메뉴 건너뛰기




Volumn 11, Issue 4, 2011, Pages 361-366

Patterns of molecular response to and relapse after combination of sorafenib, idarubicin, and cytarabine in patients with FLT3 mutant acute myeloid leukemia

Author keywords

Acute Myeloid Leukemia AML; FLT3 mutation; Sorafenib

Indexed keywords

CD135 ANTIGEN; CYTARABINE; GENOMIC DNA; IDARUBICIN; SORAFENIB; ANTINEOPLASTIC AGENT; BENZENESULFONIC ACID DERIVATIVE; PYRIDINE DERIVATIVE;

EID: 81155153252     PISSN: 21522650     EISSN: 21522669     Source Type: Journal    
DOI: 10.1016/j.clml.2011.06.007     Document Type: Article
Times cited : (25)

References (46)
  • 1
    • 0037316909 scopus 로고    scopus 로고
    • Modulation of cellular signaling pathways: Prospects for targeted therapy in hematological malignancies
    • Ravandi F, Talpaz M, Estrov Z. Modulation of cellular signaling pathways: prospects for targeted therapy in hematological malignancies. Clin Cancer Res 2003; 9:535-50. (Pubitemid 36182582)
    • (2003) Clinical Cancer Research , vol.9 , Issue.2 , pp. 535-550
    • Ravandi, F.1    Talpaz, M.2    Estrov, Z.3
  • 2
    • 67650351086 scopus 로고    scopus 로고
    • Structural and functional alterations of FLT3 in acute myeloid leukemia
    • Meshinchi S, Appelbaum FR. Structural and functional alterations of FLT3 in acute myeloid leukemia. Clin Cancer Res 2009; 15:4263-9.
    • (2009) Clin Cancer Res , vol.15 , pp. 4263-4269
    • Meshinchi, S.1    Appelbaum, F.R.2
  • 3
    • 0036720398 scopus 로고    scopus 로고
    • The roles of FLT3 in hematopoiesis and leukemia
    • DOI 10.1182/blood-2002-02-0492
    • Gilliland DG, Griffin JD. The roles of FLT3 in hematopoiesis and leukemia. Blood 2002; 100:1532-42. (Pubitemid 34925124)
    • (2002) Blood , vol.100 , Issue.5 , pp. 1532-1542
    • Gary Gilliland, D.1    Griffin, J.D.2
  • 4
    • 0141465061 scopus 로고    scopus 로고
    • The role of FLT3 in haematopoietic malignancies
    • Stirewalt DL, Radich JP. The role of FLT3 in haematopoietic malignancies. Nat Rev Cancer 2003; 3:650-65. (Pubitemid 37328820)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.9 , pp. 650-665
    • Stirewalt, D.L.1    Radich, J.P.2
  • 7
    • 0037114829 scopus 로고    scopus 로고
    • Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: A study of the AML study group Ulm
    • DOI 10.1182/blood-2002-05-1440
    • Frohling S, Schlenk RF, Breitruck J, et al. Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: a study of the AML Study Group Ulm. Blood 2002; 100:4372-80. (Pubitemid 35434129)
    • (2002) Blood , vol.100 , Issue.13 , pp. 4372-4380
    • Frohling, S.1    Schlenk, R.F.2    Breitruck, J.3    Benner, A.4    Kreitmeier, S.5    Tobis, K.6    Dohner, H.7    Dohner, K.8
  • 8
    • 0035885955 scopus 로고    scopus 로고
    • The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials
    • Kottaridis PD, Gale RE, Frew ME, et al. The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood 2001; 98:1752-9.
    • (2001) Blood , vol.98 , pp. 1752-1759
    • Kottaridis, P.D.1    Gale, R.E.2    Frew, M.E.3
  • 9
    • 0036659931 scopus 로고    scopus 로고
    • Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: Correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease
    • DOI 10.1182/blood.V100.1.59
    • Schnittger S, Schoch C, Dugas M, et al. Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease. Blood 2002; 100:59-66. (Pubitemid 35177429)
    • (2002) Blood , vol.100 , Issue.1 , pp. 59-66
    • Schnittger, S.1    Schoch, C.2    Dugas, M.3    Kern, W.4    Staib, P.5    Wuchter, C.6    Loffler, H.7    Sauerland, C.M.8    Serve, H.9    Buchner, T.10    Haferlach, T.11    Hiddemann, W.12
  • 10
    • 41949087055 scopus 로고    scopus 로고
    • Prognostic relevance of FLT3-TKD mutations in AML: The combination matters\an analysis of 3082 patients
    • Bacher U, Haferlach C, Kern W, Haferlach T, Schnittger S. Prognostic relevance of FLT3-TKD mutations in AML: the combination matters\an analysis of 3082 patients. Blood 2008; 111:2527-37.
    • (2008) Blood , vol.111 , pp. 2527-2537
    • Bacher, U.1    Haferlach, C.2    Kern, W.3    Haferlach, T.4    Schnittger, S.5
  • 12
    • 34548029756 scopus 로고    scopus 로고
    • FLT3 tyrosine kinase domain mutations are biologically distinct from and have a significantly more favorable prognosis than FLT3 internal tandem duplications in patients with acute myeloid leukemia
    • DOI 10.1182/blood-2006-04-015826
    • Mead AJ, Linch DC, Hills RK, Wheatley K, Burnett AK, Gale RE. FLT3 tyrosine kinase domain mutations are biologically distinct from and have a significantly more favorable prognosis than FLT3 internal tandem duplications in patients with acute myeloid leukemia. Blood 2007; 110:1262-70. (Pubitemid 47281424)
    • (2007) Blood , vol.110 , Issue.4 , pp. 1262-1270
    • Mead, A.J.1    Linch, D.C.2    Hills, R.K.3    Wheatley, K.4    Burnett, A.K.5    Gale, R.E.6
  • 13
    • 47649131141 scopus 로고    scopus 로고
    • Conflicting data on the prognostic significance of FLT3/TKD mutations in acute myeloid leukemia might be related to the incidence of biallelic disease
    • Mead AJ, Gale RE, Hills RK, et al. Conflicting data on the prognostic significance of FLT3/TKD mutations in acute myeloid leukemia might be related to the incidence of biallelic disease. Blood 2008; 112:444-5.
    • (2008) Blood , vol.112 , pp. 444-445
    • Mead, A.J.1    Gale, R.E.2    Hills, R.K.3
  • 15
    • 70349435515 scopus 로고    scopus 로고
    • Different clinical importance of FLT3 internal tandem duplications in AML according to FAB classification: Possible existence of distinct leukemogenesis involving monocyte differentiation pathway
    • Koh Y, Park J, Ahn KS, et al. Different clinical importance of FLT3 internal tandem duplications in AML according to FAB classification: possible existence of distinct leukemogenesis involving monocyte differentiation pathway. Ann Hematol 2009; 88:1089-97.
    • (2009) Ann Hematol , vol.88 , pp. 1089-1097
    • Koh, Y.1    Park, J.2    Ahn, K.S.3
  • 16
    • 70350504884 scopus 로고    scopus 로고
    • Insertion of FLT3 internal tandem duplication in the tyrosine kinase domain-1 is associated with resistance to chemotherapy and inferior outcome
    • Kayser S, Schlenk RF, Londono MC, et al. Insertion of FLT3 internal tandem duplication in the tyrosine kinase domain-1 is associated with resistance to chemotherapy and inferior outcome. Blood 2009; 114:2386-92.
    • (2009) Blood , vol.114 , pp. 2386-2392
    • Kayser, S.1    Schlenk, R.F.2    Londono, M.C.3
  • 19
    • 41949090673 scopus 로고    scopus 로고
    • The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia
    • Gale RE, Green C, Allen C, et al. The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia. Blood 2008; 111:2776-84.
    • (2008) Blood , vol.111 , pp. 2776-2784
    • Gale, R.E.1    Green, C.2    Allen, C.3
  • 20
    • 33646431111 scopus 로고    scopus 로고
    • Size of FLT3 internal tandem duplication has prognostic significance in patients with acute myeloid leukemia
    • Stirewalt DL, Kopecky KJ, Meshinchi S, et al. Size of FLT3 internal tandem duplication has prognostic significance in patients with acute myeloid leukemia. Blood 2006; 107:3724-6.
    • (2006) Blood , vol.107 , pp. 3724-3726
    • Stirewalt, D.L.1    Kopecky, K.J.2    Meshinchi, S.3
  • 23
    • 77955710144 scopus 로고    scopus 로고
    • Update of a phase i study of sorafenib in patients with refractory/relapsed acute myeloid leukemia or high-risk myelodysplastic syndrome
    • Delmonte J Jr, Kantarjian HM, Andreeff M, et al. Update of a phase I study of sorafenib in patients with refractory/relapsed acute myeloid leukemia or high-risk myelodysplastic syndrome. ASH Annual Meeting Abstracts 2007; 110: 893.
    • (2007) ASH Annual Meeting Abstracts , vol.110 , pp. 893
    • Delmonte Jr., J.1    Kantarjian, H.M.2    Andreeff, M.3
  • 25
    • 69249221392 scopus 로고    scopus 로고
    • Compassionate use of sorafenib in FLT3-ITD-positive acute myeloid leukemia: Sustained regression before and after alloge-neic stem cell transplantation
    • Metzelder S, Wang Y, Wollmer E, et al. Compassionate use of sorafenib in FLT3-ITD-positive acute myeloid leukemia: sustained regression before and after alloge-neic stem cell transplantation. Blood 2009; 113:6567-71.
    • (2009) Blood , vol.113 , pp. 6567-6571
    • Metzelder, S.1    Wang, Y.2    Wollmer, E.3
  • 26
    • 62949093541 scopus 로고    scopus 로고
    • Mechanisms of resistance to FLT3 inhibitors
    • Chu SH, Small D. Mechanisms of resistance to FLT3 inhibitors. Drug Resist Updat 2009; 12:8-16.
    • (2009) Drug Resist Updat , vol.12 , pp. 8-16
    • Chu, S.H.1    Small, D.2
  • 28
    • 33846936758 scopus 로고    scopus 로고
    • Prolonged exposure to FLT3 inhibitors leads to resistance via activation of parallel signaling pathways
    • DOI 10.1182/blood-2006-05-023804
    • Piloto O, Wright M, Brown P, Kim KT, Levis M, Small D. Prolonged exposure to FLT3 inhibitors leads to resistance via activation of parallel signaling pathways. Blood 2007; 109:1643-52. (Pubitemid 46239599)
    • (2007) Blood , vol.109 , Issue.4 , pp. 1643-1652
    • Piloto, O.1    Wright, M.2    Brown, P.3    Kim, K.-T.4    Levis, M.5    Small, D.6
  • 29
    • 18244362065 scopus 로고    scopus 로고
    • FLT3-ITD-TKD dual mutants associated with AML confer resistance to FLT3 PTK inhibitors and cytotoxic agents by overexpression of Bcl-x(L)
    • DOI 10.1182/blood-2004-06-2459
    • Bagrintseva K, Geisenhof S, Kern R, et al. FLT3-ITD-TKD dual mutants associated with AML confer resistance to FLT3 PTK inhibitors and cytotoxic agents by overexpression of Bcl-x (L). Blood 2005; 105:3679-85. (Pubitemid 40628216)
    • (2005) Blood , vol.105 , Issue.9 , pp. 3679-3685
    • Bagrintseva, K.1    Geisenhof, S.2    Kern, R.3    Eichenlaub, S.4    Reindl, C.5    Ellwart, J.W.6    Hiddemann, W.7    Spiekermann, K.8
  • 30
    • 84860556045 scopus 로고    scopus 로고
    • Mutations in FLT3/ITD produce varying levels of resistance to FLT3 tyrosine kinase inhibitors
    • Williams A, Nguyen B, Levis M, Brown P, Small D. Mutations in FLT3/ITD produce varying levels of resistance to FLT3 tyrosine kinase inhibitors. ASH Annual Meeting Abstracts 2009; 114:3776.
    • (2009) ASH Annual Meeting Abstracts , vol.114 , pp. 3776
    • Williams, A.1    Nguyen, B.2    Levis, M.3    Brown, P.4    Small, D.5
  • 32
    • 1542313903 scopus 로고    scopus 로고
    • Mutations in the tyrosine kinase domain of FLT3 define a new molecular mechanism of acquired drug resistance to PTK inhibitors in FLT3-ITD-transformed hematopoietic cells
    • DOI 10.1182/blood-2003-05-1653
    • Bagrintseva K, Schwab R, Kohl TM, et al. Mutations in the tyrosine kinase domain of FLT3 define a new molecular mechanism of acquired drug resistance to PTK inhibitors in FLT3-ITD-transformed hematopoietic cells. Blood 2004; 103:2266-75. (Pubitemid 38326246)
    • (2004) Blood , vol.103 , Issue.6 , pp. 2266-2275
    • Bagrintseva, K.1    Schwab, R.2    Kohl, T.M.3    Schnittger, S.4    Eichenlaub, S.5    Ellwart, J.W.6    Hiddemann, W.7    Spiekermann, K.8
  • 33
    • 77951645227 scopus 로고    scopus 로고
    • Phase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia
    • Ravandi F, Cortes JE, Jones D, et al. Phase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia. J Clin Oncol 2010; 28:1856-62.
    • (2010) J Clin Oncol , vol.28 , pp. 1856-1862
    • Ravandi, F.1    Cortes, J.E.2    Jones, D.3
  • 34
    • 33644521267 scopus 로고    scopus 로고
    • Results of intensive chemotherapy in 998 patients age 65 years or older with acute myeloid leukemia or high-risk myelodys-plastic syndrome: Predictive prognostic models for outcome
    • Kantarjian H, O'Brien S, Cortes J, et al. Results of intensive chemotherapy in 998 patients age 65 years or older with acute myeloid leukemia or high-risk myelodys-plastic syndrome: predictive prognostic models for outcome. Cancer 2006; 106: 1090-8.
    • (2006) Cancer , vol.106 , pp. 1090-1098
    • Kantarjian, H.1    O'Brien, S.2    Cortes, J.3
  • 35
    • 33749364564 scopus 로고    scopus 로고
    • Activating FLT3 mutations are detectable in chronic and blast phases of chronic myeloproliferative disorders other than chronic myeloid leukemia
    • DOI 10.1309/JT5B-E2L1-FGG8-P8Y6
    • Lin P, Jones D, Medeiros LJ, Chen W, Vega-Vazquez F, Luthra R. Activating FLT3 mutations are detectable in chronic and blast phases of chronic myeloproliferative disorders other than chronic myeloid leukemia. Am J Clin Pathol 2006; 126:530-3. (Pubitemid 44498502)
    • (2006) American Journal of Clinical Pathology , vol.126 , Issue.4 , pp. 530-533
    • Lin, P.1    Jones, D.2    Medeiros, L.J.3    Chen, W.4    Vega-Vazquez, F.5    Luthra, R.6
  • 36
    • 27244453278 scopus 로고    scopus 로고
    • Acute myeloid leukaemia with FLT3 gene mutations of both internal tandem duplication and point mutation type
    • DOI 10.1111/j.1365-2141.2005.05666.x
    • Chen W, Jones D, Medeiros LJ, Luthra R, Lin P. Acute myeloid leukaemia with FLT3 gene mutations of both internal tandem duplication and point mutation type. Br J Haematol 2005; 130:726-8. (Pubitemid 43906644)
    • (2005) British Journal of Haematology , vol.130 , Issue.5 , pp. 726-728
    • Chen, W.1    Jones, D.2    Jeffrey Medeiros, L.3    Luthra, R.4    Lin, P.5
  • 38
    • 1842420032 scopus 로고    scopus 로고
    • Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia
    • DOI 10.1182/blood-2003-11-3775
    • Smith BD, Levis M, Beran M, et al. Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia. Blood 2004; 103:3669-76. (Pubitemid 38596280)
    • (2004) Blood , vol.103 , Issue.10 , pp. 3669-3676
    • Smith, B.D.1    Levis, M.2    Beran, M.3    Giles, F.4    Kantarjian, H.5    Berg, K.6    Murphy, K.M.7    Dauses, T.8    Allebach, J.9    Small, D.10
  • 39
    • 33751173636 scopus 로고    scopus 로고
    • A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy
    • Knapper S, Burnett AK, Littlewood T, et al. A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy. Blood 2006; 108:3262-70.
    • (2006) Blood , vol.108 , pp. 3262-3270
    • Knapper, S.1    Burnett, A.K.2    Littlewood, T.3
  • 40
    • 77954474254 scopus 로고    scopus 로고
    • Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for flt3 mutant aml patients in first relapse
    • Levis M, Ravandi F, Wang ES, et al. Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for flt3 mutant aml patients in first relapse. ASH Annual Meeting Abstracts 2009; 114:788.
    • (2009) ASH Annual Meeting Abstracts , vol.114 , pp. 788
    • Levis, M.1    Ravandi, F.2    Wang, E.S.3
  • 41
    • 77950423964 scopus 로고    scopus 로고
    • A phase 1b study of midostaurin (PKC412) in combination with daunorubicin and cytarabine induction and high-dose cytara-bine consolidation in patients under age 61 with newly diagnosed de novo acute myeloid leukemia: Overall survival of patients whose blasts have FLT3 mutations is similar to those with wild-type FLT3
    • Stone RM, Fischer T, Paquette R, et al. A phase 1b study of midostaurin (PKC412) in combination with daunorubicin and cytarabine induction and high-dose cytara-bine consolidation in patients under age 61 with newly diagnosed de novo acute myeloid leukemia: overall survival of patients whose blasts have FLT3 mutations is similar to those with wild-type FLT3. ASH Annual Meeting Abstracts 2009; 114: 634.
    • (2009) ASH Annual Meeting Abstracts , vol.114 , pp. 634
    • Stone, R.M.1    Fischer, T.2    Paquette, R.3
  • 45
    • 3843142735 scopus 로고    scopus 로고
    • In vitro studies of a FLT3 inhibitor combined with chemotherapy: Sequence of administration is important to achieve synergistic cytotoxic effects
    • DOI 10.1182/blood-2004-01-0388
    • Levis M, Pham R, Smith BD, Small D. In vitro studies of a FLT3 inhibitor combined with chemotherapy: sequence of administration is important to achieve syn-ergistic cytotoxic effects. Blood 2004; 104:1145-50. (Pubitemid 39038036)
    • (2004) Blood , vol.104 , Issue.4 , pp. 1145-1150
    • Levis, M.1    Pham, R.2    Smith, B.D.3    Small, D.4
  • 46
    • 33751177110 scopus 로고    scopus 로고
    • The effects of lestaurtinib (CEP701) and PKC412 on primary AML blasts: The induction of cy-totoxicity varies with dependence on FLT3 signaling in both FLT3-mutated and wild-type cases
    • Knapper S, Mills KI, Gilkes AF, Austin SJ, Walsh V, Burnett AK. The effects of lestaurtinib (CEP701) and PKC412 on primary AML blasts: the induction of cy-totoxicity varies with dependence on FLT3 signaling in both FLT3-mutated and wild-type cases. Blood 2006; 108:3494-503.
    • (2006) Blood , vol.108 , pp. 3494-3503
    • Knapper, S.1    Mills, K.I.2    Gilkes, A.F.3    Austin, S.J.4    Walsh, V.5    Burnett, A.K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.