A novel cytoprotective peptide protects mesenchymal stem cells against mitochondrial dysfunction and apoptosis induced by starvation via Nrf2/Sirt3/FoxO3a pathway

Journal of Translational Medicine

Volumn 15, Issue 1, 2017, Pages

  Wang, Shuo ^a,b   Zhang, Chao ^a,b   Niyazi, Sidikejiang ^a,b   Zheng, Long ^a,b   Li, Jiawei ^a,b   Zhang, Weitao ^a,b   Xu, Ming ^a,b   Rong, Ruiming ^a,b   Yang, Cheng ^a,b   Zhu, Tongyu ^a,b  

^a FUDAN UNIVERSITY   (China)

^b Shanghai Key Laboratory of Organ Transplantation   (China)

Author keywords

Cyclic helix B peptide; FoxO3a; Mesenchymal stem cell; Nrf2; Sirt3; Starvation

Indexed keywords

CHOLECYSTOKININ OCTAPEPTIDE; CYCLIC HELIX B PEPTIDE; CYTOCHROME C; ERYTHROPOIETIN; LIPOCORTIN 5; POLYPEPTIDE; REACTIVE OXYGEN METABOLITE; SIRTUIN 3; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR FKHRL1; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; FOXO3 PROTEIN, MOUSE; NFE2L2 PROTEIN, MOUSE; PEPTIDE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ASSAY; CELL DIFFERENTIATION; CELL PROTECTION; CELL SELF-RENEWAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVATION; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; MESENCHYMAL STEM CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; STAINING; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CELL SURVIVAL; CYTOLOGY; DRUG EFFECTS; MESENCHYMAL STROMA CELL; METABOLISM; MITOCHONDRION; SERUM-FREE MEDIUM;

ANIMALS; APOPTOSIS; CELL SELF RENEWAL; CELL SURVIVAL; CULTURE MEDIA, SERUM-FREE; CYTOPROTECTION; FORKHEAD BOX PROTEIN O3; MESENCHYMAL STROMAL CELLS; MICE, INBRED C57BL; MITOCHONDRIA; NF-E2-RELATED FACTOR 2; PEPTIDES; SIGNAL TRANSDUCTION; SIRTUIN 3;

EID: 85014318894     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/s12967-017-1144-5     Document Type: Article

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