메뉴 건너뛰기




Volumn 38, Issue 12, 2014, Pages 1435-1440

Prevalence and prognostic significance of c-KIT mutations in core binding factor acute myeloid leukemia: A comprehensive large-scale study from a single Chinese center

Author keywords

C KIT mutations; Core binding factor acute myeloid leukemia; Inv(16); Prognosis; T(8 ; 21)

Indexed keywords

AML1 ETO PROTEIN; ANTHRACYCLINE DERIVATIVE; CORE BINDING FACTOR; CORE BINDING FACTOR BETA MYH11 PROTEIN; CYTARABINE; ETOPOSIDE; HYBRID PROTEIN; IDARUBICIN; UNCLASSIFIED DRUG; AML1-ETO FUSION PROTEIN, HUMAN; ONCOPROTEIN; STEM CELL FACTOR RECEPTOR; TRANSCRIPTION FACTOR RUNX1;

EID: 84916201282     PISSN: 01452126     EISSN: 18735835     Source Type: Journal    
DOI: 10.1016/j.leukres.2014.09.017     Document Type: Article
Times cited : (60)

References (39)
  • 1
    • 0028786125 scopus 로고
    • Functional domains of the t(8;21) fusion protein AML-1/ETO
    • Lenny N., Meyers S., Hiebert S.W. Functional domains of the t(8;21) fusion protein AML-1/ETO. Oncogene 1995, 11:1761-1769.
    • (1995) Oncogene , vol.11 , pp. 1761-1769
    • Lenny, N.1    Meyers, S.2    Hiebert, S.W.3
  • 2
    • 0027373893 scopus 로고
    • Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia
    • Liu P., Tarlé S.A., Hajra A., Claxton D.F., Marlton P., Freedman M., et al. Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia. Science 1993, 261:1041-1044.
    • (1993) Science , vol.261 , pp. 1041-1044
    • Liu, P.1    Tarlé, S.A.2    Hajra, A.3    Claxton, D.F.4    Marlton, P.5    Freedman, M.6
  • 3
    • 84872597932 scopus 로고    scopus 로고
    • The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 Trial
    • Grimwade D., Walker H., Oliver F., Wheatley K., Harrison C., Harrison G., et al. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 Trial. Blood 1998, 96:4075-4083.
    • (1998) Blood , vol.96 , pp. 4075-4083
    • Grimwade, D.1    Walker, H.2    Oliver, F.3    Wheatley, K.4    Harrison, C.5    Harrison, G.6
  • 4
    • 17544388046 scopus 로고    scopus 로고
    • Frequency of prolonged remission duration after high-dose cytarabine intensification in acute myeloid leukemia varies by cytogenetic subtype
    • Bloomfield C.D., Lawrence D., Byrd J.C., Carroll A., Pettenati M.J., Tantravahi R., et al. Frequency of prolonged remission duration after high-dose cytarabine intensification in acute myeloid leukemia varies by cytogenetic subtype. Cancer Res 1998, 58:4173-4179.
    • (1998) Cancer Res , vol.58 , pp. 4173-4179
    • Bloomfield, C.D.1    Lawrence, D.2    Byrd, J.C.3    Carroll, A.4    Pettenati, M.J.5    Tantravahi, R.6
  • 5
    • 0037114753 scopus 로고    scopus 로고
    • Cancer and Leukemia Group B (CALGB 8461), pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461)
    • Byrd J.C., Mrózek K., Dodge R.K., Carroll A.J., Edwards C.G., Arthur D.C., et al. Cancer and Leukemia Group B (CALGB 8461), pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461). Blood 2002, 100:4325-4336.
    • (2002) Blood , vol.100 , pp. 4325-4336
    • Byrd, J.C.1    Mrózek, K.2    Dodge, R.K.3    Carroll, A.J.4    Edwards, C.G.5    Arthur, D.C.6
  • 6
    • 24944464648 scopus 로고    scopus 로고
    • Prognostic factors and outcome of core binding factor acute myeloid leukemia patients with t(8;21) differ from those of patients with inv(16): a Cancer and Leukemia Group B study
    • Marcucci G., Mrózek K., Ruppert A.S., Maharry K., Kolitz J.E., Moore J.O., et al. Prognostic factors and outcome of core binding factor acute myeloid leukemia patients with t(8;21) differ from those of patients with inv(16): a Cancer and Leukemia Group B study. J Clin Oncol 2005, 23:5705-5717.
    • (2005) J Clin Oncol , vol.23 , pp. 5705-5717
    • Marcucci, G.1    Mrózek, K.2    Ruppert, A.S.3    Maharry, K.4    Kolitz, J.E.5    Moore, J.O.6
  • 7
    • 0022626874 scopus 로고
    • A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family
    • Besmer P., Murphy J.E., George P.C., Qui F., Bergold P.J., Ledermann L., et al. A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family. Nature 1986, 320:415-421.
    • (1986) Nature , vol.320 , pp. 415-421
    • Besmer, P.1    Murphy, J.E.2    George, P.C.3    Qui, F.4    Bergold, P.J.5    Ledermann, L.6
  • 8
    • 0023989811 scopus 로고
    • Primary structure of c-kit: relationship with the CSF-1/PDGF receptor kinase family oncogenic activation of v-kit involves deletion of extracellular domain and C terminus
    • Qui F., Ray P., Brown K., Barker P.E., Jhanwar S., Ruddle F.H., et al. Primary structure of c-kit: relationship with the CSF-1/PDGF receptor kinase family oncogenic activation of v-kit involves deletion of extracellular domain and C terminus. EMBO J 1988, 7:1003-1011.
    • (1988) EMBO J , vol.7 , pp. 1003-1011
    • Qui, F.1    Ray, P.2    Brown, K.3    Barker, P.E.4    Jhanwar, S.5    Ruddle, F.H.6
  • 9
    • 0027359443 scopus 로고
    • Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product
    • Furitsu T., Tsujimura T., Tono T., Ikeda H., Kitayama H., Koshimizu U., et al. Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product. J Clin Invest 1993, 92:1736-1744.
    • (1993) J Clin Invest , vol.92 , pp. 1736-1744
    • Furitsu, T.1    Tsujimura, T.2    Tono, T.3    Ikeda, H.4    Kitayama, H.5    Koshimizu, U.6
  • 10
    • 0032104728 scopus 로고    scopus 로고
    • In vivo differentiation of mast cells from acute myeloid leukemia blasts carrying a novel activating ligand-independent C-kit mutation
    • Beghini A., Cairoli R., Morra E., Larizza L. In vivo differentiation of mast cells from acute myeloid leukemia blasts carrying a novel activating ligand-independent C-kit mutation. Blood Cells Mol Dis 1998, 24:262-270.
    • (1998) Blood Cells Mol Dis , vol.24 , pp. 262-270
    • Beghini, A.1    Cairoli, R.2    Morra, E.3    Larizza, L.4
  • 11
    • 0032989226 scopus 로고    scopus 로고
    • C-kit proto-oncogene exon 8 in-frame deletion plus insertion mutations in acute myeloid leukaemia
    • Gari M., Goodeve A., Wilson G., Winship P., Langabeer S., Linch D., et al. c-kit proto-oncogene exon 8 in-frame deletion plus insertion mutations in acute myeloid leukaemia. Br J Haematol 1999, 105:894-900.
    • (1999) Br J Haematol , vol.105 , pp. 894-900
    • Gari, M.1    Goodeve, A.2    Wilson, G.3    Winship, P.4    Langabeer, S.5    Linch, D.6
  • 12
    • 26944447953 scopus 로고    scopus 로고
    • Mutations in KIT and RAS are frequent events in pediatric core-binding factor acute myeloid leukemia
    • Goemans B.F., Zwaan C.M., Miller M., Zimmermann M., Harlow A., Meshinchi S., et al. Mutations in KIT and RAS are frequent events in pediatric core-binding factor acute myeloid leukemia. Leukemia 2005, 19:1536-1542.
    • (2005) Leukemia , vol.19 , pp. 1536-1542
    • Goemans, B.F.1    Zwaan, C.M.2    Miller, M.3    Zimmermann, M.4    Harlow, A.5    Meshinchi, S.6
  • 13
    • 3943068350 scopus 로고    scopus 로고
    • KIT activating mutations: incidence in adult and pediatric acute myeloid leukemia, and identification of an internal tandem duplication
    • Beghini A., Ripamonti C.B., Cairoli R., Cazzaniga G., Colapietro P., Elice F., et al. KIT activating mutations: incidence in adult and pediatric acute myeloid leukemia, and identification of an internal tandem duplication. Haematologica 2004, 89:920-925.
    • (2004) Haematologica , vol.89 , pp. 920-925
    • Beghini, A.1    Ripamonti, C.B.2    Cairoli, R.3    Cazzaniga, G.4    Colapietro, P.5    Elice, F.6
  • 14
    • 19944431253 scopus 로고    scopus 로고
    • AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec
    • Wang Y.Y., Zhou G.B., Yin T., Chen B., Shi J.Y., Liang W.X., et al. AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec. Proc Natl Acad Sci U S A 2005, 102:1104-1109.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 1104-1109
    • Wang, Y.Y.1    Zhou, G.B.2    Yin, T.3    Chen, B.4    Shi, J.Y.5    Liang, W.X.6
  • 16
    • 33748467435 scopus 로고    scopus 로고
    • Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): a Cancer and Leukemia Group B Study
    • Paschka P., Marcucci G., Ruppert A.S., Mrózek K., Chen H., Kittles R.A., et al. Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): a Cancer and Leukemia Group B Study. J Clin Oncol 2006, 24:3904-3911.
    • (2006) J Clin Oncol , vol.24 , pp. 3904-3911
    • Paschka, P.1    Marcucci, G.2    Ruppert, A.S.3    Mrózek, K.4    Chen, H.5    Kittles, R.A.6
  • 17
    • 84881665264 scopus 로고    scopus 로고
    • Core binding factor acute myeloid leukemia: the impact of age, leukocyte count, molecular findings, and minimal residual disease
    • Hoyos M., Nomdedeu J.F., Esteve J., Duarte R., Ribera J.M., Llorente A., et al. Core binding factor acute myeloid leukemia: the impact of age, leukocyte count, molecular findings, and minimal residual disease. Eur J Haematol 2013, 91:209-218.
    • (2013) Eur J Haematol , vol.91 , pp. 209-218
    • Hoyos, M.1    Nomdedeu, J.F.2    Esteve, J.3    Duarte, R.4    Ribera, J.M.5    Llorente, A.6
  • 18
    • 33646432204 scopus 로고    scopus 로고
    • Prognostic impact of c-KIT mutations in core binding factor leukemias: an Italian retrospective study
    • Cairoli R., Beghini A., Grillo G., Nadali G., Elice F., Ripamonti C.B., et al. Prognostic impact of c-KIT mutations in core binding factor leukemias: an Italian retrospective study. Blood 2006, 107:3463-3468.
    • (2006) Blood , vol.107 , pp. 3463-3468
    • Cairoli, R.1    Beghini, A.2    Grillo, G.3    Nadali, G.4    Elice, F.5    Ripamonti, C.B.6
  • 19
    • 33744487375 scopus 로고    scopus 로고
    • Incidence and prognostic impact of c-Kit, FLT3, and Ras gene mutations in core binding factor acute myeloid leukemia (CBF-AML)
    • Boissel N., Leroy H., Brethon B., Philippe N., de Botton S., Auvrignon A., et al. Incidence and prognostic impact of c-Kit, FLT3, and Ras gene mutations in core binding factor acute myeloid leukemia (CBF-AML). Leukemia 2006, 20:965-970.
    • (2006) Leukemia , vol.20 , pp. 965-970
    • Boissel, N.1    Leroy, H.2    Brethon, B.3    Philippe, N.4    de Botton, S.5    Auvrignon, A.6
  • 20
    • 77950612017 scopus 로고    scopus 로고
    • Prevalence and prognostic significance of KIT mutations in pediatric patients with core binding factor AML enrolled on serial pediatric cooperative trials for de novo AML
    • Pollard J.A., Alonzo T.A., Gerbing R.B., Ho P.A., Zeng R., Ravindranath Y., et al. Prevalence and prognostic significance of KIT mutations in pediatric patients with core binding factor AML enrolled on serial pediatric cooperative trials for de novo AML. Blood 2010, 115:2372-2379.
    • (2010) Blood , vol.115 , pp. 2372-2379
    • Pollard, J.A.1    Alonzo, T.A.2    Gerbing, R.B.3    Ho, P.A.4    Zeng, R.5    Ravindranath, Y.6
  • 21
    • 80052097088 scopus 로고    scopus 로고
    • Prognostic impact of c-KIT mutations in core binding factor acute myeloid leukemia
    • Park S.H., Chi H.S., Min S.K., Park B.G., Jang S., Park C.J. Prognostic impact of c-KIT mutations in core binding factor acute myeloid leukemia. Leuk Res 2011, 35:1376-1383.
    • (2011) Leuk Res , vol.35 , pp. 1376-1383
    • Park, S.H.1    Chi, H.S.2    Min, S.K.3    Park, B.G.4    Jang, S.5    Park, C.J.6
  • 22
    • 33344471932 scopus 로고    scopus 로고
    • KIT mutations, and not FLT3 internal tandem duplication, are strongly associated with a poor prognosis in pediatric acute myeloid leukemia with t(8;21): a study of the Japanese Childhood AML Cooperative Study Group
    • Shimada A., Taki T., Tabuchi K., Tawa A., Horibe K., Tsuchida M., et al. KIT mutations, and not FLT3 internal tandem duplication, are strongly associated with a poor prognosis in pediatric acute myeloid leukemia with t(8;21): a study of the Japanese Childhood AML Cooperative Study Group. Blood 2006, 107:1806-1809.
    • (2006) Blood , vol.107 , pp. 1806-1809
    • Shimada, A.1    Taki, T.2    Tabuchi, K.3    Tawa, A.4    Horibe, K.5    Tsuchida, M.6
  • 23
    • 84877930402 scopus 로고    scopus 로고
    • Prospective evaluation of gene mutations and minimal residual disease in patients with core binding factor acute myeloid leukemia
    • Jourdan E., Boissel N., Chevret S., Delabesse E., Renneville A., Cornillet P., et al. Prospective evaluation of gene mutations and minimal residual disease in patients with core binding factor acute myeloid leukemia. Blood 2013, 121:2213-2223.
    • (2013) Blood , vol.121 , pp. 2213-2223
    • Jourdan, E.1    Boissel, N.2    Chevret, S.3    Delabesse, E.4    Renneville, A.5    Cornillet, P.6
  • 24
    • 84899904638 scopus 로고    scopus 로고
    • Core-binding factor acute myeloid leukemia in pediatric patients enrolled in the AIEOP AML 2002/01 trial: screening and prognostic impact of c-KIT mutations
    • Manara E., Bisio V., Masetti R., Beqiri V., Rondelli R., Menna G., et al. Core-binding factor acute myeloid leukemia in pediatric patients enrolled in the AIEOP AML 2002/01 trial: screening and prognostic impact of c-KIT mutations. Leukemia 2014, 28:1132-1134.
    • (2014) Leukemia , vol.28 , pp. 1132-1134
    • Manara, E.1    Bisio, V.2    Masetti, R.3    Beqiri, V.4    Rondelli, R.5    Menna, G.6
  • 25
    • 84872056078 scopus 로고    scopus 로고
    • Secondary genetic lesions in acute myeloid leukemia with inv(16) or t(16;16): a study of the German-Austrian AML Study Group (AMLSG)
    • Paschka P., Du J., Schlenk R.F., Gaidzik V.I., Bullinger L., Corbacioglu A., et al. Secondary genetic lesions in acute myeloid leukemia with inv(16) or t(16;16): a study of the German-Austrian AML Study Group (AMLSG). Blood 2013, 121:170-177.
    • (2013) Blood , vol.121 , pp. 170-177
    • Paschka, P.1    Du, J.2    Schlenk, R.F.3    Gaidzik, V.I.4    Bullinger, L.5    Corbacioglu, A.6
  • 26
    • 84863393263 scopus 로고    scopus 로고
    • Prognostic relevance of integrated genetic profiling in acute myeloid leukemia
    • Patel J.P., Gönen M., Figueroa M.E., Fernandez H., Sun Z., Racevskis J., et al. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. N Engl J Med 2012, 366:1079-1089.
    • (2012) N Engl J Med , vol.366 , pp. 1079-1089
    • Patel, J.P.1    Gönen, M.2    Figueroa, M.E.3    Fernandez, H.4    Sun, Z.5    Racevskis, J.6
  • 28
    • 77449159028 scopus 로고    scopus 로고
    • Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet
    • Döhner H., Estey E.H., Amadori S., Appelbaum F.R., Büchner T., Burnett A.K., et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood 2010, 115:453-474.
    • (2010) Blood , vol.115 , pp. 453-474
    • Döhner, H.1    Estey, E.H.2    Amadori, S.3    Appelbaum, F.R.4    Büchner, T.5    Burnett, A.K.6
  • 29
    • 84880991962 scopus 로고    scopus 로고
    • MRD-directed risk stratification treatment may improve outcomes of t(8;21) AML in the first complete remission: results from the AML05 multicenter trial
    • Zhu H.H., Zhang X.H., Qin Y.Z., Liu D.H., Jiang H., Chen H., et al. MRD-directed risk stratification treatment may improve outcomes of t(8;21) AML in the first complete remission: results from the AML05 multicenter trial. Blood 2013, 121:4056-4062.
    • (2013) Blood , vol.121 , pp. 4056-4062
    • Zhu, H.H.1    Zhang, X.H.2    Qin, Y.Z.3    Liu, D.H.4    Jiang, H.5    Chen, H.6
  • 30
    • 58549105899 scopus 로고    scopus 로고
    • Expression patterns of WT1 and PRAME in acute myeloid leukemia patients and their usefulness for monitoring minimal residual disease
    • Qin Y., Zhu H., Jiang B., Li J., Lu X., Li L., et al. Expression patterns of WT1 and PRAME in acute myeloid leukemia patients and their usefulness for monitoring minimal residual disease. Leuk Res 2009, 33:384-390.
    • (2009) Leuk Res , vol.33 , pp. 384-390
    • Qin, Y.1    Zhu, H.2    Jiang, B.3    Li, J.4    Lu, X.5    Li, L.6
  • 31
    • 9144222001 scopus 로고    scopus 로고
    • Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia-a Europe Against Cancer program
    • Gabert J., Beillard E., van der Velden V.H., Bi W., Grimwade D., Pallisgaard N., et al. Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia-a Europe Against Cancer program. Leukemia 2003, 17:2318-2357.
    • (2003) Leukemia , vol.17 , pp. 2318-2357
    • Gabert, J.1    Beillard, E.2    van der Velden, V.H.3    Bi, W.4    Grimwade, D.5    Pallisgaard, N.6
  • 32
    • 9144271651 scopus 로고    scopus 로고
    • Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using 'real-time' quantitative reverse-transcriptase polymerase chain reaction (RQPCR)-a Europe against cancer program
    • Beillard E., Pallisgaard N., van der Velden V.H., Bi W., Dee R., van der Schoot E., et al. Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using 'real-time' quantitative reverse-transcriptase polymerase chain reaction (RQPCR)-a Europe against cancer program. Leukemia 2003, 17:2474-2486.
    • (2003) Leukemia , vol.17 , pp. 2474-2486
    • Beillard, E.1    Pallisgaard, N.2    van der Velden, V.H.3    Bi, W.4    Dee, R.5    van der Schoot, E.6
  • 33
    • 34548776992 scopus 로고    scopus 로고
    • N822 mutation of KIT gene was frequent in pediatric acute myeloid leukemia patients with t(8;21) in Japan: a study of the Japanese childhood AML cooperative Study Group
    • Shimada A., Taki T., Kubota C., Itou T., Tawa A., Horibe K., et al. N822 mutation of KIT gene was frequent in pediatric acute myeloid leukemia patients with t(8;21) in Japan: a study of the Japanese childhood AML cooperative Study Group. Leukemia 2007, 21:2218-2219.
    • (2007) Leukemia , vol.21 , pp. 2218-2219
    • Shimada, A.1    Taki, T.2    Kubota, C.3    Itou, T.4    Tawa, A.5    Horibe, K.6
  • 34
    • 84863183137 scopus 로고    scopus 로고
    • Distinct classes of c-Kit-activating mutations differ in their ability to promote RUNX1-ETO-associated acute myeloid leukemia
    • Nick H.J., Kim H.G., Chang C.W., Harris K.W., Reddy V., Klug C.A. Distinct classes of c-Kit-activating mutations differ in their ability to promote RUNX1-ETO-associated acute myeloid leukemia. Blood 2012, 119:1522-1531.
    • (2012) Blood , vol.119 , pp. 1522-1531
    • Nick, H.J.1    Kim, H.G.2    Chang, C.W.3    Harris, K.W.4    Reddy, V.5    Klug, C.A.6
  • 36
    • 0037093053 scopus 로고    scopus 로고
    • A white blood cell index as the main prognostic factor in t(8;21) acute myeloid leukemia (AML): a survey of 161 cases from the French AML intergroup
    • Nguyen S., Leblanc T., Fenaux P., Witz F., Blaise D., Pigneux A., et al. A white blood cell index as the main prognostic factor in t(8;21) acute myeloid leukemia (AML): a survey of 161 cases from the French AML intergroup. Blood 2002, 99:3517-3523.
    • (2002) Blood , vol.99 , pp. 3517-3523
    • Nguyen, S.1    Leblanc, T.2    Fenaux, P.3    Witz, F.4    Blaise, D.5    Pigneux, A.6
  • 37
    • 20144371199 scopus 로고    scopus 로고
    • Prognostic value of real-time quantitative PCR (RQ-PCR) in AML with t(8;21)
    • Leroy H., de Botton S., Grardel-Duflos N., Darre S., Leleu X., Roumier C., et al. Prognostic value of real-time quantitative PCR (RQ-PCR) in AML with t(8;21). Leukemia 2005, 19:367-372.
    • (2005) Leukemia , vol.19 , pp. 367-372
    • Leroy, H.1    de Botton, S.2    Grardel-Duflos, N.3    Darre, S.4    Leleu, X.5    Roumier, C.6
  • 38
    • 0037330478 scopus 로고    scopus 로고
    • C-Kit point mutations in core binding factor leukemias: correlation with white blood cell count and the white blood cell index
    • Cairoli R., Grillo G., Beghini A., Tedeschi A., Ripamonti C.B., Larizza L., et al. C-Kit point mutations in core binding factor leukemias: correlation with white blood cell count and the white blood cell index. Leukemia 2003, 17:471-472.
    • (2003) Leukemia , vol.17 , pp. 471-472
    • Cairoli, R.1    Grillo, G.2    Beghini, A.3    Tedeschi, A.4    Ripamonti, C.B.5    Larizza, L.6
  • 39
    • 4644288302 scopus 로고    scopus 로고
    • Individual patient data-based meta-analysis of patients aged 16-60 years with core binding factor acute myeloid leukemia: a survey of the German Acute Myeloid Leukemia Intergroup
    • Schlenk R.F., Benner A., Krauter J., Büchner T., Sauerland C., Ehninger G., et al. Individual patient data-based meta-analysis of patients aged 16-60 years with core binding factor acute myeloid leukemia: a survey of the German Acute Myeloid Leukemia Intergroup. J Clin Oncol 2004, 22:3741-3750.
    • (2004) J Clin Oncol , vol.22 , pp. 3741-3750
    • Schlenk, R.F.1    Benner, A.2    Krauter, J.3    Büchner, T.4    Sauerland, C.5    Ehninger, G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.