Membrane cholesterol is essential for triterpenoid saponin augmentation of a saporin-based immunotoxin directed against CD19 on human lymphoma cells

Biochimica et Biophysica Acta - Biomembranes

Volumn 1859, Issue 5, 2017, Pages 993-1007

  Smith, Wendy S ^a   Baker, Ella J ^a,b   Holmes, Suzanne E ^a   Koster, Grielof ^b   Hunt, Alan N ^b   Johnston, David A ^b   Flavell, Sopsamorn U ^a   Flavell, David J ^a  

^a SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

Antibody; Cholesterol; Flow cytometry; Mass spectrometry (MS); Phospholipid; Saponin

Indexed keywords

CD19 ANTIGEN; CHOLESTEROL; FLUORESCENT DYE; IMMUNOTOXIN; SAPONIN; SYNTHECOL; UNCLASSIFIED DRUG; CD19 MOLECULE, HUMAN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEMBRANE LIPID; RIBOSOME INACTIVATING PROTEIN 1; SAPORIN; TRITERPENE;

ANALYTICAL PARAMETERS; ARTICLE; CELL LEVEL; CELL MEMBRANE; CHOLESTEROL CONTENT; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; CYTOTOXICITY; DAUDI CELL LINE; DRUG MECHANISM; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; HUMAN CELL; LIPOPHILICITY; LYMPHOMA CELL; LYSIS; SENSITIVITY ANALYSIS; CHEMISTRY; IMMUNOLOGY; LYMPHOMA; PHYSIOLOGY; TUMOR CELL LINE;

ANTIGENS, CD19; CELL LINE, TUMOR; CHOLESTEROL, LDL; HUMANS; IMMUNOTOXINS; LYMPHOMA; MEMBRANE LIPIDS; RIBOSOME INACTIVATING PROTEINS, TYPE 1; SAPONINS; TRITERPENES;

EID: 85014058434     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2017.02.013     Document Type: Article

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