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Volumn 48, Issue 3, 2017, Pages 307-312

Effects of Levosimendan on Cellular Metabolic Alterations in Patients with Septic Shock: A Randomized Controlled Pilot Study

Author keywords

Levosimendan; metabolism; microcirculation; microdialysis; septic shock

Indexed keywords

BICARBONATE; DOBUTAMINE; GLUCOSE; GLYCEROL; HEMOGLOBIN; LACTIC ACID; LEVOSIMENDAN; PYRUVIC ACID; HYDRAZONE DERIVATIVE; PYRIDAZINE DERIVATIVE; SIMENDAN;

EID: 85013748741     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0000000000000851     Document Type: Article
Times cited : (27)

References (31)
  • 1
    • 84883076264 scopus 로고    scopus 로고
    • Severe sepsis and septic shock
    • Angus DC, van der Poll T: Severe sepsis and septic shock. N Engl J Med 369(9):840-851, 2013.
    • (2013) N Engl J Med , vol.369 , Issue.9 , pp. 840-851
    • Angus, D.C.1    Van Der Poll, T.2
  • 2
    • 0034958947 scopus 로고    scopus 로고
    • Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
    • Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR: Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 29(7):1303-1310, 2001.
    • (2001) Crit Care Med , vol.29 , Issue.7 , pp. 1303-1310
    • Angus, D.C.1    Linde-Zwirble, W.T.2    Lidicker, J.3    Clermont, G.4    Carcillo, J.5    Pinsky, M.R.6
  • 4
    • 62749206780 scopus 로고    scopus 로고
    • Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis
    • Trzeciak S, McCoy JV, Phillip Dellinger R, Arnold RC, Rizzuto M, Abate NL: Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis. Intensive Care Med 34(12):2210-2217, 2008.
    • (2008) Intensive Care Med , vol.34 , Issue.12 , pp. 2210-2217
    • Trzeciak, S.1    McCoy, J.V.2    Phillip, D.R.3    Arnold, R.C.4    Rizzuto, M.5    Abate, N.L.6
  • 6
    • 84992660038 scopus 로고    scopus 로고
    • Levosimendan for the prevention of acute organ dysfunction in sepsis
    • Gordon AC, Perkins GD, Singer M: Levosimendan for the prevention of acute organ dysfunction in sepsis. N Engl J Med 375(17):1638-1648, 2016.
    • (2016) N Engl J Med , vol.375 , Issue.17 , pp. 1638-1648
    • Gordon, A.C.1    Perkins, G.D.2    Singer, M.3
  • 7
    • 84980320215 scopus 로고    scopus 로고
    • Levosimendan beyond inotropy and acute heart failure: Evidence of pleiotropic effects on the heart and other organs: AN expert panel position paper
    • Farmakis D, Alvarez J, Gal TB, Brito D, Fedele F, Fonseca C, Gordon AC, Gotsman I, Grossini E, Guarracino F, et al.: Levosimendan beyond inotropy and acute heart failure: evidence of pleiotropic effects on the heart and other organs: an expert panel position paper. Int J Cardiol 222:303-312, 2016.
    • (2016) J Cardiol , vol.222 , pp. 303-312
    • Farmakis, D.1    Alvarez, J.2    Gal, T.B.3    Brito, D.4    Fedele, F.5    Fonseca, C.6    Gordon, A.C.7    Gotsman, I.8    Grossini, E.9    Guarracino, F.10
  • 8
    • 0025994730 scopus 로고
    • Microdialysis-principles and applications for studies in animals and man
    • Ungerstedt U: Microdialysis-principles and applications for studies in animals and man. J Intern Med 230(4):365-373, 1991.
    • (1991) J Intern Med , vol.230 , Issue.4 , pp. 365-373
    • Ungerstedt, U.1
  • 9
    • 84892155179 scopus 로고    scopus 로고
    • Elevated adipose tissue lactate to pyruvate (L/P) ratio predicts poor outcome in critically ill patients with septic shock: A microdialysis study
    • Nikitas N, Kopterides P, Ilias I, Theodorakopoulou M, Vassiliadi DA, Armaganidis A: Elevated adipose tissue lactate to pyruvate (L/P) ratio predicts poor outcome in critically ill patients with septic shock: a microdialysis study. Minerva Anestesiol 79(11):1229-1237, 2013.
    • (2013) Minerva Anestesiol , vol.79 , Issue.11 , pp. 1229-1237
    • Nikitas, N.1    Kopterides, P.2    Ilias, I.3    Theodorakopoulou, M.4    Vassiliadi, D.A.5    Armaganidis, A.6
  • 11
    • 72549083779 scopus 로고    scopus 로고
    • Urea clearance: A new method to register local changes in blood flow in rat skeletal muscle based on microdialysis
    • Farnebo S, Samuelsson A, Henriksson J, Karlander L-E, Sjoberg F: Urea clearance: a new method to register local changes in blood flow in rat skeletal muscle based on microdialysis. Clin Physiol Funct Imaging 30(1):57-63, 2010.
    • (2010) Clin Physiol Funct Imaging , vol.30 , Issue.1 , pp. 57-63
    • Farnebo, S.1    Samuelsson, A.2    Henriksson, J.3    Karlander, L.-E.4    Sjoberg, F.5
  • 12
    • 77957559964 scopus 로고    scopus 로고
    • Increased muscle-to-serum lactate gradient predicts progression towards septic shock in septic patients
    • Levy B, Perez P, Gibot S, Gerard A: Increased muscle-to-serum lactate gradient predicts progression towards septic shock in septic patients. Intensive Care Med 36(10):1703-1709, 2010.
    • (2010) Intensive Care Med , vol.36 , Issue.10 , pp. 1703-1709
    • Levy, B.1    Perez, P.2    Gibot, S.3    Gerard, A.4
  • 13
    • 3042682565 scopus 로고    scopus 로고
    • Microdialysis in neurointensive care
    • Ungerstedt U, Rostami E: Microdialysis in neurointensive care. Curr Pharm 10(18):2145-2152, 2004.
    • (2004) Curr Pharm , vol.10 , Issue.18 , pp. 2145-2152
    • Ungerstedt, U.1    Rostami, E.2
  • 14
    • 84876854073 scopus 로고    scopus 로고
    • Lactate clearance for death prediction in severe sepsis or septic shock patients during the first 24 hours in Intensive Care Unit: An observational study
    • Marty P, Roquilly A, Vallée F, Luzi A, Ferré F, Fourcade O: Lactate clearance for death prediction in severe sepsis or septic shock patients during the first 24 hours in Intensive Care Unit: an observational study. Ann Intensive Care 3(1):3-7, 2013.
    • (2013) Ann Intensive Care , vol.3 , Issue.1 , pp. 3-7
    • Marty, P.1    Roquilly, A.2    Vallée, F.3    Luzi, A.4    Ferré, F.5    Fourcade, O.6
  • 15
    • 84855802430 scopus 로고    scopus 로고
    • Tissue gas tension and tissue metabolites for detection of organ hypoperfusion and ischemia
    • Waelgaard L, Dahl BM, Kvarstein G, Tonnessen T: Tissue gas tension and tissue metabolites for detection of organ hypoperfusion and ischemia. Acta Anaesthesiol Scand; 2012;(2):200-209, 2012.
    • (2012) Acta Anaesthesiol Scand , vol.2012 , Issue.2 , pp. 200-209
    • Waelgaard, L.1    Dahl, B.M.2    Kvarstein, G.3    Tonnessen, T.4
  • 16
    • 21044443575 scopus 로고    scopus 로고
    • Effects of levosimendan on systemic and regional hemodynamics in septic myocardial depression
    • Morelli A, De Castro S, Teboul J-L, Singer M, Rocco M, Conti G: Effects of levosimendan on systemic and regional hemodynamics in septic myocardial depression. Intensive Care Med 31(5):638-644, 2005.
    • (2005) Intensive Care Med , vol.31 , Issue.5 , pp. 638-644
    • Morelli, A.1    De Castro, S.2    Teboul, J.-L.3    Singer, M.4    Rocco, M.5    Conti, G.6
  • 17
    • 84861199740 scopus 로고    scopus 로고
    • The effects of levosimendan vs dobutamine added to dopamine on liver functions assessed with noninvasive liver function monitoring in patients with septic shock
    • Memiş D, Inal MT, Sut N: The effects of levosimendan vs dobutamine added to dopamine on liver functions assessed with noninvasive liver function monitoring in patients with septic shock. J Crit Care 27(3):318.e1-6, 2012.
    • (2012) J Crit Care , vol.27 , Issue.3 , pp. 318e1-3186
    • Memiş, D.1    Inal, M.T.2    Sut, N.3
  • 18
    • 33747456675 scopus 로고    scopus 로고
    • Effects of levosimendan on right ventricular afterload in patients with acute respiratory distress syndrome: A pilot study
    • Morelli A, Teboul J-L, Maggiore SM, Vieillard-Baron A, Rocco M, Conti G: Effects of levosimendan on right ventricular afterload in patients with acute respiratory distress syndrome: a pilot study. Crit CareMed 34(9):2287-2293, 2006.
    • (2006) Crit CareMed , vol.34 , Issue.9 , pp. 2287-2293
    • Morelli, A.1    Teboul, J.-L.2    Maggiore, S.M.3    Vieillard-Baron, A.4    Rocco, M.5    Conti, G.6
  • 19
    • 0037324056 scopus 로고    scopus 로고
    • Impaired mitochondrial function induced by serum from septic shock patients is attenuated by inhibition of nitric oxide synthase and poly(ADP-ribose) synthase
    • Boulos M, Astiz ME, Barua RS, Osman M: Impaired mitochondrial function induced by serum from septic shock patients is attenuated by inhibition of nitric oxide synthase and poly(ADP-ribose) synthase. Crit Care Med 31(2):353-358, 2003.
    • (2003) Crit Care Med , vol.31 , Issue.2 , pp. 353-358
    • Boulos, M.1    Astiz, M.E.2    Barua, R.S.3    Osman, M.4
  • 20
    • 79960189784 scopus 로고    scopus 로고
    • Levosimendan inhibits release of reactive oxygen species in polymorphonuclear leukocytes in vitro and in patients with acute heart failure and septic shock: A prospective observational study
    • Hasslacher J, Bijuklic K, Bertocchi C,Kountchev J,Bellmann R, Dunzendorfer S: Levosimendan inhibits release of reactive oxygen species in polymorphonuclear leukocytes in vitro and in patients with acute heart failure and septic shock: a prospective observational study. Crit Care Lond Engl 15(4):R166, 2011.
    • (2011) Crit Care Lond Engl , vol.15 , Issue.4 , pp. R166
    • Hasslacher, J.1    Bijuklic, K.2    Bertocchi, C.3    Kountchev, J.4    Bellmann, R.5    Dunzendorfer, S.6
  • 21
    • 84901811172 scopus 로고    scopus 로고
    • Effects of levosimendan on mitochondrial function in patients with septic shock: A randomized trial
    • Torraco A, Carrozzo R, Piemonte F, Pastore A, Tozzi G, Verrigni D: Effects of levosimendan on mitochondrial function in patients with septic shock: a randomized trial. Biochimie 102(1):166-173, 2014.
    • (2014) Biochimie , vol.102 , Issue.1 , pp. 166-173
    • Torraco, A.1    Carrozzo, R.2    Piemonte, F.3    Pastore, A.4    Tozzi, G.5    Verrigni, D.6
  • 22
    • 9244258916 scopus 로고    scopus 로고
    • Interstitial muscle lactate, pyruvate and potassium dynamics in the trapezius muscle during repetitive low-force arm movements, measured with microdialysis
    • Rosendal L, Blangsted AK, Kristiansen J, Sogaard K, Langberg H, Sjogaard G, Kjaer M: Interstitial muscle lactate, pyruvate and potassium dynamics in the trapezius muscle during repetitive low-force arm movements, measured with microdialysis. Acta Physiol Scand 182(4):379-388, 2004.
    • (2004) Acta Physiol Scand , vol.182 , Issue.4 , pp. 379-388
    • Rosendal, L.1    Blangsted, A.K.2    Kristiansen, J.3    Sogaard, K.4    Langberg, H.5    Sjogaard, G.6    Kjaer, M.7
  • 23
    • 45149132991 scopus 로고    scopus 로고
    • Levosimendan but not norepinephrine improves microvascular oxygenation during experimental septic shock
    • Fries M, Ince C, Rossaint R, Bleilevens C, Bickenbach J, Rex S, Mik EG: Levosimendan but not norepinephrine improves microvascular oxygenation during experimental septic shock. Crit Care Med 36(6):1886-1891, 2008.
    • (2008) Crit Care Med , vol.36 , Issue.6 , pp. 1886-1891
    • Fries, M.1    Ince, C.2    Rossaint, R.3    Bleilevens, C.4    Bickenbach, J.5    Rex, S.6    Mik, E.G.7
  • 24
    • 78650368315 scopus 로고    scopus 로고
    • Levosimendan for resuscitating the microcirculation in patients with septic shock: A randomized controlled study
    • Morelli A, Donati A, Ertmer C, Rehberg S, Lange M, Orecchioni A: Levosimendan for resuscitating the microcirculation in patients with septic shock: a randomized controlled study. Crit Care 14(6):R232, 2010.
    • (2010) Crit Care , vol.14 , Issue.6 , pp. R232
    • Morelli, A.1    Donati, A.2    Ertmer, C.3    Rehberg, S.4    Lange, M.5    Orecchioni, A.6
  • 26
    • 31344453457 scopus 로고    scopus 로고
    • The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects
    • De Backer D, Creteur J, Dubois MJ, Sakr Y, Koch M, Verdant C, Vincent JL: The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects. Crit Care Med 34(2):403-408, 2006.
    • (2006) Crit Care Med , vol.34 , Issue.2 , pp. 403-408
    • De Backer, D.1    Creteur, J.2    Dubois, M.J.3    Sakr, Y.4    Koch, M.5    Verdant, C.6    Vincent, J.L.7
  • 27
    • 84880257195 scopus 로고    scopus 로고
    • Effects of dobutamine on systemic, regional and microcirculatory perfusion parameters in septic shock: A randomized, placebo-controlled, double-blind, crossover study
    • Hernandez G, Bruhn A, Luengo C, Regueira T, Kattan E, Fuentealba A, Florez J, Castro R, Aquevedo A, Pairumani R, et al.: Effects of dobutamine on systemic, regional and microcirculatory perfusion parameters in septic shock: a randomized, placebo-controlled, double-blind, crossover study. Intensive Care Med 39(8):1435-1443, 2013.
    • (2013) Intensive Care Med , vol.39 , Issue.8 , pp. 1435-1443
    • Hernandez, G.1    Bruhn, A.2    Luengo, C.3    Regueira, T.4    Kattan, E.5    Fuentealba, A.6    Florez, J.7    Castro, R.8    Aquevedo, A.9    Pairumani, R.10
  • 28
    • 84880942599 scopus 로고    scopus 로고
    • Depletion of myocardial glucose is observed during endotoxemic but not hemorrhagic shock in a porcine model
    • Chew MS, Shekar K, Brand BA, Norin C, Barnett AG: Depletion of myocardial glucose is observed during endotoxemic but not hemorrhagic shock in a porcine model. Crit Care 17(4):R164, 2013.
    • (2013) Crit Care , vol.17 , Issue.4 , pp. R164
    • Chew, M.S.1    Shekar, K.2    Brand, B.A.3    Norin, C.4    Barnett, A.G.5
  • 30
    • 41949105919 scopus 로고    scopus 로고
    • Peripheral tissue metabolism during off-pump versus on-pump coronary artery bypass graft surgery: The microdialysis study
    • Pojar M, Mand'ák J, Cibícek N, Lonský V, Dominik J, Palicka V, Kubícek J: Peripheral tissue metabolism during off-pump versus on-pump coronary artery bypass graft surgery: the microdialysis study. Eur J Cardiothorac Surg 33(5):899-905, 2008.
    • (2008) Eur J Cardiothorac Surg , vol.33 , Issue.5 , pp. 899-905
    • Pojar, M.1    Mand'Ák, J.2    Cibícek, N.3    Lonský, V.4    Dominik, J.5    Palicka, V.6    Kubícek, J.7


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