Role for dithiolopyrrolones in disrupting bacterial metal homeostasis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 10, 2017, Pages 2717-2722

  Chan, Andrew N ^a   Shiver, Anthony L ^b   Wever, Walter J ^c   Razvi, Sayyeda Zeenat A ^d   Traxler, Matthew F ^e   Li, Bo ^a  

^a The University of North Carolina at Chapel Hill   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNC Hamner Institute for Drug Safety Sciences   (United States)

^d DUKE UNIVERSITY   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antibiotics; Metallophore; Mode of action; Natural products; Zinc chelation

Indexed keywords

ANTIBIOTIC AGENT; CARBAPENEM; DISULFIDE; DITHIOLOPYRROLONE DERIVATIVE; FRUCTOSE BISPHOSPHATE ALDOLASE; GLIOTOXIN; HOLOMYCIN; METAL; METAL CHELATE; METALLO BETA LACTAMASE; NATURAL PRODUCT; PYRROLE DERIVATIVE; RNA POLYMERASE; THIOLUTIN; UNCLASSIFIED DRUG; ZINC; ANTIINFECTIVE AGENT; BETA LACTAMASE; BIOLOGICAL PRODUCT; DITHIOL DERIVATIVE; DNA DIRECTED RNA POLYMERASE; LACTAM; METALLOPROTEIN; TOLUENE;

ANTIBIOTIC SENSITIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG POTENCY; ENZYME INHIBITION; ESCHERICHIA COLI; GENOMICS; HOMEOSTASIS; IN VITRO STUDY; METAL BINDING; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; ANTIBIOTIC RESISTANCE; CHEMISTRY; DRUG EFFECTS; ENZYME ACTIVE SITE; GENETICS; HUMAN; METABOLISM;

ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; BIOLOGICAL PRODUCTS; CATALYTIC DOMAIN; DISULFIDES; DNA-DIRECTED RNA POLYMERASES; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; GENOMICS; HOMEOSTASIS; HUMANS; LACTAMS; METALLOPROTEINS; METALS; PYRROLES; TOLUENE; ZINC;

EID: 85014734991     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1612810114     Document Type: Article

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