Chemical response pattern of different classes of C-nociceptors to pruritogens and algogens

Journal of Neurophysiology

Volumn 89, Issue 5, 2003, Pages 2441-2448

  Schmelz, M ^a,d   Schmidt, R ^b   Weidner, C ^a   Hilliges, Marita ^c   Torebjork H E ^b   Handwerker, H O ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UPPSALA UNIVERSITY   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

^d UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; BRADYKININ; CAPSAICIN; HISTAMINE; PROSTAGLANDIN E2; SEROTONIN;

ADULT; ARTICLE; ELECTROSTIMULATION; FEMALE; HUMAN; HUMAN EXPERIMENT; INFLAMMATION; MALE; MECHANORECEPTOR; MEDIATOR; MICRODIALYSIS; NERVE FIBER C; NEUROGRAPHY; NOCICEPTION; NOCICEPTIVE RECEPTOR; NOCICEPTIVE RECEPTOR C; NORMAL HUMAN; PAIN; PERCEPTIVE THRESHOLD; PRIORITY JOURNAL; PRURITUS; PSYCHOPHYSICS; SENSITIZATION; SKIN RECEPTOR; SKIN STIMULATION;

ACETYLCHOLINE; ADULT; BRADYKININ; CAPSAICIN; DINOPROSTONE; ELECTRIC STIMULATION; FEMALE; HISTAMINE; HUMANS; INFLAMMATION MEDIATORS; MALE; MICRODIALYSIS; NERVE FIBERS, UNMYELINATED; NOCICEPTORS; PAIN; PAIN MEASUREMENT; PERONEAL NERVE; PRURITUS; PSYCHOPHYSICS; REFLEX; SENSORY THRESHOLDS; SEROTONIN; SKIN; SYMPATHETIC NERVOUS SYSTEM;

EID: 0037541581     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.01139.2002     Document Type: Article

References (60)

1. Andrew D and Craig AD. Spinothalamic lamina 1 neurons selectively sensitive to histamine: a central neural pathway for itch. Nat Neurosci 4: 72-77, 2001.
2. Atanassoff PG, Brull SJ, Zhang J, Greenquist K, Silverman DG, and LaMotte RH. Enhancement of experimental pruritus and mechanically evoked dysesthesiae with local anesthesia. Somatosens Mot Res 16: 291-298, 1999.
3. Beck PW and Handwerker HO. Bradykinin and serotonin effects on various types of cutaneous nerve fibers. Pfluegers 347: 209-222, 1974.
4. Beck PW, Handwerker HO, and Zimmermann M. Nervous outflow from the cat's foot during noxious radiant heat stimulation. Brain Res 67: 373-386, 1974.
5. Brull SJ, Atanassoff PG, Silverman DG, Zhang J, and LaMotte RH. Attenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodynia. Somatosens Mot Res 16: 299-303, 1999.
6. Chen X, Tanner K, and Levine JD. Mechanical sensitization of cutaneous C-fiber nociceptors by prostaglandin E2 in the rat. Neurosci Lett 267: 105-108, 1999.
7. Forster C and Handwerker HO. Automatic classification and analysis of microneurographic spike data using a PC/AT. J Neurosci Methods 31: 109-118, 1990.
8. Gee MD, Lynn B, and Cotsell B. Activity-dependent slowing of conduction velocity provides a method for identifying different functional classes of C-fibre in the rat saphenous nerve. Neurosci 73: 667-675, 1996.
9. Green BG and Shaffer GS. The sensory response to capsaicin during repeated topical exposures: differential effects on sensations of itching and pungency. Pain 53: 323-334, 1993.
10. Groene D, Martus P, and Heyer G. Doxepin affects acetylcholine induced cutaneous reactions in atopic eczema. Exp Dermatol 10: 110-117, 2001.
11. Hagbarth KE, Hongell A, Hallin RG, and Torebjörk HE. Afferent impulses in median nerve fascicles evoked by tactile stimuli of the human hand. Brain Res 24: 423-442, 1970.
12. Hägermark O. Studies on experimental itch induced by kallikrein and bradykinin. Acta Derm Venereol 54: 397-400, 1974.
13. Hägermark O. Peripheral and central mediators of itch. Skin Pharmacol 5: 1-8, 1992.
14. Hägermark O and Strandberg K. Pruritogenic activity of prostaglandin E2. Acta Derm Venereol 57: 37-43, 1977.
15. Hallin RG and Torebjörk HE. Single unit sympathetic activity in human skin nerves during rest and various manoeuvres. Acta Physiol Scand 92: 303-317, 1974.
16. Hansson B, Forster C, and Torebjörk H. E. Matched filtering and multiple hypothesis tracking applied to C-fiber action potentials recorded in human nerves. Proc. of SPIE, Signal and Data Processing of Small Targets, Orlando, FL, Sept. 1998, vol. 3373, pp. 582-593, 1998.
17. Jeftinija S. Bradykinin excites tetrodotoxin-resistant primary afferent fibers. Brain Res 665: 69-76, 1994.
18. Juhlin L and Michaelsson G. Cutaneous vascular reactions to prostaglandins in healthy subjects and in patients with urticaria and atopic dermatitis. Acta Derm Venereol 49: 251-261, 1969.
19. Khan AA, Raja SN, Manning DC, Campbell JN, and Meyer RA. The effects of bradykinin and sequence-related analogs on the response properties of cutaneous nociceptors in monkeys. Somatosensory and Motor Research 9: 97-106, 1992.
20. Kingston WP and Greaves MW. Actions of prostaglandin E2 metabolites on skin microcirculation. Agents Actions 16: 13-14, 1985.
21. Koltzenburg M, Kress M, and Reeh PW. The nociceptor sensitization by bradykinin does not depend on sympathetic neurons. Neurosci 46: 465-473, 1992.
22. LaMotte RH, Shain CN, Simone DA, and Tsai EFP. Neurogenic hyperalgesia psychophysical studies of underlying mechanisms. J Neurophysiol 66: 190-211, 1991.
23. Lang E, Novak A, Reeh PW, and Handwerker HO. Chemosensitivity of fine afferents from rat skin in vitro. J Neurophysiol 63: 887-901, 1990.
24. Liang YF, Haake B, and Reeh PW. Sustained sensitization and recruitment of rat cutaneous nociceptors by bradykinin and a novel theory of its excitatory action. J Physiol 532: 229-239, 2001.
25. Lischetzki G, Rukwied R, Handwerker HO, and Schmelz M. Nociceptor activation and protein extravasation induced by inflammatory mediators in human skin. Eur J Pain 5: 49-57, 2001.
26. Magerl W, Westerman RA, Mohner B, and Handwerker HO. Properties of transdermal histamine iontophoresis: differential effects of season, gender, and body region. J Invest Dermatol 94: 347-352, 1990.
27. Manning DC, Raja SN, Meyer RA, and Campbell JN. Pain and hyperalgesia after intradermal injection of bradykinin in humans. Clin Pharmacol Ther 50: 721-729, 1991.
28. McMahon SB and Koltzenburg M. Itching for an explanation. Trends Neurosci 15: 497-501, 1992.
29. Mizumura K, Sato J, and Kumazawa T. Effects of prostaglandins and other putative chemical intermediaries on the activity of canine testicular polymodal receptors studied in vitro. Pfluegers 408: 565-572, 1987.
30. Mizumura K, Sato J, and Kumazawa T. Strong heat stimulation sensitizes the heat response as well as the bradykinin response of visceral polymodal receptors. J Neurophysiol 68: 1209-1215, 1992.
31. Neisius U, Olsson R, Rukwied R, Lischetzki G, and Schmelz M. Prostaglandin E2 induced vasodilation, protein extravasation and pruritus in atopic dermatitis. J Am Acad Dermatol In press.
32. Nilsson HJ, Levinsson A, and Schouenborg J. Cutaneous field stimulation (CFS): A new powerful method to combat itch. Pain 71: 49-55, 1997.
33. Odou P, Azar R, Luyckx M, Brunet C, and Dine T. A hypothesis for endogenous opioid peptides in uraemic pruritus: role of enkephalin. Nephrol Dial Transplant 16: 1953-1954, 2001.
34. Rajakulasingam K, Polosa R, Holgate ST, and Howarth PH. Comparative nasal effects of bradykinin, kallidin and [Des-Arg9]-bradykinin in atopic rhinitic and normal volunteers. J Physiol 437: 577-87: 577-587, 1991.
35. Rueff A and Dray A. Sensitization of Peripheral Afferent Fibers in the Invitro Neonatal Rat Spinal Cord Tail by Bradykinin and Prostaglandins. Neurosci 54: 527-535, 1993.
36. Rukwied R and Heyer G. Administration of acetylcholine and vasoactive intestinal polypeptide to atopic eczema patients. Exp Dermatol 8: 39-45, 1999.
37. Sabroe RA, Kennedy CT, and Archer CB. The effects of topical doxepin on responses to histamine, substance P and prostaglandin E2 in human skin. Br J Dermatol 137: 386-390, 1997.
38. Schaible HG and Schmidt RF. Excitation and sensitization of fine articular afferents from cat's knee joint by prostaglandin E2. J Physiol 403: 91-104, 1988.
39. Schepelmann K, Messlinger K, Schaible HG, and Schmidt RF. Inflammatory mediators and nociception in the joint: excitation and sensitization of slowly conducting afferent fibers of cat's knee by prostaglandin 12. Neurosci 50: 237-247, 1992.
40. Schmelz M. A neural pathway for itch. Nat Neurosci 4: 9-10, 2001.
41. Schmelz M, Forster C, Schmidt R, Ringkamp M, Handwerker HO, and Torebjörk HE. Delayed responses to electrical stimuli reflect C-fiber responsiveness in human microneurography. Exp Brain Res 104: 331-336, 1995.
42. Schmelz M, Luz O, Averbeck B, and Bickel A. Plasma extravasation and neuropeptide release in human skin as measured by intradermal microdialysis. Neurosci Lett 230: 1-4, 1997a.
43. Schmelz M, Schmidt R, Bickel A, Handwerker HO, and Torebjörk HE. Specific C-receptors for itch in human skin. J Neurosci 17: 8003-8008, 1997b.
44. Schmelz M, Schmidt R, Bickel A, Torebjörk HE, and Handwerker HO. Innervation territories of single sympathetic C fibers in human skin. J Neurophysiol 79: 1653-1660, 1998.
45. Schmelz M, Schmidt R, Ringkamp M, Handwerker HO, and Torebjörk HE. Sensitization of insensitive branches of C nociceptors in human skin. J Physiol 480: 389-394, 1994.
46. Schmidt R, Schmelz M, Forster C, Ringkamp M, Torebjörk HE, and Handwerker HO. Novel classes of responsive and unresponsive C nociceptors in human skin. J Neurosci 15: 333-341, 1995.
47. Schmidt R, Schmelz M, Ringkamp M, Handwerker HO, and Torebjörk HE. Innervation territories of mechanically activated C nociceptor units in human skin. J Neurophysiol 78: 2641-2648, 1997.
48. Schmidt R, Schmelz M, Weidner C, Handwerker HO, and Torebjörk HE, Innervation territories of mechano-insensitive C nociceptors in human skin. J Neurophysiol 88: 1859-1866, 2002.
49. Sciberras DG, Goldenberg MM, Bolognese JA, James I, and Baber NS. Inflammatory responses to intradermal injection of platelet activating factor, histamine and prostaglandin E2 in healthy volunteers: a double blind investigation. Br J Clin Pharmacol 24: 753-761, 1987.
50. Serra J, Campero M, Ochoa J, and Bostock H. Activity-dependent slowing of conduction differentiates functional subtypes of C fibres innervating human skin [see comments]. J Physiol 515(Pt 3): 799-811, 1999.
51. Thalhammer JG, Raymond SA, Popitz Bergez FA, and Strichartz GR. Modality-dependent modulation of conduction by impulse activity in functionally characterized single cutaneous afferents in the rat. Somatosens Mot Res 11: 243-257, 1994.
52. Torebjörk HE. Afferent C units responding to mechanical, thermal and chemical stimuli in human non-glabrous skin. Acta Physiol Scand 92: 374-390, 1974.
53. Torebjörk HE and Hallin RG. C-fibre units recorded from human sensory nerve fascicles in situ. A preliminary report. Acta Soc Med Ups 75: 81-84, 1970.
54. Torebjörk HE and Hallin RG. Identification of afferent C units in intact human skin nerves. Brain Res 67: 387-403, 1974.
55. Vogelgsang M, Heyer G, and Hornstein OP. Acetylcholine induces different cutaneous sensations in atopic and non-atopic subjects. Acta Derm Venereol 75: 434-436, 1995.
56. Weidner C, Schmelz M, Schmidt R, Hansson B, Handwerker HO, and Torebjörk HE. Functional attributes discriminating mechano-insensitive and mechano-responsive C nociceptors in human skin. J Neurosci 19: 10184-10190, 1999.
57. Weidner C, Schmidt R, Schmelz M, Hilliges M, Handwerker HO, and Torebjörk HE. Time course of post-excitatory effects separates afferent human C fibre classes. J Physiol 527: 185-191, 2000.
58. Weisshaar E, Ziethen B, and Gollnick H. Can a serotonin type 3 (5-HT3) receptor antagonist reduce experimentally-induced itch? Inflamm Res 46: 412-416, 1997.
59. Wolfhagen FH, Sternieri E, Hop WC, Vitale G, Bertolotti M, and Van Buuren HR. Oral naltrexone treatment for cholestatic pruritus: a doubleblind, placebo-controlled study. Gastroenterology 113: 1264-1269, 1997.
60. Woodward DF, Nieves AL, Hawley SB, Joseph R, Merlino GF, and Spada CS. The pruritogenic and inflammatory effects of prostanoids in the conjunctiva. J Ocul Pharmacol Ther 11: 139-347, 1995.