Stereoelectronic effects dictate molecular conformation and biological function of heterocyclic amides

Journal of the American Chemical Society

Volumn 136, Issue 34, 2014, Pages 11914-11917

  Reid, Robert C ^a   Yau, Mei Kwan ^a   Singh, Ranee ^a,b   Lim, Junxian ^a   Fairlie, David P ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b KHON KAEN UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

CALCULATIONS; PROTEINS;

BIOLOGICAL FUNCTIONS; BIOLOGICAL PROPERTIES; ELECTROSTATIC SURFACES; G PROTEIN COUPLED RECEPTORS; LOW-ENERGY CONFORMATIONS; MOLECULAR CONFORMATION; PROTEIN COMPLEMENT; STEREOELECTRONIC EFFECT;

AMIDES;

AMIDE; COMPLEMENT COMPONENT C3A; G PROTEIN COUPLED RECEPTOR; HETEROCYCLIC AMIDE; IMIDAZOLE DERIVATIVE; NITROGEN; SULFUR; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; CALCIUM; HETEROCYCLIC COMPOUND; IMIDAZOLE; THIAZOLE;

AGONIST; ARTICLE; BIOLOGICAL ACTIVITY; BIOLOGICAL FUNCTIONS; CHEMICAL ANALYSIS; CONFORMATION; CRYSTAL STRUCTURE; DENSITY FUNCTIONAL THEORY; DICTATE MOLECULAR CCONFORMATION; DIPOLE; ELECTRIC ACTIVITY; HUMAN; HUMAN CELL; HYDROGEN BOND; MACROPHAGE; MATHEMATICAL MODEL; STATIC ELECTRICITY; STEREOCHEMISTRY; STEREOELECTRONIC EFFECT; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; ELECTROCHEMISTRY; METABOLISM; STEREOISOMERISM; AB INITIO CALCULATION; DRUG CONFORMATION; DRUG STRUCTURE; SURFACE PROPERTY;

AMIDES; CALCIUM; CELLS, CULTURED; ELECTROCHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMANS; IMIDAZOLES; MACROPHAGES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; STEREOISOMERISM; THIAZOLES;

EID: 84906739760     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja506518t     Document Type: Article

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