The itch-producing agents histamine and cowhage activate separate populations of primate spinothalamic tract neurons

Journal of Neuroscience

Volumn 27, Issue 37, 2007, Pages 10007-10014

  Davidson, Steve ^a,b   Zhang, Xijing ^a   Yoon, Chul H ^a   Khasabov, Sergey G ^b   Simone, Donald A ^b   Giesler Jr , Glenn J ^a,b  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Capsaicin; Dorsal horn; Electrophysiology; Pain; Pruritus; Spinal cord

Indexed keywords

CAPSAICIN; HISTAMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIDROMIC STIMULATION; ARTICLE; CONTROLLED STUDY; NOCICEPTION; NONHUMAN; PRIMATE; PRIORITY JOURNAL; PRURITUS; RECEPTIVE FIELD; SPINOTHALAMIC TRACT; VELVET BEAN;

ACTION POTENTIALS; ANIMALS; FEMALE; HISTAMINE; MACACA FASCICULARIS; MACACA MULATTA; MALE; NEURONS; PRURITUS; SPINOTHALAMIC TRACTS;

EID: 34548617428     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2862-07.2007     Document Type: Article

References (44)

1. Andrew D, Craig AD (2001) Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch. Nat Neurosci 4:72-77.
2. Bickford RG (1938) Experiments relating to the itch sensation, its peripheral mechanism and central pathways. Clin Sci 3:377-386.
3. Burstein R, Dado RJ, Cliffer KD, Giesler Jr GJ (1991) Physiological characterization of spinohypothalamic tract neurons in the lumbar enlargement of rats. J Neurophysiol 66:261-284.
4. Carstens E (1997) Responses of rat spinal dorsal horn neurons to intracutaneous injection of histamine, capsaicin and other irritants. J Neurophysiol 77:2499-2514.
5. Dado RJ, Katter JT, Giesler Jr GJ (1994) Spinothalamic and spinohypothalamic tract neurons in the cervical enlargement of rats. I. Locations of antidromically identified axons in the thalamus and hypothalamus. J Neurophysiol 71:959-980.
6. Graham DT, Goodell H, Wolff HG (1951) Neural mechanisms involved in itch, "itchy skin," and tickle sensations. J Clin Invest 30:37-49.
7. Handwerker HO (1992) Pain and allodynia, itch and alloknesis: an alternative hypothesis. Am Pain Soc J 1:135-138.
8. Handwerker HO, Forster C, Kirchhoff C (1991) Discharge patterns of human C-fibers induced by itching and burning stimuli. J Neurophysiol 66:307-315.
9. Hyndman OR, Wolkin J (1943) Anterior cordotomy: further observations on the physiologic results and optimum manner of performance. Arch Neurol Psychiatry 50:129-148.
10. Ikoma A, Handwerker H, Miyachi Y, Schmelz M (2005) Electrically evoked itch in humans. Pain 113:148-154.
11. Ikoma A, Steinhoff M, Stander S, Yosipovich G, Schmelz M (2006) The neurobiology of itch. Nat Rev Neurosci 7:535-547.
12. Jinks SL, Carstens E (1998) Spinal NMDA receptor involvement in the expansion of dorsal horn neuronal receptive field area produced by intracutaneous histamine. J Neurophysiol 79:1613-1618.
13. Jinks SL, Carstens E (2000) Superficial dorsal horn neurons identified by intracutaneous histamine: chemonociceptive responses and modulation by morphine. J Neurophysiol 84:616-627.
14. Jinks SL, Carstens E (2002) Responses of superficial dorsal horn neurons to intradermal serotonin and other irritants: comparison with scratching behavior. J Neurophysiol 87:1280-1289.
15. Johanek LM, Shim B, Meyer RA, Ringkamp M (2005) Response of C-fiber nociceptors in monkey to different pruritic stimuli. Soc Neurosci Abstr 31:511.7.
16. Johanek LM, Meyer RA, Hartke T, Hobelmann JG, Maine DN, LaMotte RH, Ringkamp M (2007) Psychophysical and physiological evidence for parallel afferent pathways mediating the sensation of itch. J Neurosci 27:7490-7497.
17. Jones EG (2007) The thalamus, Ed 2. Cambridge, UK: Cambridge UP.
18. Keele CA and Armstrong D (1964) Substances producing pain and itch. Baltimore: Lippincott, Williams and Wilkins.
19. Klein PA, Clark RA (1999) An evidence-based review of the efficacy of antihistamines in relieving pruritus in atopic dermatitis. Arch Dermatol 135:1522-1525.
20. Ko MC, Naughton NN (2000) An experimental itch model in monkeys: characterization of intrathecal morphine-induced scratching and antinociception. Anesthesiology 92:795- 805.
21. Ko MC, Song MS, Edwards T, Lee H Naughton NN (2004) The role of central mu opioid receptors in opioid-induced itch in primates. J Pharmacol Exp Ther 310:169-176.
22. LaMotte RH (1996) Secondary cutaneous dysesthesias. In: Neurobiology of nociceptors (Belmonte C, Cervero F, eds), pp 391-417. Oxford: Oxford UP.
23. Lipski J (1981) Antidromic activation of neurons as an analytic tool in the study of the central nervous system. J Neurosci Methods 4:1-32.
24. Magerl W, Westerman RA, Mohner B, Handwerker HO (1990) Properties of transdermal histamine iontophoresis: differential effects of season, gender, and body region. J Invest Dermatol 94:347-352.
25. McMahon SB, Koltzenburg M (1992) Itching for an explanation. Trends Neurosci 15:497-501.
26. Nicolson TA, Bevan S, Richards CD (2002) Characterization of the calcium responses to histamine in capsaicin-sensitive and capsaicin-insensitive sensory neurons. Neuroscience 110:329-338.
27. Oaklander AL, Cohen SP, Raju SV (2002) Intractable postherpetic itch and cutaneous deafferentation after facial shingles. Pain 96:9-12.
28. Schmelz M, Schmidt M, Bickel A, Handwerker HO, Torebjork HE (1997) Specific C-receptors for itch in human skin. J Neurosci 17:8003-8008.
29. Schmelz M, Schmidt M, Weidner C, Hilleges M, Torebjork HE, Handwerker HO (2003) Chemical response pattern of different classes of C-nociceptors to pruritogens and algogens. J Neurophysiol 89:2441-2448.
30. Shelley WB, Arthur RP (1955) Studies on cowhage (Mucuna pruriens) and its pruritogenic proteinase, mucunain. AMA Arch Derm 72:399-406.
31. Shelley WB, Arthur RP (1957) The neurohistology and neurophysiology of the itch sensation in man. Arch Dermatol 76:296-323.
32. Shim WS, Tak MH, Lee MH, Kim M, Kim M, Koo JY, Lee CH, Kim M, Oh U (2007) TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase. J Neurosci 27:2331-2337.
33. Simone DA, Ngeow JY, Whitehouse J, Becerra-Cabal L, Putterman GJ, LaMotte RH (1987) The magnitude and duration of itch produced by intracutaneous injections of histamine. Somatosens Mot Res 5:81-92.
34. Simone DA, Alreja M, LaMotte RH (1991) Psychophysical studies of the itch sensation and itchy skin ("alloknesis") produced by intracutaneous injection of histamine. Somatosens Mot Res 8:271-279.
35. Simone DA, Zhang X, Li J, Zhang JM, Honda CN, LaMotte RH, Giesler Jr GJ (2004) Comparison of responses of primate spinothalamic neurons to pruritic and algogenic stimuli. J Neurophysiol 91:213-222.
36. Steinhoff M, Neisius U, Ikoma A, Fartasch M, Heyer G, Skov PS, Lugaer TA, Schmelz M (2003) Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin. J Neurosci 23:6176-6180.
37. Steinhoff M, Bienenstock J, Schmelz M, Maurer M, Wei E, Biro T (2006) Neurophysiological, neuroimmunological, and neuroendocrine basis of pruritus. J Invest Dermatol 126:1705-1718.
38. Tuckett RP (1982) Itch evoked by electrical stimulation of the skin. J Invest Dermatol 79:368-373.
39. Tuckett RP, Wei JY (1987) Response to an itch-producing substance in cat. II. Cutaneous receptor populations with unmyelinated axons. Brain Res 413:95-103.
40. Wahlgren CF (1999) Itch and atopic dermatitis: an overview. J Dermatol 26:770-779.
41. Wei JY, Tuckett RP (1991) Responses of cat ventrolateral spinal axons to an itch-producing stimulus (cowhage). Somatosens Mot Res 8:227-239.
42. White JC and Sweet WH (1969) Pain and the neurosurgeon. Springfield, IL: Charles C. Thomas.
43. Yosipovitch G, Greaves MW, Schmelz M (2003) Itch. Lancet 361:690-694.
44. Zhang X, Wenk HN, Gokin AP, Honda CN, Giesler Jr GJ (1999) Physiological studies of spinohypothalamic tract neurons in the lumbar enlargement of monkeys. J Neurophysiol 82:1054-1058.