메뉴 건너뛰기




Volumn 93, Issue 4, 2017, Pages 840-853.e5

Leaky Gate Model: Intensity-Dependent Coding of Pain and Itch in the Spinal Cord

Author keywords

gate control, Grp+ neuron; itch; leaky gate; neural circuit; pain; spinal cord

Indexed keywords

ENDORPHIN; GASTRIN RELEASING PEPTIDE; BOMBESIN RECEPTOR;

EID: 85013670964     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2017.01.012     Document Type: Article
Times cited : (113)

References (53)
  • 1
    • 70350319219 scopus 로고    scopus 로고
    • Excitation of mouse superficial dorsal horn neurons by histamine and/or PAR-2 agonist: potential role in itch
    • Akiyama, T., Carstens, M.I., Carstens, E., Excitation of mouse superficial dorsal horn neurons by histamine and/or PAR-2 agonist: potential role in itch. J. Neurophysiol. 102 (2009), 2176–2183.
    • (2009) J. Neurophysiol. , vol.102 , pp. 2176-2183
    • Akiyama, T.1    Carstens, M.I.2    Carstens, E.3
  • 2
    • 66249106714 scopus 로고    scopus 로고
    • Activation of superficial dorsal horn neurons in the mouse by a PAR-2 agonist and 5-HT: potential role in itch
    • Akiyama, T., Merrill, A.W., Carstens, M.I., Carstens, E., Activation of superficial dorsal horn neurons in the mouse by a PAR-2 agonist and 5-HT: potential role in itch. J. Neurosci. 29 (2009), 6691–6699.
    • (2009) J. Neurosci. , vol.29 , pp. 6691-6699
    • Akiyama, T.1    Merrill, A.W.2    Carstens, M.I.3    Carstens, E.4
  • 3
    • 34249079154 scopus 로고    scopus 로고
    • Network motifs: theory and experimental approaches
    • Alon, U., Network motifs: theory and experimental approaches. Nat. Rev. Genet. 8 (2007), 450–461.
    • (2007) Nat. Rev. Genet. , vol.8 , pp. 450-461
    • Alon, U.1
  • 4
    • 85007429408 scopus 로고    scopus 로고
    • Spinal neurons that contain gastrin-releasing peptide seldom express Fos or phosphorylate extracellular signal-regulated kinases in response to intradermal chloroquine
    • 1744806916649602
    • Bell, A.M., Gutierrez-Mecinas, M., Polgár, E., Todd, A.J., Spinal neurons that contain gastrin-releasing peptide seldom express Fos or phosphorylate extracellular signal-regulated kinases in response to intradermal chloroquine. Mol. Pain, 12, 2016, 10.1177/1744806916649602 1744806916649602.
    • (2016) Mol. Pain , vol.12
    • Bell, A.M.1    Gutierrez-Mecinas, M.2    Polgár, E.3    Todd, A.J.4
  • 6
    • 84899800790 scopus 로고    scopus 로고
    • Transmitting pain and itch messages: a contemporary view of the spinal cord circuits that generate gate control
    • Braz, J., Solorzano, C., Wang, X., Basbaum, A.I., Transmitting pain and itch messages: a contemporary view of the spinal cord circuits that generate gate control. Neuron 82 (2014), 522–536.
    • (2014) Neuron , vol.82 , pp. 522-536
    • Braz, J.1    Solorzano, C.2    Wang, X.3    Basbaum, A.I.4
  • 7
    • 0021165618 scopus 로고
    • Basic and regulatory mechanisms of in vitro release of Met-enkephalin from the dorsal zone of the rat spinal cord
    • Cesselin, F., Bourgoin, S., Artaud, F., Hamon, M., Basic and regulatory mechanisms of in vitro release of Met-enkephalin from the dorsal zone of the rat spinal cord. J. Neurochem. 43 (1984), 763–774.
    • (1984) J. Neurochem. , vol.43 , pp. 763-774
    • Cesselin, F.1    Bourgoin, S.2    Artaud, F.3    Hamon, M.4
  • 8
    • 34548617428 scopus 로고    scopus 로고
    • The itch-producing agents histamine and cowhage activate separate populations of primate spinothalamic tract neurons
    • Davidson, S., Zhang, X., Yoon, C.H., Khasabov, S.G., Simone, D.A., Giesler, G.J. Jr., The itch-producing agents histamine and cowhage activate separate populations of primate spinothalamic tract neurons. J. Neurosci. 27 (2007), 10007–10014.
    • (2007) J. Neurosci. , vol.27 , pp. 10007-10014
    • Davidson, S.1    Zhang, X.2    Yoon, C.H.3    Khasabov, S.G.4    Simone, D.A.5    Giesler, G.J.6
  • 9
    • 67349165698 scopus 로고    scopus 로고
    • Relief of itch by scratching: state-dependent inhibition of primate spinothalamic tract neurons
    • Davidson, S., Zhang, X., Khasabov, S.G., Simone, D.A., Giesler, G.J. Jr., Relief of itch by scratching: state-dependent inhibition of primate spinothalamic tract neurons. Nat. Neurosci. 12 (2009), 544–546.
    • (2009) Nat. Neurosci. , vol.12 , pp. 544-546
    • Davidson, S.1    Zhang, X.2    Khasabov, S.G.3    Simone, D.A.4    Giesler, G.J.5
  • 10
    • 84866396893 scopus 로고    scopus 로고
    • Pruriceptive spinothalamic tract neurons: physiological properties and projection targets in the primate
    • Davidson, S., Zhang, X., Khasabov, S.G., Moser, H.R., Honda, C.N., Simone, D.A., Giesler, G.J. Jr., Pruriceptive spinothalamic tract neurons: physiological properties and projection targets in the primate. J. Neurophysiol. 108 (2012), 1711–1723.
    • (2012) J. Neurophysiol. , vol.108 , pp. 1711-1723
    • Davidson, S.1    Zhang, X.2    Khasabov, S.G.3    Moser, H.R.4    Honda, C.N.5    Simone, D.A.6    Giesler, G.J.7
  • 12
    • 84863528231 scopus 로고    scopus 로고
    • The majority of dorsal spinal cord gastrin releasing peptide is synthesized locally whereas neuromedin B is highly expressed in pain- and itch-sensing somatosensory neurons
    • Fleming, M.S., Ramos, D., Han, S.B., Zhao, J., Son, Y.-J., Luo, W., The majority of dorsal spinal cord gastrin releasing peptide is synthesized locally whereas neuromedin B is highly expressed in pain- and itch-sensing somatosensory neurons. Mol. Pain, 8, 2012, 52.
    • (2012) Mol. Pain , vol.8 , pp. 52
    • Fleming, M.S.1    Ramos, D.2    Han, S.B.3    Zhao, J.4    Son, Y.-J.5    Luo, W.6
  • 13
    • 79955664915 scopus 로고    scopus 로고
    • Physiological properties of enkephalin-containing neurons in the spinal dorsal horn visualized by expression of green fluorescent protein in BAC transgenic mice
    • Fukushima, T., Tsuda, M., Kofuji, T., Hori, Y., Physiological properties of enkephalin-containing neurons in the spinal dorsal horn visualized by expression of green fluorescent protein in BAC transgenic mice. BMC Neurosci., 12, 2011, 36.
    • (2011) BMC Neurosci. , vol.12 , pp. 36
    • Fukushima, T.1    Tsuda, M.2    Kofuji, T.3    Hori, Y.4
  • 15
    • 0036554701 scopus 로고    scopus 로고
    • Correlations between neuronal morphology and electrophysiological features in the rodent superficial dorsal horn
    • Grudt, T.J., Perl, E.R., Correlations between neuronal morphology and electrophysiological features in the rodent superficial dorsal horn. J. Physiol. 540 (2002), 189–207.
    • (2002) J. Physiol. , vol.540 , pp. 189-207
    • Grudt, T.J.1    Perl, E.R.2
  • 16
    • 33751229313 scopus 로고    scopus 로고
    • Phospholipase Cbeta 3 mediates the scratching response activated by the histamine H1 receptor on C-fiber nociceptive neurons
    • Han, S.-K., Mancino, V., Simon, M.I., Phospholipase Cbeta 3 mediates the scratching response activated by the histamine H1 receptor on C-fiber nociceptive neurons. Neuron 52 (2006), 691–703.
    • (2006) Neuron , vol.52 , pp. 691-703
    • Han, S.-K.1    Mancino, V.2    Simon, M.I.3
  • 18
    • 0000044617 scopus 로고
    • Pain and allodynia, itch and alloknesis: An alternative hypothesis
    • Handwerker, H.O., Pain and allodynia, itch and alloknesis: An alternative hypothesis. J. Pain 1 (1992), 135–138.
    • (1992) J. Pain , vol.1 , pp. 135-138
    • Handwerker, H.O.1
  • 19
    • 0025743390 scopus 로고
    • Discharge patterns of human C-fibers induced by itching and burning stimuli
    • Handwerker, H.O., Forster, C., Kirchhoff, C., Discharge patterns of human C-fibers induced by itching and burning stimuli. J. Neurophysiol. 66 (1991), 307–315.
    • (1991) J. Neurophysiol. , vol.66 , pp. 307-315
    • Handwerker, H.O.1    Forster, C.2    Kirchhoff, C.3
  • 20
    • 0022229067 scopus 로고
    • Acetylsalicylic acid, paracetamol and morphine inhibit behavioral responses to intrathecally administered substance P or capsaicin
    • Hunskaar, S., Fasmer, O.B., Hole, K., Acetylsalicylic acid, paracetamol and morphine inhibit behavioral responses to intrathecally administered substance P or capsaicin. Life Sci. 37 (1985), 1835–1841.
    • (1985) Life Sci. , vol.37 , pp. 1835-1841
    • Hunskaar, S.1    Fasmer, O.B.2    Hole, K.3
  • 21
    • 0022485714 scopus 로고
    • Intrathecal injection of capsaicin can be used as a behavioural nociceptive test in mice
    • Hunskaar, S., Post, C., Fasmer, O.B., Arwestrom, E., Intrathecal injection of capsaicin can be used as a behavioural nociceptive test in mice. Neuropharmacology 25 (1986), 1149–1153.
    • (1986) Neuropharmacology , vol.25 , pp. 1149-1153
    • Hunskaar, S.1    Post, C.2    Fasmer, O.B.3    Arwestrom, E.4
  • 23
    • 80052997960 scopus 로고    scopus 로고
    • Mouse models of acute, chemical itch and pain in humans
    • LaMotte, R.H., Shimada, S.G., Sikand, P., Mouse models of acute, chemical itch and pain in humans. Exp. Dermatol. 20 (2011), 778–782.
    • (2011) Exp. Dermatol. , vol.20 , pp. 778-782
    • LaMotte, R.H.1    Shimada, S.G.2    Sikand, P.3
  • 24
  • 25
    • 84934275739 scopus 로고    scopus 로고
    • Distinct functions of opioid-related peptides and gastrin-releasing peptide in regulating itch and pain in the spinal cord of primates
    • Lee, H., Ko, M.-C., Distinct functions of opioid-related peptides and gastrin-releasing peptide in regulating itch and pain in the spinal cord of primates. Sci. Rep., 5, 2015, 11676.
    • (2015) Sci. Rep. , vol.5 , pp. 11676
    • Lee, H.1    Ko, M.-C.2
  • 26
    • 0001013340 scopus 로고
    • Vascular reactions of the skin to injury, part X: the intervention of a chemical stimulus illustrated especially by flare. The response to faradism
    • Lewis, T., Grant, R.T., Marvin, H.M., Vascular reactions of the skin to injury, part X: the intervention of a chemical stimulus illustrated especially by flare. The response to faradism. Heart 14 (1927), 139–160.
    • (1927) Heart , vol.14 , pp. 139-160
    • Lewis, T.1    Grant, R.T.2    Marvin, H.M.3
  • 27
    • 72249113172 scopus 로고    scopus 로고
    • Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus
    • Liu, Q., Tang, Z., Surdenikova, L., Kim, S., Patel, K.N., Kim, A., Ru, F., Guan, Y., Weng, H.-J., Geng, Y., et al. Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus. Cell 139 (2009), 1353–1365.
    • (2009) Cell , vol.139 , pp. 1353-1365
    • Liu, Q.1    Tang, Z.2    Surdenikova, L.3    Kim, S.4    Patel, K.N.5    Kim, A.6    Ru, F.7    Guan, Y.8    Weng, H.-J.9    Geng, Y.10
  • 28
    • 79960365417 scopus 로고    scopus 로고
    • The distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia
    • Liu, Q., Weng, H.J., Patel, K.N., Tang, Z., Bai, H., Steinhoff, M., Dong, X., The distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia. Sci. Signal., 4, 2011, ra45.
    • (2011) Sci. Signal. , vol.4 , pp. ra45
    • Liu, Q.1    Weng, H.J.2    Patel, K.N.3    Tang, Z.4    Bai, H.5    Steinhoff, M.6    Dong, X.7
  • 31
    • 0013851199 scopus 로고
    • Pain mechanisms: a new theory
    • Melzack, R., Wall, P.D., Pain mechanisms: a new theory. Science 150 (1965), 971–979.
    • (1965) Science , vol.150 , pp. 971-979
    • Melzack, R.1    Wall, P.D.2
  • 33
    • 84877939975 scopus 로고    scopus 로고
    • The cells and circuitry for itch responses in mice
    • Mishra, S.K., Hoon, M.A., The cells and circuitry for itch responses in mice. Science 340 (2013), 968–971.
    • (2013) Science , vol.340 , pp. 968-971
    • Mishra, S.K.1    Hoon, M.A.2
  • 34
    • 0034675014 scopus 로고    scopus 로고
    • Alteration in synaptic inputs through C-afferent fibers to substantia gelatinosa neurons of the rat spinal dorsal horn during postnatal development
    • Nakatsuka, T., Ataka, T., Kumamoto, E., Tamaki, T., Yoshimura, M., Alteration in synaptic inputs through C-afferent fibers to substantia gelatinosa neurons of the rat spinal dorsal horn during postnatal development. Neuroscience 99 (2000), 549–556.
    • (2000) Neuroscience , vol.99 , pp. 549-556
    • Nakatsuka, T.1    Ataka, T.2    Kumamoto, E.3    Tamaki, T.4    Yoshimura, M.5
  • 35
    • 0021689425 scopus 로고
    • Biochemical and functional properties of large and small dense-core vesicles in sympathetic nerves of rat and ox vas deferens
    • Neuman, B., Wiedermann, C.J., Fischer-Colbrie, R., Schober, M., Sperk, G., Winkler, H., Biochemical and functional properties of large and small dense-core vesicles in sympathetic nerves of rat and ox vas deferens. Neuroscience 13 (1984), 921–931.
    • (1984) Neuroscience , vol.13 , pp. 921-931
    • Neuman, B.1    Wiedermann, C.J.2    Fischer-Colbrie, R.3    Schober, M.4    Sperk, G.5    Winkler, H.6
  • 36
    • 0033558529 scopus 로고    scopus 로고
    • Cutaneous sensory spots and the “law of specific nerve energies”: history and development of ideas
    • Norrsell, U., Finger, S., Lajonchere, C., Cutaneous sensory spots and the “law of specific nerve energies”: history and development of ideas. Brain Res. Bull. 48 (1999), 457–465.
    • (1999) Brain Res. Bull. , vol.48 , pp. 457-465
    • Norrsell, U.1    Finger, S.2    Lajonchere, C.3
  • 37
    • 0024335599 scopus 로고
    • Sensations evoked by intraneural microstimulation of C nociceptor fibres in human skin nerves
    • Ochoa, J., Torebjörk, E., Sensations evoked by intraneural microstimulation of C nociceptor fibres in human skin nerves. J. Physiol. 415 (1989), 583–599.
    • (1989) J. Physiol. , vol.415 , pp. 583-599
    • Ochoa, J.1    Torebjörk, E.2
  • 40
    • 66049086427 scopus 로고    scopus 로고
    • Similar itch and nociceptive sensations evoked by punctate cutaneous application of capsaicin, histamine and cowhage
    • Sikand, P., Shimada, S.G., Green, B.G., LaMotte, R.H., Similar itch and nociceptive sensations evoked by punctate cutaneous application of capsaicin, histamine and cowhage. Pain 144 (2009), 66–75.
    • (2009) Pain , vol.144 , pp. 66-75
    • Sikand, P.1    Shimada, S.G.2    Green, B.G.3    LaMotte, R.H.4
  • 41
    • 79956321743 scopus 로고    scopus 로고
    • BAM8-22 peptide produces itch and nociceptive sensations in humans independent of histamine release
    • Sikand, P., Dong, X., LaMotte, R.H., BAM8-22 peptide produces itch and nociceptive sensations in humans independent of histamine release. J. Neurosci. 31 (2011), 7563–7567.
    • (2011) J. Neurosci. , vol.31 , pp. 7563-7567
    • Sikand, P.1    Dong, X.2    LaMotte, R.H.3
  • 42
    • 80055014558 scopus 로고    scopus 로고
    • Sensory responses to injection and punctate application of capsaicin and histamine to the skin
    • Sikand, P., Shimada, S.G., Green, B.G., LaMotte, R.H., Sensory responses to injection and punctate application of capsaicin and histamine to the skin. Pain 152 (2011), 2485–2494.
    • (2011) Pain , vol.152 , pp. 2485-2494
    • Sikand, P.1    Shimada, S.G.2    Green, B.G.3    LaMotte, R.H.4
  • 44
    • 0344442742 scopus 로고    scopus 로고
    • A quantitative and morphological study of projection neurons in lamina I of the rat lumbar spinal cord
    • Spike, R.C., Puskár, Z., Andrew, D., Todd, A.J., A quantitative and morphological study of projection neurons in lamina I of the rat lumbar spinal cord. Eur. J. Neurosci. 18 (2003), 2433–2448.
    • (2003) Eur. J. Neurosci. , vol.18 , pp. 2433-2448
    • Spike, R.C.1    Puskár, Z.2    Andrew, D.3    Todd, A.J.4
  • 45
    • 34547726181 scopus 로고    scopus 로고
    • A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord
    • Sun, Y.-G., Chen, Z.-F., A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord. Nature 448 (2007), 700–703.
    • (2007) Nature , vol.448 , pp. 700-703
    • Sun, Y.-G.1    Chen, Z.-F.2
  • 47
    • 78650517458 scopus 로고    scopus 로고
    • Neuronal circuitry for pain processing in the dorsal horn
    • Todd, A.J., Neuronal circuitry for pain processing in the dorsal horn. Nat. Rev. Neurosci. 11 (2010), 823–836.
    • (2010) Nat. Rev. Neurosci. , vol.11 , pp. 823-836
    • Todd, A.J.1
  • 48
    • 0026752966 scopus 로고
    • Immunohistochemical evidence that Met-enkephalin and GABA coexist in some neurones in rat dorsal horn
    • Todd, A.J., Spike, R.C., Russell, G., Johnston, H.M., Immunohistochemical evidence that Met-enkephalin and GABA coexist in some neurones in rat dorsal horn. Brain Res. 584 (1992), 149–156.
    • (1992) Brain Res. , vol.584 , pp. 149-156
    • Todd, A.J.1    Spike, R.C.2    Russell, G.3    Johnston, H.M.4
  • 49
    • 0020369765 scopus 로고
    • Itch evoked by electrical stimulation of the skin
    • Tuckett, R.P., Itch evoked by electrical stimulation of the skin. J. Invest. Dermatol. 79 (1982), 368–373.
    • (1982) J. Invest. Dermatol. , vol.79 , pp. 368-373
    • Tuckett, R.P.1
  • 50
    • 0006021465 scopus 로고
    • Zur physiologie der juckempfindung
    • Von Frey, M., Zur physiologie der juckempfindung. Arch. Neurol. Physiol, 7, 1922, 142.
    • (1922) Arch. Neurol. Physiol , vol.7 , pp. 142
    • Von Frey, M.1
  • 51
    • 0017816394 scopus 로고
    • The gate control theory of pain mechanisms. A re-examination and re-statement
    • Wall, P.D., The gate control theory of pain mechanisms. A re-examination and re-statement. Brain 101 (1978), 1–18.
    • (1978) Brain , vol.101 , pp. 1-18
    • Wall, P.D.1
  • 53
    • 0018601372 scopus 로고
    • Intrathecal capsaicin depletes substance P in the rat spinal cord and produces prolonged thermal analgesia
    • Yaksh, T.L., Farb, D.H., Leeman, S.E., Jessell, T.M., Intrathecal capsaicin depletes substance P in the rat spinal cord and produces prolonged thermal analgesia. Science 206 (1979), 481–483.
    • (1979) Science , vol.206 , pp. 481-483
    • Yaksh, T.L.1    Farb, D.H.2    Leeman, S.E.3    Jessell, T.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.