The ins and outs of selective kinase inhibitor development

Nature Chemical Biology

Volumn 11, Issue 11, 2015, Pages 818-821

  Müller, Susanne ^a   Chaikuad, Apirat ^a   Gray, Nathanael S ^b   Knapp, Stefan ^a,c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b HARVARD MEDICAL SCHOOL   (United States)

^c GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMINO ACID; IBRUTINIB; PHOSPHOTRANSFERASE INHIBITOR; THREONINE; MOLECULAR LIBRARY; PROTEIN KINASE; PROTEIN KINASE INHIBITOR;

AMINO ACID SEQUENCE; BINDING KINETICS; CATALYSIS; DRUG BINDING SITE; DRUG EFFICACY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME CONFORMATION; HYDROPHOBICITY; NOTE; PRIORITY JOURNAL; BINDING SITE; CHEMISTRY; DRUG APPROVAL; DRUG DESIGN; DRUG DEVELOPMENT; FOOD AND DRUG ADMINISTRATION; HUMAN; MOLECULAR LIBRARY; PROTEIN CONFORMATION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SYNTHESIS; UNITED STATES; X RAY CRYSTALLOGRAPHY;

ALLOSTERIC SITE; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DRUG APPROVAL; DRUG DESIGN; DRUG DISCOVERY; HUMANS; PROTEIN CONFORMATION; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SMALL MOLECULE LIBRARIES; UNITED STATES; UNITED STATES FOOD AND DRUG ADMINISTRATION;

EID: 84945245264     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.1938     Document Type: Note

References (25)

1. Knighton, D.R. et al. Science 253, 414-420 (1991).
2. Fedorov, O., Muller, S. & Knapp, S. Nat. Chem. Biol. 6, 166-169 (2010).
3. Knapp, S. & Sundstrom, M. Curr. Opin. Pharmacol. 17, 58-63 (2014).
4. Yang, J. et al. Chem. Biol. 18, 177-186 (2011).
5. Fabian, M.A. et al. Nat. Biotechnol. 23, 329-336 (2005).
6. Bantscheff, M. et al. Nat. Biotechnol. 25, 1035-1044 (2007).
7. Davis, M.I. et al. Nat. Biotechnol. 29, 1046-1051 (2011).
8. Zhao, Z. et al. ACS Chem. Biol. 9, 1230-1241 (2014).
9. Debreczeni, J.E. et al. Angew. Chem. Int. Edn. Engl. 45, 1580-1585 (2006).
10. Koeberle, S.C. et al. Nat. Chem. Biol. 8, 141-143 (2012).
11. Gammons, M.V. et al. Invest. Ophthalmol. Vis. Sci. 54, 6052-6062 (2013).
12. Liu, Q. et al. Chem. Biol. 20, 146-159 (2013).
13. Woyach, J.A. et al. N. Engl. J. Med. 370, 2286-2294 (2014).
14. Schindler, T. et al. Science 289, 1938-1942 (2000).
15. Pike, A.C. et al. EMBO J. 27, 704-714 (2008).
16. Hill, Z.B., Perera, B.G., Andrews, S.S. & Maly, D.J. ACS Chem. Biol. 7, 487-495 (2012).
17. Axten, J.M. et al. J. Med. Chem. 55, 7193-7207 (2012).
18. Wood, E.R. et al. Cancer Res. 64, 6652-6659 (2004).
19. Di Paolo, J.A. et al. Nat. Chem. Biol. 7, 41-50 (2011).
20. Guimarães, C.R. et al. J. Chem. Inf. Model. 51, 1199-1204 (2011).
21. Chaikuad, A. et al. Nat. Chem. Biol. 10, 853-860 (2014).
22. Zhang, J. et al. Nature 463, 501-506 (2010).
23. Hindie, V. et al. Nat. Chem. Biol. 5, 758-764 (2009).
24. Yap, T.A. et al. J. Clin. Oncol. 29, 4688-4695 (2011).
25. Ciceri, P. et al. Nat. Chem. Biol. 10, 305-312 (2014).