The players: Cells involved in glomerular disease

Clinical Journal of the American Society of Nephrology

Volumn 11, Issue 9, 2016, Pages 1664-1674

  Richard Kitching, A ^a,b,c   Hutton, Holly L ^a,b  

^a MONASH UNIVERSITY   (Australia)

^b Department of Nephrology ^*  (Australia)

^c MONASH MEDICAL CENTRE   (Australia)

Author keywords

Endothelial cells; Fibrosis; Glomerulus; Immunology and pathology; Inflammation; Kidney; Leukocytes; Mesangial cells; Podocytes; Prognosis

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; BIOLOGICAL MARKER; CD40 LIGAND MONOCLONAL ANTIBODY; CHEMOKINE RECEPTOR CXCR2; FIBRINOGEN RECEPTOR; INTERLEUKIN 8; JANUS KINASE 1; NEPHRIN; PHOSPHOLIPASE A2 RECEPTOR; VASCULOTROPIN RECEPTOR;

ARTICLE; AUTOIMMUNITY; CD4 LYMPHOCYTE COUNT; DIABETIC NEPHROPATHY; DISEASE SEVERITY ASSESSMENT; ELECTRON MICROSCOPY; ENDOTHELIUM CELL; ENDOTHELIUM INJURY; EXTRACELLULAR MATRIX; FIBROSIS; GENOTYPE PHENOTYPE CORRELATION; GLOMERULOPATHY; GLOMERULOSCLEROSIS; HUMAN; HYPERGLYCEMIA; HYPERTENSION; HYPERTROPHY; IMMUNE DYSREGULATION; IMMUNE RESPONSE; IMMUNOGLOBULIN A NEPHROPATHY; INFLAMMATION; MESANGIUM CELL; METABOLIC ACTIVATION; MOLECULAR PATHOLOGY; PODOCYTE; PREECLAMPSIA; SIGNAL TRANSDUCTION; ADAPTIVE IMMUNITY; GLOMERULAR FILTRATION BARRIER; GLOMERULUS; HOMEOSTASIS; IMMUNOLOGY; INNATE IMMUNITY; KIDNEY DISEASE; LEUKOCYTE; PATHOLOGY; PATHOPHYSIOLOGY; PERMEABILITY; PHYSIOLOGY;

ADAPTIVE IMMUNITY; ENDOTHELIAL CELLS; GLOMERULAR FILTRATION BARRIER; HOMEOSTASIS; HUMANS; IMMUNITY, INNATE; KIDNEY DISEASES; KIDNEY GLOMERULUS; LEUKOCYTES; MESANGIAL CELLS; PERMEABILITY; PODOCYTES;

EID: 85013592313     PISSN: 15559041     EISSN: 1555905X     Source Type: Journal    
DOI: 10.2215/CJN.13791215     Document Type: Article

References (77)

1. Shankland SJ, Smeets B, Pippin JW, Moeller MJ: The emergence of the glomerular parietal epithelial cell. Nat Rev Nephrol 10: 158-173, 2014
2. Puelles VG, Douglas-Denton RN, Cullen-McEwen LA, Li J, HughsonMD, HoyWE, Kerr PG, Bertram JF: PodocyteNumber in Children and Adults: Associations with Glomerular Size and Numbers of Other Glomerular Resident Cells. J Am Soc Nephrol 26: 2277-2288, 2015
3. SchlöndorffD, Banas B: The mesangial cell revisited: no cell is an island. J Am Soc Nephrol 20: 1179-1187, 2009
4. Saleem MA: One hundred ways to kill a podocyte. Nephrol Dial Transplant 30: 1266-1271, 2015
5. Abboud HE: Mesangial cell biology. Exp Cell Res 318: 979-985, 2012
6. Simonson MS, Ismail-Beigi F: Endothelin-1 increases collagen accumulation in renal mesangial cells by stimulating a chemokine and cytokine autocrine signaling loop. J Biol Chem 286: 11003-11008, 2011
7. Watson S, Cailhier JF, Hughes J, Savill J: Apoptosis and glomerulonephritis. Curr Dir Autoimmun 9: 188-204, 2006
8. Floege J, Eitner F, Alpers CE: A new look at platelet-derived growth factor in renal disease. J AmSoc Nephrol 19: 12-23, 2008
9. Qian Y, Feldman E, Pennathur S, KretzlerM, Brosius FC 3rd: From fibrosis to sclerosis: mechanisms of glomerulosclerosis in diabetic nephropathy. Diabetes 57: 1439-1445, 2008
10. Magistroni R, D’Agati VD, Appel GB, Kiryluk K: New developments in the genetics, pathogenesis, and therapy of IgA nephropathy. Kidney Int 88: 974-989, 2015
11. Tanaka M, Asada M, Higashi AY, Nakamura J, Oguchi A, Tomita M, Yamada S, Asada N, Takase M, Okuda T, Kawachi H, Economides AN, Robertson E, Takahashi S, Sakurai T, Goldschmeding R, Muso E, Fukatsu A, Kita T, Yanagita M: Loss of the BMP antagonist USAG-1 ameliorates disease in a mouse model of the progressive hereditary kidney disease Alport syndrome. J Clin Invest 120: 768-777, 2010
12. Salmon AH, Satchell SC: Endothelial glycocalyx dysfunction in disease: albuminuria and increased microvascular permeability. J Pathol 226: 562-574, 2012
13. Kumar P, ShenQ, Pivetti CD, Lee ES,Wu MH, Yuan SY: Molecular mechanisms of endothelial hyperpermeability: implications in inflammation. Expert Rev Mol Med 11: e19, 2009
14. Lafayette RA, Druzin M, Sibley R, Derby G, Malik T, Huie P, Polhemus C, Deen WM, Myers BD: Nature of glomerular dysfunction in pre-eclampsia. Kidney Int 54: 1240-1249, 1998
15. Toyoda M, Najafian B, Kim Y, Caramori ML, Mauer M: Podocyte detachment and reduced glomerular capillary endothelial fenestration in human type 1 diabetic nephropathy. Diabetes 56: 2155-2160, 2007
16. Nester CM, Barbour T, de Cordoba SR, Dragon-Durey MA, Fremeaux-Bacchi V, Goodship TH, Kavanagh D, Noris M, Pickering M, Sanchez-Corral P, Skerka C, Zipfel P, Smith RJ:Atypical aHUS: State of the art. Mol Immunol 67: 31-42, 2015
17. Eremina V, Jefferson JA, Kowalewska J, Hochster H, Haas M, Weisstuch J, Richardson C, Kopp JB, Kabir MG, Backx PH, Gerber HP, Ferrara N, Barisoni L, Alpers CE, Quaggin SE: VEGF inhibition and renal thrombotic microangiopathy. N Engl J Med 358: 1129-1136, 2008
18. Fan X, Rai A, Kambham N, Sung JF, Singh N, Petitt M, Dhal S, Agrawal R, Sutton RE, Druzin ML, Gambhir SS, Ambati BK, Cross JC, Nayak NR: Endometrial VEGF induces placental sFLT1 and leads to pregnancy complications. J Clin Invest 124: 4941-4952, 2014
19. ComperWD: The limited role of the glomerular endothelial cell glycocalyx as a barrier to transglomerular albumin transport. Connect Tissue Res 55: 2-7, 2014
20. Dane MJ, van den Berg BM, Lee DH, Boels MG, Tiemeier GL, Avramut MC, van Zonneveld AJ, van der Vlag J, Vink H, Rabelink TJ: A microscopic view on the renal endothelial glycocalyx. Am J Physiol Renal Physiol 308: F956-F966, 2015
21. Singh A, Fridén V, Dasgupta I, Foster RR, Welsh GI, Tooke JE, Haraldsson B, Mathieson PW, Satchell SC: High glucose causes dysfunction of the human glomerular endothelial glycocalyx. Am J Physiol Renal Physiol 300: F40-F48, 2011
22. Garg P, Rabelink T: Glomerular proteinuria: a complex interplay between unique players. Adv Chronic Kidney Dis 18: 233-242, 2011
23. Dickson LE, Wagner MC, Sandoval RM, Molitoris BA: The proximal tubule and albuminuria: really! J Am Soc Nephrol 25:443-453, 2014
24. Ballermann BJ, Obeidat M: Tipping the balance from angiogenesis to fibrosis in CKD. Kidney Int Suppl (2011) 4: 45-52, 2014
25. Lennon R, Randles MJ, Humphries MJ: The importance of podocyte adhesion for a healthy glomerulus. Front Endocrinol (Lausanne) 5: 160, 2014
26. May CJ, Saleem M, Welsh GI: Podocyte dedifferentiation: a specialized process for a specialized cell. Front Endocrinol (Lausanne) 5: 148, 2014
27. Sedor JR, Madhavan SM, Kim JH, Konieczkowski M: Out on a LIM: chronic kidney disease, podocyte phenotype and the Wilm’s tumor interacting protein (WTIP). Trans AmClin Climatol Assoc 122: 184-197, 2011
28. Kriz W, Lemley KV: A potential role for mechanical forces in the detachment of podocytes and the progression of CKD. J AmSoc Nephrol 26: 258-269, 2015
29. Wharram BL, Goyal M, Wiggins JE, Sanden SK, Hussain S, Filipiak WE, Saunders TL, Dysko RC, Kohno K, Holzman LB, Wiggins RC: Podocyte depletion causes glomerulosclerosis:diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene. J Am Soc Nephrol 16: 2941-2952, 2005
30. Wiggins RC: The spectrumof podocytopathies: a unifying viewof glomerular diseases. Kidney Int 71: 1205-1214, 2007
31. Lal MA, Young KW, Andag U: Targeting the podocyte to treat glomerular kidney disease. Drug Discov Today 20: 1228-1234, 2015
32. Hynes RO: The extracellular matrix: not just pretty fibrils. Science 326: 1216-1219, 2009
33. Has C, Sparta` G, Kiritsi D, Weibel L, Moeller A, Vega-Warner V, Waters A, He Y, Anikster Y, Esser P, Straub BK, Hausser I, Bockenhauer D, Dekel B, Hildebrandt F, Bruckner-Tuderman L, Laube GF: Integrin a3 mutations with kidney, lung, and skin disease. N Engl J Med 366: 1508-1514, 2012
34. Karamatic Crew V, Burton N, Kagan A, Green CA, Levene C, Flinter F, Brady RL, Daniels G, Anstee DJ: CD151, the first member of the tetraspanin (TM4) superfamily detected on erythrocytes, is essential for the correct assembly of human basement membranes in kidney and skin. Blood 104: 2217-2223, 2004
35. Kestilä M, Lenkkeri U, MännikköM, Lamerdin J, McCready P, Putaala H, Ruotsalainen V, Morita T, Nissinen M, Herva R, Kashtan CE, Peltonen L, Holmberg C, Olsen A, Tryggvason K: Positionally cloned gene for a novel glomerular protein- nephrin-is mutated in congenital nephrotic syndrome. Mol Cell 1: 575-582, 1998
36. BouteN,GribouvalO, Roselli S, Benessy F, Lee H, Fuchshuber A, Dahan K, Gubler MC, Niaudet P, Antignac C: NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome. Nat Genet 24: 349-354, 2000
37. New LA, Martin CE, Jones N: Advances in slit diaphragm signaling. Curr Opin Nephrol Hypertens 23: 420-430, 2014
38. Reiser J, von Gersdorff G, Loos M, Oh J, Asanuma K, Giardino L, Rastaldi MP, Calvaresi N, Watanabe H, Schwarz K, Faul C, Kretzler M, Davidson A, Sugimoto H, Kalluri R, Sharpe AH, Kreidberg JA, Mundel P: Induction of B7-1 in podocytes is associatedwith nephrotic syndrome. J Clin Invest 113: 1390-1397, 2004
39. Goldwich A, Burkard M, Olke M, Daniel C, Amann K, Hugo C, Kurts C, Steinkasserer A, Gessner A: Podocytes are nonhematopoietic professional antigen-presenting cells. J Am Soc Nephrol 24: 906-916, 2013
40. Appel D, KershawDB, Smeets B, Yuan G, Fuss A, Frye B, Elger M, Kriz W, Floege J, Moeller MJ: Recruitment of podocytes from glomerular parietal epithelial cells. J Am Soc Nephrol 20: 333-343, 2009
41. Hackl MJ, Burford JL, Villanueva K, Lam L, Suszták K, Schermer B, Benzing T, Peti-Peterdi J: Tracking the fate of glomerular epithelial cells in vivo using serial multiphoton imaging in new mouse models with fluorescent lineage tags. Nat Med 19: 1661-1666, 2013
42. Holdsworth SR, Kitching AR, Tipping PG: Th1 and Th2 T helper cell subsets affect patterns of injury and outcomes in glomerulonephritis. Kidney Int 55: 1198-1216, 1999
43. Kitching AR: Dendritic cells in progressive renal disease: some answers, many questions. Nephrol Dial Transplant 29: 2185-2193, 2014
44. Kitching AR, Holdsworth SR: The emergence of TH17 cells as effectors of renal injury. J Am Soc Nephrol 22: 235-238, 2011
45. Kitching AR, Holdsworth SR, Hickey MJ: Targeting leukocytes in immune glomerular diseases. Curr Med Chem 15: 448-458, 2008
46. Rogers NM, Ferenbach DA, Isenberg JS, Thomson AW, Hughes J:Dendritic cells and macrophages in the kidney: a spectrum of good and evil. Nat Rev Nephrol 10: 625-643, 2014
47. Devi S, Li A,Westhorpe CL, Lo CY, Abeynaike LD, Snelgrove SL, Hall P, Ooi JD, Sobey CG, Kitching AR, Hickey MJ: Multiphoton imaging reveals a new leukocyte recruitment paradigm in the glomerulus. Nat Med 19: 107-112, 2013
48. Carlin LM, Stamatiades EG, Auffray C, Hanna RN, Glover L, Vizcay-Barrena G, Hedrick CC, Cook HT, Diebold S, Geissmann F: Nr4a1-dependent Ly6C(low) monocytes monitor endothelial cells and orchestrate their disposal. Cell 153: 362-375, 2013
49. Kuligowski MP, Kitching AR, Hickey MJ: Leukocyte recruitment to the inflamed glomerulus: a critical role for platelet-derived P-selectin in the absence of rolling. J Immunol 176: 6991-6999, 2006
50. Coxon A, Cullere X, Knight S, Sethi S,Wakelin MW, Stavrakis G, Luscinskas FW, Mayadas TN: Fc gamma RIII mediates neutrophil recruitment to immune complexes. a mechanism for neutrophil accumulation in immune-mediated inflammation. Immunity 14: 693-704, 2001
51. Falk RJ, Terrell RS, Charles LA, Jennette JC: Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro. Proc Natl Acad Sci U S A 87: 4115-4119, 1990
52. Xiao H, Heeringa P, Hu P, Liu Z, Zhao M, Aratani Y, Maeda N, Falk RJ, Jennette JC: Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice. J Clin Invest 110: 955-963, 2002
53. Kessenbrock K, Krumbholz M, Schönermarck U, Back W, Gross WL, Werb Z, Gröne HJ, Brinkmann V, Jenne DE: Netting neutrophils in autoimmune small-vessel vasculitis. Nat Med 15: 623-625, 2009
54. Lee S, Huen S, Nishio H, Nishio S, Lee HK, Choi BS, Ruhrberg C, Cantley LG: Distinct macrophage phenotypes contribute to kidney injury and repair. J Am Soc Nephrol 22: 317-326, 2011
55. Soos TJ, Sims TN, Barisoni L, Lin K, Littman DR, Dustin ML, Nelson PJ: CX3CR11 interstitial dendritic cells form a contiguous network throughout the entire kidney. Kidney Int 70: 591-596, 2006
56. Lukacs-Kornek V, Burgdorf S, Diehl L, Specht S, Kornek M, Kurts C: The kidney-renal lymph node-system contributes to crosstolerance against innocuous circulating antigen. J Immunol 180: 706-715, 2008
57. Schwarz M, Taubitz A, EltrichN,Mulay SR, AllamR, Vielhauer V: Analysis of TNF-mediated recruitment and activation of glomerular dendritic cells in mouse kidneys by compartmentspecific flow cytometry. Kidney Int 84: 116-129, 2013
58. Scandiuzzi L, Beghdadi W, Daugas E, Abrink M, Tiwari N, Brochetta C, Claver J, Arouche N, Zang X, Pretolani M, Monteiro RC, Pejler G, Blank U: Mouse mast cell protease-4 deteriorates renal function by contributing to inflammation and fibrosis in immune complex-mediated glomerulonephritis. J Immunol 185: 624-633, 2010
59. Eller K, Wolf D, Huber JM, Metz M, Mayer G, McKenzie AN, Maurer M, Rosenkranz AR, Wolf AM: IL-9 production by regulatory T cells recruits mast cells that are essential for regulatory T cell-induced immune suppression. J Immunol 186: 83-91, 2011
60. Gan PY, Summers SA, Ooi JD, O’Sullivan KM, Tan DS, Muljadi RC, Odobasic D, Kitching AR, Holdsworth SR: Mast cells contribute to peripheral tolerance and attenuate autoimmune vasculitis. J Am Soc Nephrol 23: 1955-1966, 2012
61. Summers SA, Steinmetz OM, Li M, Kausman JY, Semple T, Edgtton KL, Borza DB, Braley H, Holdsworth SR, Kitching AR: Th1 and Th17 cells induce proliferative glomerulonephritis. J Am Soc Nephrol 20: 2518-2524, 2009
62. Walker A, Ellis J, Irama M, Senkungu J, Nansera D, Axton J, Coward RJ, Peat DS, Bode HH, Mathieson PW: Eosinophilic glomerulonephritis in children in Southwestern Uganda. Kidney Int 71: 569-573, 2007
63. Reynolds J,Norgan VA, BhambraU, Smith J, CookHT, Pusey CD: Anti-CD8 monoclonal antibody therapy is effective in the prevention and treatment of experimental autoimmune glomerulonephritis. J Am Soc Nephrol 13: 359-369, 2002
64. Steinmetz OM, Velden J, Kneissler U, Marx M, Klein A, Helmchen U, Stahl RA, Panzer U: Analysis and classification of B-cell infiltrates in lupus and ANCA-associated nephritis. Kidney Int 74: 448-457, 2008
65. Wolf D, Hochegger K, Wolf AM, Rumpold HF, Gastl G, Tilg H, Mayer G, Gunsilius E, Rosenkranz AR: CD41CD251 regulatory T cells inhibit experimental anti-glomerular basement membrane glomerulonephritis in mice. J Am Soc Nephrol 16: 1360-1370, 2005
66. Ooi JD, Snelgrove SL, Engel DR, Hochheiser K, Ludwig-Portugall I, Nozaki Y, O’Sullivan KM, Hickey MJ, Holdsworth SR, Kurts C, Kitching AR: Endogenous foxp3(1) T-regulatory cells suppress anti-glomerular basement membrane nephritis. Kidney Int 79: 977-986, 2011
67. WangYM, Zhang GY,HuM, Polhill T, Sawyer A, Zhou JJ, SaitoM, Watson D, Wu H, Wang Y, Wang XM, Wang Y, Harris DC, Alexander SI: CD81 regulatory T cells induced by T cell vaccination protect against autoimmune nephritis. J Am Soc Nephrol 23: 1058-1067, 2012
68. Zheng D, Cao Q, Lee VW, Wang Y, Zheng G, Wang Y, Tan TK, Wang C, Alexander SI, Harris DC,Wang Y: Lipopolysaccharidepretreated plasmacytoid dendritic cells ameliorate experimental chronic kidney disease. Kidney Int 81: 892-902, 2012
69. Wang Y, Wang YP, Zheng G, Lee VW, Ouyang L, Chang DH, Mahajan D, Coombs J, Wang YM, Alexander SI, Harris DC: Ex vivo programmed macrophages ameliorate experimental chronic inflammatory renal disease. Kidney Int 72: 290-299, 2007
70. Godfrey DI, Uldrich AP,McCluskey J, Rossjohn J, Moody DB: The burgeoning family of unconventional T cells. Nat Immunol 16: 1114-1123, 2015
71. Spada R, Rojas JM, Pé rez-Yagüe S, Mulens V, Cannata-Ortiz P, Bragado R, Barber DF: NKG2D ligand overexpression in lupus nephritis correlates with increased NK cell activity and differentiation in kidneys but not in the periphery. J Leukoc Biol 97: 583-598, 2015
72. Yang JQ,Wen X, Liu H, Folayan G, Dong X, ZhouM, Van Kaer L, Singh RR: Examining the role of CD1d and natural killer T cells in the development of nephritis in a genetically susceptible lupus model. Arthritis Rheum 56: 1219-1233, 2007
73. Mesnard L, Keller AC, Michel ML, Vandermeersch S, Rafat C, Letavernier E, Tillet Y, Rondeau E, Leite-de-Moraes MC: Invariant natural killer T cells and TGF-beta attenuate anti-GBM glomerulonephritis. J Am Soc Nephrol 20: 1282-1292, 2009
74. Turner JE, Krebs C, Tittel AP, Paust HJ, Meyer-Schwesinger C, Bennstein SB, SteinmetzOM, Prinz I, Magnus T, Korn T, Stahl RA, KurtsC, PanzerU: IL-17A production by renal gd T cells promotes kidney injury in crescentic GN. J Am Soc Nephrol 23: 1486-1495, 2012
75. Summers SA, van der Veen BS, O’Sullivan KM, Gan PY, Ooi JD, Heeringa P, Satchell SC, Mathieson PW, Saleem MA, Visvanathan K, Holdsworth SR, Kitching AR: Intrinsic renal cell and leukocyte-derived TLR4 aggravate experimental anti-MPO glomerulonephritis. Kidney Int 78: 1263-1274, 2010
76. Ruth AJ, Kitching AR, Semple TJ, Tipping PG, Holdsworth SR: Intrinsic renal cell expression of CD40 directs Th1 effectors inducing experimental crescentic glomerulonephritis. J Am Soc Nephrol 14: 2813-2822, 2003
77. Timoshanko JR, Kitching AR, Holdsworth SR, Tipping PG: Interleukin-12 from intrinsic cells is an effector of renal injury in crescentic glomerulonephritis. J Am Soc Nephrol 12: 464-471, 2001