SMND-309, a novel derivative of salvianolic acid B, protects rat brains ischemia and reperfusion injury by targeting the JAK2/STAT3 pathway

European Journal of Pharmacology

Volumn 714, Issue 1-3, 2013, Pages 23-31

  Zhu, Haibo ^a,c   Zou, Libo ^a   Tian, Jingwei ^b   Du, Guangying ^a,b   Gao, Yubai ^c  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b YANTAI UNIVERSITY   (China)

^c Luye Pharma Group Ltd   (China)

Author keywords

(2E) 2 6 (E) 2 carboxylvinyl 2,3 dihydroxyphenyl 3 (3, 4 dihydroxyphenyl) propenoic acid; Cerebral ischemia; Erythropoietin; Salvia miltiorrhiza; Salviolic acid derivative; Vascular endothelial growth factor

Indexed keywords

2 [6 (2 CARBOXYLVINYL) 2,3 DIHYDROXYPHENYL] 3 (3,4 DIHYDROXYPHENYL)PROPENOIC ACID; ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; JANUS KINASE 2; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; NEUROPROTECTIVE AGENT; PHOSPHOPROTEIN; SMND 309; STAT3 PROTEIN; SURAMIN; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION SIZE; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN NERVE CELL; CELL SURVIVAL; CONTROLLED STUDY; DRUG MECHANISM; DRUG RESPONSE; DRUG TARGETING; ENZYME PHOSPHORYLATION; HUMAN; MALE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

(2E)-2-{6-[(E)-2-CARBOXYLVINYL]-2,3-DIHYDROXYPHENYL}-3-(3,4-DIHYDROXYPHENYL) PROPENOIC ACID; CEREBRAL ISCHEMIA; ERYTHROPOIETIN; SALVIA MILTIORRHIZA; SALVIOLIC ACID DERIVATIVE; VASCULAR ENDOTHELIAL GROWTH FACTOR;

ANIMALS; ANTIGENS, CD31; AXONS; BENZOFURANS; BRAIN; BRAIN ISCHEMIA; CAFFEIC ACIDS; CEREBRAL INFARCTION; DENDRITES; ERYTHROPOIETIN; GENE EXPRESSION REGULATION; INFARCTION, MIDDLE CEREBRAL ARTERY; JANUS KINASE 2; MALE; NEOVASCULARIZATION, PHYSIOLOGIC; NEUROPROTECTIVE AGENTS; PHOSPHOPROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ERYTHROPOIETIN; RECOVERY OF FUNCTION; REPERFUSION INJURY; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; SURVIVAL ANALYSIS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2; WATER;

EID: 84879493186     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.05.043     Document Type: Article

References (45)

1. Baloyannis, S.J., Baloyannis, I.S., 2012. The vascular factor in Alzheimer's disease: a study in golgi technique and electron microscopy. J. Neurol. Sci. 322, 117-121.
2. Butler, K.L., Huffman, L.C., Koch, S.E., Hahn, H.S., Gwathmey, J.K., 2006. STAT-3 activation is necessary for ischemic preconditioning in hypertrophied myocardium. Am. J. Physiol. Heart Circ. Physiol. 291, 797-803.
3. Carmeliet, P., 2003. Angiogenesis in health and disease. Nat. Med. 9, 653-660. (Pubitemid 36749213)
4. Chen, J., Li, Y., Wang, L., Zhang, Z., Lu, D., Lu, M., Chopp, M., 2001. Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke 32, 1005-1011. (Pubitemid 32285175)
5. Chen, J., Wang, F., Lee, F.S., Wang, X., Xie, M., 2006. Separation and identification of water-soluble salvianolic acids from Salvia miltiorrhiza Bunge by high-speed counter-current chromatography and ESI-MS analysis. Talanta 69, 172-179. (Pubitemid 43165520)
6. Chen, Y.C., Wu, J.S., Yang, S.T., Huang, C.Y., Chang, C., Sun, G.Y., Lin, T.N., 2012. Stroke, angiogenesis and phytochemicals. Front. Biosci. (Scholar Ed.) 4, 599-610.
7. Chen, Y.H., Du, G.H., Zhang, J.T., 2000. Salvianolic acid B protects brain against injuries caused by ischemia-reperfusion in rats. Acta Pharmacol. Sin. 21, 463-466.
8. Chi, O.Z., Hunter, C., Liu, X., Weiss, H.R., 2007. Effects of anti-VEGF antibody on blood-brain barrier disruption in focal cerebral ischemia. Exp. Neurol. 204, 283-287. (Pubitemid 46330278)
9. Damm, J., Harden, L., Gerstberger, R., Roth, J., Rummel, C., 2011. The putative JAKSTAT inhibitor AG490 exacerbates LPS-fever, reduces sickness behavior, and alters the expression of pro- and anti-inflammatory genes in the rat brain. Brain, Behav. Immun. 25, 183-184.
10. Du, G.H., Qiu, Y., Zhang, J.T., 2000. Salvianolic acid B protects the memory functions against transient cerebral ischemia in mice. J. Asian Nat. Prod. Res. 2, 145-152.
11. Du, G., Zhu, H., Yu, P., Wang, H., He, J., L. Ye, Fu, F., Zhang, J., Tian, J., 2013. SMND-309 promotes angiogenesis in human umbilical vein endothelial cells through activating erythropoietin receptor/STAT3/VEGF pathways. Eur. J. Pharmacol. 700, 173-180.
12. Dvorak, H.F., Brown, L.F., Detmar, M., Dvorak, A.M., 1995. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am. J. Pathol. 146, 1029-1039.
13. Hicklin, D.J., Ellis, L.M., 2005. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J. Clin. Oncol. 23, 1011-1027. (Pubitemid 46202320)
14. Jinbing, Zhao, Guangzhao, Li, Yang, Zhang, Xingfen, Su, Chunhua, Hang, 2011. The potential role of JAK2/STAT3 pathway on the anti-apoptotic effect of recombinant human erythropoietin (rhEPO) after experimental traumatic brain injury of rats. Cytokine 56, 343-350.
15. Jin, K., Zhu, Y., Sun, Y., Mao, X.O., Xie, L., Greenberg, DA., 2002. Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo. Proc. Natl. Acad. Sci. 99, 11946-11950. (Pubitemid 34994504)
16. Ji, X.Y., Tan, B.K., Zhu, Y.Z., 2000. Salvia miltiorrhiza and ischemic diseases. Acta Pharmacol. Sin. 21, 1089-1094. (Pubitemid 32012715)
17. Kelemen, J., Yamada, M., 1977. Modified impregnation method for staining apical dendrite and spine (modified Golgi's method). No To Shinkei 29, 349-351. (Pubitemid 8090384)
18. Kitadai, Y., Sasaki, A., Ito, M., Tanaka, S., Oue, N., Yasui, W., Aihara, M., Imagawa, K., Haruma, K., Chayama, K., 2003. Helicobacter pylori infection influences expression of genes related to angiogenesis and invasion in human gastric carcinoma cells. Biochem. Biophys. Res. Commun. 311, 809-814. (Pubitemid 37393390)
19. Lay, I.S., Chiu, J.H., Shiao, M.S., Lui, W.Y., Wu, C.W., 2003a. Crude extract of salvia miltiorrhiza and salvianolic acid B enhance in vitro angiogenesis in murine SVR endothelial cell line. Planta Med. 69, 26-32.
20. Lay, I.S., Hsieh, C.C., Chiu, J.H., Shiao, M.S., Lui, W.Y., Wu, C.W., 2003b. Salvianolic acid B enhances in vitro angiogenesis and improves skin flap survival in Sprague-Dawley rats. J. Surg. Res. 115, 279-285.
21. Liman, T.G., Endres, M., 2012. New vessels after stroke: postischemic neovascular-ization and regeneration. Cerebrovasc. Dis. 33, 492-499.
22. Lin, Y.L., Wu, C.H., Luo, M.H., Huang, Y.J., Wang, C.N., Shiao, M.S., Huang, Y.T., 2006. In vitro protective effects of salvianolic acid B on primary hepatocytes and hepatic stellate cells. J. Ethnopharmacol. 105, 215-222.
23. Liu, C.L., Xie, L.X., Li, M., Durairajan, S.S., Goto, S., Huang, J.D., 2007. Salvianolic acid B inhibits hydrogen peroxide-induced endothelial cell apoptosis through regulating PI3K/Akt signaling. Plos One 2, e1321.
24. Longa, E.Z., Weinstein, P.R., Carlson, S., Cummins, R., 1989. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20, 84-91. (Pubitemid 19040218)
25. Manoonkitiwongsa, P.S., Schultz, R.L., McCreery, D.B., Whitter, E.F, Lyden, P.D., 2004. Neuroprotection of ischemic brain by vascular endothelial growth factor is critically dependent on proper dosage and may be compromised by angiogen-esis. J. Cereb. Blood Flow Metab. 24, 693-702. (Pubitemid 38725374)
26. Marti, H.J., Bernaudin, M., Bellail, A., Schoch, H., Euler, M., Petit, E., Risau, W., 2000. Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia. Am. J. Pathol. 156, 965-976. (Pubitemid 30626954)
27. Mirmohammadsadegh, A., Marini, A., Gustrau, A., Delia, D., Nambiar, S., Hassan, M., Hengge, U.R., 2010. Role of erythropoietin receptor expression in malignant melanoma. J. Invest. Dermatol. 130, 201-210.
28. Mowat, F.M., Gonzalez, F., Luhmann, U.F., Lange, C.A., Duran, Y., Smith, AJ., Maxwell, P.H., Ali, R.R., Bainbridge, J.W., 2012. Endogenous erythropoietin protects neuroretinal function in ischemic retinopathy. Am. J. Pathol. 180, 1726-1739.
29. Peter, Carmeliet, 2003. Angiogenesis in health and disease. Nat. Med. 9, 653-660. (Pubitemid 36749213)
30. Plate, K.H., Beck, H., Danner, S., Allegrini, P.R., Wiessner, C., 1999. Cell type specific upregulation of vascular endothelial growth factor in an MCA-occlusion model of cerebral infarct. J. Neuropathol. Exp. Neurol. 58, 654-666. (Pubitemid 29264945)
31. Swanson, R.A., Morton, M.T., Tsao-Wu, G., Savalos, R.A., Davidson, C., Sharp, F.R., 1990. A semiautomated method for measuring brain infarct volume. J. Cereb. Blood Flow Metab. 10, 290-293. (Pubitemid 20096202)
32. Tang, M., Feng, W., Zhang, Y., Zhong, J., Zhang, J., 2006. Salvianolic acid B improves motor function after cerebral ischemia in rats. Behav. Pharmacol. 17, 493-498. (Pubitemid 44325811)
33. Tang, M., Zhang, J., 2002. Prostate apoptosis response-4 involved in the protective effect of salvianolic acid B against amyloid beta peptide-induced damage in PC12 cells. Jpn. J. Pharmacol. 88, 422-427. (Pubitemid 34516568)
34. Tian, J., Fu, F., Li, G., Gao, Y., Zhang, Y., Meng, Q., Li, C., Liu, F., 2009c. Protections of SMND-309, a novel derivate of salvianolic acid B, on brain mitochondria contribute to injury amelioration in cerebral ischemia rats. Phytomedicine 16, 726-733.
35. Tian, J., Fu, F., Li, G., Wang, Y., Gao, Y., Liu, Z., Zhang, S., 2009b. SMND-309, a novel derivate of salvianolic acid B, ameliorates cerebral infarction in rats: characterization and role. Brain Res. 31, 114-121.
36. Tian, J., Li, G., Zhang, S., Gao, Y., Jiang, W., Fu, F., Liu, Z., 2009a. SMND-309, a novel derivate of salvianolic acid B, attenuates apoptosis and ameliorates mitochon-drial energy metabolism in rat cortical neurons. Basic Clin. Pharmacol. Toxicol. 104, 176-184.
37. Wang, Y., Chen, T., Han, C., He, D., Liu, H., An, H., Cai, Z., Cao, X., 2007. Lysosome associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Blood 110, 962-971. (Pubitemid 47267435)
38. Tata, D.A., Anderson, B.J., 2002. A new method for the investigation of capillary structure. J. Neurosci. Methods 113, 199-206. (Pubitemid 34076542)
39. Tsuchiya, Y., Takahashi, N., Yoshizaki, T., Tanno, S., Ohhira, M., Motomura, W., Tanno, S., Takakusaki, K., Kohgo, Y., Okumura, T., 2009. A Jak2 inhibitor, AG490, reverses lipin-1 suppression by TNF-alpha in 3T3-L1 adipocytes. Biochem. Biophys. Res. Commun. 382, 348-352.
40. Ulrich, Dirnagl, Costantino, Iadecola, Michael, A., Moskowitz, 1999. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci. 22, 391-397. (Pubitemid 29453643)
41. Vakili, A., Hosseinzadeh, F., Sadogh, T., 2007. Effect of aminoguanidine on post-ischemic brain edema in transient model of focal cerebral ischemia. Brain Res. 1170, 97-102. (Pubitemid 47374656)
42. Waltenberger, J., Mayr, U., Frank, H., Hombach, V., 1996. Suramin is a potent inhibitor of vascular endothelial growth factor. A contribution to the molecular basis of its antiangiogenic action. J. Mol. Cell. Cardiol. 28, 1523-1529. (Pubitemid 26340906)
43. Xiong, Y., Zhang, Y., Mahmood, A., Meng, Y., Qu, C., Chopp, M., 2011. Erythropoietin mediates neurobehavioral recovery and neurovascular remodeling following traumatic brain injury in rats by increasing expression of vascular endothelial growth factor. Translational Stroke Res. 2, 619-632.
44. Yamashita, T., Ninomiya, M., Hernandez Acosta, P., Garcia-Verdugo, J.M., Sunabori, T., Sakaguchi, M., Adachi, K., Kojima, T., Hirota, Y., Kawase, T., Araki, N., Abe, K., Okano, H., Sawamoto, K., 2006. Subventricular zone-derived neuroblasts migrate and diverentiate into mature neurons in the post-stroke adult striatum. J. Neurosci. 26, 6627-6636. (Pubitemid 44318344)
45. Xuan, Y.T., Guo, Y., Han, H., Zhu, Y., Bolli, R., 2001. An essential role of the JAK-STAT pathway in ischemic preconditioning. Proc. Natl. Acad. Sci. USA 98, 9050-9055. (Pubitemid 32743867)