메뉴 건너뛰기




Volumn 6, Issue 7, 2016, Pages

‘Acute myeloid leukemia: A comprehensive review and 2016 update’

Author keywords

[No Author keywords available]

Indexed keywords

CD135 ANTIGEN; CHIMERIC ANTIGEN RECEPTOR; CLOFARABINE; CRENOLANIB; ISOCITRATE DEHYDROGENASE 1; ISOCITRATE DEHYDROGENASE 2; ISOCITRATE DEHYDROGENASE INHIBITOR; MIDOSTAURIN; MONOCLONAL ANTIBODY; QUIZARTINIB; SORAFENIB; STAT3 PROTEIN;

EID: 85014421022     PISSN: None     EISSN: 20445385     Source Type: Journal    
DOI: 10.1038/bcj.2016.50     Document Type: Review
Times cited : (928)

References (121)
  • 1
    • 42449128875 scopus 로고    scopus 로고
    • Patterns of leukemia incidence in the United States by subtype and demographic characteristics, 1997-2002
    • Yamamoto JF, Goodman MT. Patterns of leukemia incidence in the United States by subtype and demographic characteristics, 1997-2002. Cancer Causes Control 2008; 19: 379–390.
    • (2008) Cancer Causes Control , vol.19 , pp. 379-390
    • Yamamoto, J.F.1    Goodman, M.T.2
  • 3
    • 84880653730 scopus 로고    scopus 로고
    • Survival and cure of acute myeloid leukaemia in England, 1971-2006: A population-based study
    • Shah A, Andersson TM, Rachet B, Bjorkholm M, Lambert PC. Survival and cure of acute myeloid leukaemia in England, 1971-2006: a population-based study. Br J Haematol 2013; 162: 509–516.
    • (2013) Br J Haematol , vol.162 , pp. 509-516
    • Shah, A.1    Andersson, T.M.2    Rachet, B.3    Bjorkholm, M.4    Lambert, P.C.5
  • 4
    • 84878758884 scopus 로고    scopus 로고
    • Medicare fee-for-service enrollees with primary acute myeloid leukemia: An analysis of treatment patterns, survival, and healthcare resource utilization and costs
    • Meyers J, Yu Y, Kaye JA, Davis KL. Medicare fee-for-service enrollees with primary acute myeloid leukemia: an analysis of treatment patterns, survival, and healthcare resource utilization and costs. Appl Health Econ Health Policy 2013; 11: 275–286.
    • (2013) Appl Health Econ Health Policy , vol.11 , pp. 275-286
    • Meyers, J.1    Yu, Y.2    Kaye, J.A.3    Davis, K.L.4
  • 5
    • 79251470793 scopus 로고    scopus 로고
    • Therapy-related myeloid neoplasms: Pathobiology and clinical characteristics
    • Sill H, Olipitz W, Zebisch A, Schulz E, Wolfler A. Therapy-related myeloid neoplasms: pathobiology and clinical characteristics. Br J Pharmacol 2011; 162; 792–805.
    • (2011) Br J Pharmacol , vol.162 , pp. 792-805
    • Sill, H.1    Olipitz, W.2    Zebisch, A.3    Schulz, E.4    Wolfler, A.5
  • 6
    • 84863393263 scopus 로고    scopus 로고
    • Prognostic relevance of integrated genetic profiling in acute myeloid leukemia
    • Patel JP, Gonen M, Figueroa ME, Fernandez H, Sun Z, Racevskis J et al. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. N Engl J Med 2012; 366: 1079–1089.
    • (2012) N Engl J Med , vol.366 , pp. 1079-1089
    • Patel, J.P.1    Gonen, M.2    Figueroa, M.E.3    Fernandez, H.4    Sun, Z.5    Racevskis, J.6
  • 7
    • 84878372012 scopus 로고    scopus 로고
    • Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med 2013; 368: 2059–2074.
    • (2013) N Engl J Med , vol.368 , pp. 2059-2074
  • 8
    • 0036720398 scopus 로고    scopus 로고
    • The roles of FLT3 in hematopoiesis and leukemia
    • Gilliland DG, Griffin JD. The roles of FLT3 in hematopoiesis and leukemia. Blood 2002; 100: 1532–1542.
    • (2002) Blood , vol.100 , pp. 1532-1542
    • Gilliland, D.G.1    Griffin, J.D.2
  • 9
    • 80052836966 scopus 로고    scopus 로고
    • Current findings for recurring mutations in acute myeloid leukemia
    • Takahashi S. Current findings for recurring mutations in acute myeloid leukemia. J Hematol Oncol 2011; 4: 36.
    • (2011) J Hematol Oncol , vol.4 , pp. 36
    • Takahashi, S.1
  • 10
    • 84905686309 scopus 로고    scopus 로고
    • Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients
    • Kihara R, Nagata Y, Kiyoi H, Kato T, Yamamoto E, Suzuki K et al. Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients. Leukemia 2014; 28: 1586–1595.
    • (2014) Leukemia , vol.28 , pp. 1586-1595
    • Kihara, R.1    Nagata, Y.2    Kiyoi, H.3    Kato, T.4    Yamamoto, E.5    Suzuki, K.6
  • 11
    • 84903190077 scopus 로고    scopus 로고
    • Role of altered growth factor receptor-mediated JAK2 signaling in growth and maintenance of human acute myeloid leukemia stem cells
    • Cook AM, Li L, Ho Y, Lin A, Li L, Stein A et al. Role of altered growth factor receptor-mediated JAK2 signaling in growth and maintenance of human acute myeloid leukemia stem cells. Blood 2014; 123: 2826–2837.
    • (2014) Blood , vol.123 , pp. 2826-2837
    • Cook, A.M.1    Li, L.2    Ho, Y.3    Lin, A.4    Li, L.5    Stein, A.6
  • 12
    • 41949110321 scopus 로고    scopus 로고
    • Epigenetic regulation of signal transducer and activator of transcription 3 in acute myeloid leukemia
    • Ghoshal Gupta S, Baumann H, Wetzler M. Epigenetic regulation of signal transducer and activator of transcription 3 in acute myeloid leukemia. Leuk Res 2008; 32: 1005–1014.
    • (2008) Leuk Res , vol.32 , pp. 1005-1014
    • Gupta, G.S.1    Baumann, H.2    Wetzler, M.3
  • 13
    • 84940830735 scopus 로고    scopus 로고
    • The role of the JAK-STAT pathway and related signal cascades in telomerase activation during the development of hematologic malignancies
    • Yamada O, Kawauchi K. The role of the JAK-STAT pathway and related signal cascades in telomerase activation during the development of hematologic malignancies. JAKSTAT 2013; 2: e25256.
    • (2013) JAKSTAT , vol.2 , pp. e25256
    • Yamada, O.1    Kawauchi, K.2
  • 14
    • 0034660463 scopus 로고    scopus 로고
    • Constitutive Stat3, Tyr705, and Ser727 phosphorylation in acute myeloid leukemia cells caused by the autocrine secretion of interleukin-6
    • Schuringa JJ, Wierenga AT, Kruijer W, Vellenga E. Constitutive Stat3, Tyr705, and Ser727 phosphorylation in acute myeloid leukemia cells caused by the autocrine secretion of interleukin-6. Blood 2000; 95: 3765–3770.
    • (2000) Blood , vol.95 , pp. 3765-3770
    • Schuringa, J.J.1    Wierenga, A.T.2    Kruijer, W.3    Vellenga, E.4
  • 15
    • 0037838661 scopus 로고    scopus 로고
    • Over-expression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells
    • Spiekermann K, Bagrintseva K, Schwab R, Schmieja K, Hiddemann W. Over-expression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells. Clin Cancer Res 2003; 9: 2140–2150.
    • (2003) Clin Cancer Res , vol.9 , pp. 2140-2150
    • Spiekermann, K.1    Bagrintseva, K.2    Schwab, R.3    Schmieja, K.4    Hiddemann, W.5
  • 16
    • 33744500207 scopus 로고    scopus 로고
    • JAK2 V617F is a rare finding in de novo acute myeloid leukemia, but STAT3 activation is common and remains unexplained
    • Steensma DP, McClure RF, Karp JE, Tefferi A, Lasho TL, Powell HL et al. JAK2 V617F is a rare finding in de novo acute myeloid leukemia, but STAT3 activation is common and remains unexplained. Leukemia 2006; 20: 971–978.
    • (2006) Leukemia , vol.20 , pp. 971-978
    • Steensma, D.P.1    McClure, R.F.2    Karp, J.E.3    Tefferi, A.4    Lasho, T.L.5    Powell, H.L.6
  • 17
    • 77449159028 scopus 로고    scopus 로고
    • Diagnosis and management of acute myeloid leukemia in adults: Recommendations from an international expert panel, on behalf of the European LeukemiaNet
    • Dohner H, Estey EH, Amadori S, Appelbaum FR, Buchner T, Burnett AK et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood 2010; 115: 453–474.
    • (2010) Blood , vol.115 , pp. 453-474
    • Dohner, H.1    Estey, E.H.2    Amadori, S.3    Appelbaum, F.R.4    Buchner, T.5    Burnett, A.K.6
  • 18
    • 70349256226 scopus 로고    scopus 로고
    • The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: Rationale and important changes
    • Vardiman JW, Thiele J, Arber DA, Brunning RD, Borowitz MJ, Porwit A et al. The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood 2009; 114:. 937–951.
    • (2009) Blood , vol.114 , pp. 937-951
    • Vardiman, J.W.1    Thiele, J.2    Arber, D.A.3    Brunning, R.D.4    Borowitz, M.J.5    Porwit, A.6
  • 19
    • 84974560145 scopus 로고    scopus 로고
    • The 2016 revision to the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia
    • Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM et al. The 2016 revision to the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia. Blood 2016; 127: 2391–2405.
    • (2016) Blood , vol.127 , pp. 2391-2405
    • Arber, D.A.1    Orazi, A.2    Hasserjian, R.3    Thiele, J.4    Borowitz, M.J.5    Le Beau, M.M.6
  • 20
    • 33644521267 scopus 로고    scopus 로고
    • Results of intensive chemotherapy in 998 patients age 65 years or older with acute myeloid leukemia or high-risk myelodysplastic syndrome: Predictive prognostic models for outcome
    • Kantarjian H, O'Brien S, Cortes J, Giles F, Faderl S, Jabbour E et al. Results of intensive chemotherapy in 998 patients age 65 years or older with acute myeloid leukemia or high-risk myelodysplastic syndrome: predictive prognostic models for outcome. Cancer 2006; 106: 1090–1098.
    • (2006) Cancer , vol.106 , pp. 1090-1098
    • Kantarjian, H.1    O'Brien, S.2    Cortes, J.3    Giles, F.4    Faderl, S.5    Jabbour, E.6
  • 21
    • 81255175041 scopus 로고    scopus 로고
    • Prediction of early death after induction therapy for newly diagnosed acute myeloid leukemia with pretreatment risk scores: A novel paradigm for treatment assignment
    • Walter RB, Othus M, Borthakur G, Ravandi F, Cortes JE, Pierce SA et al. Prediction of early death after induction therapy for newly diagnosed acute myeloid leukemia with pretreatment risk scores: a novel paradigm for treatment assignment. J Clin Oncol 2011; 29: 4417–4423.
    • (2011) J Clin Oncol , vol.29 , pp. 4417-4423
    • Walter, R.B.1    Othus, M.2    Borthakur, G.3    Ravandi, F.4    Cortes, J.E.5    Pierce, S.A.6
  • 22
    • 84923114820 scopus 로고    scopus 로고
    • Characterization and prognostic features of secondary acute myeloid leukemia in a population-based setting: A report from the Swedish Acute Leukemia Registry
    • Hulegardh E, Nilsson C, Lazarevic V, Garelius H, Antunovic P, Derolf A. Rangert et al. Characterization and prognostic features of secondary acute myeloid leukemia in a population-based setting: a report from the Swedish Acute Leukemia Registry. Am J Hematol 2015; 90: 208–214.
    • (2015) Am J Hematol , vol.90 , pp. 208-214
    • Hulegardh, E.1    Nilsson, C.2    Lazarevic, V.3    Garelius, H.4    Antunovic, P.5    Rangert, D.A.6
  • 23
    • 85007038225 scopus 로고    scopus 로고
    • Acute myeloid leukemia: 2014 update on risk-stratification and management
    • Estey EH. Acute myeloid leukemia: 2014 update on risk-stratification and management. Am J Hematol 2014; 89: 1063–1081.
    • (2014) Am J Hematol , vol.89 , pp. 1063-1081
    • Estey, E.H.1
  • 24
    • 84871774636 scopus 로고    scopus 로고
    • Prognostic significance of the European LeukemiaNet standardized system for reporting cytogenetic and molecular alterations in adults with acute myeloid leukemia
    • Mrozek K, Marcucci G, Nicolet D, Maharry KS, Becker H, Whitman SP et al. Prognostic significance of the European LeukemiaNet standardized system for reporting cytogenetic and molecular alterations in adults with acute myeloid leukemia. J Clin Oncol 2012; 30: 4515–4523.
    • (2012) J Clin Oncol , vol.30 , pp. 4515-4523
    • Mrozek, K.1    Marcucci, G.2    Nicolet, D.3    Maharry, K.S.4    Becker, H.5    Whitman, S.P.6
  • 25
    • 84916201282 scopus 로고    scopus 로고
    • Prevalence and prognostic significance of c-KIT mutations in core binding factor acute myeloid leukemia: A comprehensive large-scale study from a single Chinese center
    • Qin YZ, Zhu HH, Jiang Q, Jiang H, Zhang LP, Xu LP et al. Prevalence and prognostic significance of c-KIT mutations in core binding factor acute myeloid leukemia: a comprehensive large-scale study from a single Chinese center. Leuk Res 2014; 38: 1435–1440.
    • (2014) Leuk Res , vol.38 , pp. 1435-1440
    • Qin, Y.Z.1    Zhu, H.H.2    Jiang, Q.3    Jiang, H.4    Zhang, L.P.5    Xu, L.P.6
  • 26
    • 33748467435 scopus 로고    scopus 로고
    • Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): A Cancer and Leukemia Group B Study
    • Paschka P, Marcucci G, Ruppert AS, Mrozek K, Chen H, Kittles RA et al. Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): a Cancer and Leukemia Group B Study. J Clin Oncol 2006; 24: 3904–3911.
    • (2006) J Clin Oncol , vol.24 , pp. 3904-3911
    • Paschka, P.1    Marcucci, G.2    Ruppert, A.S.3    Mrozek, K.4    Chen, H.5    Kittles, R.A.6
  • 27
    • 80052097088 scopus 로고    scopus 로고
    • Prognostic impact of c-KIT mutations in core binding factor acute myeloid leukemia
    • Park SH, Chi HS, Min SK, Park BG, Jang S, Park CJ. Prognostic impact of c-KIT mutations in core binding factor acute myeloid leukemia. Leuk Res 2011; 35: 1376–1383.
    • (2011) Leuk Res , vol.35 , pp. 1376-1383
    • Park, S.H.1    Chi, H.S.2    Min, S.K.3    Park, B.G.4    Jang, S.5    Park, C.J.6
  • 28
    • 84929627266 scopus 로고    scopus 로고
    • Incidences and prognostic impact of c-KIT, WT1, CEBPA, and CBL mutations, and mutations associated with epigenetic modification in core binding factor acute myeloid leukemia: A multicenter study in a Korean population
    • Park SH, Lee HJ, Kim IS, Kang JE, Lee EY, Kim HJ et al. Incidences and prognostic impact of c-KIT, WT1, CEBPA, and CBL mutations, and mutations associated with epigenetic modification in core binding factor acute myeloid leukemia: a multicenter study in a Korean population. Ann Lab Med 2015; 35: 288–297.
    • (2015) Ann Lab Med , vol.35 , pp. 288-297
    • Park, S.H.1    Lee, H.J.2    Kim, I.S.3    Kang, J.E.4    Lee, E.Y.5    Kim, H.J.6
  • 29
    • 28444473100 scopus 로고    scopus 로고
    • Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: Interaction with other gene mutations
    • Dohner K, Schlenk RF, Habdank M, Scholl C, Rucker FG, Corbacioglu A et al. Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations. Blood 2005; 106: 3740–3746.
    • (2005) Blood , vol.106 , pp. 3740-3746
    • Dohner, K.1    Schlenk, R.F.2    Habdank, M.3    Scholl, C.4    Rucker, F.G.5    Corbacioglu, A.6
  • 30
    • 84926524933 scopus 로고    scopus 로고
    • Favorable prognosis of biallelic CEBPA gene mutations in acute myeloid leukemia patients: A meta-analysis
    • Li HY, Deng DH, Huang Y, Ye FH, Huang LL, Xiao Q et al. Favorable prognosis of biallelic CEBPA gene mutations in acute myeloid leukemia patients: a meta-analysis. Eur J Haematol 2015; 94: 439–448.
    • (2015) Eur J Haematol , vol.94 , pp. 439-448
    • Li, H.Y.1    Deng, D.H.2    Huang, Y.3    Ye, F.H.4    Huang, L.L.5    Xiao, Q.6
  • 31
    • 0037114829 scopus 로고    scopus 로고
    • Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: A study of the AML Study Group Ulm
    • Frohling S, Schlenk RF, Breitruck J, Benner A, Kreitmeier S, Tobis K et al. Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: a study of the AML Study Group Ulm. Blood 2002; 100: 4372–4380.
    • (2002) Blood , vol.100 , pp. 4372-4380
    • Frohling, S.1    Schlenk, R.F.2    Breitruck, J.3    Benner, A.4    Kreitmeier, S.5    Tobis, K.6
  • 32
    • 84904760463 scopus 로고    scopus 로고
    • Prognostic significance of FLT3 internal tandem duplication, nucleophosmin 1, and CEBPA gene mutations for acute myeloid leukemia patients with normal karyotype and younger than 60 years: A systematic review and meta-analysis
    • Port M, Bottcher M, Thol F, Ganser A, Schlenk R, Wasem J et al. Prognostic significance of FLT3 internal tandem duplication, nucleophosmin 1, and CEBPA gene mutations for acute myeloid leukemia patients with normal karyotype and younger than 60 years: a systematic review and meta-analysis. Ann Hematol 2014; 93: 1279–1286.
    • (2014) Ann Hematol , vol.93 , pp. 1279-1286
    • Port, M.1    Bottcher, M.2    Thol, F.3    Ganser, A.4    Schlenk, R.5    Wasem, J.6
  • 33
    • 84900424984 scopus 로고    scopus 로고
    • Role of genotype-based approach in the clinical management of adult acute myeloid leukemia with normal cytogenetics
    • Cagnetta A, Adamia S, Acharya C, Patrone F, Miglino M, Nencioni A et al. Role of genotype-based approach in the clinical management of adult acute myeloid leukemia with normal cytogenetics. Leuk Res 2014; 38: 649–659.
    • (2014) Leuk Res , vol.38 , pp. 649-659
    • Cagnetta, A.1    Adamia, S.2    Acharya, C.3    Patrone, F.4    Miglino, M.5    Nencioni, A.6
  • 34
    • 41949090673 scopus 로고    scopus 로고
    • The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia
    • Gale RE, Green C, Allen C, Mead AJ, Burnett AK, Hills RK et al. The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia. Blood 2008; 111: 2776–2784.
    • (2008) Blood , vol.111 , pp. 2776-2784
    • Gale, R.E.1    Green, C.2    Allen, C.3    Mead, A.J.4    Burnett, A.K.5    Hills, R.K.6
  • 35
    • 84864775100 scopus 로고    scopus 로고
    • Diversity of the juxtamembrane and TKD1 mutations (exons 13-15) in the FLT3 gene with regards to mutant load, sequence, length, localization, and correlation with biological data
    • Schnittger S, Bacher U, Haferlach C, Alpermann T, Kern W, Haferlach T. Diversity of the juxtamembrane and TKD1 mutations (exons 13-15) in the FLT3 gene with regards to mutant load, sequence, length, localization, and correlation with biological data. Genes Chromosomes Cancer 2012; 51: 910–924.
    • (2012) Genes Chromosomes Cancer , vol.51 , pp. 910-924
    • Schnittger, S.1    Bacher, U.2    Haferlach, C.3    Alpermann, T.4    Kern, W.5    Haferlach, T.6
  • 36
    • 84867806184 scopus 로고    scopus 로고
    • A novel hierarchical prognostic model of AML solely based on molecular mutations
    • Grossmann V, Schnittger S, Kohlmann A, Eder C, Roller A, Dicker F et al. A novel hierarchical prognostic model of AML solely based on molecular mutations. Blood 2012; 120: 2963–2972.
    • (2012) Blood , vol.120 , pp. 2963-2972
    • Grossmann, V.1    Schnittger, S.2    Kohlmann, A.3    Eder, C.4    Roller, A.5    Dicker, F.6
  • 37
    • 84886804684 scopus 로고    scopus 로고
    • DNMT3A mutation is a poor prognosis biomarker in AML: Results of a meta-analysis of 4500 AML patients
    • Shivarov V, Gueorguieva R, Stoimenov A, Tiu R. DNMT3A mutation is a poor prognosis biomarker in AML: results of a meta-analysis of 4500 AML patients. Leuk Res 2013; 37: 1445–1450.
    • (2013) Leuk Res , vol.37 , pp. 1445-1450
    • Shivarov, V.1    Gueorguieva, R.2    Stoimenov, A.3    Tiu, R.4
  • 38
    • 84937398063 scopus 로고    scopus 로고
    • Characteristics, clinical outcome, and prognostic significance of IDH mutations in AML
    • DiNardo CD, Ravandi F, Agresta S, Konopleva M, Takahashi K, Kadia T et al. Characteristics, clinical outcome, and prognostic significance of IDH mutations in AML. Am J Hematol 2015; 90: 732–736.
    • (2015) Am J Hematol , vol.90 , pp. 732-736
    • DiNardo, C.D.1    Ravandi, F.2    Agresta, S.3    Konopleva, M.4    Takahashi, K.5    Kadia, T.6
  • 39
    • 84927127471 scopus 로고    scopus 로고
    • Relation of clinical response and minimal residual disease and their prognostic impact on outcome in acute myeloid leukemia
    • Chen X, Xie H, Wood BL, Walter RB, Pagel JM, Becker PS et al. Relation of clinical response and minimal residual disease and their prognostic impact on outcome in acute myeloid leukemia. J Clin Oncol 2015; 33: 1258–1264.
    • (2015) J Clin Oncol , vol.33 , pp. 1258-1264
    • Chen, X.1    Xie, H.2    Wood, B.L.3    Walter, R.B.4    Pagel, J.M.5    Becker, P.S.6
  • 40
    • 77950480200 scopus 로고    scopus 로고
    • Effect of complete remission and responses less than complete remission on survival in acute myeloid leukemia: A combined Eastern Cooperative Oncology Group, Southwest Oncology Group, and M. D. Anderson Cancer Center Study
    • Walter RB, Kantarjian HM, Huang X, Pierce SA, Sun Z, Gundacker HM et al. Effect of complete remission and responses less than complete remission on survival in acute myeloid leukemia: a combined Eastern Cooperative Oncology Group, Southwest Oncology Group, and M. D. Anderson Cancer Center Study. J Clin Oncol 2010; 28: 1766–1771.
    • (2010) J Clin Oncol , vol.28 , pp. 1766-1771
    • Walter, R.B.1    Kantarjian, H.M.2    Huang, X.3    Pierce, S.A.4    Sun, Z.5    Gundacker, H.M.6
  • 41
    • 84881665264 scopus 로고    scopus 로고
    • Core binding factor acute myeloid leukemia: The impact of age, leukocyte count, molecular findings, and minimal residual disease
    • Hoyos M, Nomdedeu JF, Esteve J, Duarte R, Ribera JM, Llorente A et al. Core binding factor acute myeloid leukemia: the impact of age, leukocyte count, molecular findings, and minimal residual disease. Eur J Haematol 2013; 91: 209–218.
    • (2013) Eur J Haematol , vol.91 , pp. 209-218
    • Hoyos, M.1    Nomdedeu, J.F.2    Esteve, J.3    Duarte, R.4    Ribera, J.M.5    Llorente, A.6
  • 42
    • 84867297401 scopus 로고    scopus 로고
    • Minimal residual disease monitoring by quantitative RT-PCR in core binding factor AML allows risk stratification and predicts relapse: Results of the United Kingdom MRC AML-15 trial
    • Yin JA, O'Brien MA, Hills RK, Daly SB, Wheatley K, Burnett AK. Minimal residual disease monitoring by quantitative RT-PCR in core binding factor AML allows risk stratification and predicts relapse: results of the United Kingdom MRC AML-15 trial. Blood 2012; 120: 2826–2835.
    • (2012) Blood , vol.120 , pp. 2826-2835
    • Yin, J.A.1    O'Brien, M.A.2    Hills, R.K.3    Daly, S.B.4    Wheatley, K.5    Burnett, A.K.6
  • 43
    • 84855838173 scopus 로고    scopus 로고
    • Prognostic and therapeutic implications of minimal residual disease detection in acute myeloid leukemia
    • Buccisano F, Maurillo L, Del Principe MI, Del Poeta G, Sconocchia G, Lo-Coco F et al. Prognostic and therapeutic implications of minimal residual disease detection in acute myeloid leukemia. Blood 2012; 119: 332–341.
    • (2012) Blood , vol.119 , pp. 332-341
    • Buccisano, F.1    Maurillo, L.2    Del Principe, M.I.3    Del Poeta, G.4    Sconocchia, G.5    Lo-Coco, F.6
  • 44
    • 84877684716 scopus 로고    scopus 로고
    • Prognostic and therapeutic implications of minimal residual disease at the time of transplantation in acute leukemia
    • Buckley SA, Appelbaum FR, Walter RB. Prognostic and therapeutic implications of minimal residual disease at the time of transplantation in acute leukemia. Bone Marrow Transplant 2013; 48: 630–641.
    • (2013) Bone Marrow Transplant , vol.48 , pp. 630-641
    • Buckley, S.A.1    Appelbaum, F.R.2    Walter, R.B.3
  • 45
    • 84948807798 scopus 로고    scopus 로고
    • Minimal residual disease evaluation by flow cytometry is a complementary tool to cytogenetics for treatment decisions in acute myeloid leukaemia
    • Vidriales MB, Perez-Lopez E, Pegenaute C, Castellanos M, Perez JJ, Chandia M et al. Minimal residual disease evaluation by flow cytometry is a complementary tool to cytogenetics for treatment decisions in acute myeloid leukaemia. Leuk Res 2015; 40: 1–9.
    • (2015) Leuk Res , vol.40 , pp. 1-9
    • Vidriales, M.B.1    Perez-Lopez, E.2    Pegenaute, C.3    Castellanos, M.4    Perez, J.J.5    Chandia, M.6
  • 46
    • 84930642702 scopus 로고    scopus 로고
    • High doses of daunorubicin during induction therapy of newly diagnosed acute myeloid leukemia: A systematic review and meta-analysis of prospective clinical trials
    • Gong Q, Zhou L, Xu S, Li X, Zou Y, Chen J. High doses of daunorubicin during induction therapy of newly diagnosed acute myeloid leukemia: a systematic review and meta-analysis of prospective clinical trials. PLoS One 2015; 10: e0125612.
    • (2015) Plos One , vol.10 , pp. e0125612
    • Gong, Q.1    Zhou, L.2    Xu, S.3    Li, X.4    Zou, Y.5    Chen, J.6
  • 47
    • 84957789687 scopus 로고    scopus 로고
    • The effects of idarubicin versus other anthracyclines for induction therapy of patients with newly diagnosed leukaemia
    • Li X, Xu S, Tan Y, Chen J. The effects of idarubicin versus other anthracyclines for induction therapy of patients with newly diagnosed leukaemia. Cochrane Database Syst Rev 2015; 6: CD010432.
    • (2015) Cochrane Database Syst Rev , vol.6 , pp. CD010432
    • Li, X.1    Xu, S.2    Tan, Y.3    Chen, J.4
  • 48
    • 84872087060 scopus 로고    scopus 로고
    • Sense and nonsense of high-dose cytarabine for acute myeloid leukemia
    • Lowenberg B. Sense and nonsense of high-dose cytarabine for acute myeloid leukemia. Blood 2013; 121: 26–28.
    • (2013) Blood , vol.121 , pp. 26-28
    • Lowenberg, B.1
  • 50
    • 84894365265 scopus 로고    scopus 로고
    • Optimization of chemotherapy for younger patients with acute myeloid leukemia: Results of the medical research council AML15 trial
    • Burnett AK, Russell NH, Hills RK, Hunter AE, Kjeldsen L, Yin J et al. Optimization of chemotherapy for younger patients with acute myeloid leukemia: results of the medical research council AML15 trial. J Clin Oncol 2013; 31: 3360–3368.
    • (2013) J Clin Oncol , vol.31 , pp. 3360-3368
    • Burnett, A.K.1    Russell, N.H.2    Hills, R.K.3    Hunter, A.E.4    Kjeldsen, L.5    Yin, J.6
  • 51
    • 0024458031 scopus 로고
    • On the value of intensive remission-induction chemotherapy in elderly patients of 65+ years with acute myeloid leukemia: A randomized phase III study of the European Organization for Research and Treatment of Cancer Leukemia Group
    • Lowenberg B, Zittoun R, Kerkhofs H, Jehn U, Abels J, Debusscher L et al. On the value of intensive remission-induction chemotherapy in elderly patients of 65+ years with acute myeloid leukemia: a randomized phase III study of the European Organization for Research and Treatment of Cancer Leukemia Group. J Clin Oncol 1989; 7: 1268–1274.
    • (1989) J Clin Oncol , vol.7 , pp. 1268-1274
    • Lowenberg, B.1    Zittoun, R.2    Kerkhofs, H.3    Jehn, U.4    Abels, J.5    Debusscher, L.6
  • 52
    • 77449149373 scopus 로고    scopus 로고
    • Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia
    • Fenaux P, Mufti GJ, Hellstrom-Lindberg E, Santini V, Gattermann N, Germing U et al. Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia. J Clin Oncol 2010; 28: 562–569.
    • (2010) J Clin Oncol , vol.28 , pp. 562-569
    • Fenaux, P.1    Mufti, G.J.2    Hellstrom-Lindberg, E.3    Santini, V.4    Gattermann, N.5    Germing, U.6
  • 53
    • 84864063679 scopus 로고    scopus 로고
    • Multicenter, randomized, open-label, phase III trial of decitabine versus patient choice, with physician advice, of either supportive care or low-dose cytarabine for the treatment of older patients with newly diagnosed acute myeloid leukemia
    • Kantarjian HM, Thomas XG, Dmoszynska A, Wierzbowska A, Mazur G, Mayer J et al. Multicenter, randomized, open-label, phase III trial of decitabine versus patient choice, with physician advice, of either supportive care or low-dose cytarabine for the treatment of older patients with newly diagnosed acute myeloid leukemia. J Clin Oncol 2012; 30: 2670–2677.
    • (2012) J Clin Oncol , vol.30 , pp. 2670-2677
    • Kantarjian, H.M.1    Thomas, X.G.2    Dmoszynska, A.3    Wierzbowska, A.4    Mazur, G.5    Mayer, J.6
  • 54
    • 84937804118 scopus 로고    scopus 로고
    • International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with 430% blasts
    • Dombret H, Seymour JF, Butrym A, Wierzbowska A, Selleslag D, Jang JH et al. International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with 430% blasts. Blood 2015; 126: 291–299.
    • (2015) Blood , vol.126 , pp. 291-299
    • Dombret, H.1    Seymour, J.F.2    Butrym, A.3    Wierzbowska, A.4    Selleslag, D.5    Jang, J.H.6
  • 56
    • 0035038123 scopus 로고    scopus 로고
    • Treatment of "poor risk" acute myeloid leukemia with fludarabine, cytarabine and G-CSF (flag regimen): A single center study
    • Carella AM, Cascavilla N, Greco MM, Melillo L, Sajeva MR, Ladogana S et al. Treatment of "poor risk" acute myeloid leukemia with fludarabine, cytarabine and G-CSF (flag regimen): a single center study. Leuk Lymphoma 2001; 40: 295–303.
    • (2001) Leuk Lymphoma , vol.40 , pp. 295-303
    • Carella, A.M.1    Cascavilla, N.2    Greco, M.M.3    Melillo, L.4    Sajeva, M.R.5    Ladogana, S.6
  • 57
    • 0021821482 scopus 로고
    • High-dose cytosine ara-binoside therapy with and without anthracycline antibiotics for remission reinduction of acute nonlymphoblastic leukemia
    • Herzig RH, Lazarus HM, Wolff SN, Phillips GL, Herzig GP. High-dose cytosine ara-binoside therapy with and without anthracycline antibiotics for remission reinduction of acute nonlymphoblastic leukemia. J Clin Oncol 1985; 3: 992–997.
    • (1985) J Clin Oncol , vol.3 , pp. 992-997
    • Herzig, R.H.1    Lazarus, H.M.2    Wolff, S.N.3    Phillips, G.L.4    Herzig, G.P.5
  • 58
    • 0025760557 scopus 로고
    • Mitoxan-trone, etoposide, and intermediate-dose cytarabine: An effective and tolerable regimen for the treatment of refractory acute myeloid leukemia
    • Amadori S, Arcese W, Isacchi G, Meloni G, Petti MC, Monarca B et al. Mitoxan-trone, etoposide, and intermediate-dose cytarabine: an effective and tolerable regimen for the treatment of refractory acute myeloid leukemia. J Clin Oncol 1991; 9: 1210–1214.
    • (1991) J Clin Oncol , vol.9 , pp. 1210-1214
    • Amadori, S.1    Arcese, W.2    Isacchi, G.3    Meloni, G.4    Petti, M.C.5    Monarca, B.6
  • 59
    • 0028009840 scopus 로고
    • Efficacy of etoposide and mitoxantrone in patients with acute myelogenous leukemia refractory to standard induction therapy and intermediate-dose cytarabine with amsidine. Dutch Hematology-Oncology Working Group for Adults (HOVON)
    • Daenen S, Lowenberg B, Sonneveld P, van Putten WL, Verhoef G, Verdonck LF et al. Efficacy of etoposide and mitoxantrone in patients with acute myelogenous leukemia refractory to standard induction therapy and intermediate-dose cytarabine with amsidine. Dutch Hematology-Oncology Working Group for Adults (HOVON). Leukemia 1994; 8: 6–10.
    • (1994) Leukemia , vol.8 , pp. 6-10
    • Daenen, S.1    Lowenberg, B.2    Sonneveld, P.3    Van Putten, W.L.4    Verhoef, G.5    Verdonck, L.F.6
  • 60
    • 84867608512 scopus 로고    scopus 로고
    • Acute myeloid leukemia (AML): Different treatment strategies versus a common standard arm--combined prospective analysis by the German AML Intergroup
    • Buchner T, Schlenk RF, Schaich M, Dohner K, Krahl R, Krauter J et al. Acute myeloid leukemia (AML): different treatment strategies versus a common standard arm--combined prospective analysis by the German AML Intergroup. J Clin Oncol 2012; 30: 3604–3610.
    • (2012) J Clin Oncol , vol.30 , pp. 3604-3610
    • Buchner, T.1    Schlenk, R.F.2    Schaich, M.3    Dohner, K.4    Krahl, R.5    Krauter, J.6
  • 61
    • 67049164836 scopus 로고    scopus 로고
    • Allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission: Systematic review and meta-analysis of prospective clinical trials
    • Koreth J, Schlenk R, Kopecky KJ, Honda S, Sierra J, Djulbegovic BJ et al. Allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission: systematic review and meta-analysis of prospective clinical trials. JAMA 2009; 301: 2349–2361.
    • (2009) JAMA , vol.301 , pp. 2349-2361
    • Koreth, J.1    Schlenk, R.2    Kopecky, K.J.3    Honda, S.4    Sierra, J.5    Djulbegovic, B.J.6
  • 62
    • 16844374525 scopus 로고    scopus 로고
    • Efficacy of allogeneic hematopoietic stem cell transplantation depends on cytogenetic risk for acute myeloid leukemia in first disease remission: A metaanalysis
    • Yanada M, Matsuo K, Emi N, Naoe T. Efficacy of allogeneic hematopoietic stem cell transplantation depends on cytogenetic risk for acute myeloid leukemia in first disease remission: a metaanalysis. Cancer 2005; 103:. 1652–1658.
    • (2005) Cancer , vol.103 , pp. 1652-1658
    • Yanada, M.1    Matsuo, K.2    Emi, N.3    Naoe, T.4
  • 63
    • 10244249096 scopus 로고    scopus 로고
    • A randomized investigation of high-dose versus standard-dose cytosine arabi-noside with daunorubicin in patients with previously untreated acute myeloid leukemia: A Southwest Oncology Group study
    • Weick JK, Kopecky KJ, Appelbaum FR, Head DR, Kingsbury LL, Balcerzak SP et al. A randomized investigation of high-dose versus standard-dose cytosine arabi-noside with daunorubicin in patients with previously untreated acute myeloid leukemia: a Southwest Oncology Group study. Blood 1996; 88: 2841–2851.
    • (1996) Blood , vol.88 , pp. 2841-2851
    • Weick, J.K.1    Kopecky, K.J.2    Appelbaum, F.R.3    Head, D.R.4    Kingsbury, L.L.5    Balcerzak, S.P.6
  • 64
    • 84897020217 scopus 로고    scopus 로고
    • Allogeneic transplantation versus chemotherapy as postremission therapy for acute myeloid leukemia: A prospective matched pairs analysis
    • Stelljes M, Krug U, Beelen DW, Braess J, Sauerland MC, Heinecke A et al. Allogeneic transplantation versus chemotherapy as postremission therapy for acute myeloid leukemia: a prospective matched pairs analysis. J Clin Oncol 2014; 32: 288–296.
    • (2014) J Clin Oncol , vol.32 , pp. 288-296
    • Stelljes, M.1    Krug, U.2    Beelen, D.W.3    Braess, J.4    Sauerland, M.C.5    Heinecke, A.6
  • 66
    • 84922341259 scopus 로고    scopus 로고
    • Allogeneic stem-cell transplantation in patients with NPM1-mutated acute myeloid leukemia: Results from a prospective donor versus no-donor analysis of patients after upfront HLA typing within the SAL-AML 2003 trial
    • Rollig C, Bornhauser M, Kramer M, Thiede C, Ho AD, Kramer A et al. Allogeneic stem-cell transplantation in patients with NPM1-mutated acute myeloid leukemia: results from a prospective donor versus no-donor analysis of patients after upfront HLA typing within the SAL-AML 2003 trial. J Clin Oncol 2015; 33; 403–410.
    • (2015) J Clin Oncol , vol.33 , pp. 403-410
    • Rollig, C.1    Bornhauser, M.2    Kramer, M.3    Thiede, C.4    Ho, A.D.5    Kramer, A.6
  • 67
    • 34247325560 scopus 로고    scopus 로고
    • Results of a HOVON/SAKK donor versus no-donor analysis of myeloablative HLA-identical sibling stem cell transplantation in first remission acute myeloid leukemia in young and middle-aged adults: Benefits for whom?
    • Cornelissen JJ, van Putten WL, Verdonck LF, Theobald M, Jacky E, Daenen SM et al. Results of a HOVON/SAKK donor versus no-donor analysis of myeloablative HLA-identical sibling stem cell transplantation in first remission acute myeloid leukemia in young and middle-aged adults: benefits for whom? Blood 2007; 109: 3658–3666.
    • (2007) Blood , vol.109 , pp. 3658-3666
    • Cornelissen, J.J.1    Van Putten, W.L.2    Verdonck, L.F.3    Theobald, M.4    Jacky, E.5    Daenen, S.M.6
  • 68
    • 84929283886 scopus 로고    scopus 로고
    • Hematopoietic cell transplantation in patients with intermediate and high-risk AML: Results from the randomized Study Alliance Leukemia (SAL) AML 2003 trial
    • Schetelig J, Schaich M, Schafer-Eckart K, Hanel M, Aulitzky WE, Einsele H et al. Hematopoietic cell transplantation in patients with intermediate and high-risk AML: results from the randomized Study Alliance Leukemia (SAL) AML 2003 trial. Leukemia 2015; 29:. 1060–1068.
    • (2015) Leukemia , vol.29 , pp. 1060-1068
    • Schetelig, J.1    Schaich, M.2    Schafer-Eckart, K.3    Hanel, M.4    Aulitzky, W.E.5    Einsele, H.6
  • 69
    • 84941219651 scopus 로고    scopus 로고
    • Efficacy of allogeneic hematopoietic stem cell transplantation in intermediate-risk acute myeloid leukemia adult patients in first complete remission: A meta-analysis of prospective studies
    • Li D, Wang L, Zhu H, Dou L, Liu D, Fu L et al. Efficacy of allogeneic hematopoietic stem cell transplantation in intermediate-risk acute myeloid leukemia adult patients in first complete remission: a meta-analysis of prospective studies. PLoS One 2015; 10: e0132620.
    • (2015) Plos One , vol.10 , pp. e0132620
    • Li, D.1    Wang, L.2    Zhu, H.3    Dou, L.4    Liu, D.5    Fu, L.6
  • 70
    • 84914163645 scopus 로고    scopus 로고
    • Differential impact of allelic ratio and insertion site in FLT3-ITD-positive AML with respect to allogeneic transplantation
    • Schlenk RF, Kayser S, Bullinger L, Kobbe G, Casper J, Ringhoffer M et al. Differential impact of allelic ratio and insertion site in FLT3-ITD-positive AML with respect to allogeneic transplantation. Blood 2014; 124: 3441–3449.
    • (2014) Blood , vol.124 , pp. 3441-3449
    • Schlenk, R.F.1    Kayser, S.2    Bullinger, L.3    Kobbe, G.4    Casper, J.5    Ringhoffer, M.6
  • 73
    • 76349102339 scopus 로고    scopus 로고
    • A randomized phase I clinical and biologic study of two schedules of sorafenib in patients with myelodysplastic syndrome or acute myeloid leukemia: A NCIC (National Cancer Institute of Canada) Clinical Trials Group Study
    • Crump M, Hedley D, Kamel-Reid S, Leber B, Wells R, Brandwein J et al. A randomized phase I clinical and biologic study of two schedules of sorafenib in patients with myelodysplastic syndrome or acute myeloid leukemia: a NCIC (National Cancer Institute of Canada) Clinical Trials Group Study. Leuk Lymphoma 2010; 51: 252–260.
    • (2010) Leuk Lymphoma , vol.51 , pp. 252-260
    • Crump, M.1    Hedley, D.2    Kamel-Reid, S.3    Leber, B.4    Wells, R.5    Brandwein, J.6
  • 74
    • 77955714871 scopus 로고    scopus 로고
    • A pharmacody-namic study of sorafenib in patients with relapsed and refractory acute leukemias
    • Pratz KW, Cho E, Levis MJ, Karp JE, Gore SD, McDevitt M et al. A pharmacody-namic study of sorafenib in patients with relapsed and refractory acute leukemias. Leukemia 2010; 24: 1437–1444.
    • (2010) Leukemia , vol.24 , pp. 1437-1444
    • Pratz, K.W.1    Cho, E.2    Levis, M.J.3    Karp, J.E.4    Gore, S.D.5    McDevitt, M.6
  • 75
    • 81155153252 scopus 로고    scopus 로고
    • Patterns of molecular response to and relapse after combination of sorafenib, idarubicin, and cytarabine in patients with FLT3 mutant acute myeloid leukemia
    • Al-Kali A, Cortes J, Faderl S, Jones D, Abril C, Pierce S et al. Patterns of molecular response to and relapse after combination of sorafenib, idarubicin, and cytarabine in patients with FLT3 mutant acute myeloid leukemia. Clin Lymphoma Myeloma Leuk 2011; 11: 361–366.
    • (2011) Clin Lymphoma Myeloma Leuk , vol.11 , pp. 361-366
    • Al-Kali, A.1    Cortes, J.2    Faderl, S.3    Jones, D.4    Abril, C.5    Pierce, S.6
  • 76
    • 84861906112 scopus 로고    scopus 로고
    • Sorafenib treatment of FLT3-ITD(+) acute myeloid leukemia: Favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation
    • Man CH, Fung TK, Ho C, Han HH, Chow HC, Ma AC et al. Sorafenib treatment of FLT3-ITD(+) acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation. Blood 2012; 119: 5133–5143.
    • (2012) Blood , vol.119 , pp. 5133-5143
    • Man, C.H.1    Fung, T.K.2    Ho, C.3    Han, H.H.4    Chow, H.C.5    Ma, A.C.6
  • 77
    • 77951645227 scopus 로고    scopus 로고
    • Phase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia
    • Ravandi F, Cortes JE, Jones D, Faderl S, Garcia-Manero G, Konopleva MY et al. Phase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia. J Clin Oncol 2010; 28: 1856–1862.
    • (2010) J Clin Oncol , vol.28 , pp. 1856-1862
    • Ravandi, F.1    Cortes, J.E.2    Jones, D.3    Faderl, S.4    Garcia-Manero, G.5    Konopleva, M.Y.6
  • 78
  • 79
    • 84881035623 scopus 로고    scopus 로고
    • Phase 2 study of azacytidine plus sorafenib in patients with acute myeloid leukemia and FLT-3 internal tandem duplication mutation
    • Ravandi F, Alattar ML, Grunwald MR, Rudek MA, Rajkhowa T, Richie MA et al. Phase 2 study of azacytidine plus sorafenib in patients with acute myeloid leukemia and FLT-3 internal tandem duplication mutation. Blood 2013; 121: 4655–4662.
    • (2013) Blood , vol.121 , pp. 4655-4662
    • Ravandi, F.1    Alattar, M.L.2    Grunwald, M.R.3    Rudek, M.A.4    Rajkhowa, T.5    Richie, M.A.6
  • 80
    • 84886534519 scopus 로고    scopus 로고
    • Sorafenib in combination with intensive chemotherapy in elderly patients with acute myeloid leukemia: Results from a randomized, placebo-controlled trial
    • Serve H, Krug U, Wagner R, Sauerland MC, Heinecke A, Brunnberg U et al. Sorafenib in combination with intensive chemotherapy in elderly patients with acute myeloid leukemia: results from a randomized, placebo-controlled trial. J Clin Oncol 2013; 31: 3110–3118.
    • (2013) J Clin Oncol , vol.31 , pp. 3110-3118
    • Serve, H.1    Krug, U.2    Wagner, R.3    Sauerland, M.C.4    Heinecke, A.5    Brunnberg, U.6
  • 81
    • 84949484439 scopus 로고    scopus 로고
    • Addition of sorafenib versus placebo to standard therapy in patients aged 60 years or younger with newly diagnosed acute myeloid leukaemia (SORAML): A multicentre, phase 2, randomised controlled trial
    • Rollig C, Serve H, Huttmann A, Noppeney R, Muller-Tidow C, Krug U et al. Addition of sorafenib versus placebo to standard therapy in patients aged 60 years or younger with newly diagnosed acute myeloid leukaemia (SORAML): a multicentre, phase 2, randomised controlled trial. Lancet Oncol 2015; 16; 1691–1699.
    • (2015) Lancet Oncol , vol.16 , pp. 1691-1699
    • Rollig, C.1    Serve, H.2    Huttmann, A.3    Noppeney, R.4    Muller-Tidow, C.5    Krug, U.6
  • 82
    • 79953073247 scopus 로고    scopus 로고
    • FLT3 ligand impedes the efficacy of FLT3 inhibitors in vitro and in vivo
    • Sato T, Yang X, Knapper S, White P, Smith BD, Galkin S et al. FLT3 ligand impedes the efficacy of FLT3 inhibitors in vitro and in vivo. Blood 2011; 117: 3286–3293.
    • (2011) Blood , vol.117 , pp. 3286-3293
    • Sato, T.1    Yang, X.2    Knapper, S.3    White, P.4    Smith, B.D.5    Galkin, S.6
  • 83
    • 84912136912 scopus 로고    scopus 로고
    • Phase I trial of maintenance sorafenib after allogeneic hematopoietic stem cell transplantation for fms-like tyrosine kinase 3 internal tandem duplication acute myeloid leukemia
    • Chen YB, Li S, Lane AA, Connolly C, Del Rio C, Valles B et al. Phase I trial of maintenance sorafenib after allogeneic hematopoietic stem cell transplantation for fms-like tyrosine kinase 3 internal tandem duplication acute myeloid leukemia. Biol Blood Marrow Transplant 2014; 20: 2042–2048.
    • (2014) Biol Blood Marrow Transplant , vol.20 , pp. 2042-2048
    • Chen, Y.B.1    Li, S.2    Lane, A.A.3    Connolly, C.4    Del Rio, C.5    Valles, B.6
  • 84
    • 84928300286 scopus 로고    scopus 로고
    • Sorafenib maintenance appears safe and improves clinical outcomes in FLT3-ITD acute myeloid leukemia after allogeneic hematopoietic cell transplantation
    • Antar A, Kharfan-Dabaja MA, Mahfouz R, Bazarbachi A. Sorafenib maintenance appears safe and improves clinical outcomes in FLT3-ITD acute myeloid leukemia after allogeneic hematopoietic cell transplantation. Clin Lymphoma Myeloma Leuk 2015; 15: 298–302.
    • (2015) Clin Lymphoma Myeloma Leuk , vol.15 , pp. 298-302
    • Antar, A.1    Kharfan-Dabaja, M.A.2    Mahfouz, R.3    Bazarbachi, A.4
  • 85
    • 84869090342 scopus 로고    scopus 로고
    • High activity of sorafenib in FLT3-ITD-positive acute myeloid leukemia synergizes with allo-immune effects to induce sustained responses
    • Metzelder SK, Schroeder T, Finck A, Scholl S, Fey M, Gotze K et al. High activity of sorafenib in FLT3-ITD-positive acute myeloid leukemia synergizes with allo-immune effects to induce sustained responses. Leukemia 2012; 26: 2353–2359.
    • (2012) Leukemia , vol.26 , pp. 2353-2359
    • Metzelder, S.K.1    Schroeder, T.2    Finck, A.3    Scholl, S.4    Fey, M.5    Gotze, K.6
  • 86
    • 78049426367 scopus 로고    scopus 로고
    • Phase IIB trial of oral Midostaurin (PKC412), the FMS-like tyrosine kinase 3 receptor (FLT3) and multi-targeted kinase inhibitor, in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome with either wild-type or mutated FLT3
    • Fischer T, Stone RM, Deangelo DJ, Galinsky I, Estey E, Lanza C et al. Phase IIB trial of oral Midostaurin (PKC412), the FMS-like tyrosine kinase 3 receptor (FLT3) and multi-targeted kinase inhibitor, in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome with either wild-type or mutated FLT3. J Clin Oncol 2010; 28: 4339–4345.
    • (2010) J Clin Oncol , vol.28 , pp. 4339-4345
    • Fischer, T.1    Stone, R.M.2    Deangelo, D.J.3    Galinsky, I.4    Estey, E.5    Lanza, C.6
  • 87
    • 19944427559 scopus 로고    scopus 로고
    • Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412
    • Stone RM, DeAngelo DJ, Klimek V, Galinsky I, Estey E, Nimer SD et al. Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412. Blood 2005; 105: 54–60.
    • (2005) Blood , vol.105 , pp. 54-60
    • Stone, R.M.1    DeAngelo, D.J.2    Klimek, V.3    Galinsky, I.4    Estey, E.5    Nimer, S.D.6
  • 89
    • 84925345011 scopus 로고    scopus 로고
    • Phase I/II trial of the combination of midostaurin (PKC412) and 5-azacytidine for patients with acute myeloid leukemia and myelodysplastic syndrome
    • Strati P, Kantarjian H, Ravandi F, Nazha A, Borthakur G, Daver N et al. Phase I/II trial of the combination of midostaurin (PKC412) and 5-azacytidine for patients with acute myeloid leukemia and myelodysplastic syndrome. Am J Hematol 2015; 90: 276–281.
    • (2015) Am J Hematol , vol.90 , pp. 276-281
    • Strati, P.1    Kantarjian, H.2    Ravandi, F.3    Nazha, A.4    Borthakur, G.5    Daver, N.6
  • 90
    • 85033795655 scopus 로고    scopus 로고
    • 57th Annual Meeting & Exposition The Multi-Kinase Inhibitor Midostaurin (M) Prolongs Survival Compared with Placebo (P) in Combination with Daunorubicin (D)/Cytarabine (C) Induction (ind), High-Dose C Consolidation (consol), and As Maintenance (maint) Therapy in Newly Diagnosed Acute Myeloid Leukemia (AML) Patients (pts) Age 18-60 with FLT3 Mutations (muts): An International Prospective Randomized (rand)
    • Orlando, FL, USA. 5–8 December
    • Stone RM, Mandrekar S, Sanford BL, Geyer S, Bloomfield CD, Dohner K et al. 57th Annual Meeting & Exposition The Multi-Kinase Inhibitor Midostaurin (M) Prolongs Survival Compared with Placebo (P) in Combination with Daunorubicin (D)/Cytarabine (C) Induction (ind), High-Dose C Consolidation (consol), and As Maintenance (maint) Therapy in Newly Diagnosed Acute Myeloid Leukemia (AML) Patients (pts) Age 18-60 with FLT3 Mutations (muts): An International Prospective Randomized (rand) P-Controlled Double-Blind Trial.Am Soc Hematol 2015, Orlando, FL, USA. 5–8 December 2015.
    • (2015) P-controlled Double-blind Trial.am Soc Hematol 2015
    • Stone, R.M.1    Mandrekar, S.2    Sanford, B.L.3    Geyer, S.4    Bloomfield, C.D.5    Dohner, K.6
  • 91
    • 84890029517 scopus 로고    scopus 로고
    • Phase I study of quizartinib administered daily to patients with relapsed or refractory acute myeloid leukemia irrespective of FMS-like tyrosine kinase 3-internal tandem duplication status
    • Cortes JE, Kantarjian H, Foran JM, Ghirdaladze D, Zodelava M, Borthakur G et al. Phase I study of quizartinib administered daily to patients with relapsed or refractory acute myeloid leukemia irrespective of FMS-like tyrosine kinase 3-internal tandem duplication status. J Clin Oncol 2013; 31: 3681–3687.
    • (2013) J Clin Oncol , vol.31 , pp. 3681-3687
    • Cortes, J.E.1    Kantarjian, H.2    Foran, J.M.3    Ghirdaladze, D.4    Zodelava, M.5    Borthakur, G.6
  • 92
    • 79953124734 scopus 로고    scopus 로고
    • Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapse
    • Levis M, Ravandi F, Wang ES, Baer MR, Perl A, Coutre S et al. Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapse. Blood 2011; 117: 3294–3301.
    • (2011) Blood , vol.117 , pp. 3294-3301
    • Levis, M.1    Ravandi, F.2    Wang, E.S.3    Baer, M.R.4    Perl, A.5    Coutre, S.6
  • 93
    • 84875635430 scopus 로고    scopus 로고
    • Final results of a phase 2 Open-label, monotherapy efficacy and safety study of quizartinib (AC220) in patients with FLT3-ITD positive or negative relapsed/refractory acute myeloid leukemia after second-line chemotherapy or hematopoietic stem cell transplantation
    • ASH abstract 673
    • Levis MJ, Perl AE, Dombret H, Döhner H, Steffen B, Rousselot P et al. Final results of a phase 2 Open-label, monotherapy efficacy and safety study of quizartinib (AC220) in patients with FLT3-ITD positive or negative relapsed/refractory acute myeloid leukemia after second-line chemotherapy or hematopoietic stem cell transplantation. Blood 2012, 120: 673. ASH abstract 673.
    • (2012) Blood , vol.120 , pp. 673
    • Levis, M.J.1    Perl, A.E.2    Dombret, H.3    Döhner, H.4    Steffen, B.5    Rousselot, P.6
  • 94
    • 84925601425 scopus 로고    scopus 로고
    • The combination of Quizartinib with Azacitidine or low dose Cytarabine is highly active in patients (Pts) with FLT3-ITD mutated myeloid leukemias: Interim report of a phase I/II trial
    • Borthakur G, Kantarjian HM, O'Brien S, Garcia-Manero G, Jabbour E, Daver N et al. The combination of Quizartinib with Azacitidine or low dose Cytarabine is highly active in patients (Pts) with FLT3-ITD mutated myeloid leukemias: interim report of a phase I/II trial. Blood 2014; 124: 388–388.
    • (2014) Blood , vol.124 , pp. 388
    • Borthakur, G.1    Kantarjian, H.M.2    O'Brien, S.3    Garcia-Manero, G.4    Jabbour, E.5    Daver, N.6
  • 96
    • 85033773148 scopus 로고    scopus 로고
    • Results of a phase II study of crenolanib in relapsed/refractory acute myeloid leukemia patients (Pts) with activating FLT3 mutations
    • San Francisco, CA, USA
    • Randhawa JK, Kantarjian H, Borthakur G, Thompson PA, Konopleva M, Daver N et al. 57th Annual Meeting & Exposition. Results of a phase II study of crenolanib in relapsed/refractory acute myeloid leukemia patients (Pts) with activating FLT3 mutations. Am Soc Hematol 2014, San Francisco, CA, USA.
    • (2014) Am Soc Hematol
    • Randhawa, J.K.1    Kantarjian, H.2    Borthakur, G.3    Thompson, P.A.4    Konopleva, M.5    Daver, N.6
  • 97
    • 65449117656 scopus 로고    scopus 로고
    • Enhanced activation of STAT pathways and overexpression of survivin confer resistance to FLT3 inhibitors and could be therapeutic targets in AML
    • Zhou J, Bi C, Janakakumara JV, Liu SC, Chng WJ, Tay KG et al. Enhanced activation of STAT pathways and overexpression of survivin confer resistance to FLT3 inhibitors and could be therapeutic targets in AML. Blood 2009; 113: 4052–4062.
    • (2009) Blood , vol.113 , pp. 4052-4062
    • Zhou, J.1    Bi, C.2    Janakakumara, J.V.3    Liu, S.C.4    Chng, W.J.5    Tay, K.G.6
  • 98
    • 79957604461 scopus 로고    scopus 로고
    • Stat3 signaling in acute myeloid leukemia: Ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor
    • Redell MS, Ruiz MJ, Alonzo TA, Gerbing RB, Tweardy DJ. Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor. Blood 2011; 117: 5701–5709.
    • (2011) Blood , vol.117 , pp. 5701-5709
    • Redell, M.S.1    Ruiz, M.J.2    Alonzo, T.A.3    Gerbing, R.B.4    Tweardy, D.J.5
  • 99
    • 85033782095 scopus 로고    scopus 로고
    • 57th Annual Meeting & Exposition. A novel STAT3 inhibitor has potent activity in preclinical models of acute myeloid leukemia that incorporate the stromal environment
    • Orlando, FL, USA
    • Krueger MJ, Minus M, Liu W, Long X, Stevens AM, Kolosov MI et al. 57th Annual Meeting & Exposition. A novel STAT3 inhibitor has potent activity in preclinical models of acute myeloid leukemia that incorporate the stromal environment. Am Soc Hematol 2015, Orlando, FL, USA.
    • (2015) Am Soc Hematol
    • Krueger, M.J.1    Minus, M.2    Liu, W.3    Long, X.4    Stevens, A.M.5    Kolosov, M.I.6
  • 100
    • 84942941353 scopus 로고    scopus 로고
    • Phase I study of OPB-31121, an oral STAT3 inhibitor, in patients with advanced solid tumors
    • Oh DY, Lee SH, Han SW, Kim MJ, Kim TM, Kim TY et al. Phase I study of OPB-31121, an oral STAT3 inhibitor, in patients with advanced solid tumors. Cancer Res Treat 2015; 47: 607–615.
    • (2015) Cancer Res Treat , vol.47 , pp. 607-615
    • Oh, D.Y.1    Lee, S.H.2    Han, S.W.3    Kim, M.J.4    Kim, T.M.5    Kim, T.Y.6
  • 101
    • 84888424589 scopus 로고    scopus 로고
    • A novel STAT inhibitor, OPB-31121, has a significant antitumor effect on leukemia with STAT-addictive oncokinases
    • Hayakawa F, Sugimoto K, Harada Y, Hashimoto N, Ohi N, Kurahashi S et al. A novel STAT inhibitor, OPB-31121, has a significant antitumor effect on leukemia with STAT-addictive oncokinases. Blood Cancer J 2013; 3: e166.
    • (2013) Blood Cancer J , vol.3 , pp. e166
    • Hayakawa, F.1    Sugimoto, K.2    Harada, Y.3    Hashimoto, N.4    Ohi, N.5    Kurahashi, S.6
  • 102
    • 84877620952 scopus 로고    scopus 로고
    • Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation
    • Wang F, Travins J, DeLaBarre B, Penard-Lacronique V, Schalm S, Hansen E et al. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science 2013; 340: 622–626.
    • (2013) Science , vol.340 , pp. 622-626
    • Wang, F.1    Travins, J.2    DeLaBarre, B.3    Penard-Lacronique, V.4    Schalm, S.5    Hansen, E.6
  • 103
    • 84937499700 scopus 로고    scopus 로고
    • AG-221 offers a survival advantage in a primary human IDH2 mutant AML xenograft model
    • San Diego, CA
    • Ellwood-Yen K, Wang F, Travins J, Chen Y, Yang H, Straley K et al. AG-221 offers a survival advantage in a primary human IDH2 mutant AML xenograft model. in AACR Annual Meeting. 2014. San Diego, CA.
    • (2014) AACR Annual Meeting
    • Ellwood-Yen, K.1    Wang, F.2    Travins, J.3    Chen, Y.4    Yang, H.5    Straley, K.6
  • 104
    • 84973337022 scopus 로고    scopus 로고
    • Clinical safety and activity in a phase I trial of AG-120, a first in class, selective, potent inhibitor of the IDH1-mutant protein, in patients with IDH1 mutant positive advanced hematologic malignancies
    • Pollyea DA, Botton Sd, Fathi AT, Stein EM, Tallman MS, Agresta S et al. Clinical safety and activity in a phase I trial of AG-120, a first in class, selective, potent inhibitor of the IDH1-mutant protein, in patients with IDH1 mutant positive advanced hematologic malignancies. Eur J Cancer 2014; 50: 195.
    • (2014) Eur J Cancer , vol.50 , pp. 195
    • Pollyea, D.A.1    Sd, B.2    Fathi, A.T.3    Stein, E.M.4    Tallman, M.S.5    Agresta, S.6
  • 105
    • 84886859143 scopus 로고    scopus 로고
    • Clofarabine doubles the response rate in older patients with acute myeloid leukemia but does not improve survival
    • Burnett AK, Russell NH, Hunter AE, Milligan D, Knapper S, Wheatley K et al. Clofarabine doubles the response rate in older patients with acute myeloid leukemia but does not improve survival. Blood 2013; 122: 1384–1394.
    • (2013) Blood , vol.122 , pp. 1384-1394
    • Burnett, A.K.1    Russell, N.H.2    Hunter, A.E.3    Milligan, D.4    Knapper, S.5    Wheatley, K.6
  • 106
    • 77449159668 scopus 로고    scopus 로고
    • Phase II study of clofarabine monotherapy in previously untreated older adults with acute myeloid leukemia and unfavorable prognostic factors
    • Kantarjian HM, Erba HP, Claxton D, Arellano M, Lyons RM, Kovascovics T et al. Phase II study of clofarabine monotherapy in previously untreated older adults with acute myeloid leukemia and unfavorable prognostic factors. J Clin Oncol 2010; 28: 549–555.
    • (2010) J Clin Oncol , vol.28 , pp. 549-555
    • Kantarjian, H.M.1    Erba, H.P.2    Claxton, D.3    Arellano, M.4    Lyons, R.M.5    Kovascovics, T.6
  • 107
    • 52649154001 scopus 로고    scopus 로고
    • A randomized study of clofarabine versus clofarabine plus low-dose cytarabine as front-line therapy for patients aged 60 years and older with acute myeloid leukemia and high-risk myelodysplastic syndrome
    • Faderl S, Ravandi F, Huang X, Garcia-Manero G, Ferrajoli A, Estrov Z et al. A randomized study of clofarabine versus clofarabine plus low-dose cytarabine as front-line therapy for patients aged 60 years and older with acute myeloid leukemia and high-risk myelodysplastic syndrome. Blood 2008; 112: 1638–1645.
    • (2008) Blood , vol.112 , pp. 1638-1645
    • Faderl, S.1    Ravandi, F.2    Huang, X.3    Garcia-Manero, G.4    Ferrajoli, A.5    Estrov, Z.6
  • 108
    • 84864050584 scopus 로고    scopus 로고
    • Clofarabine plus cytarabine compared with cytarabine alone in older patients with relapsed or refractory acute myelogenous leukemia: Results from the CLASSIC I Trial
    • Faderl S, Wetzler M, Rizzieri D, Schiller G, Jagasia M, Stuart R et al. Clofarabine plus cytarabine compared with cytarabine alone in older patients with relapsed or refractory acute myelogenous leukemia: results from the CLASSIC I Trial. J Clin Oncol 2012; 30: 2492–2499.
    • (2012) J Clin Oncol , vol.30 , pp. 2492-2499
    • Faderl, S.1    Wetzler, M.2    Rizzieri, D.3    Schiller, G.4    Jagasia, M.5    Stuart, R.6
  • 109
    • 84934441484 scopus 로고    scopus 로고
    • Final results of a phase 2 trial of clofarabine and low-dose cytarabine alternating with decitabine in older patients with newly diagnosed acute myeloid leukemia
    • Kadia TM, Faderl S, Ravandi F, Jabbour E, Garcia-Manero G, Borthakur G et al. Final results of a phase 2 trial of clofarabine and low-dose cytarabine alternating with decitabine in older patients with newly diagnosed acute myeloid leukemia. Cancer 2015; 121: 2375–2382.
    • (2015) Cancer , vol.121 , pp. 2375-2382
    • Kadia, T.M.1    Faderl, S.2    Ravandi, F.3    Jabbour, E.4    Garcia-Manero, G.5    Borthakur, G.6
  • 110
    • 84886286103 scopus 로고    scopus 로고
    • Clofarabine, idarubicin, and cytarabine (CIA) as frontline therapy for patients p 60 years with newly diagnosed acute myeloid leukemia
    • Nazha A, Kantarjian H, Ravandi F, Huang X, Choi S, Garcia-Manero G et al. Clofarabine, idarubicin, and cytarabine (CIA) as frontline therapy for patients p 60 years with newly diagnosed acute myeloid leukemia. Am J Hematol 2013; 88: 961–966.
    • (2013) Am J Hematol , vol.88 , pp. 961-966
    • Nazha, A.1    Kantarjian, H.2    Ravandi, F.3    Huang, X.4    Choi, S.5    Garcia-Manero, G.6
  • 111
    • 84959328694 scopus 로고    scopus 로고
    • Clofarabine salvage therapy before allogeneic hematopoietic stem cell transplantation in patients with relapsed or refractory AML: Results of the BRIDGE trial
    • Middeke JM, Herbst R, Parmentier S, Bug G, Hanel M, Stuhler G et al. Clofarabine salvage therapy before allogeneic hematopoietic stem cell transplantation in patients with relapsed or refractory AML: results of the BRIDGE trial. Leukemia 2015; 30: 261–267.
    • (2015) Leukemia , vol.30 , pp. 261-267
    • Middeke, J.M.1    Herbst, R.2    Parmentier, S.3    Bug, G.4    Hanel, M.5    Stuhler, G.6
  • 112
    • 79954428318 scopus 로고    scopus 로고
    • Population pharmacokinetics of clofarabine and its metabolite 6-ketoclofarabine in adult and pediatric patients with cancer
    • Bonate PL, Cunningham CC, Gaynon P, Jeha S, Kadota R, Lam GN et al. Population pharmacokinetics of clofarabine and its metabolite 6-ketoclofarabine in adult and pediatric patients with cancer. Cancer Chemother Pharmacol 2011; 67: 875–890.
    • (2011) Cancer Chemother Pharmacol , vol.67 , pp. 875-890
    • Bonate, P.L.1    Cunningham, C.C.2    Gaynon, P.3    Jeha, S.4    Kadota, R.5    Lam, G.N.6
  • 113
    • 84942083402 scopus 로고    scopus 로고
    • A phase I/ II study of oral clofarabine plus low-dose cytarabine in previously treated acute myeloid leukaemia and high-risk myelodysplastic syndrome patients at least 60 years of age
    • Buckley SA, Mawad R, Gooley TA, Becker PS, Sandhu V, Hendrie P et al. A phase I/ II study of oral clofarabine plus low-dose cytarabine in previously treated acute myeloid leukaemia and high-risk myelodysplastic syndrome patients at least 60 years of age. Br J Haematol 2015; 170: 349–355.
    • (2015) Br J Haematol , vol.170 , pp. 349-355
    • Buckley, S.A.1    Mawad, R.2    Gooley, T.A.3    Becker, P.S.4    Sandhu, V.5    Hendrie, P.6
  • 114
    • 84881305790 scopus 로고    scopus 로고
    • A phase 3 study of gemtuzumab ozogamicin during induction and post-consolidation therapy in younger patients with acute myeloid leukemia
    • Petersdorf SH, Kopecky KJ, Slovak M, Willman C, Nevill T, Brandwein J et al. A phase 3 study of gemtuzumab ozogamicin during induction and post-consolidation therapy in younger patients with acute myeloid leukemia. Blood 2013; 121: 4854–4860.
    • (2013) Blood , vol.121 , pp. 4854-4860
    • Petersdorf, S.H.1    Kopecky, K.J.2    Slovak, M.3    Willman, C.4    Nevill, T.5    Brandwein, J.6
  • 115
    • 84905560676 scopus 로고    scopus 로고
    • Addition of gemtuzumab ozogamicin to induction chemotherapy in adult patients with acute myeloid leukaemia: A meta-analysis of individual patient data from randomised controlled trials
    • Hills RK, Castaigne S, Appelbaum FR, Delaunay J, Petersdorf S, Othus M et al. Addition of gemtuzumab ozogamicin to induction chemotherapy in adult patients with acute myeloid leukaemia: a meta-analysis of individual patient data from randomised controlled trials. Lancet Oncol 2014; 15: 986–996.
    • (2014) Lancet Oncol , vol.15 , pp. 986-996
    • Hills, R.K.1    Castaigne, S.2    Appelbaum, F.R.3    Delaunay, J.4    Petersdorf, S.5    Othus, M.6
  • 116
    • 84961671223 scopus 로고    scopus 로고
    • Gemtuzumab Ozogamicin versus best supportive care in older patients with newly diagnosed acute myeloid leukemia unsuitable for intensive chemotherapy: Results of the randomized phase III EORTC-GIMEMA AML-19 Trial
    • Amadori S, Suciu S, Selleslag D, Aversa F, Gaidano G, Musso M et al. Gemtuzumab Ozogamicin versus best supportive care in older patients with newly diagnosed acute myeloid leukemia unsuitable for intensive chemotherapy: results of the randomized phase III EORTC-GIMEMA AML-19 Trial. J Clin Oncol 2016; 34: 972–979.
    • (2016) J Clin Oncol , vol.34 , pp. 972-979
    • Amadori, S.1    Suciu, S.2    Selleslag, D.3    Aversa, F.4    Gaidano, G.5    Musso, M.6
  • 117
    • 0023243489 scopus 로고
    • Use of the monoclonal antibody WR17, identifying the CD37 gp40-45 Kd antigen complex, in the diagnosis of B-lymphoid malignancy
    • Moore K, Cooper SA, Jones DB. Use of the monoclonal antibody WR17, identifying the CD37 gp40-45 Kd antigen complex, in the diagnosis of B-lymphoid malignancy. J Pathol 1987; 152: 13–21.
    • (1987) J Pathol , vol.152 , pp. 13-21
    • Moore, K.1    Cooper, S.A.2    Jones, D.B.3
  • 118
    • 84938976564 scopus 로고    scopus 로고
    • CD33-specific chimeric antigen receptor T cells exhibit potent preclinical activity against human acute myeloid leukemia
    • Kenderian SS, Ruella M, Shestova O, Klichinsky M, Aikawa V, Morrissette JJ et al. CD33-specific chimeric antigen receptor T cells exhibit potent preclinical activity against human acute myeloid leukemia. Leukemia 2015; 29: 1637–1647.
    • (2015) Leukemia , vol.29 , pp. 1637-1647
    • Kenderian, S.S.1    Ruella, M.2    Shestova, O.3    Klichinsky, M.4    Aikawa, V.5    Morrissette, J.J.6
  • 119
    • 0032916448 scopus 로고    scopus 로고
    • Folate receptor type beta is a neutrophilic lineage marker and is differentially expressed in myeloid leukemia
    • Ross JF, Wang H, Behm FG, Mathew P, Wu M, Booth R et al. Folate receptor type beta is a neutrophilic lineage marker and is differentially expressed in myeloid leukemia. Cancer 1999; 85: 348–357.
    • (1999) Cancer , vol.85 , pp. 348-357
    • Ross, J.F.1    Wang, H.2    Behm, F.G.3    Mathew, P.4    Wu, M.5    Booth, R.6
  • 120
    • 0034670039 scopus 로고    scopus 로고
    • Differentiation-independent retinoid induction of folate receptor type beta, a potential tumor target in myeloid leukemia
    • Wang H, Zheng X, Behm FG, Ratnam M. Differentiation-independent retinoid induction of folate receptor type beta, a potential tumor target in myeloid leukemia. Blood 2000; 96: 3529–3536.
    • (2000) Blood , vol.96 , pp. 3529-3536
    • Wang, H.1    Zheng, X.2    Behm, F.G.3    Ratnam, M.4
  • 121
    • 84934878821 scopus 로고    scopus 로고
    • Targeting of folate receptor beta on acute myeloid leukemia blasts with chimeric antigen receptor-expressing T cells
    • Lynn RC, Poussin M, Kalota A, Feng Y, Low PS, Dimitrov DS et al. Targeting of folate receptor beta on acute myeloid leukemia blasts with chimeric antigen receptor-expressing T cells. Blood 2015; 125: 3466–3476.
    • (2015) Blood , vol.125 , pp. 3466-3476
    • Lynn, R.C.1    Poussin, M.2    Kalota, A.3    Feng, Y.4    Low, P.S.5    Dimitrov, D.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.