Large-scale transposition mutagenesis of Streptomyces coelicolor identifies hundreds of genes influencing antibiotic biosynthesis

Applied and Environmental Microbiology

Volumn 83, Issue 6, 2017, Pages

  Xu, Zhong ^a   Wang, Yemin ^a   Chater, Keith F ^b   Ou, Hong Yu ^a   Xu, H Howard ^c   Deng, Zixin ^a   Tao, Meifeng ^a  

^a Shanghai Jiao Tong University   (China)

^b JOHN INNES CENTRE   (United Kingdom)

^c CALIFORNIA STATE UNIVERSITY   (United States)

Author keywords

Antibiotic biosynthesis; Genome wide; Prodiginine; Streptomyces coelicolor; Transposition mutagenesis

Indexed keywords

ANTIBIOTICS; BACTERIA; BIOCHEMISTRY; BIOSYNTHESIS; CHROMOSOMES; METABOLISM; METABOLITES; MUTAGENESIS; NUCLEIC ACID SEQUENCES; NUCLEIC ACIDS; PHYSIOLOGY;

ANTIBIOTIC BIOSYNTHESIS; BIOSYNTHETIC GENE CLUSTER; BRANCHED CHAIN AMINO ACIDS; GENETIC COMPLEMENTATION; PRODIGININE; PROTEIN MODIFICATIONS; STREPTOMYCES COELICOLOR; TRANSCRIPTIONAL REGULATION;

GENES;

AMINO ACID; ANTIBIOTICS; BACTERIUM; CHROMOSOME; GENETIC ANALYSIS; MUTAGENICITY; NUCLEIC ACID; PROTEIN; SECONDARY METABOLITE;

POSIBACTERIA; STREPTOMYCES; STREPTOMYCES COELICOLOR;

ANTIINFECTIVE AGENT; PRODIGININE; PRODIGIOSIN; TN5 TRANSPOSASE; TRANSPOSASE; TRANSPOSON; UNDECYLPRODIGIOSIN;

ANALOGS AND DERIVATIVES; BIOSYNTHESIS; DNA BASE COMPOSITION; GENE EXPRESSION REGULATION; GENE LIBRARY; GENETICS; NUCLEOTIDE SEQUENCE; SECONDARY METABOLISM; STREPTOMYCES COELICOLOR; TRANSPOSON;

ANTI-BACTERIAL AGENTS; BASE COMPOSITION; BASE SEQUENCE; DNA TRANSPOSABLE ELEMENTS; GENE EXPRESSION REGULATION, BACTERIAL; GENE LIBRARY; MUTAGENESIS, INSERTIONAL; PRODIGIOSIN; SECONDARY METABOLISM; STREPTOMYCES COELICOLOR; TRANSPOSASES;

EID: 85014612636     PISSN: 00992240     EISSN: 10985336     Source Type: Journal    
DOI: 10.1128/AEM.02889-16     Document Type: Article

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