메뉴 건너뛰기




Volumn 37, Issue 8, 2017, Pages 1249-1255

Expanding the therapeutic options for renal involvement in lupus: eculizumab, available evidence

Author keywords

Antiphospholipid antibodies; Complement; Eculizumab; Lupus nephritis; Systemic lupus erythematosus

Indexed keywords

COMPLEMENT; ECULIZUMAB; MONOCLONAL ANTIBODY; URINARY TRACT AGENT;

EID: 85014182080     PISSN: 01728172     EISSN: 1437160X     Source Type: Journal    
DOI: 10.1007/s00296-017-3686-5     Document Type: Review
Times cited : (63)

References (43)
  • 1
    • 84962553077 scopus 로고    scopus 로고
    • The key culprit in the pathogenesis of systemic lupus erythematosus: aberrant DNA methylation
    • COI: 1:CAS:528:DC%2BC28XktFKhtL4%3D, PID: 26970492
    • Wu H, Zhao M, Tan L, Lu Q (2016) The key culprit in the pathogenesis of systemic lupus erythematosus: aberrant DNA methylation. Autoimmun Rev 15:684–689. doi:10.1016/j.autrev.2016.03.002
    • (2016) Autoimmun Rev , vol.15 , pp. 684-689
    • Wu, H.1    Zhao, M.2    Tan, L.3    Lu, Q.4
  • 2
    • 0035555161 scopus 로고    scopus 로고
    • Systemic lupus erythematosus: an autoimmune disease of B cell hyperactivity
    • COI: 1:CAS:528:DC%2BD3MXmsFeju7s%3D, PID: 11526379
    • Lipsky PE (2001) Systemic lupus erythematosus: an autoimmune disease of B cell hyperactivity. Nat Immunol 2:764–766. doi:10.1038/ni0901-764
    • (2001) Nat Immunol , vol.2 , pp. 764-766
    • Lipsky, P.E.1
  • 3
    • 84901001162 scopus 로고    scopus 로고
    • The pathology of T cells in systemic lupus erythematosus
    • PID: 24864268
    • Mak A, Kow NY (2014) The pathology of T cells in systemic lupus erythematosus. J Immunol Res 2014:419029. doi:10.1155/2014/419029
    • (2014) J Immunol Res , vol.2014 , pp. 419029
    • Mak, A.1    Kow, N.Y.2
  • 4
    • 84992525877 scopus 로고    scopus 로고
    • Pitfalls in lupus
    • PID: 27491566
    • Schneider M (2016) Pitfalls in lupus. Autoimmun Rev. doi:10.1016/j.autrev.2016.07.033
    • (2016) Autoimmun Rev
    • Schneider, M.1
  • 5
    • 0142009533 scopus 로고    scopus 로고
    • Development of autoantibodies before the clinical onset of systemic lupus erythematosus
    • COI: 1:CAS:528:DC%2BD3sXotFGhsrY%3D, PID: 14561795
    • Arbuckle MR, McClain MT, Rubertone MV, Scofield RH, Dennis GJ, James JA et al (2003) Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N Engl J Med 349:1526–1533. doi:10.1056/NEJMoa021933
    • (2003) N Engl J Med , vol.349 , pp. 1526-1533
    • Arbuckle, M.R.1    McClain, M.T.2    Rubertone, M.V.3    Scofield, R.H.4    Dennis, G.J.5    James, J.A.6
  • 6
    • 84956733713 scopus 로고    scopus 로고
    • Anti-DNA antibodies—quintessential biomarkers of SLE
    • PID: 26581343
    • Pisetsky DS (2015) Anti-DNA antibodies—quintessential biomarkers of SLE. Nat Rev Rheumatol 12:102–110. doi:10.1038/nrrheum.2015.151
    • (2015) Nat Rev Rheumatol , vol.12 , pp. 102-110
    • Pisetsky, D.S.1
  • 7
    • 84955215319 scopus 로고    scopus 로고
    • Systemic lupus erythematosus and atherosclerosis: review of the literature
    • COI: 1:CAS:528:DC%2BC2MXhsVOqtbvJ, PID: 26299985
    • Frieri M, Stampfl H (2016) Systemic lupus erythematosus and atherosclerosis: review of the literature. Autoimmun Rev 15:16–21. doi:10.1016/j.autrev.2015.08.007
    • (2016) Autoimmun Rev , vol.15 , pp. 16-21
    • Frieri, M.1    Stampfl, H.2
  • 8
    • 84869876940 scopus 로고    scopus 로고
    • Complement, interferon and lupus
    • COI: 1:CAS:528:DC%2BC38Xhtl2gtbrL, PID: 22999705
    • Elkon KB, Santer DM (2012) Complement, interferon and lupus. Curr Opin Immunol 24:665–670. doi:10.1016/j.coi.2012.08.004
    • (2012) Curr Opin Immunol , vol.24 , pp. 665-670
    • Elkon, K.B.1    Santer, D.M.2
  • 9
    • 0034119062 scopus 로고    scopus 로고
    • A protective role for innate immunity in autoimmune disease
    • COI: 1:CAS:528:DC%2BD3cXjt1Kjt70%3D, PID: 10729235
    • Carroll MC (2000) A protective role for innate immunity in autoimmune disease. Clin Immunol 95:S30–S38. doi:10.1006/clim.1999.4813
    • (2000) Clin Immunol , vol.95 , pp. S30-S38
    • Carroll, M.C.1
  • 10
    • 0034891226 scopus 로고    scopus 로고
    • Contribution of the innate immune system to autoimmune myocarditis: a role for complement
    • COI: 1:CAS:528:DC%2BD3MXlslKis7Y%3D, PID: 11477411
    • Kaya Z, Afanasyeva M, Wang Y, Dohmen KM, Schlichting J, Tretter T et al (2001) Contribution of the innate immune system to autoimmune myocarditis: a role for complement. Nat Immunol 2:739–745. doi:10.1038/90686
    • (2001) Nat Immunol , vol.2 , pp. 739-745
    • Kaya, Z.1    Afanasyeva, M.2    Wang, Y.3    Dohmen, K.M.4    Schlichting, J.5    Tretter, T.6
  • 11
    • 0037103222 scopus 로고    scopus 로고
    • Mice deficient in complement receptors 1 and 2 lack a tissue injury-inducing subset of the natural antibody repertoire
    • COI: 1:CAS:528:DC%2BD38XmtFejtrc%3D, PID: 12165541
    • Fleming SD, Shea-Donohue T, Guthridge JM, Kulik L, Waldschmidt TJ, Gipson MG et al (2002) Mice deficient in complement receptors 1 and 2 lack a tissue injury-inducing subset of the natural antibody repertoire. J Immunol 169:2126–2133
    • (2002) J Immunol , vol.169 , pp. 2126-2133
    • Fleming, S.D.1    Shea-Donohue, T.2    Guthridge, J.M.3    Kulik, L.4    Waldschmidt, T.J.5    Gipson, M.G.6
  • 12
    • 0033990632 scopus 로고    scopus 로고
    • The role of complement in B cell activation and tolerance
    • COI: 1:CAS:528:DC%2BD3cXivVehu7g%3D, PID: 10605604
    • Carroll MC (2000) The role of complement in B cell activation and tolerance. Adv Immunol 74:61–88
    • (2000) Adv Immunol , vol.74 , pp. 61-88
    • Carroll, M.C.1
  • 13
    • 84881389562 scopus 로고    scopus 로고
    • Targeting the complement system in systemic lupus erythematosus and other diseases
    • COI: 1:CAS:528:DC%2BC3sXmsFCmt7Y%3D, PID: 23623037
    • Barilla-LaBarca ML, Toder K, Furie R (2013) Targeting the complement system in systemic lupus erythematosus and other diseases. Clin Immunol 148:313–321. doi:10.1016/j.clim.2013.02.014
    • (2013) Clin Immunol , vol.148 , pp. 313-321
    • Barilla-LaBarca, M.L.1    Toder, K.2    Furie, R.3
  • 14
    • 0029764359 scopus 로고    scopus 로고
    • Amelioration of lupus-like autoimmune disease in NZB/WF1 mice after treatment with a blocking monoclonal antibody specific for complement component C5
    • COI: 1:CAS:528:DyaK28XkvFyktLg%3D, PID: 8710910
    • Wang Y, Hu Q, Madri JA, Rollins SA, Chodera A, Matis LA (1996) Amelioration of lupus-like autoimmune disease in NZB/WF1 mice after treatment with a blocking monoclonal antibody specific for complement component C5. Proc Natl Acad Sci USA 93:8563–8568
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 8563-8568
    • Wang, Y.1    Hu, Q.2    Madri, J.A.3    Rollins, S.A.4    Chodera, A.5    Matis, L.A.6
  • 15
    • 84864820680 scopus 로고    scopus 로고
    • Monogenic forms of systemic lupus erythematosus: new insights into SLE pathogenesis
    • PID: 22883345
    • Belot A, Cimaz R (2012) Monogenic forms of systemic lupus erythematosus: new insights into SLE pathogenesis. Pediatr Rheumatol Online J 10:21. doi:10.1186/1546-0096-10-21
    • (2012) Pediatr Rheumatol Online J , vol.10 , pp. 21
    • Belot, A.1    Cimaz, R.2
  • 16
    • 29144433522 scopus 로고    scopus 로고
    • The mannose-binding lectin gene polymorphisms and systemic lupus erythematosus: two case-control studies and a meta-analysis
    • COI: 1:CAS:528:DC%2BD28XjvF2htw%3D%3D, PID: 16320344
    • Lee YH, Witte T, Momot T, Schmidt RE, Kaufman KM, Harley JB et al (2005) The mannose-binding lectin gene polymorphisms and systemic lupus erythematosus: two case-control studies and a meta-analysis. Arthritis Rheum 52:3966–3974. doi:10.1002/art.21484
    • (2005) Arthritis Rheum , vol.52 , pp. 3966-3974
    • Lee, Y.H.1    Witte, T.2    Momot, T.3    Schmidt, R.E.4    Kaufman, K.M.5    Harley, J.B.6
  • 17
    • 84855765646 scopus 로고    scopus 로고
    • Mutations in genes encoding complement inhibitors CD46 and CFH affect the age at nephritis onset in patients with systemic lupus erythematosus
    • PID: 22171659
    • Jönsen A, Nilsson SC, Ahlqvist E, Svenungsson E, Gunnarsson I, Eriksson KG et al (2011) Mutations in genes encoding complement inhibitors CD46 and CFH affect the age at nephritis onset in patients with systemic lupus erythematosus. Arthritis Res Ther 13:R206. doi:10.1186/ar3539
    • (2011) Arthritis Res Ther , vol.13 , pp. R206
    • Jönsen, A.1    Nilsson, S.C.2    Ahlqvist, E.3    Svenungsson, E.4    Gunnarsson, I.5    Eriksson, K.G.6
  • 18
    • 10744228553 scopus 로고    scopus 로고
    • Effect of eculizumab on hemolysis and transfusion requirements in patients with paroxysmal nocturnal hemoglobinuria
    • COI: 1:CAS:528:DC%2BD2cXhtVGhtbY%3D, PID: 14762182
    • Hillmen P, Hall C, Marsh JCW, Elebute M, Bombara MP, Petro BE et al (2004) Effect of eculizumab on hemolysis and transfusion requirements in patients with paroxysmal nocturnal hemoglobinuria. N Engl J Med 350:552–559. doi:10.1056/NEJMoa031688
    • (2004) N Engl J Med , vol.350 , pp. 552-559
    • Hillmen, P.1    Hall, C.2    Marsh, J.C.W.3    Elebute, M.4    Bombara, M.P.5    Petro, B.E.6
  • 19
    • 84878589219 scopus 로고    scopus 로고
    • Terminal complement inhibitor eculizumab in atypical hemolytic-uremic syndrome
    • COI: 1:CAS:528:DC%2BC3sXpt1Oqu7k%3D, PID: 23738544
    • Legendre CM, Licht C, Muus P, Greenbaum LA, Babu S, Bedrosian C et al (2013) Terminal complement inhibitor eculizumab in atypical hemolytic-uremic syndrome. N Engl J Med 368:2169–2181. doi:10.1056/NEJMoa1208981
    • (2013) N Engl J Med , vol.368 , pp. 2169-2181
    • Legendre, C.M.1    Licht, C.2    Muus, P.3    Greenbaum, L.A.4    Babu, S.5    Bedrosian, C.6
  • 21
    • 84907170949 scopus 로고    scopus 로고
    • Targeting complement system to treat myasthenia gravis
    • COI: 1:CAS:528:DC%2BC2cXhtlaktL7N, PID: 24731953
    • Huda R, Tüzün E, Christadoss P (2014) Targeting complement system to treat myasthenia gravis. Rev Neurosci 25:575–583. doi:10.1515/revneuro-2014-0021
    • (2014) Rev Neurosci , vol.25 , pp. 575-583
    • Huda, R.1    Tüzün, E.2    Christadoss, P.3
  • 23
    • 84951812559 scopus 로고    scopus 로고
    • Treatment of neuromyelitis optica spectrum disorder: acute, preventive, and symptomatic
    • PID: 26705758
    • Kessler RA, Mealy MA, Levy M (2016) Treatment of neuromyelitis optica spectrum disorder: acute, preventive, and symptomatic. Curr Treat Options Neurol 18:2. doi:10.1007/s11940-015-0387-9
    • (2016) Curr Treat Options Neurol , vol.18 , pp. 2
    • Kessler, R.A.1    Mealy, M.A.2    Levy, M.3
  • 24
    • 84969764300 scopus 로고    scopus 로고
    • Eculizumab as a bridge to immunosuppressive therapy in severe cold agglutinin disease of anti-Pr specificity
    • Shapiro R, Chin-Yee I, Lam S (2015) Eculizumab as a bridge to immunosuppressive therapy in severe cold agglutinin disease of anti-Pr specificity. Clin Case Reports 3:942–944. doi:10.1002/ccr3.399
    • (2015) Clin Case Reports , vol.3 , pp. 942-944
    • Shapiro, R.1    Chin-Yee, I.2    Lam, S.3
  • 25
    • 84901316827 scopus 로고    scopus 로고
    • Role of monoclonal antibodies in the treatment of immune-mediated glomerular diseases
    • Manrique J, Cravedi P (2014) Role of monoclonal antibodies in the treatment of immune-mediated glomerular diseases. Nefrol Publicación Of La Soc Española Nefrol 34:388–397. doi:10.3265/Nefrologia.pre2014.Feb.12506
    • (2014) Nefrol Publicación Of La Soc Española Nefrol , vol.34 , pp. 388-397
    • Manrique, J.1    Cravedi, P.2
  • 26
    • 77951853702 scopus 로고    scopus 로고
    • Eculizumab and renal transplantation in a patient with CAPS
    • COI: 1:CAS:528:DC%2BC3cXls1yksbg%3D, PID: 20445191
    • Lonze BE, Singer AL, Montgomery RA (2010) Eculizumab and renal transplantation in a patient with CAPS. N Engl J Med 362:1744–1745. doi:10.1056/NEJMc0910965
    • (2010) N Engl J Med , vol.362 , pp. 1744-1745
    • Lonze, B.E.1    Singer, A.L.2    Montgomery, R.A.3
  • 27
    • 84858661698 scopus 로고    scopus 로고
    • Eculizumab for the treatment of dense-deposit disease
    • COI: 1:CAS:528:DC%2BC38XktlCqtbY%3D, PID: 22435383
    • Vivarelli M, Pasini A, Emma F (2012) Eculizumab for the treatment of dense-deposit disease. N Engl J Med 366:1163–1165. doi:10.1056/NEJMc1111953
    • (2012) N Engl J Med , vol.366 , pp. 1163-1165
    • Vivarelli, M.1    Pasini, A.2    Emma, F.3
  • 28
    • 84987877226 scopus 로고    scopus 로고
    • Eculizumab therapy for chronic antibody-mediated injury in kidney transplant recipients: a pilot, randomized-controlled trial
    • Kulkarni S, Kirkiles-Smith NC, Deng YH, Formica RN, Moeckel G, Broecker V et al (2016) Eculizumab therapy for chronic antibody-mediated injury in kidney transplant recipients: a pilot, randomized-controlled trial. Am J Transplant. doi:10.1111/ajt.14001
    • (2016) Am J Transplant
    • Kulkarni, S.1    Kirkiles-Smith, N.C.2    Deng, Y.H.3    Formica, R.N.4    Moeckel, G.5    Broecker, V.6
  • 29
    • 84920942686 scopus 로고    scopus 로고
    • Dramatic effects of eculizumab in a child with diffuse proliferative lupus nephritis resistant to conventional therapy
    • PID: 25173358
    • Coppo R, Peruzzi L, Amore A, Martino S, Vergano L, Lastauka I et al (2015) Dramatic effects of eculizumab in a child with diffuse proliferative lupus nephritis resistant to conventional therapy. Pediatr Nephrol 30:167–172. doi:10.1007/s00467-014-2944-y
    • (2015) Pediatr Nephrol , vol.30 , pp. 167-172
    • Coppo, R.1    Peruzzi, L.2    Amore, A.3    Martino, S.4    Vergano, L.5    Lastauka, I.6
  • 30
    • 84922373286 scopus 로고    scopus 로고
    • Thrombotic microangiopathy in systemic lupus erythematosus: efficacy of eculizumab
    • PID: 25446020
    • El-Husseini A, Hannan S, Awad A, Jennings S, Cornea V, Sawaya BP (2014) Thrombotic microangiopathy in systemic lupus erythematosus: efficacy of eculizumab. Am J Kidney Dis 65:127–130. doi:10.1053/j.ajkd.2014.07.031
    • (2014) Am J Kidney Dis , vol.65 , pp. 127-130
    • El-Husseini, A.1    Hannan, S.2    Awad, A.3    Jennings, S.4    Cornea, V.5    Sawaya, B.P.6
  • 31
    • 85026252381 scopus 로고    scopus 로고
    • Complement inhibition in the treatment of SLE-associated thrombotic thrombocytopenic purpura
    • Boneparth A, Moorthy LN, Weiss L, Rajasekhar H, Murphy S, Drachtman RA (2015) Complement inhibition in the treatment of SLE-associated thrombotic thrombocytopenic purpura. Glob Pediatr Heal 2:2015–2017. doi:10.1177/2333794X15570150
    • (2015) Glob Pediatr Heal , vol.2 , pp. 2015-2017
    • Boneparth, A.1    Moorthy, L.N.2    Weiss, L.3    Rajasekhar, H.4    Murphy, S.5    Drachtman, R.A.6
  • 32
    • 84857190406 scopus 로고    scopus 로고
    • Eculizumab in acute recurrence of thrombotic microangiopathy after renal transplantation
    • COI: 1:CAS:528:DC%2BC3MXhsFCmtLvM, PID: 21831149
    • Hadaya K, Ferrari-Lacraz S, Fumeaux D, Boehlen F, Toso C, Moll S et al (2011) Eculizumab in acute recurrence of thrombotic microangiopathy after renal transplantation. Am J Transplant 11:2523–2527. doi:10.1111/j.1600-6143.2011.03696.x
    • (2011) Am J Transplant , vol.11 , pp. 2523-2527
    • Hadaya, K.1    Ferrari-Lacraz, S.2    Fumeaux, D.3    Boehlen, F.4    Toso, C.5    Moll, S.6
  • 33
    • 84917728306 scopus 로고    scopus 로고
    • Efficacy of eculizumab in a patient with immunoadsorption-dependent catastrophic antiphospholipid syndrome: a case report
    • COI: 1:CAS:528:DC%2BC2cXitVKrsbnL
    • Kronbichler A, Frank R, Kirschfink M, Szilágyi Á, Csuka D, Prohászka Z et al (2014) Efficacy of eculizumab in a patient with immunoadsorption-dependent catastrophic antiphospholipid syndrome: a case report. Medicine (Baltimore) 93:e143. doi:10.1097/MD.0000000000000143
    • (2014) Medicine (Baltimore) , vol.93
    • Kronbichler, A.1    Frank, R.2    Kirschfink, M.3    Szilágyi, S.4    Csuka, D.5    Prohászka, Z.6
  • 35
    • 54949120973 scopus 로고    scopus 로고
    • Antiphospholipid syndrome (APS) nephropathy in catastrophic, primary, and systemic lupus erythematosus-related APS
    • COI: 1:CAS:528:DC%2BD1cXhtlWit7nE, PID: 18688914
    • Tektonidou MG, Sotsiou F, Moutsopoulos HM (2008) Antiphospholipid syndrome (APS) nephropathy in catastrophic, primary, and systemic lupus erythematosus-related APS. J Rheumatol 35:1983–1988
    • (2008) J Rheumatol , vol.35 , pp. 1983-1988
    • Tektonidou, M.G.1    Sotsiou, F.2    Moutsopoulos, H.M.3
  • 36
    • 4043055247 scopus 로고    scopus 로고
    • Antiphospholipid syndrome nephropathy in patients with systemic lupus erythematosus and antiphospholipid antibodies: prevalence, clinical associations, and long-term outcome
    • PID: 15334471
    • Tektonidou MG, Sotsiou F, Nakopoulou L, Vlachoyiannopoulos PG, Moutsopoulos HM (2004) Antiphospholipid syndrome nephropathy in patients with systemic lupus erythematosus and antiphospholipid antibodies: prevalence, clinical associations, and long-term outcome. Arthritis Rheum 50:2569–2579. doi:10.1002/art.20433
    • (2004) Arthritis Rheum , vol.50 , pp. 2569-2579
    • Tektonidou, M.G.1    Sotsiou, F.2    Nakopoulou, L.3    Vlachoyiannopoulos, P.G.4    Moutsopoulos, H.M.5
  • 37
    • 84881372189 scopus 로고    scopus 로고
    • Eculizumab improves posttransplant thrombotic microangiopathy due to antiphospholipid syndrome recurrence but fails to prevent chronic vascular changes
    • COI: 1:CAS:528:DC%2BC3sXhsVersb%2FO, PID: 23763583
    • Canaud G, Kamar N, Anglicheau D, Esposito L, Rabant M, Noël L-H et al (2013) Eculizumab improves posttransplant thrombotic microangiopathy due to antiphospholipid syndrome recurrence but fails to prevent chronic vascular changes. Am J Transplant 13:2179–2185. doi:10.1111/ajt.12319
    • (2013) Am J Transplant , vol.13 , pp. 2179-2185
    • Canaud, G.1    Kamar, N.2    Anglicheau, D.3    Esposito, L.4    Rabant, M.5    Noël, L.-H.6
  • 38
    • 85047689070 scopus 로고    scopus 로고
    • Renal involvement in antiphospholipid syndrome
    • COI: 1:CAS:528:DC%2BC2cXkvVGlt70%3D, PID: 24642799
    • Sciascia S, Cuadrado MJ, Khamashta M, Roccatello D (2014) Renal involvement in antiphospholipid syndrome. Nat Rev Nephrol 10:279–289. doi:10.1038/nrneph.2014.38
    • (2014) Nat Rev Nephrol , vol.10 , pp. 279-289
    • Sciascia, S.1    Cuadrado, M.J.2    Khamashta, M.3    Roccatello, D.4
  • 39
    • 84957624267 scopus 로고    scopus 로고
    • Pregnancy outcomes of patients with paroxysmal nocturnal hemoglobinuria treated with eculizumab: a Japanese experience and updated review
    • COI: 1:CAS:528:DC%2BC28XivVSlsrs%3D, PID: 26857155
    • Miyasaka N, Miura O, Kawaguchi T, Arima N, Morishita E, Usuki K et al (2016) Pregnancy outcomes of patients with paroxysmal nocturnal hemoglobinuria treated with eculizumab: a Japanese experience and updated review. Int J Hematol 103:703–712. doi:10.1007/s12185-016-1946-x
    • (2016) Int J Hematol , vol.103 , pp. 703-712
    • Miyasaka, N.1    Miura, O.2    Kawaguchi, T.3    Arima, N.4    Morishita, E.5    Usuki, K.6
  • 40
    • 84941219993 scopus 로고    scopus 로고
    • Eculizumab in pregnancy-associated atypical hemolytic uremic syndrome: insights for optimizing management
    • De Sousa Amorim E, Blasco M, Quintana L, Sole M, de Cordoba SR, Campistol JM (2015) Eculizumab in pregnancy-associated atypical hemolytic uremic syndrome: insights for optimizing management. J Nephrol 28:641–645. doi:10.1007/s40620-015-0173-5
    • (2015) J Nephrol , vol.28 , pp. 641-645
    • De Sousa, A.E.1    Blasco, M.2    Quintana, L.3    Sole, M.4    de Cordoba, S.R.5    Campistol, J.M.6
  • 41
    • 84961620932 scopus 로고    scopus 로고
    • Antiphospholipid Syndrome and the Kidney
    • COI: 1:CAS:528:DC%2BC2MXhslKlu7nP, PID: 26573550
    • Sciascia S, Baldovino S, Schreiber K, Solfietti L, Roccatello D (2015) Antiphospholipid Syndrome and the Kidney. Semin Nephrol 35:478–486. doi:10.1016/j.semnephrol.2015.08.009
    • (2015) Semin Nephrol , vol.35 , pp. 478-486
    • Sciascia, S.1    Baldovino, S.2    Schreiber, K.3    Solfietti, L.4    Roccatello, D.5
  • 42
    • 84978426202 scopus 로고    scopus 로고
    • Maternal outcome in pregnant women with lupus nephritis. A prospective multicenter study
    • PID: 27373903
    • Moroni G, Doria A, Giglio E et al (2016) Maternal outcome in pregnant women with lupus nephritis. A prospective multicenter study. J Autoimmun 74:194–200. doi:10.1016/j.jaut.2016.06.012
    • (2016) J Autoimmun , vol.74 , pp. 194-200
    • Moroni, G.1    Doria, A.2    Giglio, E.3
  • 43
    • 85026257019 scopus 로고    scopus 로고
    • A single dose, placebocontrolled, double blind, phase I study of the humanized anti-C5 antibody h5G1.1 in patients with systemic lupus erythematosus
    • Furie R, Matis L, Rollins S et al (2004) A single dose, placebocontrolled, double blind, phase I study of the humanized anti-C5 antibody h5G1.1 in patients with systemic lupus erythematosus. Arthritis Rheum 50:S35–S747
    • (2004) Arthritis Rheum , vol.50 , pp. S35-S747
    • Furie, R.1    Matis, L.2    Rollins, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.