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Volumn 136, Issue 1, 2017, Pages 52-62

No cognitive-enhancing effect of GLP-1 receptor agonism in antipsychotic-treated, obese patients with schizophrenia

Author keywords

cognitive impairment; neurocognition; quality of life; randomized controlled trial; schizophrenia

Indexed keywords

AMISULPRIDE; ARIPIPRAZOLE; CHLORPROTHIXENE; CLOZAPINE; EXENDIN 4; NEUROLEPTIC AGENT; OLANZAPINE; PALIPERIDONE; PERPHENAZINE; QUETIAPINE; RISPERIDONE; SERTINDOLE; ZIPRASIDONE; ZUCLOPENTHIXOL; ANTIDIABETIC AGENT; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; PEPTIDE; VENOM;

EID: 85014537141     PISSN: 0001690X     EISSN: 16000447     Source Type: Journal    
DOI: 10.1111/acps.12711     Document Type: Article
Times cited : (33)

References (54)
  • 2
    • 0031903740 scopus 로고    scopus 로고
    • Neurocognitive deficit in schizophrenia: a quantitative review of the evidence
    • Heinrichs RW, Zakzanis KK. Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology 1998;12:426–445.
    • (1998) Neuropsychology , vol.12 , pp. 426-445
    • Heinrichs, R.W.1    Zakzanis, K.K.2
  • 3
    • 78649908087 scopus 로고    scopus 로고
    • The relationship between neurocognition and social cognition with functional outcomes in schizophrenia: a meta-analysis
    • Fett A-KJ, Viechtbauer W, Dominguez MDG, Penn DL, Van Os J, Krabbendam. The relationship between neurocognition and social cognition with functional outcomes in schizophrenia: a meta-analysis. Neurosci Biobehav Rev 2011;35:573–588.
    • (2011) Neurosci Biobehav Rev , vol.35 , pp. 573-588
    • Fett, A.-K.J.1    Viechtbauer, W.2    Dominguez, M.D.G.3    Penn, D.L.4    Van Os, J.5    Krabbendam6
  • 4
    • 65349120160 scopus 로고    scopus 로고
    • The dopamine hypothesis of schizophrenia: version III–the final common pathway
    • Howes OD, Kapur S. The dopamine hypothesis of schizophrenia: version III–the final common pathway. Schizophr Bull 2009;35:549–562.
    • (2009) Schizophr Bull , vol.35 , pp. 549-562
    • Howes, O.D.1    Kapur, S.2
  • 5
    • 84942980678 scopus 로고    scopus 로고
    • The use of continuous treatment versus placebo or intermittent treatment strategies in stabilized patients with schizophrenia: a systematic review and meta-analysis of randomized controlled trials with first- and second-generation antipsychotics
    • De Hert M et al. The use of continuous treatment versus placebo or intermittent treatment strategies in stabilized patients with schizophrenia: a systematic review and meta-analysis of randomized controlled trials with first- and second-generation antipsychotics. CNS Drugs 2015;29:637–658.
    • (2015) CNS Drugs , vol.29 , pp. 637-658
    • De Hert, M.1
  • 6
    • 33744795750 scopus 로고    scopus 로고
    • Epidemiology, clinical consequences, and psychosocial treatment of nonadherence in schizophrenia
    • Leucht S, Heres S. Epidemiology, clinical consequences, and psychosocial treatment of nonadherence in schizophrenia. J Clin Psychiatry 2006;67(Suppl 5):3–8.
    • (2006) J Clin Psychiatry , vol.67 , pp. 3-8
    • Leucht, S.1    Heres, S.2
  • 7
    • 84997907263 scopus 로고    scopus 로고
    • Medication adherence in schizophrenia: factors influencing adherence and consequences of nonadherence, a systematic literature review
    • Higashi K et al. Medication adherence in schizophrenia: factors influencing adherence and consequences of nonadherence, a systematic literature review. Ther Adv Psychopharmacol 2013;3:200–218.
    • (2013) Ther Adv Psychopharmacol , vol.3 , pp. 200-218
    • Higashi, K.1
  • 8
    • 84994444688 scopus 로고    scopus 로고
    • Somatic comorbidity in schizophrenia: some possible biological mechanisms across the life span
    • Dieset I, Andreassen OA, Haukvik UK. Somatic comorbidity in schizophrenia: some possible biological mechanisms across the life span. Schizophr Bull 2016;42:1316–1319.
    • (2016) Schizophr Bull , vol.42 , pp. 1316-1319
    • Dieset, I.1    Andreassen, O.A.2    Haukvik, U.K.3
  • 9
    • 55249091422 scopus 로고    scopus 로고
    • Schizophrenia: a concise overview of incidence, prevalence, and mortality
    • McGrath J, Saha S, Chant D, Welham J. Schizophrenia: a concise overview of incidence, prevalence, and mortality. Epidemiol Rev 2008;30:67–76.
    • (2008) Epidemiol Rev , vol.30 , pp. 67-76
    • McGrath, J.1    Saha, S.2    Chant, D.3    Welham, J.4
  • 10
    • 34147163415 scopus 로고    scopus 로고
    • What can imaging reveal about obesity and the brain?
    • Jagust W. What can imaging reveal about obesity and the brain? Curr Alzheimer Res 2007;4:135–139.
    • (2007) Curr Alzheimer Res , vol.4 , pp. 135-139
    • Jagust, W.1
  • 11
    • 0029869755 scopus 로고    scopus 로고
    • Glucose regulation and cognitive functions: relation to Alzheimer's disease and diabetes
    • Messier C, Gagnon M. Glucose regulation and cognitive functions: relation to Alzheimer's disease and diabetes. Behav Brain Res 1996;75:1–11.
    • (1996) Behav Brain Res , vol.75 , pp. 1-11
    • Messier, C.1    Gagnon, M.2
  • 12
    • 35748957503 scopus 로고    scopus 로고
    • The physiology of glucagon-like peptide 1
    • Holst JJ. The physiology of glucagon-like peptide 1. Physiol Rev 2007;87:1409–1439.
    • (2007) Physiol Rev , vol.87 , pp. 1409-1439
    • Holst, J.J.1
  • 13
    • 84959871979 scopus 로고    scopus 로고
    • A review of head-to-head comparisons of GLP-1 receptor agonists
    • Madsbad S. A review of head-to-head comparisons of GLP-1 receptor agonists. Diabetes Obes Metab 2015;18:317–332.
    • (2015) Diabetes Obes Metab , vol.18 , pp. 317-332
    • Madsbad, S.1
  • 14
    • 34248223285 scopus 로고    scopus 로고
    • Biology of Incretins: GLP-1 and GIP
    • Baggio LL, Drucker DJ. Biology of Incretins: GLP-1 and GIP. Gastroenterology 2007;132:2131–2157.
    • (2007) Gastroenterology , vol.132 , pp. 2131-2157
    • Baggio, L.L.1    Drucker, D.J.2
  • 15
    • 0033545166 scopus 로고    scopus 로고
    • Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system
    • Merchenthaler I, Lane M, Shughrue P. Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system. J Comp Neurol 1999;403:261–280.
    • (1999) J Comp Neurol , vol.403 , pp. 261-280
    • Merchenthaler, I.1    Lane, M.2    Shughrue, P.3
  • 16
    • 13644268431 scopus 로고    scopus 로고
    • The expression of GLP-1 receptor mRNA and protein allows the effect of GLP-1 on glucose metabolism in the human hypothalamus and brainstem
    • Alvarez E et al. The expression of GLP-1 receptor mRNA and protein allows the effect of GLP-1 on glucose metabolism in the human hypothalamus and brainstem. J Neurochem 2005;92:798–806.
    • (2005) J Neurochem , vol.92 , pp. 798-806
    • Alvarez, E.1
  • 17
    • 0141461415 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor is involved in learning and neuroprotection
    • During MJ et al. Glucagon-like peptide-1 receptor is involved in learning and neuroprotection. Nat Med 2003;9:1173–1179.
    • (2003) Nat Med , vol.9 , pp. 1173-1179
    • During, M.J.1
  • 18
    • 38849196303 scopus 로고    scopus 로고
    • Peptide hormone exendin-4 stimulates subventricular zone neurogenesis in the adult rodent brain and induces recovery in an animal model of Parkinson ‘s disease
    • Bertilsson G. et al. Peptide hormone exendin-4 stimulates subventricular zone neurogenesis in the adult rodent brain and induces recovery in an animal model of Parkinson ‘s disease. J Neurosci Res 2008;338:326–338.
    • (2008) J Neurosci Res , vol.338 , pp. 326-338
    • Bertilsson, G.1
  • 19
    • 77649187436 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: a link between diabetes and Alzheimer's disease
    • McClean PL, Gault VA, Harriott P, Hölscher C. Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: a link between diabetes and Alzheimer's disease. Eur J Pharmacol 2010;630:158–162.
    • (2010) Eur J Pharmacol , vol.630 , pp. 158-162
    • McClean, P.L.1    Gault, V.A.2    Harriott, P.3    Hölscher, C.4
  • 20
    • 79955749452 scopus 로고    scopus 로고
    • The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease
    • McClean PL, Parthsarathy V, Faivre E, Hölscher C. The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease. J Neurosci 2011;31:6587–6594.
    • (2011) J Neurosci , vol.31 , pp. 6587-6594
    • McClean, P.L.1    Parthsarathy, V.2    Faivre, E.3    Hölscher, C.4
  • 21
    • 84866972198 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 cleavage product GLP-1(9-36) amide rescues synaptic plasticity and memory deficits in Alzheimer's disease model mice
    • Ma T et al. Glucagon-like peptide-1 cleavage product GLP-1(9-36) amide rescues synaptic plasticity and memory deficits in Alzheimer's disease model mice. J Neurosci 2012;32:13701–13708.
    • (2012) J Neurosci , vol.32 , pp. 13701-13708
    • Ma, T.1
  • 22
    • 63249091158 scopus 로고    scopus 로고
    • Exendin-4 improves glycemic control, ameliorates brain and pancreatic pathologies, and extends survival in a mouse model of huntington ‘s disease
    • Martin B et al. Exendin-4 improves glycemic control, ameliorates brain and pancreatic pathologies, and extends survival in a mouse model of huntington ‘s disease. Diabetes 2009;58:318–328.
    • (2009) Diabetes , vol.58 , pp. 318-328
    • Martin, B.1
  • 23
    • 84879366324 scopus 로고    scopus 로고
    • Exenatide promotes cognitive enhancement and positive brain metabolic changes in PS1-KI mice but has no effects in 3xTg-AD animals
    • Bomba M et al. Exenatide promotes cognitive enhancement and positive brain metabolic changes in PS1-KI mice but has no effects in 3xTg-AD animals. Cell Death Dis 2013;4:e612.
    • (2013) Cell Death Dis , vol.4
    • Bomba, M.1
  • 24
    • 84977517025 scopus 로고    scopus 로고
    • Exenatide enhances cognitive performance and upregulates neurotrophic factor gene expression levels in diabetic mice
    • Gumuslu E et al. Exenatide enhances cognitive performance and upregulates neurotrophic factor gene expression levels in diabetic mice. Fundam Clin Pharmacol 2016;30:376–384.
    • (2016) Fundam Clin Pharmacol , vol.30 , pp. 376-384
    • Gumuslu, E.1
  • 25
    • 80054840462 scopus 로고    scopus 로고
    • Intentional weight loss in overweight and obese individuals and cognitive function: a systematic review and meta-analysis
    • Siervo M et al. Intentional weight loss in overweight and obese individuals and cognitive function: a systematic review and meta-analysis. Obes Rev 2011;12:968–983.
    • (2011) Obes Rev , vol.12 , pp. 968-983
    • Siervo, M.1
  • 26
    • 84867435685 scopus 로고    scopus 로고
    • The neuroprotective effects of GLP-1: possible treatments for cognitive deficits in individuals with mood disorders
    • McIntyre RS et al. The neuroprotective effects of GLP-1: possible treatments for cognitive deficits in individuals with mood disorders. Behav Brain Res 2013;237:164–171.
    • (2013) Behav Brain Res , vol.237 , pp. 164-171
    • McIntyre, R.S.1
  • 27
    • 84864950589 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 analogs against antipsychotic-induced weight gain: potential physiological benefits
    • Ebdrup BH et al. Glucagon-like peptide-1 analogs against antipsychotic-induced weight gain: potential physiological benefits. BMC Med 2012;10:92–99.
    • (2012) BMC Med , vol.10 , pp. 92-99
    • Ebdrup, B.H.1
  • 28
    • 84882262707 scopus 로고    scopus 로고
    • Sustained weight loss after treatment with a glucagon-like Peptide-1 receptor agonist in an obese patient with schizophrenia and type 2 diabetes
    • Ishøy PL, Knop FK, Vilsbøll T, Glenthøj BY, Ebdrup BH. Sustained weight loss after treatment with a glucagon-like Peptide-1 receptor agonist in an obese patient with schizophrenia and type 2 diabetes. Am J Psychiatry 2013;170:681–682.
    • (2013) Am J Psychiatry , vol.170 , pp. 681-682
    • Ishøy, P.L.1    Knop, F.K.2    Vilsbøll, T.3    Glenthøj, B.Y.4    Ebdrup, B.H.5
  • 29
    • 84964696261 scopus 로고    scopus 로고
    • Treatment of antipsychotic-associated obesity with a GLP-1 receptor agonist — protocol for an investigator- initiated prospective, randomised, intervention study: the TAO study protocol
    • Ishøy PL et al. Treatment of antipsychotic-associated obesity with a GLP-1 receptor agonist — protocol for an investigator- initiated prospective, randomised, intervention study: the TAO study protocol. BMJ Open 2014;4:e004158.
    • (2014) BMJ Open , vol.4
    • Ishøy, P.L.1
  • 30
    • 85006371317 scopus 로고    scopus 로고
    • Effect of GLP-1 receptor agonist treatment on body weight in obese antipsychotic-treated patients with schizophrenia: a randomized. Placebo-controlled Trial Byline
    • Ishøy PL et al. Effect of GLP-1 receptor agonist treatment on body weight in obese antipsychotic-treated patients with schizophrenia: a randomized. Placebo-controlled Trial Byline. Diabetes Obes Metab 2017;19:162–171.
    • (2017) Diabetes Obes Metab , vol.19 , pp. 162-171
    • Ishøy, P.L.1
  • 31
    • 84856235433 scopus 로고    scopus 로고
    • CONSORT 2010 Explanation and Elaboration : updated guidelines for reporting parallel group randomised trials
    • Moher D et al. CONSORT 2010 Explanation and Elaboration : updated guidelines for reporting parallel group randomised trials. BMJ 2010;10:28–55.
    • (2010) BMJ , vol.10 , pp. 28-55
    • Moher, D.1
  • 32
    • 1942536959 scopus 로고    scopus 로고
    • The Brief Assessment of Cognition in Schizophrenia: reliability, sensitivity, and comparison with a standard neurocognitive battery
    • Keefe RSE et al. The Brief Assessment of Cognition in Schizophrenia: reliability, sensitivity, and comparison with a standard neurocognitive battery. Schizophr Res 2004;68:283–297.
    • (2004) Schizophr Res , vol.68 , pp. 283-297
    • Keefe, R.S.E.1
  • 33
    • 0030063652 scopus 로고    scopus 로고
    • Development and preliminary standardization of the ‘extended complex figure test’ (ECFT)
    • Fastenau PS. Development and preliminary standardization of the ‘extended complex figure test’ (ECFT). J Clin Exp Neuropsychol 1996;18:63–76.
    • (1996) J Clin Exp Neuropsychol , vol.18 , pp. 63-76
    • Fastenau, P.S.1
  • 34
    • 39549107542 scopus 로고    scopus 로고
    • Efficiency of the CATIE and BACS neuropsychological batteries in assessing cognitive effects of antipsychotic treatments in schizophrenia
    • Hill SK et al. Efficiency of the CATIE and BACS neuropsychological batteries in assessing cognitive effects of antipsychotic treatments in schizophrenia. J Int Neuropsychol Soc 2008;14:209–221.
    • (2008) J Int Neuropsychol Soc , vol.14 , pp. 209-221
    • Hill, S.K.1
  • 36
    • 80054868441 scopus 로고    scopus 로고
    • Neuropsychological performance in older patients with schizophrenia: a meta-analysis of cross-sectional and longitudinal studies
    • Irani F, Kalkstein S, Moberg EA, Moberg PJ. Neuropsychological performance in older patients with schizophrenia: a meta-analysis of cross-sectional and longitudinal studies. Schizophr Bull 2011;37:1318–1326.
    • (2011) Schizophr Bull , vol.37 , pp. 1318-1326
    • Irani, F.1    Kalkstein, S.2    Moberg, E.A.3    Moberg, P.J.4
  • 39
    • 0026443916 scopus 로고
    • International quality of life assessment (IQOLA) project
    • Aaronson NK et al. International quality of life assessment (IQOLA) project. Qual Life Res 1992;1:349–351.
    • (1992) Qual Life Res , vol.1 , pp. 349-351
    • Aaronson, N.K.1
  • 40
    • 0034022621 scopus 로고    scopus 로고
    • Development, reliability and acceptability of a new version of the DSM-IV Social and Occupational Functioning Assessment Scale (SOFAS) to assess routine social funtioning
    • Morosini P-L, Magliano L, Brambilla L, Ugolini S, Pioli R. Development, reliability and acceptability of a new version of the DSM-IV Social and Occupational Functioning Assessment Scale (SOFAS) to assess routine social funtioning. Acta Psychiatr Scand 2000;101:323–329.
    • (2000) Acta Psychiatr Scand , vol.101 , pp. 323-329
    • Morosini, P.-L.1    Magliano, L.2    Brambilla, L.3    Ugolini, S.4    Pioli, R.5
  • 41
    • 0023606101 scopus 로고
    • The positive and negative syndrome scale (PANSS) for schizophrenia
    • Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 1987;13:261–276.
    • (1987) Schizophr Bull , vol.13 , pp. 261-276
    • Kay, S.R.1    Fiszbein, A.2    Opler, L.A.3
  • 42
    • 0035183126 scopus 로고    scopus 로고
    • Guideline for Good Clinical Practice
    • ICH harmonized tripartite guideline: Guideline for Good Clinical Practice. J Postgrad Med 2001;47:45–50.
    • (2001) J Postgrad Med , vol.47 , pp. 45-50
  • 43
    • 84907495472 scopus 로고    scopus 로고
    • The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss
    • Secher A et al. The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss. J Clin Invest 2014;124:4473–4488.
    • (2014) J Clin Invest , vol.124 , pp. 4473-4488
    • Secher, A.1
  • 44
    • 84919725884 scopus 로고    scopus 로고
    • Expression and distribution of glucagon-like peptide-1 receptor mRNA, protein and binding in the male nonhuman primate (Macaca mulatta) brain
    • Heppner KM et al. Expression and distribution of glucagon-like peptide-1 receptor mRNA, protein and binding in the male nonhuman primate (Macaca mulatta) brain. Endocrinology 2015;156:255–267.
    • (2015) Endocrinology , vol.156 , pp. 255-267
    • Heppner, K.M.1
  • 45
    • 0037349072 scopus 로고    scopus 로고
    • Entry of exendin-4 into brain is rapid but may be limited at high doses
    • Kastin AJ, Akerstrom V. Entry of exendin-4 into brain is rapid but may be limited at high doses. Int J Obes Relat Metab Disord 2003;27:313–318.
    • (2003) Int J Obes Relat Metab Disord , vol.27 , pp. 313-318
    • Kastin, A.J.1    Akerstrom, V.2
  • 46
    • 84947022827 scopus 로고    scopus 로고
    • Transfer of liraglutide from blood to cerebrospinal fluid is minimal in patients with type 2 diabetes
    • Christensen M et al. Transfer of liraglutide from blood to cerebrospinal fluid is minimal in patients with type 2 diabetes. Int J Obes (Lond) 2015;39:1651–1654.
    • (2015) Int J Obes (Lond) , vol.39 , pp. 1651-1654
    • Christensen, M.1
  • 47
    • 84974559551 scopus 로고    scopus 로고
    • In Alzheimer's disease, 6-month treatment with GLP-1 analog prevents decline of brain glucose metabolism: randomized, placebo-controlled. Double-blind clinical trial
    • Gejl M et al. In Alzheimer's disease, 6-month treatment with GLP-1 analog prevents decline of brain glucose metabolism: randomized, placebo-controlled. Double-blind clinical trial. Front Aging Neurosci 2016;8:108.
    • (2016) Front Aging Neurosci , vol.8 , pp. 108
    • Gejl, M.1
  • 48
    • 85007593139 scopus 로고    scopus 로고
    • Liraglutide promotes improvements in objective measures of cognitive dysfunction in individuals with mood disorders: a pilot, open-label study
    • Mansur RB et al. Liraglutide promotes improvements in objective measures of cognitive dysfunction in individuals with mood disorders: a pilot, open-label study. J Affect Disord 2016;207:114–120.
    • (2016) J Affect Disord , vol.207 , pp. 114-120
    • Mansur, R.B.1
  • 49
    • 2442467689 scopus 로고    scopus 로고
    • Effects of low-dose risperidone and low-dose zuclopenthixol on cognitive functions in first-episode drug-naive schizophrenic patients
    • Fagerlund B, Mackeprang T, Gade A, Glenthøj BY. Effects of low-dose risperidone and low-dose zuclopenthixol on cognitive functions in first-episode drug-naive schizophrenic patients. CNS Spectr 2004;9:364–374.
    • (2004) CNS Spectr , vol.9 , pp. 364-374
    • Fagerlund, B.1    Mackeprang, T.2    Gade, A.3    Glenthøj, B.Y.4
  • 50
    • 84989158706 scopus 로고    scopus 로고
    • Eulogy for the metabolic clinical investigator?
    • Vella A, Jensen MD, Nair KS. Eulogy for the metabolic clinical investigator? Diabetes 2016;65:2821–2823.
    • (2016) Diabetes , vol.65 , pp. 2821-2823
    • Vella, A.1    Jensen, M.D.2    Nair, K.S.3
  • 51
    • 84999277949 scopus 로고    scopus 로고
    • Weight loss is associated with improvements in cognitive function among overweight and obese people: a systematic review and meta-analysis
    • Veronese N et al. Weight loss is associated with improvements in cognitive function among overweight and obese people: a systematic review and meta-analysis. Neurosci Biobehav Rev 2017;72:87–94.
    • (2017) Neurosci Biobehav Rev , vol.72 , pp. 87-94
    • Veronese, N.1
  • 52
    • 79959956349 scopus 로고    scopus 로고
    • Psychological and quality of life changes in patients using GLP-1 analogues
    • Grant P, Lipscomb D, Quin J. Psychological and quality of life changes in patients using GLP-1 analogues. J Diabetes Complications 2011;25:244–246.
    • (2011) J Diabetes Complications , vol.25 , pp. 244-246
    • Grant, P.1    Lipscomb, D.2    Quin, J.3
  • 53
    • 84936753582 scopus 로고    scopus 로고
    • Treatments of negative symptoms in schizophrenia: meta-analysis of 168 randomized placebo-controlled trials
    • Fusar-Poli P et al. Treatments of negative symptoms in schizophrenia: meta-analysis of 168 randomized placebo-controlled trials. Schizophr Bull 2015;41:892–899.
    • (2015) Schizophr Bull , vol.41 , pp. 892-899
    • Fusar-Poli, P.1
  • 54
    • 84874511848 scopus 로고    scopus 로고
    • Clinical trials of potential cognitive-enhancing drugs in schizophrenia: what have we learned so far?
    • Keefe RSE et al. Clinical trials of potential cognitive-enhancing drugs in schizophrenia: what have we learned so far? Schizophr Bull 2013;39:417–435.
    • (2013) Schizophr Bull , vol.39 , pp. 417-435
    • Keefe, R.S.E.1


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