Oncogenic potential of retinoic acid receptor-γ in hepatocellular carcinoma

Cancer Research

Volumn 70, Issue 6, 2010, Pages 2285-2296

  Yan, Ting Dong ^a   Wu, Hua ^a   Zhang, Hai Ping ^b   Lu, Na ^a   Ye, Ping ^c   Yu, Feng Hai ^c   Zhou, Hu ^d   Li, Wen Gang ^b   Cao, Xihua ^d   Lin, Ya Yu ^a   He, Jia You ^a   Gao, Wei Wei ^a   Zhao, Yi ^a   Xie, Lei ^a   Chen, Jie Bo ^d   Zhang, Xiao Kun ^a,d   Zeng, Jin Zhang ^a  

^a XIAMEN UNIVERSITY   (China)

^b First Hospital of Xiamen   (China)

^c EASTERN HEPATOBILIARY SURGERY HOSPITAL   (China)

^d BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA FETOPROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P85; RETINOIC ACID RECEPTOR GAMMA; SMALL INTERFERING RNA;

ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CARCINOGENICITY; CELL STRAIN HEPG2; CLINICAL ARTICLE; COLONY FORMATION; CONTROLLED STUDY; CYTOPLASM; DOWN REGULATION; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR GROWTH; XENOGRAFT;

ALPHA-FETOPROTEINS; ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL GROWTH PROCESSES; HUMANS; LIVER NEOPLASMS; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASTIC STEM CELLS; RECEPTORS, RETINOIC ACID; RNA, SMALL INTERFERING; TRANSFECTION; TRANSPLANTATION, HETEROLOGOUS;

EID: 77950255064     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-2968     Document Type: Article

References (45)

1. Kastner P, Mark M, Chambon P. Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life? Cell 1995;83:859-869
2. Germain P, Chambon P, Eichele G, et al. International Union of Pharmacology: LX. Retinoic acid receptors. Pharmacol Rev 2006;58:712-725
3. Altucci L, Leibowitz MD, Ogilvie KM, de Lera AR, Gronemeyer H. RAR and RXR modulation in cancer and metabolic disease. Nat Rev Drug Discov 2007;6:793-810.
4. Khetchoumian K, Teletin M, Tisserand J, et al. Loss of Trim24 (Tif1α) gene function confers oncogenic activity to retinoic acid receptor α. Nat Genet 2007;39:1500-1506
5. Sano K, Takayama T, Murakami K, Saiki I, Makuuchi M. Overexpression of retinoic acid receptor α in hepatocellular carcinoma. Clin Cancer Res 2003;9:3679-3683
6. Dejean A, de The H. Hepatitis B virus as an insertional mutagene in a human hepatocellular carcinoma. Mol Biol Med 1990;7:213-222
7. Feitelson MA, Lee J. Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis. Cancer Lett 2007;252:157-170
8. Matsushima-Nishiwaki R, Okuno M, Adachi S, et al. Phosphorylation of retinoid X receptor α at serine 260 impairs its metabolism and function in human hepatocellular carcinoma. Cancer Res 2001;61:7675-7682
9. Nomura Y, Nagaya T, Yamaguchi S, Katunuma N, Seo H. Cleavage of RXRα by a lysosomal enzyme, cathepsin L-type protease. Biochem Biophys Res Commun 1999;254:388-394
10. Germain P, Chambon P, Eichele G, et al. International Union of Pharmacology: LXIII. Retinoid X receptors. Pharmacol Rev 2006;58:760-772
11. Zeng JZ, Zhang XK. Nongenomic actions of retinoids: role of Nur77 and RXR in the regulation of apoptosis and inflammation. Anti-inflamm Antiallergy Agents Med Chem 2007;6:315-331
12. Gronemeyer H, Gustafsson JA, Laudet V. Principles for modulation of the nuclear receptor superfamily. Nat Rev Drug Discov 2004;3:950-964
13. Chen N, Napoli JL. All-trans-retinoic acid stimulates translation and induces spine formation in hippocampal neurons through a membrane- associated RARα. FASEB J 2008;22:236-245
14. Dey N, De PK, Wang M, et al. CSK controls retinoic acid receptor (RAR) signaling: a RAR-c-SRC signaling axis is required for neuritogenic differentiation. Mol Cell Biol 2007;27:4179-4197
15. Masia S, Alvarez S, de Lera AR, Barettino D. Rapid, nongenomic actions of retinoic acid on phosphatidylinositol-3-kinase signaling pathway mediated by the retinoic acid receptor. Mol Endocrinol 2007;21:2391-2402
16. Lopez-Carballo G, Moreno L, Masia S, Perez P, Barettino D. Activation of the phosphatidylinositol 3-kinase/Akt signaling pathway by retinoic acid is required for neural differentiation of SH-SY5Y human neuroblastoma cells. J Biol Chem 2002;277:25297-25304
17. Ohashi E, Kogai T, Kagechika H, Brent GA. Activation of the PI3 kinase pathway by retinoic acid mediates sodium/iodide symporter induction and iodide transport in MCF-7 breast cancer cells. Cancer Res 2009;69:3443-3450
18. Dufour JM, Kim KH. Cellular and subcellular localization of six retinoid receptors in rat testis during postnatal development: identification of potential heterodimeric receptors. Biol Reprod 1999;61:1300-1308
19. Fukunaka K, Saito T, Wataba K, Ashihara K, Ito E, Kudo R. Changes in expression and subcellular localization of nuclear retinoic acid receptors in human endometrial epithelium during the menstrual cycle. Mol Hum Reprod 2001;7:437-446
20. Katagiri Y, Takeda K, Yu ZX, Ferrans VJ, Ozato K, Guroff G. Modulation of retinoid signalling through NGF-induced nuclear export of NGFI-B. Nat Cell Biol 2000;2:435-440
21. Cao X, Liu W, Lin F, et al. Retinoid X receptor regulates Nur77/TR3-dependent apoptosis by modulating its nuclear export and mitochondrial targeting. Mol Cell Biol 2004;24:9705-9725
22. Ghose R, Mulder J, von Furstenberg RJ, Thevananther S, Kuipers F, Karpen SJ. Rosiglitazone attenuates suppression of RXRα-dependent gene expression in inflamed liver. J Hepatol 2007;46:115-123
23. Yu X, Mertz JE. Critical roles of nuclear receptor response elements in replication of hepatitis B virus. J Virol 2001;75:11354-11364
24. Wang K, Wan YJ. Nuclear receptors and inflammatory diseases. Exp Biol Med (Maywood) 2008;233:496-506.
25. Gyamfi MA, He L, French SW, Damjanov I, Wan YJ. Hepatocyte retinoid X receptor α-dependent regulation of lipid homeostasis and inflammatory cytokine expression contributes to alcohol-induced liver injury. J Pharmacol Exp Ther 2008;324:443-453
26. Ghose R, Zimmerman TL, Thevananther S, Karpen SJ. Endotoxin leads to rapid subcellular re-localization of hepatic RXRα: a novel mechanism for reduced hepatic gene expression in inflammation. Nucl Recept 2004;2:4.
27. Han YH, Zhou H, Kim JH, et al. A unique cytoplasmic localization of RARγ and its regulations. J Biol Chem 2009;284:18503-18514
28. McIntire KR, Vogel CL, Princler GL, Patel IR. Serum α-fetoprotein as a biochemical marker for hepatocellular carcinoma. Cancer Res 1972;32:1941-1946
29. Marrero JA, Feng Z, Wang Y, et al. α-Fetoprotein, des-γ carboxyprothrombin, and lectin-bound α-fetoprotein in early hepatocellular carcinoma. Gastroenterology 2009;137:110-118
30. Rubinson DA, Dillon CP, Kwiatkowski AV, et al. A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat Genet 2003;33:401-406
31. Pan XB, Wei L, Chen HS, Liu F, Gao Y. Liver-derived cell lines QSG-7701 and HepG2 support different HBV replication patterns. Arch Virol 2007;152:1159-1173
32. Hou J, Wang D, Zhang R, Wang H. Experimental therapy of hepatoma with artemisinin and its derivatives: in vitro and in vivo activity, chemosensitization, and mechanisms of action. Clin Cancer Res 2008;14:5519-5530
33. Liu J, Zhou W, Li SS, et al. Modulation of orphan nuclear receptor Nur77-mediated apoptotic pathway by acetylshikonin and analogs. Cancer Res 2008;68:8871-8880
34. Maeda S, Kamata H, Luo JL, Leffert H, Karin M. IKKβ couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 2005;121:977-990
35. Karin M, Greten FR. NF-κB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 2005;5:749-759
36. Tak PP, Firestein GS. NF-κB: a key role in inflammatory diseases. J Clin Invest 2001;107:7-11.
37. Roberts LR, Gores GJ. Hepatocellular carcinoma: molecular pathways and new therapeutic targets. Semin Liver Dis 2005;25:212-225
38. Han YH, Cao X, Lin B, et al. Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt. Oncogene 2006;25:2974-2986
39. Meyskens FL, Jakobson J, Nguyen B, Weiss GR, Gandara DR, MacDonald JS. Phase II trial of oral β-all trans-retinoic acid in hepatocellular carcinoma (SWOG 9157). Invest New Drugs 1998;16:171-173
40. Kang S, Duell EA, Fisher GJ, et al. Application of retinol to human skin in vivo induces epidermal hyperplasia and cellular retinoid binding proteins characteristic of retinoic acid but without measurable retinoic acid levels or irritation. J Invest Dermatol 1995;105:549-556
41. Ferrari N, Pfahl M, Levi G. Retinoic acid receptor γ1 (RARγ1) levels control RARβ2 expression in SK-N-BE2(c) neuroblastoma cells and regulate a differentiation-apoptosis switch. Mol Cell Biol 1998;18:6482-6492
42. Vivanco I, Sawyers CL. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2002;2:489-501.
43. El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007;132:2557-2576
44. Factor V, Oliver AL, Panta GR, Thorgeirsson SS, Sonenshein GE, Arsura M. Roles of Akt/PKB and IKK complex in constitutive induction of NF-κB in hepatocellular carcinomas of transforming growth factor α/c-myc transgenic mice. Hepatology 2001;34:32-41.
45. De Bosscher K, Vanden Berghe W, Haegeman G. Cross-talk between nuclear receptors and nuclear factor κB. Oncogene 2006;25:6868-6886