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Volumn 2017, Issue 3, 2017, Pages

Antibiotic treatment for Clostridium difficile-associated diarrhoea in adults

Author keywords

[No Author keywords available]

Indexed keywords

BACITRACIN; FIDAXOMICIN; FUSIDIC ACID; METRONIDAZOLE; TEICOPLANIN; VANCOMYCIN; AMINOGLYCOSIDE; ANTIINFECTIVE AGENT;

EID: 85014323548     PISSN: None     EISSN: 1469493X     Source Type: Journal    
DOI: 10.1002/14651858.CD004610.pub5     Document Type: Review
Times cited : (36)

References (97)
  • 1
    • 0028332370 scopus 로고
    • Treatment of Clostridium difficile-associated diarrhea and colitis with an oral preparation of teicoplanin; a dose finding study. The Swedish CDAD Study Group
    • 5295765
    • Anonymous . Treatment of Clostridium difficile-associated diarrhea and colitis with an oral preparation of teicoplanin; a dose finding study. The Swedish CDAD Study Group. Scandinavian Journal of Infectious Diseases 1994;26(3):309-16. 5295765
    • (1994) Scandinavian Journal of Infectious Diseases , vol.26 , Issue.3 , pp. 309-316
  • 2
    • 0007714298 scopus 로고
    • Treatment of pseudomembranous colitis: a randomized controlled trial with rifaximin vs vancomycin Terapia della colite da Clostridium difficile: risultati di uno studio randomizzato aperto rifaximina vs. vancomicina]
    • 3265027
    • Boero M, Berti E, Morgando A, Verme G. Treatment of pseudomembranous colitis: a randomized controlled trial with rifaximin vs vancomycin [Terapia della colite da Clostridium difficile: risultati di uno studio randomizzato aperto rifaximina vs. vancomicina]. Microbiologia Medica 1990;5(2):74-7. 3265027
    • (1990) Microbiologia Medica , vol.5 , Issue.2 , pp. 74-77
    • Boero, M.1    Berti, E.2    Morgando, A.3    Verme, G.4
  • 3
    • 84859007390 scopus 로고    scopus 로고
    • Fidaxomicin versus vancomycin for infection with Clostridium difficile in Europe, Canada, and the USA: a double-blind, non-inferiority, randomised controlled trial
    • 5295766
    • Cornely OA, Crook DW, Esposito R, Poirier A, Somero MS, Weiss K, et al. Fidaxomicin versus vancomycin for infection with Clostridium difficile in Europe, Canada, and the USA: a double-blind, non-inferiority, randomised controlled trial. Lancet Infectious Diseases 2012;12(4):281-9. 5295766
    • (2012) Lancet Infectious Diseases , vol.12 , Issue.4 , pp. 281-289
    • Cornely, O.A.1    Crook, D.W.2    Esposito, R.3    Poirier, A.4    Somero, M.S.5    Weiss, K.6
  • 4
    • 0026784482 scopus 로고
    • Prospective study of oral teicoplanin versus oral vancomycin for therapy of pseudomembranous colitis and Clostridium difficile-associated diarrhea
    • 5295767
    • De Lalla F, Nicolin R, Rinaldi E, Scarpellini P, Rigoli R, Manfrin V, et al. Prospective study of oral teicoplanin versus oral vancomycin for therapy of pseudomembranous colitis and Clostridium difficile-associated diarrhea. Antimicrobial Agents and Chemotherapy 1992;36(10):2192-6. 5295767
    • (1992) Antimicrobial Agents and Chemotherapy , vol.36 , Issue.10 , pp. 2192-2196
    • De Lalla, F.1    Nicolin, R.2    Rinaldi, E.3    Scarpellini, P.4    Rigoli, R.5    Manfrin, V.6
  • 6
    • 0024492975 scopus 로고
    • Treatment of antibiotic-associated Clostridium difficile colitis with oral vancomycin: comparison of two dosage regimens
    • 5295769
    • Fekety R, Silva J, Kauffman C, Buggy B, Deery HG. Treatment of antibiotic-associated Clostridium difficile colitis with oral vancomycin: comparison of two dosage regimens. American Journal of Medicine 1989;86(1):15-9. 5295769
    • (1989) American Journal of Medicine , vol.86 , Issue.1 , pp. 15-19
    • Fekety, R.1    Silva, J.2    Kauffman, C.3    Buggy, B.4    Deery, H.G.5
  • 7
    • 81855199757 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled pilot study to assess the ability of rifaximin to prevent recurrent diarrhoea in patients with Clostridium difficile infection
    • 5295770
    • Garey KW, Ghantoji SS, Shah DN, Habib M, Arora V, Jiang ZD, et al. A randomized, double-blind, placebo-controlled pilot study to assess the ability of rifaximin to prevent recurrent diarrhoea in patients with Clostridium difficile infection. Journal of Antimicrobial Chemotherapy 2011;66(12):2850-5. 5295770
    • (2011) Journal of Antimicrobial Chemotherapy , vol.66 , Issue.12 , pp. 2850-2855
    • Garey, K.W.1    Ghantoji, S.S.2    Shah, D.N.3    Habib, M.4    Arora, V.5    Jiang, Z.D.6
  • 8
    • 84905057299 scopus 로고    scopus 로고
    • Vancomycin, metronidazole, or tolevamer for Clostridium difficile infection: results from two multinational, randomized, controlled trials
    • 5295771
    • Johnson S, Louie TJ, Gerding DN, Cornely OA, Chasan-Taber S, Fitts D, et al. Vancomycin, metronidazole, or tolevamer for Clostridium difficile infection: results from two multinational, randomized, controlled trials. Clinical Infectious Diseases 2014;59(3):345-54. 5295771
    • (2014) Clinical Infectious Diseases , vol.59 , Issue.3 , pp. 345-354
    • Johnson, S.1    Louie, T.J.2    Gerding, D.N.3    Cornely, O.A.4    Chasan-Taber, S.5    Fitts, D.6
  • 9
    • 0018220731 scopus 로고
    • Randomised controlled trial of vancomycin for pseudomembranous colitis and postoperative diarrhoea
    • 3265043
    • Keighley MR, Burdon DW, Arabi Y, Williams JA, Thompson H, Youngs D, et al. Randomised controlled trial of vancomycin for pseudomembranous colitis and postoperative diarrhoea. British Medical Journal 1978;2(6153):1667-9. 3265043
    • (1978) British Medical Journal , vol.2 , Issue.6153 , pp. 1667-1669
    • Keighley, M.R.1    Burdon, D.W.2    Arabi, Y.3    Williams, J.A.4    Thompson, H.5    Youngs, D.6
  • 10
    • 33747603490 scopus 로고    scopus 로고
    • Prospective, randomized inpatient study of oral metronidazole versus oral metronidazole and rifampin for treatment of primary episode of Clostridium difficile-associated diarrhea
    • 5295772
    • Lagrottereria D, Holmes S, Smieja M, Smaill F, Lee C. Prospective, randomized inpatient study of oral metronidazole versus oral metronidazole and rifampin for treatment of primary episode of Clostridium difficile-associated diarrhea. Clinical Infectious Diseases 2006;43(5):547-52. 5295772
    • (2006) Clinical Infectious Diseases , vol.43 , Issue.5 , pp. 547-552
    • Lagrottereria, D.1    Holmes, S.2    Smieja, M.3    Smaill, F.4    Lee, C.5
  • 11
    • 84994691299 scopus 로고    scopus 로고
    • Surotomycin versus vancomycin for Clostridium difficile infection: Phase 2, randomized, controlled, double-blind, non-inferiority, multicentre trial
    • 5295774
    • Lee CH, Patino H, Stevens C, Rege S, Chesnel L, Louie T, et al. Surotomycin versus vancomycin for Clostridium difficile infection: Phase 2, randomized, controlled, double-blind, non-inferiority, multicentre trial. Journal of Antimicrobial Chemotherapy 2016;71(10):2964-71. 5295774
    • (2016) Journal of Antimicrobial Chemotherapy , vol.71 , Issue.10 , pp. 2964-2971
    • Lee, C.H.1    Patino, H.2    Stevens, C.3    Rege, S.4    Chesnel, L.5    Louie, T.6
  • 12
    • 59749084849 scopus 로고    scopus 로고
    • Clinical outcomes, safety and pharmacokinetics of OPT-80 in a phase 2 trial with patients with Clostridium difficile infection
    • 3265047
    • Louie T, Miller M, Donskey C, Mullane K, Goldstein EJ. Clinical outcomes, safety and pharmacokinetics of OPT-80 in a phase 2 trial with patients with Clostridium difficile infection. Antimicrobial Agents and Chemotherapy 2009;53(1):223-8. 3265047
    • (2009) Antimicrobial Agents and Chemotherapy , vol.53 , Issue.1 , pp. 223-228
    • Louie, T.1    Miller, M.2    Donskey, C.3    Mullane, K.4    Goldstein, E.J.5
  • 14
    • 84942850284 scopus 로고    scopus 로고
    • Multicenter, double-blind, randomized, phase 2 study evaluating the novel antibiotic cadazolid in patients with Clostridium difficile infection
    • 5295776
    • Louie T, Nord CE, Talbot GH, Wilcox M, Gerding DN, Buitrago M, et al. Multicenter, double-blind, randomized, phase 2 study evaluating the novel antibiotic cadazolid in patients with Clostridium difficile infection. Antimicrobial Agents and Chemotherapy 2015;59(10):6266-73. 5295776
    • (2015) Antimicrobial Agents and Chemotherapy , vol.59 , Issue.10 , pp. 6266-6273
    • Louie, T.1    Nord, C.E.2    Talbot, G.H.3    Wilcox, M.4    Gerding, D.N.5    Buitrago, M.6
  • 15
    • 84923252565 scopus 로고    scopus 로고
    • Multicenter, randomized clinical trial to compare the safety and efficacy of LFF571 and vancomycin for Clostridium difficile infections
    • 3265053
    • Mullane K, Lee C, Bressler A, Buitrago M, Weiss K, Dabovic K, et al. Multicenter, randomized clinical trial to compare the safety and efficacy of LFF571 and vancomycin for Clostridium difficile infections. Antimicrobial Agents and Chemotherapy 2015;59(3):1435-40. 3265053
    • (2015) Antimicrobial Agents and Chemotherapy , vol.59 , Issue.3 , pp. 1435-1440
    • Mullane, K.1    Lee, C.2    Bressler, A.3    Buitrago, M.4    Weiss, K.5    Dabovic, K.6
  • 17
    • 58749112167 scopus 로고    scopus 로고
    • Nitazoxanide versus vancomycin in Clostridium difficile infection: a randomized, double-blind study
    • 5295778
    • Musher DM, Logan N, Bressler AM, Johnson DP, Rossignol JF. Nitazoxanide versus vancomycin in Clostridium difficile infection: a randomized, double-blind study. Clinical Infectious Diseases 2009;48(4):41-6. 5295778
    • (2009) Clinical Infectious Diseases , vol.48 , Issue.4 , pp. 41-46
    • Musher, D.M.1    Logan, N.2    Bressler, A.M.3    Johnson, D.P.4    Rossignol, J.F.5
  • 18
    • 0021038539 scopus 로고
    • Prospective randomised trial of metronidazole versus vancomycin for Clostridium difficile-associated diarrhoea and colitis
    • 5295779
    • Teasley DG, Gerding DN, Olson MM, Peterson LR, Gebhard RL, Schwartz MJ, et al. Prospective randomised trial of metronidazole versus vancomycin for Clostridium difficile-associated diarrhoea and colitis. Lancet 1983;2(8358):1043-6. 5295779
    • (1983) Lancet , vol.2 , Issue.8358 , pp. 1043-1046
    • Teasley, D.G.1    Gerding, D.N.2    Olson, M.M.3    Peterson, L.R.4    Gebhard, R.L.5    Schwartz, M.J.6
  • 19
    • 0030056217 scopus 로고    scopus 로고
    • Comparison of vancomycin, teicoplanin, metronidazole, and fusidic acid for the treatment of Clostridium difficile-associated diarrhea
    • 5295780
    • Wenisch C, Parschalk B, Hasenhundl M, Hirschl AM, Graninger W. Comparison of vancomycin, teicoplanin, metronidazole, and fusidic acid for the treatment of Clostridium difficile-associated diarrhea. Clinical Infectious Diseases 1996;22(5):813-8. 5295780
    • (1996) Clinical Infectious Diseases , vol.22 , Issue.5 , pp. 813-818
    • Wenisch, C.1    Parschalk, B.2    Hasenhundl, M.3    Hirschl, A.M.4    Graninger, W.5
  • 20
    • 3543083961 scopus 로고    scopus 로고
    • A double-blind randomized controlled trial of fusidic acid and metronidazole for treatment of an initial episode of Clostridium difficile-associated diarrhoea
    • 5295781
    • Wullt M, Odenholt I. A double-blind randomized controlled trial of fusidic acid and metronidazole for treatment of an initial episode of Clostridium difficile-associated diarrhoea. Journal of Antimicrobial Chemotherapy 2004;54(1):211-6. 5295781
    • (2004) Journal of Antimicrobial Chemotherapy , vol.54 , Issue.1 , pp. 211-216
    • Wullt, M.1    Odenholt, I.2
  • 21
    • 0022382249 scopus 로고
    • Antibiotic-associated colitis due to Clostridium difficile: double-blind comparison of vancomycin with bacitracin
    • 5295782
    • Young GP, Ward PB, Bayley N, Gordon D, Higgins G, Trapani JA, et al. Antibiotic-associated colitis due to Clostridium difficile: double-blind comparison of vancomycin with bacitracin. Gastroenterology 1985;89(5):1038-45. 5295782
    • (1985) Gastroenterology , vol.89 , Issue.5 , pp. 1038-1045
    • Young, G.P.1    Ward, P.B.2    Bayley, N.3    Gordon, D.4    Higgins, G.5    Trapani, J.A.6
  • 22
    • 34547133720 scopus 로고    scopus 로고
    • A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity
    • 5295783
    • Zar FA, Bakkanagari SR, Moorthi KM, Davis MB. A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity. Clinical Infectious Diseases 2007;45(3):302-7. 5295783
    • (2007) Clinical Infectious Diseases , vol.45 , Issue.3 , pp. 302-307
    • Zar, F.A.1    Bakkanagari, S.R.2    Moorthi, K.M.3    Davis, M.B.4
  • 23
    • 84938088352 scopus 로고    scopus 로고
    • Probiotics for Clostridium difficile infection in adults (PICO): Study protocol for a double-blind, randomized controlled trial
    • 5295785
    • Barker A, Duster M, Valentine S, Archbald-Pannone L, Guerrant R, Safdar N. Probiotics for Clostridium difficile infection in adults (PICO): Study protocol for a double-blind, randomized controlled trial. Contemporary Clinical Trials 2015;44:26-32. 5295785
    • (2015) Contemporary Clinical Trials , vol.44 , pp. 26-32
    • Barker, A.1    Duster, M.2    Valentine, S.3    Archbald-Pannone, L.4    Guerrant, R.5    Safdar, N.6
  • 24
    • 85014371390 scopus 로고    scopus 로고
    • Comparison of nitazoxanide and vancomycin taper regimens as a salvage therapy for patients with recurrent mild to moderate Clostridium difficile infection (CDI)
    • 5295786
    • Basu P, Krishnaswamy N, Shah J, Tang C. Comparison of nitazoxanide and vancomycin taper regimens as a salvage therapy for patients with recurrent mild to moderate Clostridium difficile infection (CDI). Gastroenteology 2011;140(5):s325. 5295786
    • (2011) Gastroenteology , vol.140 , Issue.5
    • Basu, P.1    Krishnaswamy, N.2    Shah, J.3    Tang, C.4
  • 26
    • 84926417736 scopus 로고    scopus 로고
    • Randomised clinical trial: Faecal microbiota transplantation by colonoscopy vs. vancomycin for the treatment of recurrent Clostridium difficile infection
    • 5295790
    • Cammarota G, Masucci L, Ianiro G, Bibbo S, Dinoi G, Costamagna G, et al. Randomised clinical trial: Faecal microbiota transplantation by colonoscopy vs. vancomycin for the treatment of recurrent Clostridium difficile infection. Alimentary Pharmacology and Therapeutics 2015;41(9):835-43. 5295790
    • (2015) Alimentary Pharmacology and Therapeutics , vol.41 , Issue.9 , pp. 835-843
    • Cammarota, G.1    Masucci, L.2    Ianiro, G.3    Bibbo, S.4    Dinoi, G.5    Costamagna, G.6
  • 27
    • 84961967639 scopus 로고    scopus 로고
    • Defining the optimal formulation and schedule of a candidate toxoid vaccine against Clostridium difficile infection: A randomized phase 2 clinical trial
    • 5295792
    • De Bruyn G, Saleh J, Workman D, Pollak R, Elinoff V, Fraser NJ, et al. Defining the optimal formulation and schedule of a candidate toxoid vaccine against Clostridium difficile infection: A randomized phase 2 clinical trial. Vaccine 2016;34(19):2170-8. 5295792
    • (2016) Vaccine , vol.34 , Issue.19 , pp. 2170-2178
    • De Bruyn, G.1    Saleh, J.2    Workman, D.3    Pollak, R.4    Elinoff, V.5    Fraser, N.J.6
  • 28
    • 85006164645 scopus 로고    scopus 로고
    • Influence of antibiotics and case exposure on hospital-acquired Clostridium difficile infection independent of illness severity
    • 2016 Oct 14 [Epub ahead of print]
    • Forster AJ, Daneman N, van Walraven C. Influence of antibiotics and case exposure on hospital-acquired Clostridium difficile infection independent of illness severity. Journal of Hospital Infection 2016 Oct 14 [Epub ahead of print]. [DOI: 10.1016/j.jhin.2016.10.007]5295794
    • Journal of Hospital Infection
    • Forster, A.J.1    Daneman, N.2    van Walraven, C.3
  • 29
    • 84960097300 scopus 로고    scopus 로고
    • Susceptibility of Clostridium difficile isolates from a phase 2 clinical trial of cadazolid and vancomycin in C. difficile infection
    • 5295795
    • Gerding DN, Hecht DW, Louie T, Nord CE, Talbot GH, Cornely OA, et al. Susceptibility of Clostridium difficile isolates from a phase 2 clinical trial of cadazolid and vancomycin in C. difficile infection. Journal of Antimicrobial Chemotherapy 2016;71(1):213-9. 5295795
    • (2016) Journal of Antimicrobial Chemotherapy , vol.71 , Issue.1 , pp. 213-219
    • Gerding, D.N.1    Hecht, D.W.2    Louie, T.3    Nord, C.E.4    Talbot, G.H.5    Cornely, O.A.6
  • 30
    • 85031861708 scopus 로고    scopus 로고
    • Cost-effectiveness analysis of fidaxomicin versus oral vancomycin for the treatment of Clostridium difficile infection in Egypt
    • 5295797
    • Hossam M, Elsisi G. Cost-effectiveness analysis of fidaxomicin versus oral vancomycin for the treatment of Clostridium difficile infection in Egypt. Value in Health 2016;19(7):A513. 5295797
    • (2016) Value in Health , vol.19 , Issue.7 , pp. A513
    • Hossam, M.1    Elsisi, G.2
  • 31
    • 0026663447 scopus 로고
    • Treatment of asymptomatic Clostridium difficile carriers (fecal excretors) with vancomycin or metronidazole. A randomized, placebo-controlled trial
    • 5295798
    • Johnson S, Homann SR, Bettin KM, Quick JN, Clabots CR, Peterson LR, et al. Treatment of asymptomatic Clostridium difficile carriers (fecal excretors) with vancomycin or metronidazole. A randomized, placebo-controlled trial. Annals of Internal Medicine 1992;117(4):297-302. 5295798
    • (1992) Annals of Internal Medicine , vol.117 , Issue.4 , pp. 297-302
    • Johnson, S.1    Homann, S.R.2    Bettin, K.M.3    Quick, J.N.4    Clabots, C.R.5    Peterson, L.R.6
  • 32
    • 85014309541 scopus 로고    scopus 로고
    • Does extending Clostridium difficile treatment in patients who are receiving concomitant antibiotics reduce the rate of relapse?
    • 5295800
    • Kaki R, Brooks A, Main C, Jayaratne P, Mertz D. Does extending Clostridium difficile treatment in patients who are receiving concomitant antibiotics reduce the rate of relapse?. Internet Journal of Infectious Diseases 2016;15(1):1-5. 5295800
    • (2016) Internet Journal of Infectious Diseases , vol.15 , Issue.1 , pp. 1-5
    • Kaki, R.1    Brooks, A.2    Main, C.3    Jayaratne, P.4    Mertz, D.5
  • 33
    • 84954543513 scopus 로고    scopus 로고
    • Frozen vs fresh fecal microbiota transplantation and clinical resolution of diarrhea in patients with recurrent Clostridium difficile infection: A randomized clinical trial
    • 5295802
    • Lee CH, Steiner T, Petrof EO, Smieja M, Roscoe D, Nematallah A, et al. Frozen vs fresh fecal microbiota transplantation and clinical resolution of diarrhea in patients with recurrent Clostridium difficile infection: A randomized clinical trial. JAMA 2016;315(2):142-9. 5295802
    • (2016) JAMA , vol.315 , Issue.2 , pp. 142-149
    • Lee, C.H.1    Steiner, T.2    Petrof, E.O.3    Smieja, M.4    Roscoe, D.5    Nematallah, A.6
  • 35
    • 33746656237 scopus 로고    scopus 로고
    • Tolevamer, a novel nonantibiotic polymer, compared with vancomycin in the treatment of mild to moderately severe Clostridium difficile-associated diarrhea
    • 5295805
    • Louie TJ, Peppe J, Watt CK, Johnson D, Mohammed R, Dow G, et al. Tolevamer, a novel nonantibiotic polymer, compared with vancomycin in the treatment of mild to moderately severe Clostridium difficile-associated diarrhea. Clinical Infectious Diseases 2006;43(4):411-20. 5295805
    • (2006) Clinical Infectious Diseases , vol.43 , Issue.4 , pp. 411-420
    • Louie, T.J.1    Peppe, J.2    Watt, C.K.3    Johnson, D.4    Mohammed, R.5    Dow, G.6
  • 37
    • 50549086810 scopus 로고    scopus 로고
    • A randomized, double-blind study comparing Clostridium difficile immune whey and metronidazole for recurrent Clostridium difficile-associated diarrhoea: Efficacy and safety of a prematurely interrupted trial
    • 5295807
    • Mattila E, Anttila VJ, Broas M, Marttila H, Poukka P, Kuusisto K, et al. A randomized, double-blind study comparing Clostridium difficile immune whey and metronidazole for recurrent Clostridium difficile-associated diarrhoea: Efficacy and safety of a prematurely interrupted trial. Scandinavian Journal of Infectious Diseases 2008;40(9):702-8. 5295807
    • (2008) Scandinavian Journal of Infectious Diseases , vol.40 , Issue.9 , pp. 702-708
    • Mattila, E.1    Anttila, V.J.2    Broas, M.3    Marttila, H.4    Poukka, P.5    Kuusisto, K.6
  • 38
    • 0036311186 scopus 로고    scopus 로고
    • Breaking the cycle: treatment strategies for 163 cases of recurrent Clostridium difficile disease
    • 5295808
    • McFarland LV, Elmer GW, Surawicz CM. Breaking the cycle: treatment strategies for 163 cases of recurrent Clostridium difficile disease. American Journal of Gastroenterology 2002;97(7):1769-75. 5295808
    • (2002) American Journal of Gastroenterology , vol.97 , Issue.7 , pp. 1769-1775
    • McFarland, L.V.1    Elmer, G.W.2    Surawicz, C.M.3
  • 39
    • 84995383604 scopus 로고    scopus 로고
    • Outcomes of deflect-1: A multicenter, blinded, randomized clinical trial of fidaxomicin (FDX) vs. placebo (PLC) for prophylaxis of Clostridium difficile-associated diarrhea (CDAD) in subjects undergoing hematopoietic stem cell transplantation (HSCT)
    • 5295810
    • Mullane KM, Adachi J, Dubberke E, Alexander B, Broyde N, Sears P. Outcomes of deflect-1: A multicenter, blinded, randomized clinical trial of fidaxomicin (FDX) vs. placebo (PLC) for prophylaxis of Clostridium difficile-associated diarrhea (CDAD) in subjects undergoing hematopoietic stem cell transplantation (HSCT). Biology of Blood and Marrow Transplantation 2016;22(3 Suppl 1):S171. 5295810
    • (2016) Biology of Blood and Marrow Transplantation , vol.22 , Issue.3 , pp. S171
    • Mullane, K.M.1    Adachi, J.2    Dubberke, E.3    Alexander, B.4    Broyde, N.5    Sears, P.6
  • 40
    • 33748703903 scopus 로고    scopus 로고
    • Frequent emergence of resistance in Clostridium difficile during treatment of C. difficile-associated diarrhea with fusidic acid
    • 5295811
    • Noren T, Wullt M, Akerlund T, Back E, Odenholt I, Burman LG. Frequent emergence of resistance in Clostridium difficile during treatment of C. difficile-associated diarrhea with fusidic acid. Antimicrobial Agents and Chemotherapy 2006;50(9):3028-32. 5295811
    • (2006) Antimicrobial Agents and Chemotherapy , vol.50 , Issue.9 , pp. 3028-3032
    • Noren, T.1    Wullt, M.2    Akerlund, T.3    Back, E.4    Odenholt, I.5    Burman, L.G.6
  • 41
    • 34249813402 scopus 로고    scopus 로고
    • Clostridium difficile-associated diarrhoea: bovine anti-clostridium difficile whey protein to help aid the prevention of relapses
    • 5295812
    • Numan SC, Veldkamp P, Kuijper EJ, van den Berg RJ, van Dissel JT. Clostridium difficile-associated diarrhoea: bovine anti-clostridium difficile whey protein to help aid the prevention of relapses. Gut 2007;56(6):888-9. 5295812
    • (2007) Gut , vol.56 , Issue.6 , pp. 888-889
    • Numan, S.C.1    Veldkamp, P.2    Kuijper, E.J.3    van den Berg, R.J.4    van Dissel, J.T.5
  • 42
    • 84937634872 scopus 로고    scopus 로고
    • Impact of vancomycin faecal concentrations on clinical and microbiological outcomes in Clostridium difficile infection
    • 5295814
    • Thabit AK, Nicolau DP. Impact of vancomycin faecal concentrations on clinical and microbiological outcomes in Clostridium difficile infection. International Journal of Antimicrobial Agents 2015;46(2):205-8. 5295814
    • (2015) International Journal of Antimicrobial Agents , vol.46 , Issue.2 , pp. 205-208
    • Thabit, A.K.1    Nicolau, D.P.2
  • 43
    • 84999018325 scopus 로고    scopus 로고
    • Effect of an antimicrobial stewardship intervention on outcomes for patients with Clostridium difficile infection
    • 5295816
    • Welch HK, Nagel JL, Patel TS, Gandhi TN, Chen B, De Leon J, et al. Effect of an antimicrobial stewardship intervention on outcomes for patients with Clostridium difficile infection. American Journal of Infection Control 2016;44(12):1539-43. 5295816
    • (2016) American Journal of Infection Control , vol.44 , Issue.12 , pp. 1539-1543
    • Welch, H.K.1    Nagel, J.L.2    Patel, T.S.3    Gandhi, T.N.4    Chen, B.5    De Leon, J.6
  • 44
    • 84872956938 scopus 로고    scopus 로고
    • The efficacy and safety of rifaximin vs. vancomycin in the treatment of mild to moderate C. difficile infection: A randomized double-blind active comparator trial
    • 5295817
    • Pardi DS, Brennan R, Spinnell M, Gareca MG, Greenberg E, Tian W, et al. The efficacy and safety of rifaximin vs. vancomycin in the treatment of mild to moderate C. difficile infection: A randomized double-blind active comparator trial. Gastroenterology 2012;142(5 Suppl 1):S599. 5295817
    • (2012) Gastroenterology , vol.142 , Issue.5 , pp. S599
    • Pardi, D.S.1    Brennan, R.2    Spinnell, M.3    Gareca, M.G.4    Greenberg, E.5    Tian, W.6
  • 45
    • 85014393172 scopus 로고    scopus 로고
    • Oral vancomycin plus intravenous metronidazole versus oral vancomycin in severe Clostridium difficile-associated diarrhea: a single center study
    • 5295818
    • Shyh G, Todorov D, Cohen H, Mukhtarzad R, Brooks S. Oral vancomycin plus intravenous metronidazole versus oral vancomycin in severe Clostridium difficile-associated diarrhea: a single center study. Pharmacotherapy 2014;34(10):259-60. 5295818
    • (2014) Pharmacotherapy , vol.34 , Issue.10 , pp. 259-260
    • Shyh, G.1    Todorov, D.2    Cohen, H.3    Mukhtarzad, R.4    Brooks, S.5
  • 46
    • 85014338095 scopus 로고    scopus 로고
    • A multi-center, randomized, double-blind study to compare the efficacy and safety of cadazolid versus vancomycin in subjects with Clostridium difficile-associated diarrhea (CDAD)
    • (accessed 7 November 2013). 5295819
    • NCT01983683 . A multi-center, randomized, double-blind study to compare the efficacy and safety of cadazolid versus vancomycin in subjects with Clostridium difficile-associated diarrhea (CDAD). clinicaltrials.gov/ct2/show/NCT01983683 (accessed 7 November 2013). 5295819
  • 47
    • 85014338095 scopus 로고    scopus 로고
    • A multi-center, randomized, double-blind study to compare the efficacy and safety of cadazolid versus vancomycin in subjects with Clostridium difficile-associated diarrhea (CDAD)
    • (accessed 7 November 2013). 3265093
    • NCT01987895 . A multi-center, randomized, double-blind study to compare the efficacy and safety of cadazolid versus vancomycin in subjects with Clostridium difficile-associated diarrhea (CDAD). clinicaltrials.gov/ct2/show/NCT01987895 (accessed 7 November 2013). 3265093
  • 48
    • 85014362611 scopus 로고    scopus 로고
    • Early diagnosis, prevention and treatment of Clostridium difficile: Update
    • March, 2016
    • Minnesota Evidence-based Practice Center. Early diagnosis, prevention and treatment of Clostridium difficile: Update. AHRQ Publication No. 16-EHC012-EF March, 2016; Vol. #172:1-37.
    • AHRQ Publication No. 16-EHC012-EF , vol.172 , pp. 1-37
  • 49
    • 0034712491 scopus 로고    scopus 로고
    • Subgroup analysis and other (mis)uses of baseline data in clinical trials
    • Assmann SF, Pocock SJ, Enos LE, Kasten LE. Subgroup analysis and other (mis)uses of baseline data in clinical trials. Lancet 2000;355(9209):1064-9.
    • (2000) Lancet , vol.355 , Issue.9209 , pp. 1064-1069
    • Assmann, S.F.1    Pocock, S.J.2    Enos, L.E.3    Kasten, L.E.4
  • 50
    • 84921767408 scopus 로고    scopus 로고
    • Diagnosis and treatment of Clostridium difficile in adults: a systematic review
    • Bagdasarian N, Rao K, Malani PN. Diagnosis and treatment of Clostridium difficile in adults: a systematic review. JAMA 2015;313(4):398-408.
    • (2015) JAMA , vol.313 , Issue.4 , pp. 398-408
    • Bagdasarian, N.1    Rao, K.2    Malani, P.N.3
  • 51
    • 2642514351 scopus 로고    scopus 로고
    • The transitive fallacy for randomized trials: if A bests B and B bests C in separate trials, is A better than C?
    • Baker SG, Kramer BS. The transitive fallacy for randomized trials: if A bests B and B bests C in separate trials, is A better than C?. BMC Medical Research Methodology 2002;2:13.
    • (2002) BMC Medical Research Methodology , vol.2 , pp. 13
    • Baker, S.G.1    Kramer, B.S.2
  • 53
    • 0025093525 scopus 로고
    • Clostridium difficile: clinical considerations
    • Bartlett JG. Clostridium difficile: clinical considerations. Reviews of Infectious Diseases 1990;12 Suppl 2:S243-51.
    • (1990) Reviews of Infectious Diseases , vol.12 , pp. S243-S251
    • Bartlett, J.G.1
  • 54
    • 0037204196 scopus 로고    scopus 로고
    • Clinical practice. Antibiotic-associated diarrhea
    • Bartlett JG. Clinical practice. Antibiotic-associated diarrhea. New England Journal of Medicine 2002;346(5):334-9.
    • (2002) New England Journal of Medicine , vol.346 , Issue.5 , pp. 334-339
    • Bartlett, J.G.1
  • 55
    • 70649107673 scopus 로고    scopus 로고
    • European society of clinical microbiology and infectious diseases (ESCMID): treatment guidance for Clostridium difficile infection (CDI)
    • Bauer MP, Kuijper EJ, van Dissel JT. European society of clinical microbiology and infectious diseases (ESCMID): treatment guidance for Clostridium difficile infection (CDI). Clinical Microbiology and Infection 2009;15(12):1067-79.
    • (2009) Clinical Microbiology and Infection , vol.15 , Issue.12 , pp. 1067-1079
    • Bauer, M.P.1    Kuijper, E.J.2    van Dissel, J.T.3
  • 56
    • 40449138792 scopus 로고    scopus 로고
    • Vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea
    • Bishara J, Wattad M, Paul M. Vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea. Clinical Infectious Diseases 2007;45(12):1646-7.
    • (2007) Clinical Infectious Diseases , vol.45 , Issue.12 , pp. 1646-1647
    • Bishara, J.1    Wattad, M.2    Paul, M.3
  • 57
    • 0019454759 scopus 로고
    • Pseudomembranous enterocolitis: mechanism for restoring floral homeostasis
    • Bowden TA Jr, Mansberger AR Jr, Lykins LE. Pseudomembranous enterocolitis: mechanism for restoring floral homeostasis. American Surgeon 1981;47(4):178-83.
    • (1981) American Surgeon , vol.47 , Issue.4 , pp. 178-183
    • Bowden, T.A.1    Mansberger, A.R.2    Lykins, L.E.3
  • 58
    • 77951026738 scopus 로고    scopus 로고
    • Clinical practice guidelines for clostridium difficile infection in adults: 2010 update for the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA)
    • Cohen SH, Gerding DN, Johnson S, Kelly CP, Loo VG, McDonald LC, et al. Clinical practice guidelines for clostridium difficile infection in adults: 2010 update for the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA). Infection Control and Hospital Epidemiology 2010;31(5):431-55.
    • (2010) Infection Control and Hospital Epidemiology , vol.31 , Issue.5 , pp. 431-455
    • Cohen, S.H.1    Gerding, D.N.2    Johnson, S.3    Kelly, C.P.4    Loo, V.G.5    McDonald, L.C.6
  • 59
    • 84938201869 scopus 로고    scopus 로고
    • A meta-analysis of metronidazole and vancomycin for the treatment of Clostridium difficile infection, stratified by disease severity
    • PUBMED: 26001980]
    • Di X, Bai N, Zhang X, Liu B, Ni W, Wang J, et al. A meta-analysis of metronidazole and vancomycin for the treatment of Clostridium difficile infection, stratified by disease severity. Brazilian Journal of Infectious Diseases 2015;19(4):339-49. [PUBMED: 26001980]
    • (2015) Brazilian Journal of Infectious Diseases , vol.19 , Issue.4 , pp. 339-349
    • Di, X.1    Bai, N.2    Zhang, X.3    Liu, B.4    Ni, W.5    Wang, J.6
  • 61
    • 0027396469 scopus 로고
    • Diagnosis and treatment of Clostridium difficile colitis
    • Fekety R, Shah AB. Diagnosis and treatment of Clostridium difficile colitis. JAMA 1993;269(1):71-5.
    • (1993) JAMA , vol.269 , Issue.1 , pp. 71-75
    • Fekety, R.1    Shah, A.B.2
  • 62
    • 0030969261 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and management of Clostridium difficile-associated diarrhea and colitis
    • Fekety R. Guidelines for the diagnosis and management of Clostridium difficile-associated diarrhea and colitis. American Journal of Gastroenterology 1997;92(5):739-50.
    • (1997) American Journal of Gastroenterology , vol.92 , Issue.5 , pp. 739-750
    • Fekety, R.1
  • 63
    • 36549021534 scopus 로고    scopus 로고
    • Non-inferiority trials are unethical because they disregard patients' interests
    • Garattini S, Bertele V. Non-inferiority trials are unethical because they disregard patients' interests. Lancet 2007;370:1875-6.
    • (2007) Lancet , vol.370 , pp. 1875-1876
    • Garattini, S.1    Bertele, V.2
  • 64
    • 0019949758 scopus 로고
    • Clostridium difficile and its cytotoxin in feces of patients with antimicrobial agent-associated diarrhea and miscellaneous conditions
    • George WL, Rolfe RD, Finegold SM. Clostridium difficile and its cytotoxin in feces of patients with antimicrobial agent-associated diarrhea and miscellaneous conditions. Journal of Clinical Microbiology 1982;15(6):1049-53.
    • (1982) Journal of Clinical Microbiology , vol.15 , Issue.6 , pp. 1049-1053
    • George, W.L.1    Rolfe, R.D.2    Finegold, S.M.3
  • 66
    • 33644815619 scopus 로고    scopus 로고
    • Lessons from and cautions about noninferiority and equivalence randomized trials
    • Gotzsche P. Lessons from and cautions about noninferiority and equivalence randomized trials. JAMA 2006;295(10):1172-4.
    • (2006) JAMA , vol.295 , Issue.10 , pp. 1172-1174
    • Gotzsche, P.1
  • 68
    • 85014374599 scopus 로고    scopus 로고
    • Teicoplanin
    • Johns Hopkins. Teicoplanin. www.hopkins-abxguide.org/antibiotics/antibacterial/glycopeptide/teicoplanin.html?contentInstanceId=254836 2009.
    • (2009)
    • Johns, H.1
  • 69
    • 71549173774 scopus 로고    scopus 로고
    • Clostridium difficile infection: How to deal with the problem
    • (accessed 26 January 2017)
    • Health Protection Agency of the Department of Health, UK . Clostridium difficile infection: How to deal with the problem. www.gov.uk/government/uploads/system/uploads/attachment_data/file/340851/Clostridium_difficile_infection_how_to_deal_with_the_problem.pdf (accessed 26 January 2017).
  • 70
    • 85014403957 scopus 로고    scopus 로고
    • Deaths involving Clostridium difficile or MRSA, Wales: 2015
    • (accessed 26 January 2017)
    • Health Protection Agency. Deaths involving Clostridium difficile or MRSA, Wales: 2015. www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths/bulletins/deathsinvolvingclostridiumdifficilewales/2015 (accessed 26 January 2017).
  • 71
    • 84864378893 scopus 로고    scopus 로고
    • Sustained clinical response as an endpoint in treatment trials of Clostridium difficile-associated diarrhea
    • Johnson S, Gerding DN, Louie TJ, Ruiz NM, Gorbach SL. Sustained clinical response as an endpoint in treatment trials of Clostridium difficile-associated diarrhea. Antimicrobial Agents and Chemotherapy 2012;56(8):4043-5.
    • (2012) Antimicrobial Agents and Chemotherapy , vol.56 , Issue.8 , pp. 4043-4045
    • Johnson, S.1    Gerding, D.N.2    Louie, T.J.3    Ruiz, N.M.4    Gorbach, S.L.5
  • 72
    • 77953809436 scopus 로고    scopus 로고
    • A review of mortality due to Clostridium difficile infection
    • Karas JA, Enoch DA, Aliyu SH. A review of mortality due to Clostridium difficile infection. Journal of Infection 2010;61(1):1-8.
    • (2010) Journal of Infection , vol.61 , Issue.1 , pp. 1-8
    • Karas, J.A.1    Enoch, D.A.2    Aliyu, S.H.3
  • 74
    • 77951700268 scopus 로고    scopus 로고
    • Changes in the composition of the human fecal microbiome after bacteriotherapy for recurrent Clostridium difficile-associated diarrhea
    • Khoruts A, Dicksved J, Jansson JK, Sadowsky MJ. Changes in the composition of the human fecal microbiome after bacteriotherapy for recurrent Clostridium difficile-associated diarrhea. Journal of Clinical Gastroenterology 2010;44(5):354-60.
    • (2010) Journal of Clinical Gastroenterology , vol.44 , Issue.5 , pp. 354-360
    • Khoruts, A.1    Dicksved, J.2    Jansson, J.K.3    Sadowsky, M.J.4
  • 75
    • 85014397501 scopus 로고    scopus 로고
    • Deaths from "dirty hospital bug" double in five years
    • 26 May, 2006:
    • Laurence J. Deaths from "dirty hospital bug" double in five years. The Independant 26 May, 2006:11.
    • The Independant , pp. 11
    • Laurence, J.1
  • 77
    • 84893515123 scopus 로고    scopus 로고
    • Investigations of the mode of action and resistance development of cadazolid, a new antibiotic for treatment of Clostridium difficile infections
    • Locher HH, Caspers P, Bruyere T, Schroeder S, Pfaff P, Knezevic A, et al. Investigations of the mode of action and resistance development of cadazolid, a new antibiotic for treatment of Clostridium difficile infections. Antimicrobial Agents and Chemotherapy 2014;58(2):901-8.
    • (2014) Antimicrobial Agents and Chemotherapy , vol.58 , Issue.2 , pp. 901-908
    • Locher, H.H.1    Caspers, P.2    Bruyere, T.3    Schroeder, S.4    Pfaff, P.5    Knezevic, A.6
  • 78
    • 27544468303 scopus 로고    scopus 로고
    • How should we respond to the highly toxogenic NAP1/ribotype 027 strain of Clostridium difficile?
    • Louie TJ. How should we respond to the highly toxogenic NAP1/ribotype 027 strain of Clostridium difficile?. Canadian Medical Association Journal 2005;173(9):1049-50.
    • (2005) Canadian Medical Association Journal , vol.173 , Issue.9 , pp. 1049-1050
    • Louie, T.J.1
  • 82
    • 77951608360 scopus 로고    scopus 로고
    • The relationship between inpatient fluoroquinolone use and Clostridium difficile-associated diarrhea
    • Novell MJ, Morreale CA. The relationship between inpatient fluoroquinolone use and Clostridium difficile-associated diarrhea. Annals of Pharmacotherapy 2010;44(5):826-31.
    • (2010) Annals of Pharmacotherapy , vol.44 , Issue.5 , pp. 826-831
    • Novell, M.J.1    Morreale, C.A.2
  • 83
    • 27544511378 scopus 로고    scopus 로고
    • Mortality attributable to nosocomial Clostridium difficile-associated disease during an epidemic caused by a hypervirulent strain in Quebec
    • Pepin J, Valiquette L, Cossette B. Mortality attributable to nosocomial Clostridium difficile-associated disease during an epidemic caused by a hypervirulent strain in Quebec. Canadian Medical Association Journal 2005;173(9):1037-42.
    • (2005) Canadian Medical Association Journal , vol.173 , Issue.9 , pp. 1037-1042
    • Pepin, J.1    Valiquette, L.2    Cossette, B.3
  • 84
    • 0025967193 scopus 로고
    • Prosepctive study of Clostridium difficile intestinal colonization and disease following single-dose antibiotic prophylaxis in surgery
    • Privitera G, Scarpellini P, Ortisi G, Nicastro G, Nicolin R, de Lalla F. Prosepctive study of Clostridium difficile intestinal colonization and disease following single-dose antibiotic prophylaxis in surgery. Antimicrobial Agents and Chemotherapy 1991;35(1):208-10.
    • (1991) Antimicrobial Agents and Chemotherapy , vol.35 , Issue.1 , pp. 208-210
    • Privitera, G.1    Scarpellini, P.2    Ortisi, G.3    Nicastro, G.4    Nicolin, R.5    de Lalla, F.6
  • 85
    • 34848836638 scopus 로고    scopus 로고
    • Increase in Clostridium difficile-related mortality rates, United States, 1999-2004
    • Redelings MD, Sorvillo F, Mascola L. Increase in Clostridium difficile-related mortality rates, United States, 1999-2004. Emerging Infectious Diseases 2007;13(9):1417-9.
    • (2007) Emerging Infectious Diseases , vol.13 , Issue.9 , pp. 1417-1419
    • Redelings, M.D.1    Sorvillo, F.2    Mascola, L.3
  • 87
    • 84908144445 scopus 로고    scopus 로고
    • Multiple hypothesis testing and Bonferroni's correction
    • Sedgwick P. Multiple hypothesis testing and Bonferroni's correction. BMJ (Clinical research ed.) 2014;349:g6284.
    • (2014) BMJ (Clinical research ed.) , vol.349
    • Sedgwick, P.1
  • 88
    • 78649775786 scopus 로고    scopus 로고
    • Efficacy of experimental treatments compared with standard treatments in non-inferiority trials: a meta-analysis of randomized controlled trials.
    • Soonawala D, Middelberg RA, Egger M, Vandenbroucke JP, Dekkers OM. Efficacy of experimental treatments compared with standard treatments in non-inferiority trials: a meta-analysis of randomized controlled trials.. International Journal of Epidemiology 2010;39(6):1567-81.
    • (2010) International Journal of Epidemiology , vol.39 , Issue.6 , pp. 1567-1581
    • Soonawala, D.1    Middelberg, R.A.2    Egger, M.3    Vandenbroucke, J.P.4    Dekkers, O.M.5
  • 89
    • 20244383137 scopus 로고    scopus 로고
    • Clostridium difficile toxoid vaccine in recurrent C. difficile-associated diarrhea
    • Sougioultzis S, Kyne L, Drudy D, Keates S, Maroo S, Pothoulakis C, et al. Clostridium difficile toxoid vaccine in recurrent C. difficile-associated diarrhea. Gastroenterology 2005;128(3):764-70.
    • (2005) Gastroenterology , vol.128 , Issue.3 , pp. 764-770
    • Sougioultzis, S.1    Kyne, L.2    Drudy, D.3    Keates, S.4    Maroo, S.5    Pothoulakis, C.6
  • 90
    • 85014412614 scopus 로고    scopus 로고
    • HCUP projections: Clostridium difficile hospitalizations
    • Steiner C, Barrett M, Sun Y. HCUP projections: Clostridium difficile hospitalizations. HCUP Projections Report 2015;02:1-12.
    • (2015) HCUP Projections Report , vol.2 , pp. 1-12
    • Steiner, C.1    Barrett, M.2    Sun, Y.3
  • 91
    • 84880996085 scopus 로고    scopus 로고
    • Is colectomy for fulminant Clostridium difficile colitis life saving? A systematic review
    • Stewart DB, Hollenbeak CS, Wilson MZ. Is colectomy for fulminant Clostridium difficile colitis life saving? A systematic review. Colorectal Disease 2013;15(7):798-804.
    • (2013) Colorectal Disease , vol.15 , Issue.7 , pp. 798-804
    • Stewart, D.B.1    Hollenbeak, C.S.2    Wilson, M.Z.3
  • 92
    • 0038648403 scopus 로고    scopus 로고
    • Antibiotics and hospital-acquired Clostridium difficile-associated diarrhoea: a systematic review
    • Thomas C, Stevenson M, Riley TV. Antibiotics and hospital-acquired Clostridium difficile-associated diarrhoea: a systematic review. Journal of Antimicrobial Chemotherapy 2003;51(6):1339-50.
    • (2003) Journal of Antimicrobial Chemotherapy , vol.51 , Issue.6 , pp. 1339-1350
    • Thomas, C.1    Stevenson, M.2    Riley, T.V.3
  • 94
    • 84861884807 scopus 로고    scopus 로고
    • Treatment failure and recurrence of Clostridium difficile infection following treatment with vancomycin or metronidazole: a systematic review of the evidence
    • Vardakas KZ, Polyzos KA, Patouni K, Rafailidis PI, Samonis G, Falagas ME. Treatment failure and recurrence of Clostridium difficile infection following treatment with vancomycin or metronidazole: a systematic review of the evidence. International Journal of Antimicrobial Agents 2012;40(1):1-8.
    • (2012) International Journal of Antimicrobial Agents , vol.40 , Issue.1 , pp. 1-8
    • Vardakas, K.Z.1    Polyzos, K.A.2    Patouni, K.3    Rafailidis, P.I.4    Samonis, G.5    Falagas, M.E.6
  • 96
    • 85014323548 scopus 로고    scopus 로고
    • Antibiotic treatment for Clostridium difficile-associated diarrhea in adults
    • Nelson R. Antibiotic treatment for Clostridium difficile-associated diarrhea in adults. Cochrane Database of Systematic Reviews 2007, Issue 3. [DOI: 10.1002/14651858.CD004610.pub3]
    • (2007) Cochrane Database of Systematic Reviews , Issue.3
    • Nelson, R.1


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