Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

Journal of Medicinal Chemistry

Volumn 60, Issue 4, 2017, Pages 1247-1261

  Harris, Philip A ^a   Berger, Scott B ^a   Jeong, Jae U ^a   Nagilla, Rakesh ^a   Bandyopadhyay, Deepak ^a   Campobasso, Nino ^a   Capriotti, Carol A ^a   Cox, Julie A ^a   Dare, Lauren ^a   Dong, Xiaoyang ^a   Eidam, Patrick M ^a   Finger, Joshua N ^a   Hoffman, Sandra J ^a   Kang, James ^a   Kasparcova, Viera ^a   King, Bryan W ^a   Lehr, Ruth ^a   Lan, Yunfeng ^a   Leister, Lara K ^a   Lich, John D ^a   MacDonald, Thomas T ^b   Miller, Nathan A ^a   Ouellette, Michael T ^a   Pao, Christina S ^a   Rahman, Attiq ^a   Reilly, Michael A ^a   Rendina, Alan R ^a   Rivera, Elizabeth J ^a   Schaeffer, Michelle C ^a   Sehon, Clark A ^a   Singhaus, Robert R ^a   Sun, Helen H ^a   Swift, Barbara A ^a   Totoritis, Rachel D ^a   Vossenkämper, Anna ^a   Ward, Paris ^b   Wisnoski, David D ^a   Zhang, Daohua ^a   Marquis, Robert W ^a   Gough, Peter J ^a   Bertin, John ^a   more..

^a GLAXOSMITHKLINE   (United States)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5 BENZYL N (5 METHYL 4 OXO 2,3,4,5 TETRAHYDROBENZO[B][1,4]OXAZEPIN 3 YL) 1H 1,2,4 TRIAZOLE 3 CARBOXAMIDE; ANTIINFLAMMATORY AGENT; DIBENZOXAZEPINE DERIVATIVE; INTERLEUKIN 1BETA; INTERLEUKIN 6; PHOSPHOTRANSFERASE; PREDNISOLONE; RECEPTOR INTERACTING PROTEIN 1; RECEPTOR INTERACTING PROTEIN 1 KINASE INHIBITOR; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; BENZAZEPINE DERIVATIVE; CYTOKINE; PROTEIN KINASE INHIBITOR; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RIPK1 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOKINE PRODUCTION; DNA LIBRARY; DRUG POTENCY; DRUG PROTEIN BINDING; ENZYME SPECIFICITY; EXPLANT; HUMAN; HUMAN CELL; HUMAN TISSUE; IC50; INFLAMMATION; INFLAMMATORY DISEASE; NECROPTOSIS; NONHUMAN; PHYSICOCHEMICAL MODEL; STRUCTURE ACTIVITY RELATION; ULCERATIVE COLITIS; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; COLITIS, ULCERATIVE; DOG; HAPLORHINI; IMMUNOLOGY; MINIPIG; MOLECULAR DOCKING; MOUSE; PIG; RABBITS AND HARES; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BENZAZEPINES; COLITIS, ULCERATIVE; CYTOKINES; DOGS; HAPLORHINI; HUMANS; INFLAMMATION; MICE; MOLECULAR DOCKING SIMULATION; PROTEIN KINASE INHIBITORS; RABBITS; RATS; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; SWINE; SWINE, MINIATURE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 85013762798     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.6b01751     Document Type: Article

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