-
1
-
-
84918815964
-
Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
-
J. Ferlay, I. Soerjomataram, R. Dikshit, S. Eser, C. Mathers, M. Rebelo, and et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012 Int J Cancer 136 2015 E359 E386
-
(2015)
Int J Cancer
, vol.136
, pp. E359-E386
-
-
Ferlay, J.1
Soerjomataram, I.2
Dikshit, R.3
Eser, S.4
Mathers, C.5
Rebelo, M.6
-
2
-
-
84892805731
-
Cancer statistics, 2014
-
R. Siegel, J. Ma, Z. Zou, and A. Jemal Cancer statistics, 2014 CA Cancer J Clin 64 2014 9 29
-
(2014)
CA Cancer J Clin
, vol.64
, pp. 9-29
-
-
Siegel, R.1
Ma, J.2
Zou, Z.3
Jemal, A.4
-
3
-
-
84905190648
-
European cancer mortality predictions for the year 2014
-
M. Malvezzi, P. Bertuccio, F. Levi, C. La Vecchia, and E. Negri European cancer mortality predictions for the year 2014 Ann Oncol Off J Eur Soc Med Oncol/ESMO 25 2014 1650 1656
-
(2014)
Ann Oncol off J Eur Soc Med Oncol/ESMO
, vol.25
, pp. 1650-1656
-
-
Malvezzi, M.1
Bertuccio, P.2
Levi, F.3
La Vecchia, C.4
Negri, E.5
-
4
-
-
80051700067
-
Pancreatic cancer
-
A. Vincent, J. Herman, R. Schulick, R.H. Hruban, and M. Goggins Pancreatic cancer Lancet 378 2011 607 620
-
(2011)
Lancet
, vol.378
, pp. 607-620
-
-
Vincent, A.1
Herman, J.2
Schulick, R.3
Hruban, R.H.4
Goggins, M.5
-
6
-
-
34247188535
-
Meta-analyses of chemotherapy for locally advanced and metastatic pancreatic cancer
-
A. Sultana, C.T. Smith, D. Cunningham, N. Starling, J.P. Neoptolemos, and P. Ghaneh Meta-analyses of chemotherapy for locally advanced and metastatic pancreatic cancer J Clin Oncol Off J Am Soc Clin Oncol 25 2007 2607 2615
-
(2007)
J Clin Oncol off J Am Soc Clin Oncol
, vol.25
, pp. 2607-2615
-
-
Sultana, A.1
Smith, C.T.2
Cunningham, D.3
Starling, N.4
Neoptolemos, J.P.5
Ghaneh, P.6
-
7
-
-
8244254377
-
Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
-
H.A. Burris 3rd, M.J. Moore, J. Andersen, M.R. Green, M.L. Rothenberg, M.R. Modiano, and et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial J Clin Oncol Off J Am Soc Clin Oncol 15 1997 2403 2413
-
(1997)
J Clin Oncol off J Am Soc Clin Oncol
, vol.15
, pp. 2403-2413
-
-
Burris, H.A.1
Moore, M.J.2
Andersen, J.3
Green, M.R.4
Rothenberg, M.L.5
Modiano, M.R.6
-
8
-
-
79955921754
-
Folfirinox versus gemcitabine for metastatic pancreatic cancer
-
T. Conroy, F. Desseigne, M. Ychou, O. Bouche, R. Guimbaud, Y. Becouarn, and et al. Folfirinox versus gemcitabine for metastatic pancreatic cancer N Engl J Med 2011 1817-1825 364
-
(1817)
N Engl J Med
, vol.2011
, pp. 364
-
-
Conroy, T.1
Desseigne, F.2
Ychou, M.3
Bouche, O.4
Guimbaud, R.5
Becouarn, Y.6
-
9
-
-
20644464360
-
Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: Results of a GERCOR and GISCAD phase III trial
-
C. Louvet, R. Labianca, P. Hammel, G. Lledo, M.G. Zampino, T. Andre, and et al. Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: results of a GERCOR and GISCAD phase III trial J Clin Oncol Off J Am Soc Clin Oncol 23 2005 3509 3516
-
(2005)
J Clin Oncol off J Am Soc Clin Oncol
, vol.23
, pp. 3509-3516
-
-
Louvet, C.1
Labianca, R.2
Hammel, P.3
Lledo, G.4
Zampino, M.G.5
Andre, T.6
-
10
-
-
73949135518
-
Phase III randomized comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer
-
D. Cunningham, I. Chau, D.D. Stocken, J.W. Valle, D. Smith, W. Steward, and et al. Phase III randomized comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer J Clin Oncol Off J Am Soc Clin Oncol 27 2009 5513 5518
-
(2009)
J Clin Oncol off J Am Soc Clin Oncol
, vol.27
, pp. 5513-5518
-
-
Cunningham, D.1
Chau, I.2
Stocken, D.D.3
Valle, J.W.4
Smith, D.5
Steward, W.6
-
11
-
-
84886741654
-
Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine
-
D.D. Von Hoff, T. Ervin, F.P. Arena, E.G. Chiorean, J. Infante, M. Moore, and et al. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine N Engl J Med 369 2013 1691 1703
-
(2013)
N Engl J Med
, vol.369
, pp. 1691-1703
-
-
Von Hoff, D.D.1
Ervin, T.2
Arena, F.P.3
Chiorean, E.G.4
Infante, J.5
Moore, M.6
-
12
-
-
84872677684
-
Role of gemcitabine-based combination therapy in the management of advanced pancreatic cancer: A meta-analysis of randomised trials
-
D. Ciliberto, C. Botta, P. Correale, M. Rossi, M. Caraglia, P. Tassone, and et al. Role of gemcitabine-based combination therapy in the management of advanced pancreatic cancer: a meta-analysis of randomised trials Eur J cancer 49 2013 593 603
-
(2013)
Eur J Cancer
, vol.49
, pp. 593-603
-
-
Ciliberto, D.1
Botta, C.2
Correale, P.3
Rossi, M.4
Caraglia, M.5
Tassone, P.6
-
13
-
-
77749285632
-
Options for the treatment of gemcitabine-resistant advanced pancreatic cancer
-
I. Gounaris, K. Zaki, and P. Corrie Options for the treatment of gemcitabine-resistant advanced pancreatic cancer JOP J Pancreas 11 2010 113 123
-
(2010)
JOP J Pancreas
, vol.11
, pp. 113-123
-
-
Gounaris, I.1
Zaki, K.2
Corrie, P.3
-
14
-
-
43549094700
-
New therapeutic directions for advanced pancreatic cancer: Targeting the epidermal growth factor and vascular endothelial growth factor pathways
-
H. Burris 3rd, and C. Rocha-Lima New therapeutic directions for advanced pancreatic cancer: targeting the epidermal growth factor and vascular endothelial growth factor pathways Oncologist 13 2008 289 298
-
(2008)
Oncologist
, vol.13
, pp. 289-298
-
-
Burris, H.1
Rocha-Lima, C.2
-
15
-
-
34548241874
-
Shh signaling and pancreatic cancer: Implications for therapy?
-
J.P. Morton, and B.C. Lewis Shh signaling and pancreatic cancer: implications for therapy? Cell Cycle 6 2007 1553 1557
-
(2007)
Cell Cycle
, vol.6
, pp. 1553-1557
-
-
Morton, J.P.1
Lewis, B.C.2
-
16
-
-
78650635358
-
The molecular targets for the diagnosis and treatment of pancreatic cancer
-
A.S. Strimpakos, K.N. Syrigos, and M.W. Saif The molecular targets for the diagnosis and treatment of pancreatic cancer Gut Liver 4 2010 433 449
-
(2010)
Gut Liver
, vol.4
, pp. 433-449
-
-
Strimpakos, A.S.1
Syrigos, K.N.2
Saif, M.W.3
-
17
-
-
34249933404
-
Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the national cancer institute of Canada clinical trials group
-
M.J. Moore, D. Goldstein, J. Hamm, A. Figer, J.R. Hecht, S. Gallinger, and et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase iii trial of the national cancer institute of canada clinical trials group J Clin Oncol Off J Am Soc Clin Oncol 25 2007 1960 1966
-
(2007)
J Clin Oncol off J Am Soc Clin Oncol
, vol.25
, pp. 1960-1966
-
-
Moore, M.J.1
Goldstein, D.2
Hamm, J.3
Figer, A.4
Hecht, J.R.5
Gallinger, S.6
-
18
-
-
77955887676
-
Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: Phase III trial of the cancer and Leukemia Group B (CALGB 80303)
-
H.L. Kindler, D. Niedzwiecki, D. Hollis, S. Sutherland, D. Schrag, H. Hurwitz, and et al. Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: phase III trial of the cancer and Leukemia Group B (CALGB 80303) J Clin Oncol Off J Am Soc Clin Oncol 28 2010 3617 3622
-
(2010)
J Clin Oncol off J Am Soc Clin Oncol
, vol.28
, pp. 3617-3622
-
-
Kindler, H.L.1
Niedzwiecki, D.2
Hollis, D.3
Sutherland, S.4
Schrag, D.5
Hurwitz, H.6
-
19
-
-
58249085318
-
Oral mTOR inhibitor everolimus in patients with gemcitabine-refractory metastatic pancreatic cancer
-
B.M. Wolpin, A.F. Hezel, T. Abrams, L.S. Blaszkowsky, J.A. Meyerhardt, J.A. Chan, and et al. Oral mTOR inhibitor everolimus in patients with gemcitabine-refractory metastatic pancreatic cancer J Clin Oncol Off J Am Soc Clin Oncol 27 2009 193 198
-
(2009)
J Clin Oncol off J Am Soc Clin Oncol
, vol.27
, pp. 193-198
-
-
Wolpin, B.M.1
Hezel, A.F.2
Abrams, T.3
Blaszkowsky, L.S.4
Meyerhardt, J.A.5
Chan, J.A.6
-
20
-
-
84918811818
-
Pilot clinical trial of hedgehog pathway inhibitor GDC-0449 (vismodegib) in combination with gemcitabine in patients with metastatic pancreatic adenocarcinoma
-
E.J. Kim, V. Sahai, E.V. Abel, K.A. Griffith, J.K. Greenson, N. Takebe, and et al. Pilot clinical trial of hedgehog pathway inhibitor GDC-0449 (vismodegib) in combination with gemcitabine in patients with metastatic pancreatic adenocarcinoma Clin Cancer Res Off J Am Assoc Cancer Res 20 2014 5937 5945
-
(2014)
Clin Cancer Res off J Am Assoc Cancer Res
, vol.20
, pp. 5937-5945
-
-
Kim, E.J.1
Sahai, V.2
Abel, E.V.3
Griffith, K.A.4
Greenson, J.K.5
Takebe, N.6
-
21
-
-
0031613437
-
Meta-analyses and large randomized, controlled trials
-
author reply 61-62
-
L.A. Stewart, M.K. Parmar, and J.F. Tierney Meta-analyses and large randomized, controlled trials N Engl J Med 338 61 1998 author reply 61-62
-
(1998)
N Engl J Med
, vol.338
, Issue.61
-
-
Stewart, L.A.1
Parmar, M.K.2
Tierney, J.F.3
-
22
-
-
0032583387
-
Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints
-
M.K. Parmar, V. Torri, and L. Stewart Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints Stat Med 17 1998 2815 2834
-
(1998)
Stat Med
, vol.17
, pp. 2815-2834
-
-
Parmar, M.K.1
Torri, V.2
Stewart, L.3
-
23
-
-
0029737052
-
Meta-analyses of randomised trials: When the whole is more than just the sum of the parts
-
M.K. Parmar, L.A. Stewart, and D.G. Altman Meta-analyses of randomised trials: when the whole is more than just the sum of the parts Br J Cancer 74 1996 496 501
-
(1996)
Br J Cancer
, vol.74
, pp. 496-501
-
-
Parmar, M.K.1
Stewart, L.A.2
Altman, D.G.3
-
24
-
-
68549101842
-
The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: Explanation and elaboration
-
A. Liberati, D.G. Altman, J. Tetzlaff, C. Mulrow, P.C. Gotzsche, J.P. Ioannidis, and et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration BMJ 339 2009 b2700
-
(2009)
BMJ
, vol.339
, pp. b2700
-
-
Liberati, A.1
Altman, D.G.2
Tetzlaff, J.3
Mulrow, C.4
Gotzsche, P.C.5
Ioannidis, J.P.6
-
26
-
-
84855558418
-
Assessment of study quality for systematic reviews: A comparison of the Cochrane collaboration risk of bias tool and the effective public health practice project quality assessment tool: Methodological research
-
S. Armijo-Olivo, C.R. Stiles, N.A. Hagen, P.D. Biondo, and G.G. Cummings Assessment of study quality for systematic reviews: a comparison of the Cochrane collaboration risk of bias tool and the effective public health practice project quality assessment tool: methodological research J Eval Clin Pract 18 2012 12 18
-
(2012)
J Eval Clin Pract
, vol.18
, pp. 12-18
-
-
Armijo-Olivo, S.1
Stiles, C.R.2
Hagen, N.A.3
Biondo, P.D.4
Cummings, G.G.5
-
27
-
-
0026524708
-
Incorporating variations in the quality of individual randomized trials into meta-analysis
-
A.S. Detsky, C.D. Naylor, K. O'Rourke, A.J. McGeer, and K.A. L'Abbe Incorporating variations in the quality of individual randomized trials into meta-analysis J Clin Epidemiol 45 1992 255 265
-
(1992)
J Clin Epidemiol
, vol.45
, pp. 255-265
-
-
Detsky, A.S.1
Naylor, C.D.2
O'Rourke, K.3
McGeer, A.J.4
L'Abbe, K.A.5
-
28
-
-
78049398953
-
Systematic review and meta-analysis methodology
-
M. Crowther, W. Lim, and M.A. Crowther Systematic review and meta-analysis methodology Blood 116 2010 3140 3146
-
(2010)
Blood
, vol.116
, pp. 3140-3146
-
-
Crowther, M.1
Lim, W.2
Crowther, M.A.3
-
29
-
-
77649237289
-
-
Application of Stata software to test heterogeneity in meta-analysis method
-
D. Wang, Z.Y. Mou, J.X. Zhai, H.X. Zong, and X.D. Zhao Application of Stata software to test heterogeneity in meta-analysis method Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 29 2008 726 729
-
(2008)
Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi
, vol.29
, pp. 726-729
-
-
Wang, D.1
Mou, Z.Y.2
Zhai, J.X.3
Zong, H.X.4
Zhao, X.D.5
-
30
-
-
0033581227
-
Resolving discrepancies between a meta-analysis and a subsequent large controlled trial
-
R. DerSimonian, and R.J. Levine Resolving discrepancies between a meta-analysis and a subsequent large controlled trial JAMA J Am Med Assoc 282 1999 664 670
-
(1999)
JAMA J Am Med Assoc
, vol.282
, pp. 664-670
-
-
DerSimonian, R.1
Levine, R.J.2
-
31
-
-
33845571913
-
Random-effects model for meta-analysis of clinical trials: An update
-
R. DerSimonian, and R. Kacker Random-effects model for meta-analysis of clinical trials: an update Contemp Clin Trials 28 2007 105 114
-
(2007)
Contemp Clin Trials
, vol.28
, pp. 105-114
-
-
DerSimonian, R.1
Kacker, R.2
-
32
-
-
79961238388
-
Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials
-
J.A. Sterne, A.J. Sutton, J.P. Ioannidis, N. Terrin, D.R. Jones, J. Lau, and et al. Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials BMJ 343 2011 d4002
-
(2011)
BMJ
, vol.343
, pp. d4002
-
-
Sterne, J.A.1
Sutton, A.J.2
Ioannidis, J.P.3
Terrin, N.4
Jones, D.R.5
Lau, J.6
-
33
-
-
0346848728
-
Stata: A statistical analysis system for examining biomedical data
-
R.C. Boston, and A.E. Sumner Stata: a statistical analysis system for examining biomedical data Adv Exp Med Biol 537 2003 353 369
-
(2003)
Adv Exp Med Biol
, vol.537
, pp. 353-369
-
-
Boston, R.C.1
Sumner, A.E.2
-
34
-
-
84862531853
-
A randomized, placebo-controlled phase 2 study of ganitumab (AMG 479) or conatumumab (AMG 655) in combination with gemcitabine in patients with metastatic pancreatic cancer
-
H.L. Kindler, D.A. Richards, L.E. Garbo, E.B. Garon, J.J. Stephenson Jr., C.M. Rocha-Lima, and et al. A randomized, placebo-controlled phase 2 study of ganitumab (AMG 479) or conatumumab (AMG 655) in combination with gemcitabine in patients with metastatic pancreatic cancer Ann Oncol Off J Eur Soc Med Oncol/ESMO 23 2012 2834 2842
-
(2012)
Ann Oncol off J Eur Soc Med Oncol/ESMO
, vol.23
, pp. 2834-2842
-
-
Kindler, H.L.1
Richards, D.A.2
Garbo, L.E.3
Garon, E.B.4
Stephenson, J.J.5
Rocha-Lima, C.M.6
-
35
-
-
84875215526
-
Phase II randomised proof-of-concept study of the urokinase inhibitor upamostat (WX-671) in combination with gemcitabine compared with gemcitabine alone in patients with non-resectable, locally advanced pancreatic cancer
-
V. Heinemann, M.P. Ebert, R.P. Laubender, P. Bevan, C. Mala, and S. Boeck Phase II randomised proof-of-concept study of the urokinase inhibitor upamostat (WX-671) in combination with gemcitabine compared with gemcitabine alone in patients with non-resectable, locally advanced pancreatic cancer Br J Cancer 108 2013 766 770
-
(2013)
Br J Cancer
, vol.108
, pp. 766-770
-
-
Heinemann, V.1
Ebert, M.P.2
Laubender, R.P.3
Bevan, P.4
Mala, C.5
Boeck, S.6
-
36
-
-
84903527674
-
Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): An open-label, randomised, phase 3 trial
-
G. Middleton, P. Silcocks, T. Cox, J. Valle, J. Wadsley, D. Propper, and et al. Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): an open-label, randomised, phase 3 trial Lancet Oncol 15 2014 829 840
-
(2014)
Lancet Oncol
, vol.15
, pp. 829-840
-
-
Middleton, G.1
Silcocks, P.2
Cox, T.3
Valle, J.4
Wadsley, J.5
Propper, D.6
-
37
-
-
84929083437
-
A phase 3 randomized, double-blind, placebo-controlled trial of ganitumab or placebo in combination with gemcitabine as first-line therapy for metastatic adenocarcinoma of the pancreas: The gamma trialdagger
-
C.S. Fuchs, S. Azevedo, T. Okusaka, J.L. Van Laethem, L.R. Lipton, H. Riess, and et al. A phase 3 randomized, double-blind, placebo-controlled trial of ganitumab or placebo in combination with gemcitabine as first-line therapy for metastatic adenocarcinoma of the pancreas: the gamma trialdagger Ann Oncol Off J Eur Soc Med Oncol/ESMO 26 2015 921 927
-
(2015)
Ann Oncol off J Eur Soc Med Oncol/ESMO
, vol.26
, pp. 921-927
-
-
Fuchs, C.S.1
Azevedo, S.2
Okusaka, T.3
Van Laethem, J.L.4
Lipton, L.R.5
Riess, H.6
-
38
-
-
84886793895
-
Maintenance sunitinib or observation in metastatic pancreatic adenocarcinoma: A phase II randomised trial
-
M. Reni, S. Cereda, M. Milella, A. Novarino, A. Passardi, A. Mambrini, and et al. Maintenance sunitinib or observation in metastatic pancreatic adenocarcinoma: a phase II randomised trial Eur J Cancer 49 2013 3609 3615
-
(2013)
Eur J Cancer
, vol.49
, pp. 3609-3615
-
-
Reni, M.1
Cereda, S.2
Milella, M.3
Novarino, A.4
Passardi, A.5
Mambrini, A.6
-
39
-
-
77955914277
-
Phase III study comparing gemcitabine plus cetuximab versus gemcitabine in patients with advanced pancreatic adenocarcinoma: Southwest Oncology Group-directed intergroup trial s0205
-
P.A. Philip, J. Benedetti, C.L. Corless, R. Wong, E.M. O'Reilly, P.J. Flynn, and et al. Phase III study comparing gemcitabine plus cetuximab versus gemcitabine in patients with advanced pancreatic adenocarcinoma: Southwest Oncology Group-directed intergroup trial s0205 J Clin Oncol Off J Am Soc Clin Oncol 28 2010 3605 3610
-
(2010)
J Clin Oncol off J Am Soc Clin Oncol
, vol.28
, pp. 3605-3610
-
-
Philip, P.A.1
Benedetti, J.2
Corless, C.L.3
Wong, R.4
O'Reilly, E.M.5
Flynn, P.J.6
-
40
-
-
79952036599
-
Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: A double-blind randomised phase 3 study
-
H.L. Kindler, T. Ioka, D.J. Richel, J. Bennouna, R. Letourneau, T. Okusaka, and et al. Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study Lancet Oncol 12 2011 256 262
-
(2011)
Lancet Oncol
, vol.12
, pp. 256-262
-
-
Kindler, H.L.1
Ioka, T.2
Richel, D.J.3
Bennouna, J.4
Letourneau, R.5
Okusaka, T.6
-
41
-
-
45449090215
-
Efficacy of gemcitabine plus axitinib compared with gemcitabine alone in patients with advanced pancreatic cancer: An open-label randomised phase II study
-
J.P. Spano, C. Chodkiewicz, J. Maurel, R. Wong, H. Wasan, C. Barone, and et al. Efficacy of gemcitabine plus axitinib compared with gemcitabine alone in patients with advanced pancreatic cancer: an open-label randomised phase II study Lancet 371 2008 2101 2108
-
(2008)
Lancet
, vol.371
, pp. 2101-2108
-
-
Spano, J.P.1
Chodkiewicz, C.2
Maurel, J.3
Wong, R.4
Wasan, H.5
Barone, C.6
-
42
-
-
79151469315
-
Gemcitabine plus enzastaurin or single-agent gemcitabine in locally advanced or metastatic pancreatic cancer: Results of a phase II, randomized, noncomparative study
-
D.A. Richards, P.R. Kuefler, C. Becerra, L.S. Wilfong, R.H. Gersh, K.A. Boehm, and et al. Gemcitabine plus enzastaurin or single-agent gemcitabine in locally advanced or metastatic pancreatic cancer: results of a phase II, randomized, noncomparative study Investig New Drugs 29 2011 144 153
-
(2011)
Investig New Drugs
, vol.29
, pp. 144-153
-
-
Richards, D.A.1
Kuefler, P.R.2
Becerra, C.3
Wilfong, L.S.4
Gersh, R.H.5
Boehm, K.A.6
-
43
-
-
84868107516
-
Baypan study: A double-blind phase III randomized trial comparing gemcitabine plus sorafenib and gemcitabine plus placebo in patients with advanced pancreatic cancer
-
A. Goncalves, M. Gilabert, E. Francois, L. Dahan, H. Perrier, R. Lamy, and et al. Baypan study: a double-blind phase iii randomized trial comparing gemcitabine plus sorafenib and gemcitabine plus placebo in patients with advanced pancreatic cancer Ann Oncol Off J Eur Soc Med Oncol/ESMO 23 2012 2799 2805
-
(2012)
Ann Oncol off J Eur Soc Med Oncol/ESMO
, vol.23
, pp. 2799-2805
-
-
Goncalves, A.1
Gilabert, M.2
Francois, E.3
Dahan, L.4
Perrier, H.5
Lamy, R.6
-
44
-
-
84883811812
-
Global, multicenter, randomized, phase II trial of gemcitabine and gemcitabine plus AGS-1C4D4 in patients with previously untreated, metastatic pancreatic cancer
-
B.M. Wolpin, E.M. O'Reilly, Y.J. Ko, L.S. Blaszkowsky, M. Rarick, C.M. Rocha-Lima, and et al. Global, multicenter, randomized, phase II trial of gemcitabine and gemcitabine plus AGS-1C4D4 in patients with previously untreated, metastatic pancreatic cancer Ann Oncol Off J Eur Soc Med Oncol/ESMO 24 2013 1792 1801
-
(2013)
Ann Oncol off J Eur Soc Med Oncol/ESMO
, vol.24
, pp. 1792-1801
-
-
Wolpin, B.M.1
O'Reilly, E.M.2
Ko, Y.J.3
Blaszkowsky, L.S.4
Rarick, M.5
Rocha-Lima, C.M.6
-
45
-
-
38049041406
-
Erlotinib/gemcitabine for first-line treatment of locally advanced or metastatic adenocarcinoma of the pancreas
-
discussion 1706-1699, 1712, 1715
-
A.M. Senderowicz, J.R. Johnson, R. Sridhara, P. Zimmerman, R. Justice, and R. Pazdur Erlotinib/gemcitabine for first-line treatment of locally advanced or metastatic adenocarcinoma of the pancreas Oncol Willist Park 21 2007 1696 1706 discussion 1706-1699, 1712, 1715
-
(2007)
Oncol Willist Park
, vol.21
, pp. 1696-1706
-
-
Senderowicz, A.M.1
Johnson, J.R.2
Sridhara, R.3
Zimmerman, P.4
Justice, R.5
Pazdur, R.6
-
46
-
-
59649129193
-
Patient-reported outcomes as a component of the primary endpoint in a double-blind, placebo-controlled trial in advanced pancreatic cancer
-
S.G. Eckhardt, P. De Porre, D. Smith, J. Maurel, W.P. Steward, O. Bouche, and et al. Patient-reported outcomes as a component of the primary endpoint in a double-blind, placebo-controlled trial in advanced pancreatic cancer J Pain Symptom Manag 37 2009 135 143
-
(2009)
J Pain Symptom Manag
, vol.37
, pp. 135-143
-
-
Eckhardt, S.G.1
De Porre, P.2
Smith, D.3
Maurel, J.4
Steward, W.P.5
Bouche, O.6
-
47
-
-
84879952361
-
Randomised, placebo-controlled, double-blind, parallel-group phase III study evaluating aflibercept in patients receiving first-line treatment with gemcitabine for metastatic pancreatic cancer
-
P. Rougier, H. Riess, R. Manges, P. Karasek, Y. Humblet, C. Barone, and et al. Randomised, placebo-controlled, double-blind, parallel-group phase iii study evaluating aflibercept in patients receiving first-line treatment with gemcitabine for metastatic pancreatic cancer Eur J cancer 49 2013 2633 2642
-
(2013)
Eur J Cancer
, vol.49
, pp. 2633-2642
-
-
Rougier, P.1
Riess, H.2
Manges, R.3
Karasek, P.4
Humblet, Y.5
Barone, C.6
-
48
-
-
84908500883
-
Dual blockade of epidermal growth factor receptor and insulin-like growth factor receptor-1 signaling in metastatic pancreatic cancer: Phase ib and randomized phase II trial of gemcitabine, erlotinib, and cixutumumab versus gemcitabine plus erlotinib (SWOG S0727)
-
P.A. Philip, B. Goldman, R.K. Ramanathan, H.J. Lenz, A.M. Lowy, R.P. Whitehead, and et al. Dual blockade of epidermal growth factor receptor and insulin-like growth factor receptor-1 signaling in metastatic pancreatic cancer: phase ib and randomized phase II trial of gemcitabine, erlotinib, and cixutumumab versus gemcitabine plus erlotinib (SWOG S0727) Cancer 120 2014 2980 2985
-
(2014)
Cancer
, vol.120
, pp. 2980-2985
-
-
Philip, P.A.1
Goldman, B.2
Ramanathan, R.K.3
Lenz, H.J.4
Lowy, A.M.5
Whitehead, R.P.6
-
49
-
-
84893652695
-
Sorafenib does not improve efficacy of chemotherapy in advanced pancreatic cancer: A GISCAD randomized phase II study
-
S. Cascinu, R. Berardi, A. Sobrero, P. Bidoli, R. Labianca, S. Siena, and et al. Sorafenib does not improve efficacy of chemotherapy in advanced pancreatic cancer: a GISCAD randomized phase ii study Dig Liver Dis Off J Ital Soc Gastroenterol Ital Assoc Study Liver 46 2014 182 186
-
(2014)
Dig Liver Dis off J Ital Soc Gastroenterol Ital Assoc Study Liver
, vol.46
, pp. 182-186
-
-
Cascinu, S.1
Berardi, R.2
Sobrero, A.3
Bidoli, P.4
Labianca, R.5
Siena, S.6
-
50
-
-
84903729284
-
Phase II, randomized, biomarker identification trial (MARK) for erlotinib in patients with advanced pancreatic carcinoma
-
D. Propper, I. Davidenko, J. Bridgewater, L. Kupcinskas, A. Fittipaldo, C. Hillenbach, and et al. Phase II, randomized, biomarker identification trial (MARK) for erlotinib in patients with advanced pancreatic carcinoma Ann Oncol Off J Eur Soc Med Oncol/ESMO 25 2014 1384 1390
-
(2014)
Ann Oncol off J Eur Soc Med Oncol/ESMO
, vol.25
, pp. 1384-1390
-
-
Propper, D.1
Davidenko, I.2
Bridgewater, J.3
Kupcinskas, L.4
Fittipaldo, A.5
Hillenbach, C.6
-
51
-
-
84904063663
-
A randomised, double-blind, placebo-controlled trial of trametinib, an oral MEK inhibitor, in combination with gemcitabine for patients with untreated metastatic adenocarcinoma of the pancreas
-
J.R. Infante, B.G. Somer, J.O. Park, C.P. Li, M.E. Scheulen, S.M. Kasubhai, and et al. A randomised, double-blind, placebo-controlled trial of trametinib, an oral MEK inhibitor, in combination with gemcitabine for patients with untreated metastatic adenocarcinoma of the pancreas Eur J Cancer 50 2014 2072 2081
-
(2014)
Eur J Cancer
, vol.50
, pp. 2072-2081
-
-
Infante, J.R.1
Somer, B.G.2
Park, J.O.3
Li, C.P.4
Scheulen, M.E.5
Kasubhai, S.M.6
-
52
-
-
84892789527
-
Randomized double-blinded, placebo-controlled phase II trial of simvastatin and gemcitabine in advanced pancreatic cancer patients
-
J.Y. Hong, E.M. Nam, J. Lee, J.O. Park, S.C. Lee, S.Y. Song, and et al. Randomized double-blinded, placebo-controlled phase ii trial of simvastatin and gemcitabine in advanced pancreatic cancer patients Cancer Chemother Pharmacol 73 2014 125 130
-
(2014)
Cancer Chemother Pharmacol
, vol.73
, pp. 125-130
-
-
Hong, J.Y.1
Nam, E.M.2
Lee, J.3
Park, J.O.4
Lee, S.C.5
Song, S.Y.6
-
53
-
-
84936985276
-
Randomized phase II/III clinical trial of elpamotide for patients with advanced pancreatic cancer; PEGASUS-PC study
-
H. Yamaue, T. Tsunoda, M. Tani, M. Miyazawa, K. Yamao, N. Mizuno, and et al. Randomized phase II/III clinical trial of elpamotide for patients with advanced pancreatic cancer; PEGASUS-PC study Cancer Sci. 106 7 2015 883 890
-
(2015)
Cancer Sci.
, vol.106
, Issue.7
, pp. 883-890
-
-
Yamaue, H.1
Tsunoda, T.2
Tani, M.3
Miyazawa, M.4
Yamao, K.5
Mizuno, N.6
-
54
-
-
84925402726
-
A prospective randomised phase-II trial with gemcitabine versus gemcitabine plus sunitinib in advanced pancreatic cancer: A study of the Cesar Central European Society for Anticancer Drug Research-EWIV
-
L. Bergmann, L. Maute, G. Heil, J. Russel, E. Weidmann, D. Koberle, and et al. A prospective randomised phase-ii trial with gemcitabine versus gemcitabine plus sunitinib in advanced pancreatic cancer: a study of the Cesar Central European Society for Anticancer Drug Research-EWIV Eur J Cancer 51 2015 27 36
-
(2015)
Eur J Cancer
, vol.51
, pp. 27-36
-
-
Bergmann, L.1
Maute, L.2
Heil, G.3
Russel, J.4
Weidmann, E.5
Koberle, D.6
-
55
-
-
84925045632
-
Phase II randomized trial of MEK inhibitor pimasertib or placebo combined with gemcitabine in the first-line treatment of metastatic pancreatic cancer
-
E. Van Cutsem, M. Hidalgo, I. Bazin, J.-L. Canon, E. Poddubskaya, N. Manojlovic, and et al. Phase II randomized trial of MEK inhibitor pimasertib or placebo combined with gemcitabine in the first-line treatment of metastatic pancreatic cancer ASCO Meet Abstr 33 2015 344
-
(2015)
ASCO Meet Abstr
, vol.33
, pp. 344
-
-
Van Cutsem, E.1
Hidalgo, M.2
Bazin, I.3
Canon, J.-L.4
Poddubskaya, E.5
Manojlovic, N.6
-
56
-
-
84936938604
-
A phase II/III randomized study to compare the efficacy and safety of rigosertib plus gemcitabine versus gemcitabine alone in patients with previously untreated metastatic pancreatic cancer
-
A.J. Scott, B.H. O'Neil, C. Gomes, J.C. Baranda, S.J. Cohen, M.A. Tejani, and et al. A phase II/III randomized study to compare the efficacy and safety of rigosertib plus gemcitabine versus gemcitabine alone in patients with previously untreated metastatic pancreatic cancer ASCO Meet Abstr 33 2015 342
-
(2015)
ASCO Meet Abstr
, vol.33
, pp. 342
-
-
Scott, A.J.1
O'Neil, B.H.2
Gomes, C.3
Baranda, J.C.4
Cohen, S.J.5
Tejani, M.A.6
-
57
-
-
84929321103
-
Masitinib in nonresectable pancreatic cancer: Results of a phase III randomized placebo-controlled trial
-
G. Deplanque, M. Demarchi, M. Hebbar, P.J. Flynn, B. Melichar, J. Atkins, and et al. Masitinib in nonresectable pancreatic cancer: results of a phase iii randomized placebo-controlled trial ASCO Meet Abstr 31 2013 158
-
(2013)
ASCO Meet Abstr
, vol.31
, pp. 158
-
-
Deplanque, G.1
Demarchi, M.2
Hebbar, M.3
Flynn, P.J.4
Melichar, B.5
Atkins, J.6
-
58
-
-
84925045641
-
The IMAGE i Trial Investigators: A multicenter randomized, open-label, proof-of-concept, phase II trial comparing gemcitabine with and without IMM-101 in advanced pancreatic cancer
-
A.G. Dalgleish The IMAGE I Trial Investigators: a multicenter randomized, open-label, proof-of-concept, phase ii trial comparing gemcitabine with and without IMM-101 in advanced pancreatic cancer ASCO Meet Abstr 33 2015 336
-
(2015)
ASCO Meet Abstr
, vol.33
, pp. 336
-
-
Dalgleish, A.G.1
-
59
-
-
22044445517
-
Erlotinib in previously treated non-small-cell lung cancer
-
F.A. Shepherd, J. Rodrigues Pereira, T. Ciuleanu, E.H. Tan, V. Hirsh, S. Thongprasert, and et al. Erlotinib in previously treated non-small-cell lung cancer N Engl J Med 353 2005 123 132
-
(2005)
N Engl J Med
, vol.353
, pp. 123-132
-
-
Shepherd, F.A.1
Rodrigues Pereira, J.2
Ciuleanu, T.3
Tan, E.H.4
Hirsh, V.5
Thongprasert, S.6
-
60
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
T.J. Lynch, D.W. Bell, R. Sordella, S. Gurubhagavatula, R.A. Okimoto, B.W. Brannigan, and et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib N Engl J Med 350 2004 2129 2139
-
(2004)
N Engl J Med
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
Gurubhagavatula, S.4
Okimoto, R.A.5
Brannigan, B.W.6
-
61
-
-
84904794425
-
Comparison of gemcitabine combined with targeted agent therapy versus gemcitabine monotherapy in the management of advanced pancreatic cancer
-
Q. Li, Z. Yuan, H. Yan, Z. Wen, R. Zhang, and B. Cao Comparison of gemcitabine combined with targeted agent therapy versus gemcitabine monotherapy in the management of advanced pancreatic cancer Clin Ther 36 2014 1054 1063
-
(2014)
Clin Ther
, vol.36
, pp. 1054-1063
-
-
Li, Q.1
Yuan, Z.2
Yan, H.3
Wen, Z.4
Zhang, R.5
Cao, B.6
-
62
-
-
84961889348
-
Locally advanced or metastatic pancreatic tumors: Molecular biology may help to know it and to select the optimal treatment
-
L. Faloppi, K. Andrikou, C. Loretelli, A. Mandolesi, M. Bianconi, M. Scartozzi, and et al. Locally advanced or metastatic pancreatic tumors: molecular biology may help to know it and to select the optimal treatment ASCO Meet Abstr 31 2013 201
-
(2013)
ASCO Meet Abstr
, vol.31
, pp. 201
-
-
Faloppi, L.1
Andrikou, K.2
Loretelli, C.3
Mandolesi, A.4
Bianconi, M.5
Scartozzi, M.6
-
63
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 2011 646 674
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
64
-
-
67349181841
-
Immunosurveillance of pancreatic adenocarcinoma: Insights from genetically engineered mouse models of cancer
-
C.E. Clark, G.L. Beatty, and R.H. Vonderheide Immunosurveillance of pancreatic adenocarcinoma: Insights from genetically engineered mouse models of cancer Cancer Lett 279 2009 1 7
-
(2009)
Cancer Lett
, vol.279
, pp. 1-7
-
-
Clark, C.E.1
Beatty, G.L.2
Vonderheide, R.H.3
-
65
-
-
84937123903
-
Progress in the treatment of metastatic pancreatic cancer and the search for next opportunities
-
A.H. Ko Progress in the treatment of metastatic pancreatic cancer and the search for next opportunities J Clin Oncol Off J Am Soc Clin Oncol 33 2015 1779 1786
-
(2015)
J Clin Oncol off J Am Soc Clin Oncol
, vol.33
, pp. 1779-1786
-
-
Ko, A.H.1
-
66
-
-
84915817439
-
Myeloid-derived suppressor cells in multiple myeloma: Pre-clinical research and translational opportunities
-
C. Botta, A. Gulla, P. Correale, P. Tagliaferri, and P. Tassone Myeloid-derived suppressor cells in multiple myeloma: pre-clinical research and translational opportunities Front Oncol 4 2014 348
-
(2014)
Front Oncol
, vol.4
, pp. 348
-
-
Botta, C.1
Gulla, A.2
Correale, P.3
Tagliaferri, P.4
Tassone, P.5
-
67
-
-
84995752686
-
Current and future systemic treatment options in metastatic pancreatic cancer
-
C. Arslan, and S. Yalcin Current and future systemic treatment options in metastatic pancreatic cancer J Gastrointest Oncol 5 2014 280 295
-
(2014)
J Gastrointest Oncol
, vol.5
, pp. 280-295
-
-
Arslan, C.1
Yalcin, S.2
-
68
-
-
84927916016
-
A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma
-
S. Haider, J. Wang, A. Nagano, A. Desai, P. Arumugam, L. Dumartin, and et al. A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma Genome Med 6 2014 105
-
(2014)
Genome Med
, vol.6
, pp. 105
-
-
Haider, S.1
Wang, J.2
Nagano, A.3
Desai, A.4
Arumugam, P.5
Dumartin, L.6
-
69
-
-
79953756460
-
Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy
-
E.A. Collisson, A. Sadanandam, P. Olson, W.J. Gibb, M. Truitt, S. Gu, and et al. Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy Nat Med 17 2011 500 503
-
(2011)
Nat Med
, vol.17
, pp. 500-503
-
-
Collisson, E.A.1
Sadanandam, A.2
Olson, P.3
Gibb, W.J.4
Truitt, M.5
Gu, S.6
-
70
-
-
84930671005
-
Phase IB study of FOLFIRINOX plus PF-04136309 in patients with borderline resectable and locally advanced pancreatic adenocarcinoma (PC)
-
A. Wang-Gillam, T.M. Nywening, D.E. Sanford, A.C. Lockhart, R. Suresh, B.R. Tan, and et al. Phase IB study of FOLFIRINOX plus PF-04136309 in patients with borderline resectable and locally advanced pancreatic adenocarcinoma (PC) ASCO Meet Abstr 33 2015 338
-
(2015)
ASCO Meet Abstr
, vol.33
, pp. 338
-
-
Wang-Gillam, A.1
Nywening, T.M.2
Sanford, D.E.3
Lockhart, A.C.4
Suresh, R.5
Tan, B.R.6
-
71
-
-
84903143748
-
A phase II study of vismodegib, a hedgehog (Hh) pathway inhibitor, combined with gemcitabine and nab-paclitaxel (nab-P) in patients (pts) with untreated metastatic pancreatic ductal adenocarcinoma (PDA)
-
A. De Jesus-Acosta, P.J. O'Dwyer, R.K. Ramanathan, D.D. Von Hoff, A. Maitra, Z. Rasheed, and et al. A phase II study of vismodegib, a hedgehog (Hh) pathway inhibitor, combined with gemcitabine and nab-paclitaxel (nab-P) in patients (pts) with untreated metastatic pancreatic ductal adenocarcinoma (PDA) ASCO Meet Abstr 32 2014 257
-
(2014)
ASCO Meet Abstr
, vol.32
, pp. 257
-
-
De Jesus-Acosta, A.1
O'Dwyer, P.J.2
Ramanathan, R.K.3
Von Hoff, D.D.4
Maitra, A.5
Rasheed, Z.6
-
72
-
-
84927784086
-
Outcome of gemcitabine plus molecular targeted agent for treatment of pancreatic cancer: A meta-analysis of prospective phase III studies
-
L. Chen, M. Zhang, and S. Luo Outcome of gemcitabine plus molecular targeted agent for treatment of pancreatic cancer: a meta-analysis of prospective phase iii studies Tumour Biol J Int Soc Oncodev Biol Med 35 2014 11551 11558
-
(2014)
Tumour Biol J Int Soc Oncodev Biol Med
, vol.35
, pp. 11551-11558
-
-
Chen, L.1
Zhang, M.2
Luo, S.3
|