Cromolyn Sodium Attenuates Paraquat-Induced Lung Injury by Modulation of Proinflammatory Cytokines

Drug Research

Volumn 67, Issue 5, 2017, Pages 283-288

  Harchegani, Amir Larki ^a   Hemmati, Ali Asghar ^b   Nili Ahmadabadi, Amir ^a   Darabi, Borhan ^b   Shabib, Somayeh ^c  

^a HAMADAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b AHVAZ JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

cromolyn sodium; paraquat; proinflammatory cytokines

Indexed keywords

COLLAGEN; CROMOGLYCATE DISODIUM; HYDROXYPROLINE; INTERLEUKIN 1BETA; INTERLEUKIN 8; PARAQUAT; TUMOR NECROSIS FACTOR; CYTOKINE; INTERLEUKIN 6;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; HISTOLOGY; HISTOPATHOLOGY; LUNG INJURY; LUNG PARENCHYMA; NONHUMAN; PROTEIN BLOOD LEVEL; RAT; ANIMAL; CHEMICALLY INDUCED; DRUG EFFECTS; INFLAMMATION; LUNG; LUNG EDEMA; METABOLISM; WISTAR RAT;

ANIMALS; CROMOLYN SODIUM; CYTOKINES; FEMALE; INFLAMMATION; INTERLEUKIN-1BETA; INTERLEUKIN-6; LUNG; LUNG INJURY; PARAQUAT; PULMONARY EDEMA; RATS; RATS, WISTAR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 85013427613     PISSN: 21949379     EISSN: 21949387     Source Type: Journal    
DOI: 10.1055/s-0042-123711     Document Type: Article

References (29)

1. Chen Y. Nie Y. C. Luo Y. L. et al. Protective effects of naringin against paraquat-induced acute lung injury and pulmonary fibrosis in mice. Food Chem Toxicol: 2013; 58 133 140
2. Pourgholamhossein F. Sharififar F. Rasooli R. et al. Thymoquinone effectively alleviates lung fibrosis induced by paraquat herbicide through down-regulation of pro-fibrotic genes and inhibition of oxidative stress. Environ Toxicol Pharmacol: 2016; 45 340 345
3. Sun Y. Zhang J. Yan Y. et al. The protective effect of C-phycocyanin on paraquat-induced acute lung injury in rats. Environ Toxicol Pharmacol: 2011; 32 168 174
4. Charão M. F. Baierle M. Gauer B. et al. Protective effects of melatonin-loaded lipid-core nanocapsules on paraquat-induced cytotoxicity and genotoxicity in a pulmonary cell line. Mutat Res Genet Toxicol Environ Mutagen: 2015; 784 1 9
5. Amirshahrokhi K. Anti-inflammatory effect of thalidomide in paraquat-induced pulmonary injury in mice. Int Immunopharmacol: 2013; 17 210 215
6. Suntres Z. E. Role of antioxidants in paraquat toxicity. Toxicology: 2002; 180 65 77
7. Rocco P. R. Souza A. B. Faffe D. S. et al. Effect of corticosteroid on lung parenchyma remodeling at an early phase of acute lung injury. Am J Respir Crit Care Med: 2003; 168 677 684
8. Dinis-Oliveira R. J. Sousa C. Remião F. et al. Sodium salicylate prevents paraquat-induced apoptosis in the rat lung. Free Radic Biol Med: 2007; 43 48 61
9. Dinis-Oliveira R. J. Pontes H. Bastos M. L. et al. An effective antidote for paraquat poisonings: the treatment with lysine acetylsalicylate. Toxicology: 2009; 255 187 193
10. Hei Z-Q. Gan X-L. Luo G-J. et al. Pretreatment of cromolyn sodium prior to reperfusion attenuates early reperfusion injury after the small intestine ischemia in rats. World J Gastroenterol: 2007; 13 5139 5146
11. Hu Y. J. Liu Y. Sun T. Q. et al. Binding of anti-inflammatory drug cromolyn sodium to bovine serum albumin. Int J Biol Macromol: 2006; 39 280 285
12. Kanellakis P. Ditiatkovski M. Kostolias G. et al. A profibrotic role for interleukin-4 in cardiac pressure overload. Cardiovasc Res: 2012; 95 75 85
13. Veerappan A. O'Connor N. J. Brazin J. et al. Mast cells: a pivotal role in pulmonary fibrosis. DNA Cell Biol: 2013; 32 206 218
14. Toygar M. Aydin I. Agilli M. et al. The relation between oxidative stress, inflammation, and neopterin in the paraquat-induced lung toxicity. Hum Exp Toxicol: 2015; 34 198 204
15. Khalighi Z. Rahmani A. Cheraghi J. et al. Perfluorocarbon attenuates inflammatory cytokines, oxidative stress and histopathologic changes in paraquat-induced acute lung injury in rats. Environ Toxicol Pharmacol: 2016; 42 9 15
16. Edwards C. A. O'Brien WD J. Modified assay for determination of hydroxyproline in a tissue hydrolyzate. Clin Chim Acta: 1980; 104 161 167
17. 2 and two key cytokines involved in bleomycin-induced pulmonary fibrosis. Iran J Basic Med Sci: 2013; 16 850 857
18. Ball S. L. Mann D. A. Wilson J. A. et al. The role of the fibroblast in inflammatory upper airway conditions. Am J Pathol: 2016; 186 225 233
19. Xie H. Wang R. Tang X. et al. Paraquat-induced pulmonary fibrosis starts at an early stage of inflammation in rats. Immunotherapy: 2012; 4 1809 1815
20. Hemmati A. A. Nazari Z. Motlagh M. E. et al. The role of sodium cromolyn in treatment of paraquat-induced pulmonary fibrosis in rat. Pharmacol Res: 2002; 46 229 234
21. Erroi A. Bianchi M. Ghezzi P. The pneumotoxicant paraquat potentiates IL-1 and TNF production by human mononuclear cells. Agents Actions: 1992; 36 66 69
22. Aires R. D. Capettini LS A. Silva J. F. et al. Paraquat poisoning induces TNF-alpha-dependent iNOS/NO mediated hyporesponsiveness of the aorta to vasoconstrictors in rats. PLoS One: 2013; 8 1 13
23. Mukhopadhyay S. Hoidal J. R. Mukherjee T. K. Role of TNFα in pulmonary pathophysiology. Respir Res: 2006; 7 1 9
24. Lee I. T. Yang C. M. Role of NADPH oxidase/ROS in pro-inflammatory mediators-induced airway and pulmonary diseases. Biochem Pharmacol: 2012; 84 581 590
25. He X. Wang L. Szklarz G. Resveratrol inhibits paraquat-induced oxidative stress and fibrogenic response by activating the nuclear factor erythroid 2-related factor 2 pathway. J Pharmacol Exp Ther: 2012; 342 81 90
26. Allen T. C. Kurdowska A. Interleukin 8 and acute lung injury. Arch Pathol Lab Med: 2014; 138 266 269
27. Zhu Y. M. Webster S. J. Flower D. et al. Interleukin-8/CXCL8 is a growth factor for human lung cancer cells. Br J Cancer: 2004; 91 1970 1976
28. Car B. D. Meloni F. Luisetti M. et al. Elevated IL-8 and MCP-1 in the bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis. Am J Respir Crit Care Med: 1994; 149 655 659
29. Larki A. Hemmati A. A. Arzi A. et al. Regulatory effect of caffeic acid phenethyl ester on type I collagen and interferon-gamma in bleomycin-induced pulmonary fibrosis in rat. Res Pharm Sci: 2013; 8 243 252