Influence of endosome-destabilizing peptides on efficacy of anti-HIV immunotoxins

Bioconjugate Chemistry

Volumn 8, Issue 1, 1997, Pages 38-43

  Tolstikov, Vladimir V ^a   Cole, Robert ^a   Fang, Hua ^a   Pincus, Seth H ^a,b  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b MONTANA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOLOGY; DISEASES; SULFUR COMPOUNDS; VIRUSES;

AMPHIPATHIC; AMPHIPATHIC PEPTIDES; ANTI-HIV; ANTIGEN BINDING; BAFILOMYCIN; BINDING CHARACTERISTICS; ENDOSOMAL MEMBRANE; ENDOSOMES; IMMUNOTOXINS; INFLUENZA VIRUS;

PEPTIDES;

ANIMALIA; CAVIA PORCELLUS; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; INFLUENZA VIRUS; ORYCTOLAGUS CUNICULUS; SUS SCROFA;

EID: 0031055663     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc9600729     Document Type: Article

References (20)

1. van Oosterhout, Y. V., Preijers, F. W., Wessels, H. M., and de-Witte, T. (1992) Cytotoxicity of CD3-ricin A chain immunotoxins in relation to cellular uptake and degradation kinetics. Cancer Res. 52, 5921-5925.
2. Goldenberg, D. M. (1993) Monoclonal antibodies in cancer detection and therapy. Am. J. Med. 94, 297-312.
3. Pincus, S. H., McClure, J., and Fang, H. (1994) Use of anti-HIV immunotoxins as probes of the biology of HIV-infected cells. Can. J. Infect. Dis. 5 (Suppl. A), 23A-27A.
4. Wagner, E., Plank, C., Zatloukal, K., Cotten, M., and Birnstiel, M. L. (1992) Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle. Proc. Natl. Acad. Sci. U.S.A. 89, 7934-7938.
5. Plank, C., Oberhauser, B., Mechtler, K., Koch, C., and Wagner, E. (1994) The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems. J. Biol. Chem. 269, 12918-12924.
6. Bongartz, J.-P., Aubertin, A.-M., Milhaud, P. G., and Lebleu, B. (1994) Improved biological activity of antisense oligonucleotides conjugated to a fusogenic peptide. Nucleic Acids Res. 22, 4681-4688.
7. Pincus, S. H., Cole, R. L., Hersh, E. M., Lake, D., Masuho, Y., Durda, P. J., and McClure, J. (1991) In vitro efficacy of anti-HIV immunotoxins targeted by various antibodies to the envelope protein. J. Immunol. 146, 4315-4324.
8. Pincus, S. H., and McClure, J. (1993) Soluble CD4 enhances the efficacy of immunotoxins directed against gp41 of the human immunodeficiency virus. Proc. Natl. Acad. Sci. U.S.A. 90, 332-336.
9. Pincus, S. H., and Tolstikov, V. V. (1995) Anti-human immunodeficiency virus immunoconjugates. Adv. Pharmacol. 32, 205-242.
10. Berger, E. A., Clouse, K. A., Chaudhary, V. K., Chakrabarti, S., FitzGerald, D. J., Pastan, I., and Moss, B. (1989) CD4-Pseudomonas exotoxin hybrid protein blocks the spread of human immunodeficiency virus infection in vitro and is active against cells expressing the envelope glycoproteins from diverse primate immunodeficiency retroviruses. Proc. Natl. Acad. Sci. U.S.A. 86, 9539-9543.
11. Pincus, S. H., Stocks, Jr., C. J., and Ewing, L. P. (1982) Monoclonal anti-(T,G)-A-L antibodies: characterization of fine specificity and idiotype expression. Mol. Immunol. 19, 1551-1559.
12. Fulton, R. J., Uhr, J. W., and Vitetta, E. S. (1986) The effect of antibody valency and lysosomotropic amines on the synergy between ricin A chain- and ricin B chain-containing immuntoxins. J. Immunol. 136, 3103-3109.
13. Pincus, S. H., Wehrly, K., and Chesebro, B. (1989) Treatment of HIV tissue culture infection with monoclonal antibody-ricin A chain conjugates. J. Immunol. 142, 3070-3075.
14. Carlsson, J., Drevin, H., and Axen, R. (1978) Protein thiolation and reversible protein-protein conjugation. Biochem. J. 173, 723-737.
15. Knowles, P. P., and Thorpe, P. E. (1987) Purification of immunotoxins containing ricin A-chain and abrin A-chain using blue sepharose CL-6B. Anal. Biochem. 160, 440-443.
16. Chaudhary, V. K., Mizukami, T., Fuerst, T. R., FitzGerald, D. J., Moss, B., Pastan, I., and Berger, E. A. (1988) Selective killing of HIV-infected cells by recombinant human CD4-Pseudomonas exotoxin hybrid protein. Nature 335, 369-372.
17. Pincus, S. H., Messer, K. G., Schwartz, D. H., Lewis, G. K., Graham, B. S., Blattner, W. A., and Fisher, G. (1993) Differences in the antibody response to human immunodeficiency virus-1 envelope glycoprotein (gp160) in infected laboratory workers and vaccinees. J. Clin. Invest. 91, 1987-1996.
18. Adachi, A., Gendelman, H. E., Koenig, S., Folks, T., Willey, R., Rabson, A., and Martin, M. A. (1986) Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone. J. Virol. 59, 284-291.
19. Pincus, S. H., and Wehrly, K. (1990) AZT demonstrates anti-HIV-1 activity in persistently infected cell lines: implications for combination chemotherapy and immunotherapy. J. Infect. Dis. 162, 1233-1238.
20. Chignola, R., Anselmi, C., Dalla Serra, M., Franceschi, A., Fracasso, G., Pasti, M., Chiesa, E., Lord, J. M., Tridente, G., and Colombatti, M. (1995) Self-potentiation of ligand-toxin conjugates containing ricin A chain fused with viral structures. J. Biol. Chem. 270, 23345-23351.