Establishing a reliable framework for harnessing the creative power of the scientific crowd

PLoS Biology

Volumn 15, Issue 2, 2017, Pages

  Carter, Adrian J ^a   Donner, Amy ^b   Lee, Wen Hwa ^c   Bountra, Chas ^c  

^a BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^b The Chemical Probes Portal   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACCESS TO INFORMATION; ARTICLE; COMPETITION; CONCEPTUAL FRAMEWORK; COOPERATION; DRUG DEVELOPMENT; DRUG INDUSTRY; INFORMATION PROCESSING; INTERNET; OPEN INNOVATION; SCIENTIST; CREATIVITY; HUMAN; MEDICAL RESEARCH; ORGANIZATION; SCIENCE;

BIOMEDICAL RESEARCH; COOPERATIVE BEHAVIOR; CREATIVITY; DRUG DISCOVERY; HUMANS; ORGANIZATIONAL INNOVATION; SCIENCE;

EID: 85014509390     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.2001387     Document Type: Article

References (34)

1. Mullard A, 2015 FDA drug approvals. Nat Rev Drug Discov. 2016;15(2):73–6. doi: 10.1038/nrd.2016.1526837582
2. Kinch MS, 2015 in review: FDA approval of new drugs. Drug Discov Today. 2016;21(7):1046–50. doi: 10.1016/j.drudis.2016.04.00827109618
3. Hay MT, Thomas DW, Craighead JL, Economides C, Rosenthal J, Clinical development success rates for investigational drugs.pdf. Nature Biotechnology. 2014;32:40–51. PubMed Central PMCID: PMC 24406927 doi: 10.1038/nbt.278624406927
4. DiMasi JA, Grabowski HG, Hansen RW, Innovation in the pharmaceutical industry: New estimates of R&D costs. J Health Econ. 2016;47:20–33. doi: 10.1016/j.jhealeco.2016.01.01226928437
5. Huggett B, Reinventing tech transfer. Nat Biotechnol. 2014;32(12):1184–91. doi: 10.1038/nbt.308525489831
6. Savage N, Unlikely partnerships. Nature. 2016;533:56–8. PubMed Central PMCID: PMC27167391.
7. Bender E, Crowdsourced solutions. Nature. 2016;533:3. PubMed Central PMCID: PMC27167394
8. Chesbrough HB, J. S. Open Innovation. Harvard Buisness School Press. 2003.
9. Holmes DA, M. A New Chapter In Innovation. Nature. 2016;533:S54–S5. PubMed Central PMCID: PMC27167390 doi: 10.1038/533S54a27167390
10. Moody G. Open source, open data, open innovation 2011 [cited 2016 15th September]. http://www.slideshare.net/glynmoody/glyn-moody-open-data-open-innovation.
11. Salus PH, The Daemon, the Gnu, and the Penguin. Reed Media Services. Epub2011.
12. Henkel J, Selective revealing in open innovation processes: The case of embedded Linux. Research Policy. 2006;35(7):953–69.
13. Alexy O, George G, Salter AJ, Cui Bono? The Selective Revealing of Knowledge and Its Implications for Innovative Activity. Academy of Management Review. 2013;38(2):270–91.
14. Mittleman B, Neil G, Cutcher-Gershenfeld J, Precompetitive consortia in biomedicine—how are we doing?Nat Biotechnol. 2013;31(11):979–85. doi: 10.1038/nbt.273124213770
15. Papadaki M, Hirsch G, Curing Consortium Fatigue. Science Translational Medicine. 2013;5(200):200fs35. PubMed Central PMCID: PMC23986397 doi: 10.1126/scitranslmed.300690323986397
16. Sachidanandam R, Weissman D, Schmidt SC, Kakol JM, Stein LD, Marth G, et al. A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature. 2001;409(6822):928–33. doi: 10.1038/3505714911237013
17. Consortium TIH, The International HapMap Project. Nature. 2003;426(6968):789–96. Epub 2003/12/20. doi: 10.1038/nature0216814685227
18. Edwards AM, Bountra C, Kerr DJ, Willson TM, Open access chemical and clinical probes to support drug discovery. Nat Chem Biol. 2009;5(7):436–40. doi: 10.1038/nchembio0709-43619536100
19. Huston A, Arrowsmith CH, Knapp S, Schapira M, Probing the epigenome. Nat Chem Biol. 2015;11(8):542–5. doi: 10.1038/nchembio.187126196765
20. Filippakopoulos P, Qi J, Picaud S, Shen Y, Smith WB, Fedorov O, et al. Selective inhibition of BET bromodomains. Nature. 2010;468(7327):1067–73. PubMed Central PMCID: PMC3010259. doi: 10.1038/nature0950420871596
21. Zuber J, Shi J, Wang E, Rappaport AR, Herrmann H, Sison EA, et al. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature. 2011;478(7370):524–8. PubMed Central PMCID: PMC3328300. doi: 10.1038/nature1033421814200
22. Lee WH, Open access target validation is a more efficient way to accelerate drug discovery. PLoS Biol. 2015;13(6):e1002164. PubMed Central PMCID: PMC4456377. doi: 10.1371/journal.pbio.100216426042736
23. Arshad Z, Smith J, Roberts M, Lee WH, Davies B, Bure K, et al. Open Access Could Transform Drug Discovery: A Case Study of JQ1. Expert Opin Drug Discov. 2016;11(3):321–32. doi: 10.1517/17460441.2016.114458726791045
24. Hohmann AF, Vakoc CR, A rationale to target the SWI/SNF complex for cancer therapy. Trends Genet. 2014;30(8):356–63. PubMed Central PMCID: PMC4112150. doi: 10.1016/j.tig.2014.05.00124932742
25. Martin LJ, Koegl M, Bader G, Cockcroft XL, Fedorov O, Fiegen D, et al. Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor. J Med Chem. 2016;59(10):4462–75. PubMed Central PMCID: PMC4885110. doi: 10.1021/acs.jmedchem.5b0186526914985
26. Karim RS, E. An Advanced Tool to Interrogate BRD9. Journal of Medicinal Chemistry. 2016. PubMed Central PMCID: PMC 27120693. doi: 10.1021/acs.jmedchem.6b00550
27. Edwards A, Reproducibility. Team up with industry. Nature. 2016;531:299–301. PubMed Central PMCID: PMC26983524. doi: 10.1038/531299a26983524
28. Nelson MR, Tipney H, Painter JL, Shen J, Nicoletti P, Shen Y, et al. The support of human genetic evidence for approved drug indications. Nat Genet. 2015;47(8):856–60. doi: 10.1038/ng.331426121088
29. Edwards AM, Arrowsmith CH, Bountra C, Bunnage ME, Feldmann M, Knight JC, et al. Preclinical target validation using patient-derived cells. Nat Rev Drug Discov. 2015;14(3):149–50. doi: 10.1038/nrd456525722227
30. Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, et al. The promise and peril of chemical probes. Nat Chem Biol. 2015;11(8):536–41. PubMed Central PMCID: PMC4706458. doi: 10.1038/nchembio.186726196764
31. Howe J. The Rise of Crowdsourcing: wired.com; 2006 [cited 2016 15th September]. https://www.wired.com/2006/06/crowds/.
32. Bentzien J, Bharadwaj R, Thompson DC, Crowdsourcing in pharma: a strategic framework. Drug Discov Today. 2015;20(7):874–83. doi: 10.1016/j.drudis.2015.01.01125637169
33. Dorsch H, Jurock AE, Schoepe S, Lessl M, Asadullah K, Grants4Targets: an open innovation initiative to foster drug discovery collaborations. Nat Rev Drug Discov. 2015;14(1):74–6. doi: 10.1038/nrd3078-c225430867
34. Taylor NP. Boehringer finalizes team for crowdsourced COPD R&D initiative 2016 [cited 2016 15th September]. http://www.fiercebiotech.com/financials/boehringer-finalizes-team-for-crowdsourced-copd-r-d-initiative.