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Volumn 94, Issue 5, 2015, Pages 439-448

Favorable prognosis of biallelic CEBPA gene mutations in acute myeloid leukemia patients: A meta-analysis

Author keywords

Acute myeloid leukemia; Biallelic CEBPA mutations; Meta analysis; Prognosis

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; CCAAT ENHANCER BINDING PROTEIN; CEBPA PROTEIN, HUMAN;

EID: 84926524933     PISSN: 09024441     EISSN: 16000609     Source Type: Journal    
DOI: 10.1111/ejh.12450     Document Type: Article
Times cited : (40)

References (39)
  • 1
    • 0037114753 scopus 로고    scopus 로고
    • Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461)
    • Byrd JC, Mrozek K, Dodge RK, et al. Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461). Blood 2002;100:4325-36.
    • (2002) Blood , vol.100 , pp. 4325-4336
    • Byrd, J.C.1    Mrozek, K.2    Dodge, R.K.3
  • 2
    • 0032188805 scopus 로고    scopus 로고
    • The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties
    • Grimwade D, Walker H, Oliver F, et al. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1, 612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties. Blood 1998;92:2322-33.
    • (1998) Blood , vol.92 , pp. 2322-2333
    • Grimwade, D.1    Walker, H.2    Oliver, F.3
  • 4
    • 77449159028 scopus 로고    scopus 로고
    • Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet
    • Dohner H, Estey EH, Amadori S, et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood 2010;115:453-74.
    • (2010) Blood , vol.115 , pp. 453-474
    • Dohner, H.1    Estey, E.H.2    Amadori, S.3
  • 5
    • 1442356729 scopus 로고    scopus 로고
    • CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations
    • Frohling S, Schlenk RF, Stolze I, Bihlmayr J, Benner A, Kreitmeier S, Tobis K, Dohner H, Dohner K. CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations. J Clin Oncol 2004;22:624-33.
    • (2004) J Clin Oncol , vol.22 , pp. 624-633
    • Frohling, S.1    Schlenk, R.F.2    Stolze, I.3    Bihlmayr, J.4    Benner, A.5    Kreitmeier, S.6    Tobis, K.7    Dohner, H.8    Dohner, K.9
  • 6
    • 0037108111 scopus 로고    scopus 로고
    • Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: a study from the Acute Leukemia French Association (ALFA)
    • Preudhomme C, Sagot C, Boissel N, et al. Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: a study from the Acute Leukemia French Association (ALFA). Blood 2002;100:2717-23.
    • (2002) Blood , vol.100 , pp. 2717-2723
    • Preudhomme, C.1    Sagot, C.2    Boissel, N.3
  • 8
    • 28444473100 scopus 로고    scopus 로고
    • Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations
    • Dohner K, Schlenk RF, Habdank M, Scholl C, Rucker FG, Corbacioglu A, Bullinger L, Frohling S, Dohner H. Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations. Blood 2005;106:3740-6.
    • (2005) Blood , vol.106 , pp. 3740-3746
    • Dohner, K.1    Schlenk, R.F.2    Habdank, M.3    Scholl, C.4    Rucker, F.G.5    Corbacioglu, A.6    Bullinger, L.7    Frohling, S.8    Dohner, H.9
  • 9
    • 28444446313 scopus 로고    scopus 로고
    • Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance
    • Verhaak RG, Goudswaard CS, van Putten W, et al. Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance. Blood 2005;106:3747-54.
    • (2005) Blood , vol.106 , pp. 3747-3754
    • Verhaak, R.G.1    Goudswaard, C.S.2    van Putten, W.3
  • 10
    • 33646557337 scopus 로고    scopus 로고
    • Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML)
    • Thiede C, Koch S, Creutzig E, Steudel C, Illmer T, Schaich M, Ehninger G. Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML). Blood 2006;107:4011-20.
    • (2006) Blood , vol.107 , pp. 4011-4020
    • Thiede, C.1    Koch, S.2    Creutzig, E.3    Steudel, C.4    Illmer, T.5    Schaich, M.6    Ehninger, G.7
  • 11
    • 0035476264 scopus 로고    scopus 로고
    • Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study
    • Whitman SP, Archer KJ, Feng L, et al. Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study. Cancer Res 2001;61:7233-9.
    • (2001) Cancer Res , vol.61 , pp. 7233-7239
    • Whitman, S.P.1    Archer, K.J.2    Feng, L.3
  • 12
    • 0037114829 scopus 로고    scopus 로고
    • Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: a study of the AML Study Group Ulm
    • Frohling S, Schlenk RF, Breitruck J, Benner A, Kreitmeier S, Tobis K, Dohner H, Dohner K. Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: a study of the AML Study Group Ulm. Blood 2002;100:4372-80.
    • (2002) Blood , vol.100 , pp. 4372-4380
    • Frohling, S.1    Schlenk, R.F.2    Breitruck, J.3    Benner, A.4    Kreitmeier, S.5    Tobis, K.6    Dohner, H.7    Dohner, K.8
  • 13
    • 0037097716 scopus 로고    scopus 로고
    • Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis
    • Thiede C, Steudel C, Mohr B, et al. Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis. Blood 2002;99:4326-35.
    • (2002) Blood , vol.99 , pp. 4326-4335
    • Thiede, C.1    Steudel, C.2    Mohr, B.3
  • 14
    • 0036659931 scopus 로고    scopus 로고
    • Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease
    • Schnittger S, Schoch C, Dugas M, et al. Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease. Blood 2002;100:59-66.
    • (2002) Blood , vol.100 , pp. 59-66
    • Schnittger, S.1    Schoch, C.2    Dugas, M.3
  • 17
    • 2342544921 scopus 로고    scopus 로고
    • C/EBPα mutations in acute myeloid leukaemias
    • Nerlov C. C/EBPα mutations in acute myeloid leukaemias. Nat Rev Cancer 2004;4:394-400.
    • (2004) Nat Rev Cancer , vol.4 , pp. 394-400
    • Nerlov, C.1
  • 18
    • 0033869876 scopus 로고    scopus 로고
    • Translational control of C/EBPalpha and C/EBPbeta isoform expression
    • Calkhoven CF, Muller C, Leutz A. Translational control of C/EBPalpha and C/EBPbeta isoform expression. Genes Dev 2000;14:1920-32.
    • (2000) Genes Dev , vol.14 , pp. 1920-1932
    • Calkhoven, C.F.1    Muller, C.2    Leutz, A.3
  • 19
    • 35348908269 scopus 로고    scopus 로고
    • Transcriptional dysregulation during myeloid transformation in AML
    • Pabst T, Mueller BU. Transcriptional dysregulation during myeloid transformation in AML. Oncogene 2007;26:6829-37.
    • (2007) Oncogene , vol.26 , pp. 6829-6837
    • Pabst, T.1    Mueller, B.U.2
  • 20
    • 63849241865 scopus 로고    scopus 로고
    • Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome
    • Wouters BJ, Lowenberg B, Erpelinck-Verschueren CA, van Putten WL, Valk PJ, Delwel R. Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome. Blood 2009;113:3088-91.
    • (2009) Blood , vol.113 , pp. 3088-3091
    • Wouters, B.J.1    Lowenberg, B.2    Erpelinck-Verschueren, C.A.3    van Putten, W.L.4    Valk, P.J.5    Delwel, R.6
  • 21
    • 64949122396 scopus 로고    scopus 로고
    • Heterogeneity within AML with CEBPA mutations; only CEBPA double mutations, but not single CEBPA mutations are associated with favourable prognosis
    • Pabst T, Eyholzer M, Fos J, Mueller BU. Heterogeneity within AML with CEBPA mutations; only CEBPA double mutations, but not single CEBPA mutations are associated with favourable prognosis. Br J Cancer 2009;100:1343-6.
    • (2009) Br J Cancer , vol.100 , pp. 1343-1346
    • Pabst, T.1    Eyholzer, M.2    Fos, J.3    Mueller, B.U.4
  • 22
    • 77449146413 scopus 로고    scopus 로고
    • Acute myeloid leukemia with biallelic CEBPA gene mutations and normal karyotype represents a distinct genetic entity associated with a favorable clinical outcome
    • Dufour A, Schneider F, Metzeler KH, et al. Acute myeloid leukemia with biallelic CEBPA gene mutations and normal karyotype represents a distinct genetic entity associated with a favorable clinical outcome. J Clin Oncol 2010;28:570-7.
    • (2010) J Clin Oncol , vol.28 , pp. 570-577
    • Dufour, A.1    Schneider, F.2    Metzeler, K.H.3
  • 23
    • 77954921625 scopus 로고    scopus 로고
    • Prognostic significance of CEBPA mutations in a large cohort of younger adult patients with acute myeloid leukemia: impact of double CEBPA mutations and the interaction with FLT3 and NPM1 mutations
    • Green CL, Koo KK, Hills RK, Burnett AK, Linch DC, Gale RE. Prognostic significance of CEBPA mutations in a large cohort of younger adult patients with acute myeloid leukemia: impact of double CEBPA mutations and the interaction with FLT3 and NPM1 mutations. J Clin Oncol 2010;28:2739-47.
    • (2010) J Clin Oncol , vol.28 , pp. 2739-2747
    • Green, C.L.1    Koo, K.K.2    Hills, R.K.3    Burnett, A.K.4    Linch, D.C.5    Gale, R.E.6
  • 24
    • 81555228423 scopus 로고    scopus 로고
    • Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia
    • Shen Y, Zhu YM, Fan X, et al. Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia. Blood 2011;118:5593-603.
    • (2011) Blood , vol.118 , pp. 5593-5603
    • Shen, Y.1    Zhu, Y.M.2    Fan, X.3
  • 25
    • 79952122978 scopus 로고    scopus 로고
    • Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: further evidence for CEBPA double mutant AML as a distinctive disease entity
    • Taskesen E, Bullinger L, Corbacioglu A, et al. Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: further evidence for CEBPA double mutant AML as a distinctive disease entity. Blood 2011;117:2469-75.
    • (2011) Blood , vol.117 , pp. 2469-2475
    • Taskesen, E.1    Bullinger, L.2    Corbacioglu, A.3
  • 26
    • 79960973763 scopus 로고    scopus 로고
    • Risk stratification of intermediate-risk acute myeloid leukemia: integrative analysis of a multitude of gene mutation and gene expression markers
    • Rockova V, Abbas S, Wouters BJ, Erpelinck CA, Beverloo HB, Delwel R, van Putten WL, Lowenberg B, Valk PJ. Risk stratification of intermediate-risk acute myeloid leukemia: integrative analysis of a multitude of gene mutation and gene expression markers. Blood 2011;118:1069-76.
    • (2011) Blood , vol.118 , pp. 1069-1076
    • Rockova, V.1    Abbas, S.2    Wouters, B.J.3    Erpelinck, C.A.4    Beverloo, H.B.5    Delwel, R.6    van Putten, W.L.7    Lowenberg, B.8    Valk, P.J.9
  • 27
    • 84862762733 scopus 로고    scopus 로고
    • Monoallelic CEBPA mutations in normal karyotype acute myeloid leukemia: independent favorable prognostic factor within NPM1 mutated patients
    • Dufour A, Schneider F, Hoster E, et al. Monoallelic CEBPA mutations in normal karyotype acute myeloid leukemia: independent favorable prognostic factor within NPM1 mutated patients. Ann Hematol 2012;91:1051-63.
    • (2012) Ann Hematol , vol.91 , pp. 1051-1063
    • Dufour, A.1    Schneider, F.2    Hoster, E.3
  • 28
    • 84862909358 scopus 로고    scopus 로고
    • DNMT3A mutations in acute myeloid leukemia: stability during disease evolution and clinical implications
    • Hou HA, Kuo YY, Liu CY, et al. DNMT3A mutations in acute myeloid leukemia: stability during disease evolution and clinical implications. Blood 2012;119:559-68.
    • (2012) Blood , vol.119 , pp. 559-568
    • Hou, H.A.1    Kuo, Y.Y.2    Liu, C.Y.3
  • 29
    • 0032583387 scopus 로고    scopus 로고
    • Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints
    • Parmar MK, Torri V, Stewart L. Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Stat Med 1998;17:2815-34.
    • (1998) Stat Med , vol.17 , pp. 2815-2834
    • Parmar, M.K.1    Torri, V.2    Stewart, L.3
  • 30
    • 84861214425 scopus 로고    scopus 로고
    • Multilineage dysplasia does not influence prognosis in CEBPA-mutated AML, supporting the WHO proposal to classify these patients as a unique entity
    • Bacher U, Schnittger S, Macijewski K, et al. Multilineage dysplasia does not influence prognosis in CEBPA-mutated AML, supporting the WHO proposal to classify these patients as a unique entity. Blood 2012;119:4719-22.
    • (2012) Blood , vol.119 , pp. 4719-4722
    • Bacher, U.1    Schnittger, S.2    Macijewski, K.3
  • 32
    • 55549103713 scopus 로고    scopus 로고
    • Prognostic significance of, and gene and microRNA expression signatures associated with, CEBPA mutations in cytogenetically normal acute myeloid leukemia with high-risk molecular features: a Cancer and Leukemia Group B Study
    • Marcucci G, Maharry K, Radmacher MD, et al. Prognostic significance of, and gene and microRNA expression signatures associated with, CEBPA mutations in cytogenetically normal acute myeloid leukemia with high-risk molecular features: a Cancer and Leukemia Group B Study. J Clin Oncol 2008;26:5078-87.
    • (2008) J Clin Oncol , vol.26 , pp. 5078-5087
    • Marcucci, G.1    Maharry, K.2    Radmacher, M.D.3
  • 33
    • 48749123878 scopus 로고    scopus 로고
    • Prognostic implications of gene mutations in acute myeloid leukemia with normal cytogenetics
    • Gaidzik V, Dohner K. Prognostic implications of gene mutations in acute myeloid leukemia with normal cytogenetics. Semin Oncol 2008;35:346-55.
    • (2008) Semin Oncol , vol.35 , pp. 346-355
    • Gaidzik, V.1    Dohner, K.2
  • 34
    • 42949142189 scopus 로고    scopus 로고
    • Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia
    • Schlenk RF, Dohner K, Krauter J, et al. Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. N Engl J Med 2008;358:1909-18.
    • (2008) N Engl J Med , vol.358 , pp. 1909-1918
    • Schlenk, R.F.1    Dohner, K.2    Krauter, J.3
  • 35
    • 77951241272 scopus 로고    scopus 로고
    • Prognostic significance of CEBPA mutations and BAALC expression in acute myeloid leukemia Egyptian patients with normal karyotype
    • El-Sharnouby JA, Ahmed LM, Taha AM, Kamal O. Prognostic significance of CEBPA mutations and BAALC expression in acute myeloid leukemia Egyptian patients with normal karyotype. Egypt J Immunol 2008;15:131-43.
    • (2008) Egypt J Immunol , vol.15 , pp. 131-143
    • El-Sharnouby, J.A.1    Ahmed, L.M.2    Taha, A.M.3    Kamal, O.4
  • 36
    • 0028009840 scopus 로고
    • Efficacy of etoposide and mitoxantrone in patients with acute myelogenous leukemia refractory to standard induction therapy and intermediate-dose cytarabine with amsidine. Dutch Hematology-Oncology Working Group for Adults (HOVON)
    • Daenen S, Lowenberg B, Sonneveld P, van Putten WL, Verhoef G, Verdonck LF, van Veldhoven M, Huijgens PC. Efficacy of etoposide and mitoxantrone in patients with acute myelogenous leukemia refractory to standard induction therapy and intermediate-dose cytarabine with amsidine. Dutch Hematology-Oncology Working Group for Adults (HOVON). Leukemia 1994;8:6-10.
    • (1994) Leukemia , vol.8 , pp. 6-10
    • Daenen, S.1    Lowenberg, B.2    Sonneveld, P.3    van Putten, W.L.4    Verhoef, G.5    Verdonck, L.F.6    van Veldhoven, M.7    Huijgens, P.C.8
  • 38
    • 84862530664 scopus 로고    scopus 로고
    • Favorable effect of priming with granulocyte colony-stimulating factor in remission induction of acute myeloid leukemia restricted to dose escalation of cytarabine
    • Pabst T, Vellenga E, van Putten W, et al. Favorable effect of priming with granulocyte colony-stimulating factor in remission induction of acute myeloid leukemia restricted to dose escalation of cytarabine. Blood 2012;119:5367-73.
    • (2012) Blood , vol.119 , pp. 5367-5373
    • Pabst, T.1    Vellenga, E.2    van Putten, W.3
  • 39
    • 84888032250 scopus 로고    scopus 로고
    • The value of allogeneic and autologous hematopoietic stem cell transplantation in prognostically favorable acute myeloid leukemia with double mutant CEBPA
    • Schlenk RF, Taskesen E, van Norden Y, et al. The value of allogeneic and autologous hematopoietic stem cell transplantation in prognostically favorable acute myeloid leukemia with double mutant CEBPA. Blood 2013;122:1576-82.
    • (2013) Blood , vol.122 , pp. 1576-1582
    • Schlenk, R.F.1    Taskesen, E.2    van Norden, Y.3


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