Interleukin-12 from intrinsic cells is an effector of renal injury in crescentic glomerulonephritis

Journal of the American Society of Nephrology

Volumn 12, Issue 3, 2001, Pages 464-471

  Timoshanko, J R ^a   Kitching, A R ^a   Holdsworth, S R ^a   Tipping, P G ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ANTIBODY; CREATININE; CYTOKINE; GLOBULIN; INTERLEUKIN 12;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; BONE MARROW; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DELAYED HYPERSENSITIVITY; FEMALE; GLOMERULONEPHRITIS; GLOMERULUS BASEMENT MEMBRANE; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; KIDNEY CELL; KIDNEY FUNCTION; KIDNEY INJURY; KIDNEY PROXIMAL TUBULE; MACROPHAGE; MALE; MESANGIUM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEINURIA; T LYMPHOCYTE; TH1 CELL;

EID: 0035126594     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Participation of cell-mediated immunity in deposition of fibrin in glomerulonephritis
2. Prominence of cell-mediated immunity effectors in "pauci-immune" glomerulonephritis
3. Evidence for delayed-type hypersensitivity mechanisms in glomerular crescent formation
4. Th1 responsiveness to nephritogenic antigens determines susceptibility to crescentic glomerulonephritis in mice
5. Crescentic glomerulonephritis in CD4- and CD8-deficient mice. Requirement for CD4 but not CD8 cells
6. Susceptibility to anti-glomerular basement membrane disease and Goodpasture syndrome is linked to MHC class II genes and the emergence of T cell-mediated immunity in mice
7. IFN-γ mediates crescent formation and cell-mediated immune injury in murine glomerulonephritis
8. IL-12 directs severe renal injury, crescent formation and Th1 responses in murine glomerulonephritis
9. Immune modulation with interleukin-4 and interleukin-10 prevents crescent formation and glomerular injury in experimental glomerulonephritis
10. Interleukin-4 deficiency enhances Th1 responses and crescentic glomerulonephritis in mice
11. Endogenous IL- 10 regulates Th1 responses that induce crescentic glomerulonephritis
12. Cloning and expression of murine IL-12
13. Molecular cloning and characterization of murine IL-12 genes
14. Activated T cells induce interleukin-12 production by monocytes via CD40-CD40 ligand interaction
15. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells
16. Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
17. Interleukin-12: A bridge between innate resistance and adaptive immunity with a role in infection and acquired immunodeficiency
18. Up-regulation of tubular epithelial interleukin-12 in autoimmune MRL-Fas (1pr) mice with renal injury
19. Interleukin-12 is synthesized by mesangial cells and stimulates platelet-activating factor synthesis, cytoskeletal reorganization, and cell shape change
20. IL-12-deficient mice are defective in IFN γ production and type 1 cytokine responses
21. Antibody independent crescentic glomerulonephritis in μ chain deficient mice
22. P-selectin directs T lymphocyte-mediated injury in delayed-type hypersensitivity responses: Studies in glomerulonephritis and cutaneous delayed-type hypersensitivity
23. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
24. The interleukin-12/interleukin-12 receptor system: Role in normal and pathologic immune responses
25. An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease
26. An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus
27. Interleukin-12 and its role in cutaneous sensitization
28. IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines
29. Identification and induction of human keratinocyte-derived IL-12
30. Interleukin-12-induced adhesion molecule expression in murine liver
31. Transient gene transfer of IL-12 regulates chemokine expression and disease severity in experimental arthritis
32. IL-12 exacerbates helminth-mediated corneal pathology by augmenting inflammatory cell recruitment and chemokine expression
33. MHC class II expression by intrinsic renal cells is required for crescentic glomerulonephritis
34. Interleukin-12 regulates the proliferation of Th1, but not Th2 or Th0, clones
35. The role of IL12 in the regulation of Th1 and Th2 differentiation
36. The role of IL 12 in helper T-cell differentiation
37. Gamma interferon stimulates monocyte chemotactic protein (MCP-1) in human mesangial cells
38. Crescentic glomerulonephritis in interferon-gamma receptor deficient mice
39. Phenotypic characterization of cytokine expression in patients with IgA nephropathy