:12189556; http://dx.doi.org/10.1038/sj.bjc.6600496
9. Yan TD, Wu H, Zhang HP, Lu N, Ye P, Yu FH, Zhou H, Li WG, Cao X, Lin YY, et al. Oncogenic potential of retinoic acid receptor-gamma in hepatocellular carcinoma. Cancer Res 2010; 70:2285-95; PMID:20197465; http://dx.doi.org/10.1158/0008-5472.CAN-09-2968
10. Kumar A, Kaur J, Chattopadhyay TK, Mathur M, Ralhan R. Differential expression of retinoic acid receptors in normal and malignant esophageal tissues. J Exp Ther Oncol 2004; 4:1-8; PMID:15255287
11. Huang GL, Luo Q, Rui G, Zhang W, Zhang QY, Chen QX, Shen DY. Oncogenic activity of retinoic acid receptor gamma is exhibited through activation of the Akt/NF-kappaB and Wnt/beta-catenin pathways in cholangiocarcinoma. Mol Cell Biol 2013; 33:3416-25; PMID:23798555; http://dx.doi.org/10.1128/MCB.00384-13
12. Zhu H, Liu Z, Tang L, Liu J, Zhou M, Xie F, Wang Z, Wang Y, Shen S, Hu L, et al. Reversal of P-gp and MRP1-mediated multidrug resistance by H6, a gypenoside aglycon from Gynostemma pentaphyllum, in vincristine-resistant human oral cancer (KB/VCR) cells. Eur J Pharmacol 2012; 696:43-53; PMID:23051672; http://dx.doi.org/10.1016/j.ejphar.2012.09.046
13. Rocchi E, Khodjakov A, Volk EL, Yang CH, Litman T, Bates SE, Schneider E. The product of the ABC half-transporter gene ABCG2 (BCRP/MXR/ABCP) is expressed in the plasma membrane. Biochem Biophys Res Commun 2000; 271:42-6; PMID:10777678; http://dx.doi.org/10.1006/bbrc.2000.2590
14. Kimura Y, Morita SY, Matsuo M, Ueda K. Mechanism of multidrug recognition by MDR1/ABCB1. Cancer Sci 2007; 98:1303-10; PMID:17608770; http://dx.doi.org/10.1111/j.1349-7006.2007.00538.x
15. Sharom FJ. ABC multidrug transporters:Structure, function and role in chemoresistance. Pharmacogenomics 2008; 9:105-27; PMID:18154452; http://dx.doi.org/10.2217/14622416.9.1.105
16. Balcerczak E, Panczyk M, Piaskowski S, Pasz-Walczak G, Salagacka A, Mirowski M. ABCB1/MDR1 gene polymorphisms as a prognostic factor in colorectal cancer. Int J Colorectal Dis 2010; 25:1167-76; PMID:20533057; http://dx.doi.org/10.1007/s00384-010-0961-2
17. Zhang H, Zhang X, Wu X, Li W, Su P, Cheng H, Xiang L, Gao P, Zhou G. Interference of Frizzled 1 (FZD1) reverses multidrug resistance in breast cancer cells through the Wnt/beta-catenin pathway. Cancer Lett 2012; 323:106-13; PMID:22484497; http://dx.doi.org/10.1016/j.canlet.2012.03.039
18. Hu T, To KK, Wang L, Zhang L, Lu L, Shen J, Chan RL, Li M, Yeung JH, Cho CH. Reversal of P-glycoprotein (P-gp) mediated multidrug resistance in colon cancer cells by cryptotanshinone and dihydrotanshinone of Salvia miltiorrhiza. Phytomedicine 2014; 21:1264-72; PMID:25172788; http://dx.doi.org/10.1016/j.phymed.2014.06.013
19. Rubinson DA, Dillon CP, Kwiatkowski AV, Sievers C, Yang L, Kopinja J, Rooney DL, Zhang M, Ihrig MM, McManus MT, et al. A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat Genet 2003; 33:401-6; PMID:12590264; http://dx.doi.org/10.1038/ng1117
20. Huang GL, Zhang W, Ren HY, Shen XY, Chen QX, Shen DY. Retinoid X receptor alpha enhances human cholangiocarcinoma growth through simultaneous activation of Wnt/beta-catenin and nuclear factor-kappaB pathways. Cancer Sci 2015; 106:1515-23; PMID:26310932; http://dx.doi.org/10.1111/cas.12802
21. Huang GL, Shen DY, Cai CF, Zhang QY, Ren HY, Chen QX. Beta-escin reverses multidrug resistance through inhibition of the GSK3beta/beta-catenin pathway in cholangiocarcinoma. World J Gastroenterol 2015; 21:1148-57; PMID:25632187; http://dx.doi.org/10.3748/wjg.v21.i4.1148
22. Han YH, Zhou H, Kim JH, Yan TD, Lee KH, Wu H, Lin F, Lu N, Liu J, Zeng JZ, et al. A unique cytoplasmic localization of retinoic acid receptor-gamma and its regulations. J Biol Chem 2009; 284:18503-14; PMID:19416983; http://dx.doi.org/10.1074/jbc.M109.007708
23. Hanahan D, Weinberg RA. Hallmarks of cancer:The next generation. Cell 2011; 144:646-74; PMID:21376230; http://dx.doi.org/10.1016/j.cell.2011.02.013
24. Ng L, Wan T, Chow A, Iyer D, Man J, Chen G, Yau TC, Lo O, Foo CC, Poon JT, et al. Osteopontin overexpression induced tumor progression and chemoresistance to oxaliplatin through induction of stem-like properties in human colorectal cancer. Stem Cells Int 2015; 2015:247892; PMID:26106421; http://dx.doi.org/10.1155/2015/247892
25. Kim KJ, Moon SM, Kim SA, Kang KW, Yoon JH, Ahn SG. Transcriptional regulation of MDR-1 by HOXC6 in multidrug-resistant cells. Oncogene 2013; 32:3339-49; PMID:22907429; http://dx.doi.org/10.1038/onc.2012.354
26. Ozben T. Mechanisms and strategies to overcome multiple drug resistance in cancer. FEBS Lett 2006; 580:2903-9; PMID:16497299; http://dx.doi.org/10.1016/j.febslet.2006.02.020
27. Mochida Y, Taguchi K, Taniguchi S, Tsuneyoshi M, Kuwano H, Tsuzuki T, Kuwano M, Wada M. The role of P-glycoprotein in intestinal tumorigenesis:Disruption of mdr1a suppresses polyp formation in Apc(Min/+) mice. Carcinogenesis 2003; 24:1219-24; PMID:12807720; http://dx.doi.org/10.1093/carcin/bgg073
28. Yasunaga M, Matsumura Y. Role of SLC6A6 in promoting the survival and multidrug resistance of colorectal cancer. Sci Rep 2014; 4:4852; PMID:24781822; http://dx.doi.org/10.1038/srep04852
29. Logan CY, Nusse R. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 2004; 20:781-810; PMID:15473860; http://dx.doi.org/10.1146/annurev.cellbio.20.010403.113126
30. Cancer Genome Atlas N. Comprehensive molecular characterization of human colon and rectal cancer. Nature 2012; 487:330-7; PMID:22810696; http://dx.doi.org/10.1038/nature11252
31. Voloshanenko O, Erdmann G, Dubash TD, Augustin I, Metzig M, Moffa G, Hundsrucker C, Kerr G, Sandmann T, Anchang B, et al. Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells. Nat Commun 2013; 4:2610; PMID:24162018; http://dx.doi.org/10.1038/ncomms3610