Saponins modulate the intracellular trafficking of protein toxins

Journal of Controlled Release

Volumn 164, Issue 1, 2012, Pages 74-86

  Weng, Alexander ^a   Thakur, Mayank ^b   Von Mallinckrodt, Benedicta ^a   Beceren Braun, Figen ^a   Gilabert Oriol, Roger ^a   Wiesner, Burkard ^c   Eichhorst, Jenny ^c   Böttger, Stefan ^b   Melzig, Matthias F ^b   Fuchs, Hendrik ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c Leibnitz Institut fuer molekulare Pharmakologie FMP   (Germany)

Author keywords

Modulation of trafficking; Saponins; Type I RIPs

Indexed keywords

ANTI-TUMORS; BINDING ANALYSIS; CELLULAR COMPARTMENTS; CYTOSOLIC; CYTOSOLS; IN-VIVO; INTRACELLULAR COMPARTMENTS; INTRACELLULAR TRAFFICKING; LATE ENDOSOMES; PH-DEPENDENT; PROTEIN TOXINS; RIBOSOME-INACTIVATING PROTEIN; SAPONINS; SAPORIN; TUMOR CELLS; TUMOR MODELS; TYPE I RIPS;

CELL MEMBRANES; TOXIC MATERIALS; TUMORS;

METABOLITES;

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; SA 1641; SA 1657; SAPONIN; SAPORIN; TOXIN; UNCLASSIFIED DRUG;

ACIDIFICATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL COMPARTMENTALIZATION; CELL MEMBRANE; CONTROLLED STUDY; CYTOSOL; DRUG CYTOTOXICITY; DRUG RELEASE; ENDOSOME; IN VIVO STUDY; INTRACELLULAR TRANSPORT; LYSOSOME; MEDICINAL PLANT; MOUSE; NONHUMAN; PH; PRIORITY JOURNAL; SAPONARIA OFFICINALIS; TUMOR MODEL;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE; CELL SURVIVAL; CELL TRACKING; CYTOSOL; DRUG CARRIERS; ENDOCYTOSIS; EPIDERMAL GROWTH FACTOR; HUMANS; HYDROGEN-ION CONCENTRATION; MICE; MICE, INBRED BALB C; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEIN TRANSPORT; RIBOSOME INACTIVATING PROTEINS, TYPE 1; SAPONINS; SINGLE-CELL ANALYSIS; SURFACE PLASMON RESONANCE; TISSUE DISTRIBUTION; TOXICITY TESTS, ACUTE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84868460015     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.10.002     Document Type: Article

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