-
1
-
-
14044261316
-
What's wrong with our cancer models?
-
Kamb, A., What's wrong with our cancer models?. Nat. Rev. Drug Discov. 4:2 (2005), 161–165.
-
(2005)
Nat. Rev. Drug Discov.
, vol.4
, Issue.2
, pp. 161-165
-
-
Kamb, A.1
-
2
-
-
79251468712
-
Mouse models of advanced spontaneous metastasis for experimental therapeutics
-
Francia, G., Cruz-Munoz, W., Man, S., Xu, P., Kerbel, R.S., Mouse models of advanced spontaneous metastasis for experimental therapeutics. Nat. Rev. Cancer. 11 (2011), 135–141.
-
(2011)
Nat. Rev. Cancer.
, vol.11
, pp. 135-141
-
-
Francia, G.1
Cruz-Munoz, W.2
Man, S.3
Xu, P.4
Kerbel, R.S.5
-
3
-
-
84860120032
-
Why do phase III clinical trials in oncology fail so often?
-
Amiri-Kordestani, L., Fojo, T., Why do phase III clinical trials in oncology fail so often?. J. Natl. Cancer Inst. 104:8 (2012), 568–569.
-
(2012)
J. Natl. Cancer Inst.
, vol.104
, Issue.8
, pp. 568-569
-
-
Amiri-Kordestani, L.1
Fojo, T.2
-
4
-
-
85019502597
-
Phase III trial failures: costly, but preventable
-
Grignolo, A., Pretorius, S., Phase III trial failures: costly, but preventable. Appl. Clin. Trials., 25(8), 2016.
-
(2016)
Appl. Clin. Trials.
, vol.25
, Issue.8
-
-
Grignolo, A.1
Pretorius, S.2
-
5
-
-
84883375630
-
Evaluating outcomes of antiangiogenic and chemotherapy in preclinical mouse models mimicking postsurgical adjuvant or metastatic breast cancer therapy
-
Kerbel, R.S., Guerin, E., Francia, G., Xu, P., Lee, C.R., Ebos, J.M.L., et al. Evaluating outcomes of antiangiogenic and chemotherapy in preclinical mouse models mimicking postsurgical adjuvant or metastatic breast cancer therapy. Breast 22 (2013), S57–S65.
-
(2013)
Breast
, vol.22
, pp. S57-S65
-
-
Kerbel, R.S.1
Guerin, E.2
Francia, G.3
Xu, P.4
Lee, C.R.5
Ebos, J.M.L.6
-
6
-
-
60649087564
-
Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
-
Ebos, J.M.L., Lee, C.R., Cruz-Munoz, W., Bjarnason, G.A., Christensen, J.G., Kerbel, R.S., Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell. 15 (2009), 232–239.
-
(2009)
Cancer Cell.
, vol.15
, pp. 232-239
-
-
Ebos, J.M.L.1
Lee, C.R.2
Cruz-Munoz, W.3
Bjarnason, G.A.4
Christensen, J.G.5
Kerbel, R.S.6
-
7
-
-
85003028819
-
Efficacy of cotargeting Angiopoietin-2 and the VEGF pathway in the adjuvant postsurgical setting for early breast, colorectal, and renal cancers
-
Wu, F.T., Man, S., Xu, P., Chow, A., Paez-Ribes, M., Lee, C.R., et al. Efficacy of cotargeting Angiopoietin-2 and the VEGF pathway in the adjuvant postsurgical setting for early breast, colorectal, and renal cancers. Cancer Res. 76 (2016), 6988–7000.
-
(2016)
Cancer Res.
, vol.76
, pp. 6988-7000
-
-
Wu, F.T.1
Man, S.2
Xu, P.3
Chow, A.4
Paez-Ribes, M.5
Lee, C.R.6
-
8
-
-
84995400193
-
Aflibercept and Ang1 supplementation improve neoadjuvant or adjuvant chemotherapy in a preclinical model of resectable breast cancer
-
Wu, F.T., Paez-Ribes, M., Xu, P., Man, S., Bogdanovic, E., Thurston, G., et al. Aflibercept and Ang1 supplementation improve neoadjuvant or adjuvant chemotherapy in a preclinical model of resectable breast cancer. Sci. Rep., 6, 2016, 36694.
-
(2016)
Sci. Rep.
, vol.6
, pp. 36694
-
-
Wu, F.T.1
Paez-Ribes, M.2
Xu, P.3
Man, S.4
Bogdanovic, E.5
Thurston, G.6
-
9
-
-
84977633044
-
Development of patient derived xenograft models of overt spontaneous breast cancer metastasis: a cautionary note
-
Paez-Ribes, M., Man, S., Xu, P., Kerbel, R.S., Development of patient derived xenograft models of overt spontaneous breast cancer metastasis: a cautionary note. PLoS One., 11(6), 2016, e0158034.
-
(2016)
PLoS One.
, vol.11
, Issue.6
, pp. e0158034
-
-
Paez-Ribes, M.1
Man, S.2
Xu, P.3
Kerbel, R.S.4
-
10
-
-
85019524034
-
Modelling therapy of late or early stage metastatic disease in mice
-
in press
-
Kerbel, R.S., Paez-Ribes, M., Man, S., Xu, P., Guerin, E., Cruz-Munoz, W., et al. Modelling therapy of late or early stage metastatic disease in mice. Cancer Med., 2016 in press.
-
(2016)
Cancer Med.
-
-
Kerbel, R.S.1
Paez-Ribes, M.2
Man, S.3
Xu, P.4
Guerin, E.5
Cruz-Munoz, W.6
-
11
-
-
82455208939
-
Genetically modified mouse models of cancer invasion and metastasis
-
Rampetsreiter, P., Casanova, E., Eferi, R., Genetically modified mouse models of cancer invasion and metastasis. Drug Discov. Today Dis. Models. 9 (2011), 67–74.
-
(2011)
Drug Discov. Today Dis. Models.
, vol.9
, pp. 67-74
-
-
Rampetsreiter, P.1
Casanova, E.2
Eferi, R.3
-
12
-
-
84875810421
-
Rebuilding cancer metastasis in the mouse
-
Saxena, M., Christofori, G., Rebuilding cancer metastasis in the mouse. Mol. Oncol. 7:2 (2013), 283–296.
-
(2013)
Mol. Oncol.
, vol.7
, Issue.2
, pp. 283-296
-
-
Saxena, M.1
Christofori, G.2
-
13
-
-
84895823244
-
RapidCaP, a novel GEM model for metastatic prostate cancer analysis and therapy, reveals myc as a driver of Pten-mutant metastasis
-
Cho, H., Herzka, T., Zheng, W., Qi, J., Wilkinson, J.E., Bradner, J.E., et al. RapidCaP, a novel GEM model for metastatic prostate cancer analysis and therapy, reveals myc as a driver of Pten-mutant metastasis. Cancer Discov. 4:3 (2014), 318–333.
-
(2014)
Cancer Discov.
, vol.4
, Issue.3
, pp. 318-333
-
-
Cho, H.1
Herzka, T.2
Zheng, W.3
Qi, J.4
Wilkinson, J.E.5
Bradner, J.E.6
-
14
-
-
33645744835
-
Highly efficacious non-toxic treatment for advanced metastatic breast cancer using combination UFT-cyclophosphamide metronomic chemotherapy
-
Munoz, R., Man, S., Shaked, Y., Lee, C., Wong, J., Francia, G., et al. Highly efficacious non-toxic treatment for advanced metastatic breast cancer using combination UFT-cyclophosphamide metronomic chemotherapy. Cancer Res. 66 (2006), 3386–3391.
-
(2006)
Cancer Res.
, vol.66
, pp. 3386-3391
-
-
Munoz, R.1
Man, S.2
Shaked, Y.3
Lee, C.4
Wong, J.5
Francia, G.6
-
15
-
-
84872084645
-
Metronomic oral topotecan prolongs survival and reduces liver metastasis in improved preclinical orthotopic and adjuvant therapy colon cancer models
-
Hackl, C., Man, S., Francia, G., Xu, P., Kerbel, R.S., Metronomic oral topotecan prolongs survival and reduces liver metastasis in improved preclinical orthotopic and adjuvant therapy colon cancer models. Gut 62 (2013), 259–271.
-
(2013)
Gut
, vol.62
, pp. 259-271
-
-
Hackl, C.1
Man, S.2
Francia, G.3
Xu, P.4
Kerbel, R.S.5
-
16
-
-
84927618369
-
Orthotopic primary and postsurgical adjuvant or metastatic renal cell carcinoma therapy models reveal potent anti-tumor activity of minimally toxic metronomic oral topotecan with pazopanib
-
282ra250
-
Jedeszko, C., Paez-Ribes, M., Di Desidero, T., Bocci, G., Man, S., Lee, C.R., et al. Orthotopic primary and postsurgical adjuvant or metastatic renal cell carcinoma therapy models reveal potent anti-tumor activity of minimally toxic metronomic oral topotecan with pazopanib. Sci. Transl. Med., 7(282), 2015 282ra250.
-
(2015)
Sci. Transl. Med.
, vol.7
, Issue.282
-
-
Jedeszko, C.1
Paez-Ribes, M.2
Di Desidero, T.3
Bocci, G.4
Man, S.5
Lee, C.R.6
-
17
-
-
77950815444
-
Potent preclinical impact of metronomic low-dose oral topotecan combined with the antiangiogenic drug pazopanib for the treatment of ovarian cancer
-
Hashimoto, K., Man, S., Xu, P., Cruz-Munoz, W., Tang, T., Kumar, R., et al. Potent preclinical impact of metronomic low-dose oral topotecan combined with the antiangiogenic drug pazopanib for the treatment of ovarian cancer. Mol. Cancer Ther. 9 (2010), 996–1006.
-
(2010)
Mol. Cancer Ther.
, vol.9
, pp. 996-1006
-
-
Hashimoto, K.1
Man, S.2
Xu, P.3
Cruz-Munoz, W.4
Tang, T.5
Kumar, R.6
-
18
-
-
49649109964
-
Development of a preclinical model of spontaneous human melanoma CNS metastasis
-
Cruz-Munoz, W., Man, S., Xu, P., Kerbel, R.S., Development of a preclinical model of spontaneous human melanoma CNS metastasis. Cancer Res. 68 (2008), 4500–4505.
-
(2008)
Cancer Res.
, vol.68
, pp. 4500-4505
-
-
Cruz-Munoz, W.1
Man, S.2
Xu, P.3
Kerbel, R.S.4
-
19
-
-
77949597294
-
Impact of UFT/cyclophosphamide metronomic chemotherapy and antiangiogenic drug assessed in a new preclinical model of locally advanced orthotopic hepatocellular carcinoma
-
Tang, T.C., Man, S., Lee, C.R., Xu, P., Kerbel, R.S., Impact of UFT/cyclophosphamide metronomic chemotherapy and antiangiogenic drug assessed in a new preclinical model of locally advanced orthotopic hepatocellular carcinoma. Neoplasia 12 (2010), 264–274.
-
(2010)
Neoplasia
, vol.12
, pp. 264-274
-
-
Tang, T.C.1
Man, S.2
Lee, C.R.3
Xu, P.4
Kerbel, R.S.5
-
20
-
-
34250193290
-
The biology of metastasis to a sanctuary site
-
Palmieri, D., Chambers, A.F., Felding-Habermann, B., Huang, S., Steeg, P.S., The biology of metastasis to a sanctuary site. Clin. Cancer Res. 13:6 (2007), 1656–1662.
-
(2007)
Clin. Cancer Res.
, vol.13
, Issue.6
, pp. 1656-1662
-
-
Palmieri, D.1
Chambers, A.F.2
Felding-Habermann, B.3
Huang, S.4
Steeg, P.S.5
-
21
-
-
34250174543
-
Brain metastases: the HER2 paradigm
-
Lin, N.U., Winer, E.P., Brain metastases: the HER2 paradigm. Clin. Cancer Res. 13:6 (2007), 1648–1655.
-
(2007)
Clin. Cancer Res.
, vol.13
, Issue.6
, pp. 1648-1655
-
-
Lin, N.U.1
Winer, E.P.2
-
22
-
-
84877746890
-
A model of postsurgical advanced metastatic breast cancer more accurately replicates the clinical efficacy of antiangiogenic drugs
-
Guerin, E., Man, S., Xu, P., Kerbel, R.S., A model of postsurgical advanced metastatic breast cancer more accurately replicates the clinical efficacy of antiangiogenic drugs. Cancer Res. 73 (2013), 2743–2748.
-
(2013)
Cancer Res.
, vol.73
, pp. 2743-2748
-
-
Guerin, E.1
Man, S.2
Xu, P.3
Kerbel, R.S.4
-
23
-
-
37549040613
-
Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
-
Miller, K., Wang, M., Gralow, J., Dickler, M., Cobleigh, M., Perez, E.A., et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N. Engl. J. Med. 357:26 (2007), 2666–2676.
-
(2007)
N. Engl. J. Med.
, vol.357
, Issue.26
, pp. 2666-2676
-
-
Miller, K.1
Wang, M.2
Gralow, J.3
Dickler, M.4
Cobleigh, M.5
Perez, E.A.6
-
24
-
-
85006889134
-
Vessel co-option is common in human lung metastases and mediates resistance to anti-angiogenic therapy in preclinical lung metastasis models
-
epub ahead of print
-
Bridgeman, V.L., Vermeulen, P.B., Foo, S., Bilecz, A., Kostaras, L., Daley, F., et al. Vessel co-option is common in human lung metastases and mediates resistance to anti-angiogenic therapy in preclinical lung metastasis models. J. Pathol., 2016, 10.1002/path.4845 epub ahead of print.
-
(2016)
J. Pathol.
-
-
Bridgeman, V.L.1
Vermeulen, P.B.2
Foo, S.3
Bilecz, A.4
Kostaras, L.5
Daley, F.6
-
25
-
-
84883050174
-
Adjuvant bevacizumab-containing therapy in triple-negative breast cancer (BEATRICE): primary results of a randomised, phase 3 trial
-
Cameron, D., Brown, J., Dent, R., Jackisch, C., Mackey, J., Pivot, X., et al. Adjuvant bevacizumab-containing therapy in triple-negative breast cancer (BEATRICE): primary results of a randomised, phase 3 trial. Lancet Oncol. 14:10 (2013), 933–942.
-
(2013)
Lancet Oncol.
, vol.14
, Issue.10
, pp. 933-942
-
-
Cameron, D.1
Brown, J.2
Dent, R.3
Jackisch, C.4
Mackey, J.5
Pivot, X.6
-
26
-
-
84938657323
-
Potential pro-invasive or metastatic effects of preclinical antiangiogenic therapy are prevented by concurrent chemotherapy
-
Paez-Ribes, M., Man, S., Xu, P., Kerbel, R.S., Potential pro-invasive or metastatic effects of preclinical antiangiogenic therapy are prevented by concurrent chemotherapy. Clin. Cancer Res. 21 (2015), 5488–5498.
-
(2015)
Clin. Cancer Res.
, vol.21
, pp. 5488-5498
-
-
Paez-Ribes, M.1
Man, S.2
Xu, P.3
Kerbel, R.S.4
-
27
-
-
84940606731
-
Neoadjuvant plus adjuvant bevacizumab in early breast cancer (NSABP B-40 [NRG Oncology]): secondary outcomes of a phase 3, randomised controlled trial
-
Bear, H.D., Tang, G., Rastogi, P., Geyer, C.E. Jr., Liu, Q., Robidoux, A., et al. Neoadjuvant plus adjuvant bevacizumab in early breast cancer (NSABP B-40 [NRG Oncology]): secondary outcomes of a phase 3, randomised controlled trial. Lancet Oncol. 16:9 (2015), 1037–1048.
-
(2015)
Lancet Oncol.
, vol.16
, Issue.9
, pp. 1037-1048
-
-
Bear, H.D.1
Tang, G.2
Rastogi, P.3
Geyer, C.E.4
Liu, Q.5
Robidoux, A.6
-
28
-
-
0030498145
-
Angiogenesis in primary lung cancer and lung secondaries
-
Pezzella, F., Di, B.A., Andreola, S., Nicholson, A.G., Pastorino, U., Harris, A.L., Angiogenesis in primary lung cancer and lung secondaries. Eur. J. Cancer. 32A:14 (1996), 2494–2500.
-
(1996)
Eur. J. Cancer.
, vol.32A
, Issue.14
, pp. 2494-2500
-
-
Pezzella, F.1
Di, B.A.2
Andreola, S.3
Nicholson, A.G.4
Pastorino, U.5
Harris, A.L.6
-
29
-
-
84896866862
-
Vessel co-option in primary human tumors and metastases: an obstacle to effective anti-angiogenic treatment?
-
Donnem, T., Hu, J., Ferguson, M., Adighibe, O., Snell, C., Harris, A.L., et al. Vessel co-option in primary human tumors and metastases: an obstacle to effective anti-angiogenic treatment?. Cancer Med. 2:4 (2013), 427–436.
-
(2013)
Cancer Med.
, vol.2
, Issue.4
, pp. 427-436
-
-
Donnem, T.1
Hu, J.2
Ferguson, M.3
Adighibe, O.4
Snell, C.5
Harris, A.L.6
-
30
-
-
0034782184
-
Liver metastases from colorectal adenocarcinomas grow in three patterns with different angiogenesis and desmoplasia
-
Vermeulen, P.B., Colpaert, C., Salgado, R., Royers, R., Hellemans, H., Van den Heuvel, E., et al. Liver metastases from colorectal adenocarcinomas grow in three patterns with different angiogenesis and desmoplasia. J. Pathol. 195:3 (2001), 336–342.
-
(2001)
J. Pathol.
, vol.195
, Issue.3
, pp. 336-342
-
-
Vermeulen, P.B.1
Colpaert, C.2
Salgado, R.3
Royers, R.4
Hellemans, H.5
Van den Heuvel, E.6
-
31
-
-
84992401796
-
Co-option of liver vessels and not sprouting angiogenesis drives acquired sorafenib resistance in hepatocellular carcinoma
-
Kuczynski, E.A., Yin, M., Bar-Zion, A., Lee, C.R., Butz, H., Man, S., et al. Co-option of liver vessels and not sprouting angiogenesis drives acquired sorafenib resistance in hepatocellular carcinoma. J. Natl. Cancer Inst., 108(8), 2016.
-
(2016)
J. Natl. Cancer Inst.
, vol.108
, Issue.8
-
-
Kuczynski, E.A.1
Yin, M.2
Bar-Zion, A.3
Lee, C.R.4
Butz, H.5
Man, S.6
-
32
-
-
84991735476
-
Vessel co-option mediates resistance to antiangiogenic therapy in liver metastases
-
Frentzas, S., Bridgeman, V.L., Simoneau, E., Vermeulen, P.B., Foo, S., Wotherspoon, A., et al. Vessel co-option mediates resistance to antiangiogenic therapy in liver metastases. Nat. Med. 22:11 (2016), 1294–1302.
-
(2016)
Nat. Med.
, vol.22
, Issue.11
, pp. 1294-1302
-
-
Frentzas, S.1
Bridgeman, V.L.2
Simoneau, E.3
Vermeulen, P.B.4
Foo, S.5
Wotherspoon, A.6
-
33
-
-
0034032882
-
Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer
-
Browder, T., Butterfield, C.E., Kraling, B.M., Marshall, B., O'Reilly, M.S., Folkman, J., Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res. 60 (2000), 1878–1886.
-
(2000)
Cancer Res.
, vol.60
, pp. 1878-1886
-
-
Browder, T.1
Butterfield, C.E.2
Kraling, B.M.3
Marshall, B.4
O'Reilly, M.S.5
Folkman, J.6
-
34
-
-
0034087691
-
Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity
-
Klement, G., Baruchel, S., Rak, J., Man, S., Clark, K., Hicklin, D., et al. Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity. J. Clin. Invest. 105 (2000), R15–R24.
-
(2000)
J. Clin. Invest.
, vol.105
, pp. R15-R24
-
-
Klement, G.1
Baruchel, S.2
Rak, J.3
Man, S.4
Clark, K.5
Hicklin, D.6
-
35
-
-
77955172181
-
Metronomic chemotherapy: new rationale for new directions
-
Pasquier, E., Kavallaris, M., Andre, N., Metronomic chemotherapy: new rationale for new directions. Nat. Rev. Clin. Oncol. 7:8 (2010), 455–465.
-
(2010)
Nat. Rev. Clin. Oncol.
, vol.7
, Issue.8
, pp. 455-465
-
-
Pasquier, E.1
Kavallaris, M.2
Andre, N.3
-
36
-
-
2942615257
-
Antiangiogenic basis of low-dose metronomic chemotherapy
-
Kerbel, R.S., Kamen, B.A., Antiangiogenic basis of low-dose metronomic chemotherapy. Nat. Rev. Cancer. 4 (2004), 423–436.
-
(2004)
Nat. Rev. Cancer.
, vol.4
, pp. 423-436
-
-
Kerbel, R.S.1
Kamen, B.A.2
-
37
-
-
0034105964
-
Chemotherapeutic drugs–more really is not better
-
Fidler, I.J., Ellis, L.M., Chemotherapeutic drugs–more really is not better. Nat. Med. 6:5 (2000), 500–502.
-
(2000)
Nat. Med.
, vol.6
, Issue.5
, pp. 500-502
-
-
Fidler, I.J.1
Ellis, L.M.2
-
38
-
-
68049148642
-
Effective treatment of advanced human melanoma metastasis in immunodeficient mice using combination metronomic chemotherapy regimens
-
Cruz-Munoz, W., Man, S., Kerbel, R.S., Effective treatment of advanced human melanoma metastasis in immunodeficient mice using combination metronomic chemotherapy regimens. Clin. Cancer Res. 15:15 (2009), 4867–4874.
-
(2009)
Clin. Cancer Res.
, vol.15
, Issue.15
, pp. 4867-4874
-
-
Cruz-Munoz, W.1
Man, S.2
Kerbel, R.S.3
-
39
-
-
14644446018
-
A multitargeted, metronomic, and maximum-tolerated dose “chemo-switch” regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer
-
Pietras, K., Hanahan, D., A multitargeted, metronomic, and maximum-tolerated dose “chemo-switch” regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer. J. Clin. Oncol. 23:5 (2005), 939–952.
-
(2005)
J. Clin. Oncol.
, vol.23
, Issue.5
, pp. 939-952
-
-
Pietras, K.1
Hanahan, D.2
-
40
-
-
84990043408
-
Low-dose oral cyclophosphamide and methotrexate maintenance for hormone receptor-negative early breast cancer: international breast cancer study group trial 22-00
-
Colleoni, M., Gray, K.P., Gelber, S., Lang, I., Thurlimann, B., Gianni, L., et al. Low-dose oral cyclophosphamide and methotrexate maintenance for hormone receptor-negative early breast cancer: international breast cancer study group trial 22-00. J. Clin. Oncol. 34:28 (2016), 3400–3408.
-
(2016)
J. Clin. Oncol.
, vol.34
, Issue.28
, pp. 3400-3408
-
-
Colleoni, M.1
Gray, K.P.2
Gelber, S.3
Lang, I.4
Thurlimann, B.5
Gianni, L.6
-
41
-
-
84929514070
-
Maintenance treatment with capecitabine and bevacizumab in metastatic colorectal cancer, the phase 3 CAIRO3 study of the Dutch Colorectal Cancer Group (DCCG)
-
Simkens, L.H.J., van Tinteren, H., May, A., Ten Tije, A.J., Creemers, G.-J.M., Loosveld, O.J.L., et al. Maintenance treatment with capecitabine and bevacizumab in metastatic colorectal cancer, the phase 3 CAIRO3 study of the Dutch Colorectal Cancer Group (DCCG). Lancet 385 (2015), 1843–1852.
-
(2015)
Lancet
, vol.385
, pp. 1843-1852
-
-
Simkens, L.H.J.1
van Tinteren, H.2
May, A.3
Ten Tije, A.J.4
Creemers, G.-J.M.5
Loosveld, O.J.L.6
-
42
-
-
23844538059
-
Low-dose metronomic combined with intermittent bolus-dose cyclophosphamide is an effective long-term chemotherapy treatment strategy
-
Shaked, Y., Emmenegger, U., Francia, G., Chen, L., Lee, C.R., Man, S., et al. Low-dose metronomic combined with intermittent bolus-dose cyclophosphamide is an effective long-term chemotherapy treatment strategy. Cancer Res. 65:16 (2005), 7045–7051.
-
(2005)
Cancer Res.
, vol.65
, Issue.16
, pp. 7045-7051
-
-
Shaked, Y.1
Emmenegger, U.2
Francia, G.3
Chen, L.4
Lee, C.R.5
Man, S.6
-
43
-
-
0035256620
-
Immunomodulation by anticancer chemotherapy: more is not always better (review)
-
Zagozdzon, R., Golab, J., Immunomodulation by anticancer chemotherapy: more is not always better (review). Int. J. Oncol. 18:2 (2001), 417–424.
-
(2001)
Int. J. Oncol.
, vol.18
, Issue.2
, pp. 417-424
-
-
Zagozdzon, R.1
Golab, J.2
-
44
-
-
0347626100
-
Synergistic effect of metronomic dosing of cyclophosphamide combined with specific antitumor immunotherapy in a murine melanoma model
-
Hermans, I.F., Chong, T.W., Palmowski, M.J., Harris, A.L., Cerundolo, V., Synergistic effect of metronomic dosing of cyclophosphamide combined with specific antitumor immunotherapy in a murine melanoma model. Cancer Res. 63:23 (2003), 8408–8413.
-
(2003)
Cancer Res.
, vol.63
, Issue.23
, pp. 8408-8413
-
-
Hermans, I.F.1
Chong, T.W.2
Palmowski, M.J.3
Harris, A.L.4
Cerundolo, V.5
-
45
-
-
84955701712
-
A randomized phase II clinical trial of personalized peptide vaccination with metronomic low-dose cyclophosphamide in patients with metastatic castration-resistant prostate cancer
-
Noguchi, M., Moriya, F., Koga, N., Matsueda, S., Sasada, T., Yamada, A., et al. A randomized phase II clinical trial of personalized peptide vaccination with metronomic low-dose cyclophosphamide in patients with metastatic castration-resistant prostate cancer. Cancer Immunol. Immunother. 65:2 (2016), 151–160.
-
(2016)
Cancer Immunol. Immunother.
, vol.65
, Issue.2
, pp. 151-160
-
-
Noguchi, M.1
Moriya, F.2
Koga, N.3
Matsueda, S.4
Sasada, T.5
Yamada, A.6
-
46
-
-
84940720866
-
Novel metronomic chemotherapy and cancer vaccine combinatorial strategy for hepatocellular carcinoma in a mouse model
-
Tagliamonte, M., Petrizzo, A., Napolitano, M., Luciano, A., Arra, C., Maiolino, P., et al. Novel metronomic chemotherapy and cancer vaccine combinatorial strategy for hepatocellular carcinoma in a mouse model. Cancer Immunol. Immunother. 64:10 (2015), 1305–1314.
-
(2015)
Cancer Immunol. Immunother.
, vol.64
, Issue.10
, pp. 1305-1314
-
-
Tagliamonte, M.1
Petrizzo, A.2
Napolitano, M.3
Luciano, A.4
Arra, C.5
Maiolino, P.6
-
47
-
-
77953134540
-
Metronomic chemotherapy enhances antitumor effects of cancer vaccine by depleting regulatory T lymphocytes and inhibiting tumor angiogenesis
-
Chen, C.A., Ho, C.M., Chang, M.C., Sun, W.Z., Chen, Y.L., Chiang, Y.C., et al. Metronomic chemotherapy enhances antitumor effects of cancer vaccine by depleting regulatory T lymphocytes and inhibiting tumor angiogenesis. Mol. Ther. 18:6 (2010), 1233–1243.
-
(2010)
Mol. Ther.
, vol.18
, Issue.6
, pp. 1233-1243
-
-
Chen, C.A.1
Ho, C.M.2
Chang, M.C.3
Sun, W.Z.4
Chen, Y.L.5
Chiang, Y.C.6
-
48
-
-
85008400933
-
Impact of CTLA-4 blockade in conjunction with metronomic chemotherapy on preclinical breast cancer growth
-
Parra, K., Valenzuela, P., Lerma, N., Gallegos, A., Reza, L.C., Rodriguez, G., et al. Impact of CTLA-4 blockade in conjunction with metronomic chemotherapy on preclinical breast cancer growth. Br. J. Cancer. 116:3 (2017), 324–334.
-
(2017)
Br. J. Cancer.
, vol.116
, Issue.3
, pp. 324-334
-
-
Parra, K.1
Valenzuela, P.2
Lerma, N.3
Gallegos, A.4
Reza, L.C.5
Rodriguez, G.6
-
49
-
-
84981301487
-
Metronomic cyclophosphamide activation of anti-tumor immunity: tumor model, mouse host, and drug schedule dependence of gene responses and their upstream regulators
-
Wu, J., Jordan, M., Waxman, D.J., Metronomic cyclophosphamide activation of anti-tumor immunity: tumor model, mouse host, and drug schedule dependence of gene responses and their upstream regulators. BMC Cancer., 16, 2016, 623.
-
(2016)
BMC Cancer.
, vol.16
, pp. 623
-
-
Wu, J.1
Jordan, M.2
Waxman, D.J.3
-
50
-
-
84857723974
-
VEGF receptor inhibitors block the ability of metronomically dosed cyclophosphamide to activate innate immunity-induced tumor regression
-
Doloff, J.C., Waxman, D.J., VEGF receptor inhibitors block the ability of metronomically dosed cyclophosphamide to activate innate immunity-induced tumor regression. Cancer Res. 72:5 (2012), 1103–1115.
-
(2012)
Cancer Res.
, vol.72
, Issue.5
, pp. 1103-1115
-
-
Doloff, J.C.1
Waxman, D.J.2
-
51
-
-
84908669231
-
Metronomic cyclophosphamide schedule-dependence of innate immune cell recruitment and tumor regression in an implanted glioma model
-
Wu, J., Waxman, D.J., Metronomic cyclophosphamide schedule-dependence of innate immune cell recruitment and tumor regression in an implanted glioma model. Cancer Lett. 353:2 (2014), 272–280.
-
(2014)
Cancer Lett.
, vol.353
, Issue.2
, pp. 272-280
-
-
Wu, J.1
Waxman, D.J.2
-
52
-
-
68349083269
-
Chemomodulation of human dendritic cell function by antineoplastic agents in low noncytotoxic concentrations
-
Kaneno, R., Shurin, G.V., Tourkova, I.L., Shurin, M.R., Chemomodulation of human dendritic cell function by antineoplastic agents in low noncytotoxic concentrations. J. Transl. Med., 7, 2009, 58.
-
(2009)
J. Transl. Med.
, vol.7
, pp. 58
-
-
Kaneno, R.1
Shurin, G.V.2
Tourkova, I.L.3
Shurin, M.R.4
-
53
-
-
84907394550
-
Anti-Bv8 antibody and metronomic gemcitabine improve pancreatic adenocarcinoma treatment outcome following weekly gemcitabine therapy
-
Hasnis, E., Alishekevitz, D., Gingis-Veltski, S., Bril, R., Fremder, E., Voloshin, T., et al. Anti-Bv8 antibody and metronomic gemcitabine improve pancreatic adenocarcinoma treatment outcome following weekly gemcitabine therapy. Neoplasia 16:6 (2014), 501–510.
-
(2014)
Neoplasia
, vol.16
, Issue.6
, pp. 501-510
-
-
Hasnis, E.1
Alishekevitz, D.2
Gingis-Veltski, S.3
Bril, R.4
Fremder, E.5
Voloshin, T.6
-
54
-
-
84991594138
-
Evidence implicating immunological host effects in the efficacy of metronomic low-dose chemotherapy
-
Shaked, Y., Pham, E., Hariharan, S., Magidey, K., Beyar-Katz, O., Xu, P., et al. Evidence implicating immunological host effects in the efficacy of metronomic low-dose chemotherapy. Cancer Res. 76:20 (2016), 5983–5993.
-
(2016)
Cancer Res.
, vol.76
, Issue.20
, pp. 5983-5993
-
-
Shaked, Y.1
Pham, E.2
Hariharan, S.3
Magidey, K.4
Beyar-Katz, O.5
Xu, P.6
-
55
-
-
79960561470
-
Low-dose cyclophosphamide selectively decreases regulatory T cells and inhibits angiogenesis in dogs with soft tissue sarcoma
-
Burton, J.H., Mitchell, L., Thamm, D.H., Dow, S.W., Biller, B.J., Low-dose cyclophosphamide selectively decreases regulatory T cells and inhibits angiogenesis in dogs with soft tissue sarcoma. J. Vet. Intern Med. 25:4 (2011), 920–926.
-
(2011)
J. Vet. Intern Med.
, vol.25
, Issue.4
, pp. 920-926
-
-
Burton, J.H.1
Mitchell, L.2
Thamm, D.H.3
Dow, S.W.4
Biller, B.J.5
-
56
-
-
68549112974
-
Treg depletion with a low-dose metronomic temozolomide regimen in a rat glioma model
-
Banissi, C., Ghiringhelli, F., Chen, L., Carpentier, A.F., Treg depletion with a low-dose metronomic temozolomide regimen in a rat glioma model. Cancer Immunol. Immunother. 58:10 (2009), 1627–1634.
-
(2009)
Cancer Immunol. Immunother.
, vol.58
, Issue.10
, pp. 1627-1634
-
-
Banissi, C.1
Ghiringhelli, F.2
Chen, L.3
Carpentier, A.F.4
-
57
-
-
84860815596
-
Metronomic cyclophosphamide treatment in metastasized breast cancer patients: immunological effects and clinical outcome
-
Ge, Y., Domschke, C., Stoiber, N., Schott, S., Heil, J., Rom, J., et al. Metronomic cyclophosphamide treatment in metastasized breast cancer patients: immunological effects and clinical outcome. Cancer Immunol. Immunother. 61:3 (2012), 353–362.
-
(2012)
Cancer Immunol. Immunother.
, vol.61
, Issue.3
, pp. 353-362
-
-
Ge, Y.1
Domschke, C.2
Stoiber, N.3
Schott, S.4
Heil, J.5
Rom, J.6
-
58
-
-
84863291227
-
Chemotherapeutics and radiation stimulate MHC class I expression through elevated interferon-beta signaling in breast cancer cells
-
Wan, S., Pestka, S., Jubin, R.G., Lyu, Y.L., Tsai, Y.C., Liu, L.F., Chemotherapeutics and radiation stimulate MHC class I expression through elevated interferon-beta signaling in breast cancer cells. PLoS One., 7(3), 2012, e32542.
-
(2012)
PLoS One.
, vol.7
, Issue.3
, pp. e32542
-
-
Wan, S.1
Pestka, S.2
Jubin, R.G.3
Lyu, Y.L.4
Tsai, Y.C.5
Liu, L.F.6
-
59
-
-
70350220627
-
Contribution of G-CSF to the acute mobilization of endothelial precursor cells by vascular disrupting agents
-
Shaked, Y., Tang, T., Woloszynek, J., Daenen, L., Man, S., Xu, P., et al. Contribution of G-CSF to the acute mobilization of endothelial precursor cells by vascular disrupting agents. Cancer Res. 69 (2009), 7524–7528.
-
(2009)
Cancer Res.
, vol.69
, pp. 7524-7528
-
-
Shaked, Y.1
Tang, T.2
Woloszynek, J.3
Daenen, L.4
Man, S.5
Xu, P.6
-
60
-
-
0041589524
-
Maximum tolerable dose and low-dose metronomic chemotherapy have opposite effects on the mobilization and viability of circulating endothelial progenitor cells
-
Bertolini, F., Paul, S., Mancuso, P., Monestiroli, S., Gobbi, A., Shaked, Y., et al. Maximum tolerable dose and low-dose metronomic chemotherapy have opposite effects on the mobilization and viability of circulating endothelial progenitor cells. Cancer Res. 63 (2003), 4342–4346.
-
(2003)
Cancer Res.
, vol.63
, pp. 4342-4346
-
-
Bertolini, F.1
Paul, S.2
Mancuso, P.3
Monestiroli, S.4
Gobbi, A.5
Shaked, Y.6
-
61
-
-
34547617338
-
Antiangiogenic strategies on defense: blocking rebound by the tumor vasculature after chemotherapy
-
Shaked, Y., Kerbel, R.S., Antiangiogenic strategies on defense: blocking rebound by the tumor vasculature after chemotherapy. Cancer Res. 67 (2007), 7055–7058.
-
(2007)
Cancer Res.
, vol.67
, pp. 7055-7058
-
-
Shaked, Y.1
Kerbel, R.S.2
-
62
-
-
70350231754
-
Low-dose metronomic cyclophosphamide combined with vascular disrupting therapy induces potent anti-tumor activity in preclinical human tumor xenograft models
-
Daenen, L.G., Shaked, Y., Man, S., Xu, P., Voest, E.E., Hoffman, R.M., et al. Low-dose metronomic cyclophosphamide combined with vascular disrupting therapy induces potent anti-tumor activity in preclinical human tumor xenograft models. Mol. Cancer Ther. 8 (2009), 2872–2881.
-
(2009)
Mol. Cancer Ther.
, vol.8
, pp. 2872-2881
-
-
Daenen, L.G.1
Shaked, Y.2
Man, S.3
Xu, P.4
Voest, E.E.5
Hoffman, R.M.6
-
63
-
-
84973866691
-
Balancing efficacy of and host immune responses to cancer therapy: the yin and yang effects
-
Shaked, Y., Balancing efficacy of and host immune responses to cancer therapy: the yin and yang effects. Nat. Rev. Clin. Oncol. 13:10 (2016), 611–626.
-
(2016)
Nat. Rev. Clin. Oncol.
, vol.13
, Issue.10
, pp. 611-626
-
-
Shaked, Y.1
-
64
-
-
82955189189
-
Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer
-
Shree, T., Olson, O.C., Elie, B.T., Kester, J.C., Garfall, A.L., Simpson, K., et al. Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer. Genes Dev. 25:23 (2011), 2465–2479.
-
(2011)
Genes Dev.
, vol.25
, Issue.23
, pp. 2465-2479
-
-
Shree, T.1
Olson, O.C.2
Elie, B.T.3
Kester, J.C.4
Garfall, A.L.5
Simpson, K.6
-
65
-
-
84994759902
-
Macrophage-induced lymphangiogenesis and metastasis following paclitaxel chemotherapy is regulated by VEGFR3
-
Alishekevitz, D., Gingis-Velitski, S., Kaidar-Person, O., Gutter-Kapon, L., Scherer, S.D., Raviv, Z., et al. Macrophage-induced lymphangiogenesis and metastasis following paclitaxel chemotherapy is regulated by VEGFR3. Cell Rep. 17:5 (2016), 1344–1356.
-
(2016)
Cell Rep.
, vol.17
, Issue.5
, pp. 1344-1356
-
-
Alishekevitz, D.1
Gingis-Velitski, S.2
Kaidar-Person, O.3
Gutter-Kapon, L.4
Scherer, S.D.5
Raviv, Z.6
-
66
-
-
84890812467
-
Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A
-
Lotti, F., Jarrar, A.M., Pai, R.K., Hitomi, M., Lathia, J., Mace, A., et al. Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A. J. Exp. Med. 210:13 (2013), 2851–2872.
-
(2013)
J. Exp. Med.
, vol.210
, Issue.13
, pp. 2851-2872
-
-
Lotti, F.1
Jarrar, A.M.2
Pai, R.K.3
Hitomi, M.4
Lathia, J.5
Mace, A.6
-
67
-
-
85008433322
-
Metronomic chemotherapy prevents therapy-induced stromal activation and induction of tumor-initiating cells
-
Chan, T.-S., Hsu, C.-C., Pai, V.C., Liao, W.-Y., Huang, S.-S., Tan, K.-T., et al. Metronomic chemotherapy prevents therapy-induced stromal activation and induction of tumor-initiating cells. J. Exp. Med. 213 (2016), 2967–2988.
-
(2016)
J. Exp. Med.
, vol.213
, pp. 2967-2988
-
-
Chan, T.-S.1
Hsu, C.-C.2
Pai, V.C.3
Liao, W.-Y.4
Huang, S.-S.5
Tan, K.-T.6
-
68
-
-
70349747011
-
Glioma tumor stem-like cells promote tumor angiogenesis and vasculogenesis via vascular endothelial growth factor and stromal-derived factor 1
-
Folkins, C., Shaked, Y., Man, S., Tang, T., Lee, C.R., Zhu, Z., et al. Glioma tumor stem-like cells promote tumor angiogenesis and vasculogenesis via vascular endothelial growth factor and stromal-derived factor 1. Cancer Res. 69:18 (2009), 7243–7251.
-
(2009)
Cancer Res.
, vol.69
, Issue.18
, pp. 7243-7251
-
-
Folkins, C.1
Shaked, Y.2
Man, S.3
Tang, T.4
Lee, C.R.5
Zhu, Z.6
-
69
-
-
80055003796
-
A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumours
-
Beck, B., Driessens, G., Goossens, S., Youssef, K.K., Kuchnio, A., Caauwe, A., et al. A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumours. Nature 478:7369 (2011), 399–403.
-
(2011)
Nature
, vol.478
, Issue.7369
, pp. 399-403
-
-
Beck, B.1
Driessens, G.2
Goossens, S.3
Youssef, K.K.4
Kuchnio, A.5
Caauwe, A.6
-
70
-
-
85008462922
-
Therapy-activated stromal cells can dictate tumor fate
-
Kerbel, R.S., Shaked, Y., Therapy-activated stromal cells can dictate tumor fate. J. Exp. Med. 213:13 (2016), 2831–2833.
-
(2016)
J. Exp. Med.
, vol.213
, Issue.13
, pp. 2831-2833
-
-
Kerbel, R.S.1
Shaked, Y.2
|