Gemcitabine mono-therapy versus gemcitabine plus targeted therapy in advanced pancreatic cancer: a meta-analysis of randomized phase III trials

Acta Oncologica

Volumn 56, Issue 3, 2017, Pages 377-383

  Ottaiano, Alessandro ^a   Capozzi, Monica ^a   De Divitiis, Chiara ^a   De Stefano, Alfonso ^a   Botti, Gerardo ^a   Avallone, Antonio ^a   Tafuto, Salvatore ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AFLIBERCEPT; AXITINIB; BEVACIZUMAB; CETUXIMAB; ELPAMOTIDE; ERLOTINIB; GANITUMAB; GEMCITABINE; MASITINIB; PLACEBO; RIGOSERTIB; ANTINEOPLASTIC AGENT; ANTINEOPLASTIC ANTIMETABOLITE; DEOXYCYTIDINE; MONOCLONAL ANTIBODY; THIAZOLE DERIVATIVE;

ADVANCED CANCER; ANTIANGIOGENIC THERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER PATIENT; CANCER REGISTRY; DATA EXTRACTION; DRUG EFFICACY; EFFECT SIZE; HAZARD RATIO; HUMAN; MEDLINE; META ANALYSIS; MOLECULARLY TARGETED THERAPY; MONOTHERAPY; NATIONAL HEALTH ORGANIZATION; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PANCREAS CANCER; PRIORITY JOURNAL; PUBLISHING; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SURVIVAL RATE; TREATMENT RESPONSE; ANALOGS AND DERIVATIVES; DISEASE COURSE; PANCREATIC NEOPLASMS; PATHOLOGY; PHASE 3 CLINICAL TRIAL (TOPIC); PROCEDURES; STATISTICS AND NUMERICAL DATA; SURVIVAL ANALYSIS;

ANTIBODIES, MONOCLONAL; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CLINICAL TRIALS, PHASE III AS TOPIC; DEOXYCYTIDINE; DISEASE PROGRESSION; HUMANS; MOLECULAR TARGETED THERAPY; PANCREATIC NEOPLASMS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SURVIVAL ANALYSIS; THIAZOLES;

EID: 85014534885     PISSN: 0284186X     EISSN: 1651226X     Source Type: Journal    
DOI: 10.1080/0284186X.2017.1288922     Document Type: Review

References (25)

1. Worni M, Guller U, White RR, et al. Modest improvement in overall survival for patients with metastatic pancreatic cancer:a trend analysis using the surveillance, epidemiology, and end results registry from 1988 to 2008. Pancreas. 2013;42:1157–1163.
2. Kamisawa T, Wood LD, Itoi T, et al. Pancreatic cancer. Lancet. 2016;388:73–85.
3. Moore MJ, Goldstein D, Hamm J, et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer:a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol. 2007;25:1960–1966.
4. Conroy T, Desseigne F, Ychou M, et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med. 2011;364:1817–1825.
5. Von Hoff DD, Ervin T, Arena FP, et al. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med. 2013;369:1691–1703.
6. Kawalec P, Łopuch S, Mikrut A., Effectiveness of targeted therapy in patients with previously untreated metastatic breast cancer:a systematic review and meta-analysis. Clin Breast Cancer. 2015;15:90–100.
7. Soria JC, Mauguen A, Reck M, et al. Systematic review and meta-analysis of randomised, phase II/III trials adding bevacizumab to platinum-based chemotherapy as first-line treatment in patients with advanced non-small-cell lung cancer. Ann Oncol. 2013;24:20–30.
8. Tran NH, Cavalcante LL, Lubner SJ, et al. Precision medicine in colorectal cancer:the molecular profile alters treatment strategies. Ther Adv Med Oncol. 2015;7:252–262.
9. Liddle J, Williamson M, Irwig L, Method for evaluating research and guideline evidence. NSW Health Department, Sydney; 1996.
10. Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629–634.
11. O'Neil BH, Scott AJ, Ma WW, et al. A phase II/III randomized study to compare the efficacy and safety of rigosertib plus gemcitabine versus gemcitabine alone in patients with previously untreated metastatic pancreatic cancer. Ann Oncol. 2015;26:1923–1929.
12. Yamaue H, Tsunoda T, Tani M, et al. Randomized phase II/III clinical trial of elpamotide for patients with advanced pancreatic cancer:PEGASUS-PC Study. Cancer Sci. 2015;106:883–890.
13. Deplanque G, Demarchi M, Hebbar M, et al. A randomized, placebo-controlled phase III trial of masitinib plus gemcitabine in the treatment of advanced pancreatic cancer. Ann Oncol. 2015;26:1194–1200.
14. Fuchs CS, Azevedo S, Okusaka T, et al. A phase 3 randomized, double-blind, placebo-controlled trial of ganitumab or placebo in combination with gemcitabine as first-line therapy for metastatic adenocarcinoma of the pancreas:the GAMMA trial. Ann Oncol. 2015;26:921–927.
15. Rougier P, Riess H, Manges R, et al. Randomised, placebo-controlled, double-blind, parallel-group phase III study evaluating aflibercept in patients receiving first-line treatment with gemcitabine for metastatic pancreatic cancer. Eur J Cancer. 2013;49:2633–2642.
16. Kindler HL, Ioka T, Richel DJ, et al. Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma:a double-blind randomised phase 3 study. Lancet Oncol. 2011;12:256–262.
17. Kindler HL, Niedzwiecki D, Hollis D, et al. Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer:phase III trial of the cancer and leukemia group B (CALGB 80303). J Clin Oncol. 2010;28:3617–3622.
18. Philip AP, Benedetti J, Corless CL, et al. Phase III study comparing gemcitabine plus cetuximab versus gemcitabine in patients with advanced pancreatic adenocarcinoma:southwest oncology group-directed intergroup trial S0205. J Clin Oncol. 2010;28:3605–3610.
19. Ciliberto D, Staropoli N, Chiellino S, et al. Systematic review and meta-analysis on targeted therapy in advanced pancreatic cancer. Pancreatology. 2016;16:249–258.
20. De La O JP, Murtaugh LC., Notch and Kras in pancreatic cancer:at the crossroads of mutation, differentiation and signaling. Cell Cycle. 2009;8:1860–1864.
21. Sahin IH, Iacobuzio-Donahue CA, O'reilly EM., Molecular signature of pancreatic adenocarcinoma:an insight from genotype to phenotype and challenges for targeted therapy. Expert Opin Ther Targets. 2016;20:341–359.
22. Trajkovic-Arsic M, Kalideris E, Siveke JT., The role of insulin and IGF system in pancreatic cancer. J Mol Endocrinol. 2013;50:R67–R74.
23. Balic A, Dorado J, Alonso-Gómez M, et al. Stem cells as the root of pancreatic ductal adenocarcinoma. Exp Cell Res. 2012;318:691–704.
24. Beuran M, Negoi I, Paun S, et al. The epithelial to mesenchymal transition in pancreatic cancer:a systematic review. Pancreatology. 2015;15:217–225.
25. Sousa CM, Biancur DE, Wang X, et al. Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Nature. 2016;536:479–483.