메뉴 건너뛰기




Volumn 15, Issue 2, 2015, Pages 90-100.e1

Effectiveness of targeted therapy in patients with previously untreated metastatic breast cancer: A systematic review and meta-analysis

Author keywords

First line treatment; HER2 and; HR status; Metastatic breast cancer; Systematic review and meta analysis; Targeted therapy

Indexed keywords

ANASTROZOLE; BEVACIZUMAB; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EVEROLIMUS; LAPATINIB; LETROZOLE; PERTUZUMAB; TRASTUZUMAB EMTANSINE; ANTINEOPLASTIC AGENT;

EID: 84924907482     PISSN: 15268209     EISSN: 19380666     Source Type: Journal    
DOI: 10.1016/j.clbc.2014.10.006     Document Type: Review
Times cited : (38)

References (56)
  • 1
    • 84924902789 scopus 로고    scopus 로고
    • International Agency for Research on Cancer Accessed: February 11, 2014
    • International Agency for Research on Cancer. GLOBOCAN 2012 Cancer Incidence and Mortality Worldwide. Available at: http://globocan.iarc.fr/Pages/fact-sheets-cancer.aspx. Accessed: February 11, 2014.
    • GLOBOCAN 2012 Cancer Incidence and Mortality Worldwide
  • 2
    • 84872853140 scopus 로고    scopus 로고
    • Estimates of global cancer prevalence for 27 sites in the adult population in 2008
    • F. Bray, J.S. Ren, E. Masuyer, and J. Ferlay Estimates of global cancer prevalence for 27 sites in the adult population in 2008 Int J Cancer 132 2013 1133 1145
    • (2013) Int J Cancer , vol.132 , pp. 1133-1145
    • Bray, F.1    Ren, J.S.2    Masuyer, E.3    Ferlay, J.4
  • 3
    • 84866597106 scopus 로고    scopus 로고
    • Locally recurrent or metastatic breast cancer: ESMO Clinical Practice Guidelines for diagnosis treatment and follow-up
    • F. Cardoso, N. Harbeck, and L. Fallowfield Locally recurrent or metastatic breast cancer: ESMO Clinical Practice Guidelines for diagnosis treatment and follow-up Ann Oncol 23 2012 11 19
    • (2012) Ann Oncol , vol.23 , pp. 11-19
    • Cardoso, F.1    Harbeck, N.2    Fallowfield, L.3
  • 5
    • 79954801217 scopus 로고    scopus 로고
    • Breast
    • S.B. Edge, D.R. Byrd, C.C. Compton, A.G. Fritz, F.L. Greene, A. Trotti, 7th ed Springer New York, NY
    • S.B. Edge, D.R. Byrd, and C.C. Compton Breast S.B. Edge, D.R. Byrd, C.C. Compton, A.G. Fritz, F.L. Greene, A. Trotti, AJCC Cancer Staging Manual 7th ed 2010 Springer New York, NY 347 376
    • (2010) AJCC Cancer Staging Manual , pp. 347-376
    • Edge, S.B.1    Byrd, D.R.2    Compton, C.C.3
  • 6
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • C.M. Perou, T. Sørlie, and M.B. Eisen Molecular portraits of human breast tumours Nature 406 2000 747 752
    • (2000) Nature , vol.406 , pp. 747-752
    • Perou, C.M.1    Sørlie, T.2    Eisen, M.B.3
  • 7
    • 0035845511 scopus 로고    scopus 로고
    • Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    • T. Sørlie, C.M. Perou, and R. Tibshirani Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications Proc Natl Acad Sci U S A 98 2001 10869 10874
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 10869-10874
    • Sørlie, T.1    Perou, C.M.2    Tibshirani, R.3
  • 8
    • 84862544485 scopus 로고    scopus 로고
    • 1st international consensus guidelines for advanced breast cancer (ABC1)
    • F. Cardoso, A. Costa, and L. Norton 1st international consensus guidelines for advanced breast cancer (ABC1) Breast 21 2012 242 252
    • (2012) Breast , vol.21 , pp. 242-252
    • Cardoso, F.1    Costa, A.2    Norton, L.3
  • 9
    • 78650382003 scopus 로고    scopus 로고
    • Biologically targeted cancer therapy and marginal benefits: Are we making too much of too little or are we achieving too little by giving too much
    • T. Fojo, and D.R. Parkinson Biologically targeted cancer therapy and marginal benefits: are we making too much of too little or are we achieving too little by giving too much Clin Cancer Res 16 2010 5972 5980
    • (2010) Clin Cancer Res , vol.16 , pp. 5972-5980
    • Fojo, T.1    Parkinson, D.R.2
  • 10
    • 41649114164 scopus 로고    scopus 로고
    • Enabling personalized cancer medicine through analysis of gene-expression patterns
    • L.J. van't Veer, and R. Bernards Enabling personalized cancer medicine through analysis of gene-expression patterns Nature 452 2008 564 570
    • (2008) Nature , vol.452 , pp. 564-570
    • Van'T Veer, L.J.1    Bernards, R.2
  • 11
    • 84924890749 scopus 로고    scopus 로고
    • European Medicine Agency Web site. Accessed: February 11, 2014
    • European Medicine Agency Web site. Available at: http://www.ema.europa.eu. Accessed: February 11, 2014.
  • 12
    • 84924890748 scopus 로고    scopus 로고
    • Food and Drug Administration. Accessed: February 11, 2014
    • Food and Drug Administration. Available at: http://www.fda.gov. Accessed: February 11, 2014.
  • 13
    • 34347395733 scopus 로고    scopus 로고
    • Trastuzumab - Mechanism of action and use in clinical practice
    • C.A. Hudis Trastuzumab - mechanism of action and use in clinical practice N Engl J Med 357 2007 39 51
    • (2007) N Engl J Med , vol.357 , pp. 39-51
    • Hudis, C.A.1
  • 14
    • 34447306848 scopus 로고    scopus 로고
    • Trastuzumab: Mechanism of action, resistance and future perspectives in HER2-overexpressing breast cancer
    • G. Valabrega, F. Montemurro, and M. Aglietta Trastuzumab: mechanism of action, resistance and future perspectives in HER2-overexpressing breast cancer Ann Oncol 18 2007 977 984
    • (2007) Ann Oncol , vol.18 , pp. 977-984
    • Valabrega, G.1    Montemurro, F.2    Aglietta, M.3
  • 15
    • 84862554194 scopus 로고    scopus 로고
    • Role of pertuzumab in the treatment of HER2-positive breast cancer
    • M. Hubalek, C. Brantner, and C. Marth Role of pertuzumab in the treatment of HER2-positive breast cancer Breast Cancer (Dove Med Press) 4 2012 65 73
    • (2012) Breast Cancer (Dove Med Press) , vol.4 , pp. 65-73
    • Hubalek, M.1    Brantner, C.2    Marth, C.3
  • 16
    • 80054092983 scopus 로고    scopus 로고
    • Trastuzumab emtansine: A unique antibody-drug conjugate in development for human epidermal growth factor receptor 2-positive cancer
    • P.M. LoRusso, D. Weiss, and E. Guardino Trastuzumab emtansine: a unique antibody-drug conjugate in development for human epidermal growth factor receptor 2-positive cancer Clin Cancer Res 17 2011 6437 6447
    • (2011) Clin Cancer Res , vol.17 , pp. 6437-6447
    • Lorusso, P.M.1    Weiss, D.2    Guardino, E.3
  • 17
    • 33750373924 scopus 로고    scopus 로고
    • Mechanisms of action of bevacizumab as component of therapy for metastatic colorectal cancer
    • L.M. Ellis Mechanisms of action of bevacizumab as component of therapy for metastatic colorectal cancer Semin Oncol 33 2006 S1 7
    • (2006) Semin Oncol , vol.33 , pp. S1-7
    • Ellis, L.M.1
  • 18
    • 77952838828 scopus 로고    scopus 로고
    • Lapatinib - Member of a new generation of ErbB-targeting drugs
    • M. Untch, and H.J. Luck Lapatinib - member of a new generation of ErbB-targeting drugs Breast Care 5 2010 8 12
    • (2010) Breast Care , vol.5 , pp. 8-12
    • Untch, M.1    Luck, H.J.2
  • 20
    • 79953902794 scopus 로고    scopus 로고
    • Mechanism of action of everolimus in renal cell carcinoma
    • B. Escudier, and J.A. Thompson Mechanism of action of everolimus in renal cell carcinoma Med Oncol 26 2009 S32 S39
    • (2009) Med Oncol , vol.26 , pp. S32-S39
    • Escudier, B.1    Thompson, J.A.2
  • 21
    • 68249144780 scopus 로고    scopus 로고
    • Breast cancer subtypes based on ER/PR and Her2 expression: Comparison of clinicopathologic features and survival
    • A.A. Ontilio, J.M. Engel, R.T. Greenlee, and B.N. Mukesh Breast cancer subtypes based on ER/PR and Her2 expression: comparison of clinicopathologic features and survival Clin Med Res 7 2009 4 13
    • (2009) Clin Med Res , vol.7 , pp. 4-13
    • Ontilio, A.A.1    Engel, J.M.2    Greenlee, R.T.3    Mukesh, B.N.4
  • 22
    • 84858817538 scopus 로고    scopus 로고
    • Occurrence of breast cancer subtypes in adolescent and young adult women
    • T.H.M. Keegan, M.C. DeRouen, and D.J. Press Occurrence of breast cancer subtypes in adolescent and young adult women Breast Cancer Res 14 2012 R55 63
    • (2012) Breast Cancer Res , vol.14 , pp. R55-63
    • Keegan, T.H.M.1    Derouen, M.C.2    Press, D.J.3
  • 23
    • 77950512587 scopus 로고    scopus 로고
    • Breast cancer subtypes and the risk of local and regional relapse
    • K.D. Voduc, M.C.U. Cheang, and S. Tyldesley Breast cancer subtypes and the risk of local and regional relapse J Clin Oncol 28 2010 1684 1691
    • (2010) J Clin Oncol , vol.28 , pp. 1684-1691
    • Voduc, K.D.1    Cheang, M.C.U.2    Tyldesley, S.3
  • 24
    • 84876266920 scopus 로고    scopus 로고
    • Molecular mechanisms of trastuzumab-based treatment in HER2-ovserexpressing breast cancer
    • R. Nahta Molecular mechanisms of trastuzumab-based treatment in HER2-ovserexpressing breast cancer ISRN Oncol 2012 2012 428062
    • (2012) ISRN Oncol , vol.2012 , pp. 428062
    • Nahta, R.1
  • 25
    • 0029914622 scopus 로고    scopus 로고
    • Assessing the quality of reports of randomized clinical trials: Is blinding necessary?
    • A.R. Jadad, R.A. Moore, and D. Carroll Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 17 1996 1 12
    • (1996) Control Clin Trials , vol.17 , pp. 1-12
    • Jadad, A.R.1    Moore, R.A.2    Carroll, D.3
  • 26
    • 69449100622 scopus 로고    scopus 로고
    • Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
    • D. Moher, A. Liberati, and J. Tetzlaff Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA Statement BMJ 339 2009 332 336
    • (2009) BMJ , vol.339 , pp. 332-336
    • Moher, D.1    Liberati, A.2    Tetzlaff, J.3
  • 28
    • 33846477245 scopus 로고    scopus 로고
    • Randomized phase II trial of weekly paclitaxel alone versus trastuzumab plus weekly paclitaxel as first-line therapy of patients with Her-2 positive advanced breast cancer
    • G. Gasparini, M. Gion, and L. Mariani Randomized phase II trial of weekly paclitaxel alone versus trastuzumab plus weekly paclitaxel as first-line therapy of patients with Her-2 positive advanced breast cancer Breast Cancer Res Treat 101 2007 355 365
    • (2007) Breast Cancer Res Treat , vol.101 , pp. 355-365
    • Gasparini, G.1    Gion, M.2    Mariani, L.3
  • 29
    • 22344446208 scopus 로고    scopus 로고
    • Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: The M77001 study group
    • M. Marty, F. Cognetti, and D. Maraninchi Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: the M77001 study group J Clin Oncol 23 2005 4265 4274
    • (2005) J Clin Oncol , vol.23 , pp. 4265-4274
    • Marty, M.1    Cognetti, F.2    Maraninchi, D.3
  • 30
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • D.J. Slamon, B. Leyland-Jones, and S. Shak Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2 N Engl J Med 344 2001 783 792
    • (2001) N Engl J Med , vol.344 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3
  • 31
    • 84856319982 scopus 로고    scopus 로고
    • Higher efficacy of letrozole in combination with trastuzumab compared to letrozole monotherapy as first-line treatment in patients with HER2+, hormone-receptor-positive metastatic breast cancer - Results of the eLEcTRA trial
    • J. Huober, P.A. Fasching, and M. Barsoum Higher efficacy of letrozole in combination with trastuzumab compared to letrozole monotherapy as first-line treatment in patients with HER2+, hormone-receptor-positive metastatic breast cancer - results of the eLEcTRA trial Breast 21 2012 27 33
    • (2012) Breast , vol.21 , pp. 27-33
    • Huober, J.1    Fasching, P.A.2    Barsoum, M.3
  • 32
    • 73949105921 scopus 로고    scopus 로고
    • Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: Results from the randomized phase III TAnDEM study
    • B. Kaufman, J.R. Mackey, and M.R. Clemens Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: results from the randomized phase III TAnDEM study J Clin Oncol 27 2009 5529 5537
    • (2009) J Clin Oncol , vol.27 , pp. 5529-5537
    • Kaufman, B.1    MacKey, J.R.2    Clemens, M.R.3
  • 33
    • 84862914692 scopus 로고    scopus 로고
    • Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer
    • J. Baselga, J. Cortés, and S.B. Kim Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer N Engl J Med 366 2012 109 119
    • (2012) N Engl J Med , vol.366 , pp. 109-119
    • Baselga, J.1    Cortés, J.2    Kim, S.B.3
  • 34
    • 84876970810 scopus 로고    scopus 로고
    • Pertuzumab, trastuzumab, and docetaxel for HER2+ metastatic breast cancer (CLEOPATRA study): Overall survival results from a randomised, double-blind, placebo-controlled, phase 3 study
    • S.M. Swain, S.B. Kim, and J. Cortés Pertuzumab, trastuzumab, and docetaxel for HER2+ metastatic breast cancer (CLEOPATRA study): overall survival results from a randomised, double-blind, placebo-controlled, phase 3 study Lancet Oncol 14 2013 461 471
    • (2013) Lancet Oncol , vol.14 , pp. 461-471
    • Swain, S.M.1    Kim, S.B.2    Cortés, J.3
  • 35
    • 57149096463 scopus 로고    scopus 로고
    • Phase III, double-blind, randomized study comparing lapatinib plus paclitaxel with placebo plus paclitaxel as first-line treatment for metastatic breast cancer
    • A. Di Leo, H.L. Gomez, and Z. Aziz Phase III, double-blind, randomized study comparing lapatinib plus paclitaxel with placebo plus paclitaxel as first-line treatment for metastatic breast cancer J Clin Oncol 26 2008 5544 5552
    • (2008) J Clin Oncol , vol.26 , pp. 5544-5552
    • Di Leo, A.1    Gomez, H.L.2    Aziz, Z.3
  • 36
    • 77649100030 scopus 로고    scopus 로고
    • Lapatinib plus letrozole as first-line therapy for HER-2+ hormone receptor-positive metastatic breast cancer
    • L.S. Schwartzberg, S.X. Franco, and A. Florance Lapatinib plus letrozole as first-line therapy for HER-2+ hormone receptor-positive metastatic breast cancer Oncologist 15 2010 122 129
    • (2010) Oncologist , vol.15 , pp. 122-129
    • Schwartzberg, L.S.1    Franco, S.X.2    Florance, A.3
  • 37
    • 73149115341 scopus 로고    scopus 로고
    • Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer
    • S. Johnston, J. Pippen Jr., and X. Pivot Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer J Clin Oncol 27 2009 5538 5546
    • (2009) J Clin Oncol , vol.27 , pp. 5538-5546
    • Johnston, S.1    Pippen, Jr.J.2    Pivot, X.3
  • 38
    • 84880452171 scopus 로고    scopus 로고
    • Randomized trial of lapatinib versus placebo added to paclitaxel in the treatment of human epidermal growth factor receptor 2 - Overexpressing metastatic breast cancer
    • Z. Guan, B. Xu, and M.L. DeSilvio Randomized trial of lapatinib versus placebo added to paclitaxel in the treatment of human epidermal growth factor receptor 2 - overexpressing metastatic breast cancer J Clin Oncol 31 2013 1947 1953
    • (2013) J Clin Oncol , vol.31 , pp. 1947-1953
    • Guan, Z.1    Xu, B.2    Desilvio, M.L.3
  • 39
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
    • K. Miller, M. Wang, and J. Gralow Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer N Engl J Med 357 2007 2666 2676
    • (2007) N Engl J Med , vol.357 , pp. 2666-2676
    • Miller, K.1    Wang, M.2    Gralow, J.3
  • 40
    • 77954700380 scopus 로고    scopus 로고
    • Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer
    • D.W. Miles, A. Chan, and L.Y. Dirix Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer J Clin Oncol 28 2010 3239 3247
    • (2010) J Clin Oncol , vol.28 , pp. 3239-3247
    • Miles, D.W.1    Chan, A.2    Dirix, L.Y.3
  • 41
    • 79953874259 scopus 로고    scopus 로고
    • RIBBON-1: Randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer
    • N.J. Robert, V. Diéras, and J. Glaspy RIBBON-1: randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer J Clin Oncol 29 2011 1252 1260
    • (2011) J Clin Oncol , vol.29 , pp. 1252-1260
    • Robert, N.J.1    Diéras, V.2    Glaspy, J.3
  • 42
    • 84879477431 scopus 로고    scopus 로고
    • AVEREL: A randomized phase III trial evaluating bevacizumab in combination with docetaxel and trastuzumab as first-line therapy for HER2+ locally recurrent/metastatic breast cancer
    • L. Gianni, G.H. Romieu, and M. Lichinitser AVEREL: a randomized phase III trial evaluating bevacizumab in combination with docetaxel and trastuzumab as first-line therapy for HER2+ locally recurrent/metastatic breast cancer J Clin Oncol 31 2013 1719 1725
    • (2013) J Clin Oncol , vol.31 , pp. 1719-1725
    • Gianni, L.1    Romieu, G.H.2    Lichinitser, M.3
  • 43
    • 79957864200 scopus 로고    scopus 로고
    • The efficacy of HER2-targeted therapy agents in metastatic breast cancer: A meta-analysis
    • C.A. Harris, R.L. Ward, and T.A. Dobbins The efficacy of HER2-targeted therapy agents in metastatic breast cancer: a meta-analysis Ann Oncol 22 2011 1308 1317
    • (2011) Ann Oncol , vol.22 , pp. 1308-1317
    • Harris, C.A.1    Ward, R.L.2    Dobbins, T.A.3
  • 44
    • 84867338601 scopus 로고    scopus 로고
    • Bevacizumab and breast cancer: A meta-analysis of first-line phase III studies and a critical reappraisal of available evidence
    • J.R. Rossari, O. Metzger-Filho, and M. Paesmans Bevacizumab and breast cancer: a meta-analysis of first-line phase III studies and a critical reappraisal of available evidence J Oncol 2012 2012 417673
    • (2012) J Oncol , vol.2012 , pp. 417673
    • Rossari, J.R.1    Metzger-Filho, O.2    Paesmans, M.3
  • 45
    • 80053223437 scopus 로고    scopus 로고
    • The role of chemotherapy and targeted agents in patients with metastatic breast cancer
    • S.R. Johnston The role of chemotherapy and targeted agents in patients with metastatic breast cancer Eur J Cancer 47 2011 38 47
    • (2011) Eur J Cancer , vol.47 , pp. 38-47
    • Johnston, S.R.1
  • 46
    • 0021688634 scopus 로고
    • The neu oncogene: An erb-B-related gene encoding a 185,000-Mr tumour antigen
    • A.L. Schechter, D.F. Stern, and L. Vaidyanathan The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen Nature 312 1984 513 516
    • (1984) Nature , vol.312 , pp. 513-516
    • Schechter, A.L.1    Stern, D.F.2    Vaidyanathan, L.3
  • 47
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the Her-2/neu oncogene
    • D.J. Slamon, G.M. Clark, and S.G. Wong Human breast cancer: correlation of relapse and survival with amplification of the Her-2/neu oncogene Science 235 1987 177 182
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3
  • 48
    • 34547854801 scopus 로고    scopus 로고
    • The oncogene HER2: Its signaling and transforming functions and its role in human cancer pathogenesis
    • M.M. Moasser The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis Oncogene 26 2007 6469 6487
    • (2007) Oncogene , vol.26 , pp. 6469-6487
    • Moasser, M.M.1
  • 49
    • 56949108012 scopus 로고    scopus 로고
    • Her2-positive breast cancer: Herceptin and beyond
    • W. Dean-Colomb, and F.J. Esteva Her2-positive breast cancer: Herceptin and beyond Eur J Cancer 44 2008 2806 2812
    • (2008) Eur J Cancer , vol.44 , pp. 2806-2812
    • Dean-Colomb, W.1    Esteva, F.J.2
  • 50
    • 84863078767 scopus 로고    scopus 로고
    • Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer
    • J. Baselaga, M. Campone, and M. Piccart Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer N Engl J Med 366 2012 520 529
    • (2012) N Engl J Med , vol.366 , pp. 520-529
    • Baselaga, J.1    Campone, M.2    Piccart, M.3
  • 51
    • 18144387234 scopus 로고    scopus 로고
    • The role of growth factor receptor pathways in human breast cancer cells adapted to long-term estrogen deprivation
    • G.J. Sabinis, D. Jelovac, B. Long, and A. Brodie The role of growth factor receptor pathways in human breast cancer cells adapted to long-term estrogen deprivation Cancer Res 65 2005 3903 3910
    • (2005) Cancer Res , vol.65 , pp. 3903-3910
    • Sabinis, G.J.1    Jelovac, D.2    Long, B.3    Brodie, A.4
  • 52
    • 82155187061 scopus 로고    scopus 로고
    • Different mechanisms for resistance to trastuzumab versus lapatinib in HER2-posistive breast cancers - Role of estrogen receptor and HER reactivation
    • Y.C. Wang, G. Morris, and R. Gillihan Different mechanisms for resistance to trastuzumab versus lapatinib in HER2-posistive breast cancers - role of estrogen receptor and HER reactivation Breast Cancer Res 13 2011 R121 R139
    • (2011) Breast Cancer Res , vol.13 , pp. R121-R139
    • Wang, Y.C.1    Morris, G.2    Gillihan, R.3
  • 53
    • 2942652871 scopus 로고    scopus 로고
    • Mechanisms of tamoxifen resistance: Increased estrogen receptor-HER2/neu cross-talk in ER/HER2+ breast cancer
    • J. Shou, S. Massarweh, and C.K. Osborne Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2+ breast cancer J Natl Cancer Inst 96 2004 925 956
    • (2004) J Natl Cancer Inst , vol.96 , pp. 925-956
    • Shou, J.1    Massarweh, S.2    Osborne, C.K.3
  • 54
    • 51149092061 scopus 로고    scopus 로고
    • The role of hormonal therapy in the management of hormonal-receptor-positive breast cancer with co-expression of HER2
    • A. Prat, and J. Baselaga The role of hormonal therapy in the management of hormonal-receptor-positive breast cancer with co-expression of HER2 Oncology 5 2008 531 542
    • (2008) Oncology , vol.5 , pp. 531-542
    • Prat, A.1    Baselaga, J.2
  • 55
    • 15744401575 scopus 로고    scopus 로고
    • Correlation of HER-2 status with estrogen and progesterone receptors and histologic features in 3,655 invasive breast carcinomas
    • P. Lal, L.K. Tan, and B. Chen Correlation of HER-2 status with estrogen and progesterone receptors and histologic features in 3,655 invasive breast carcinomas Am J Clin Pathol 125 2005 541 546
    • (2005) Am J Clin Pathol , vol.125 , pp. 541-546
    • Lal, P.1    Tan, L.K.2    Chen, B.3
  • 56
    • 32944462896 scopus 로고    scopus 로고
    • Hormone receptor status does not affect the clinical benefit of trastuzumab therapy for patients with metastatic breast cancer
    • A. Brufsky, B. Lembersky, and K. Schiffman Hormone receptor status does not affect the clinical benefit of trastuzumab therapy for patients with metastatic breast cancer Clin Breast Cancer 6 2005 247 252
    • (2005) Clin Breast Cancer , vol.6 , pp. 247-252
    • Brufsky, A.1    Lembersky, B.2    Schiffman, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.