Neuroprotective effect of salvianolic acid B against cerebral ischemic injury in rats via the CD40/NF-κB pathway associated with suppression of platelets activation and neuroinflammation

Brain Research

Volumn 1661, Issue , 2017, Pages 37-48

  Xu, Shixin ^a   Zhong, Aiqin ^a   Ma, Huining ^b   Li, Dan ^a   Hu, Yue ^b   Xu, Yingzhi ^a   Zhang, Junping ^a  

^a FIRST TEACHING HOSPITAL OF TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Cerebral ischemia reperfusion injury; Inflammation; Platelets activation; Salvianolic acid B

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTITHROMBOCYTIC AGENT; BIOLOGICAL MARKER; CD40 LIGAND; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; NEUROPROTECTIVE AGENT; PADGEM PROTEIN; SALVIANOLIC ACID B; TRANSCRIPTION FACTOR RELA; BENZOFURAN DERIVATIVE; CD40 ANTIGEN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN NERVE CELL; CELL VACUOLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOPLASM; DNA DAMAGE; DNA FRAGMENTATION; DOSE RESPONSE; DOWN REGULATION; DRUG DOSE COMPARISON; DRUG MECHANISM; DRUG MEGADOSE; EXPERIMENTAL BRAIN INJURY; EXPERIMENTAL CEREBRAL ISCHEMIA; GLIA CELL; HIPPOCAMPAL CA1 REGION; IMMUNOCOMPETENT CELL; LOW DRUG DOSE; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NISSL SUBSTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION; THROMBOCYTE ACTIVATION; ANIMAL; BRAIN ISCHEMIA; CEREBRAL ARTERY DISEASE; COMPLICATION; DRUG EFFECTS; IMMUNOMODULATION; INFLAMMATION; METABOLISM; PATHOPHYSIOLOGY; REPERFUSION; THROMBOCYTE; WISTAR RAT;

ANIMALS; ANTIGENS, CD40; BENZOFURANS; BLOOD PLATELETS; BRAIN ISCHEMIA; CA1 REGION, HIPPOCAMPAL; DOSE-RESPONSE RELATIONSHIP, DRUG; INFARCTION, MIDDLE CEREBRAL ARTERY; INFLAMMATION; MALE; NEUROIMMUNOMODULATION; NEUROPROTECTIVE AGENTS; NF-KAPPA B; PLATELET ACTIVATION; RATS; RATS, WISTAR; REPERFUSION; REPERFUSION INJURY; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA;

EID: 85013661397     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2017.02.011     Document Type: Article

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