Thymoquinone effectively alleviates lung fibrosis induced by paraquat herbicide through down-regulation of pro-fibrotic genes and inhibition of oxidative stress

Environmental Toxicology and Pharmacology

Volumn 45, Issue , 2016, Pages 340-345

  Pourgholamhossein, Fatemeh ^a,b   Sharififar, Fariba ^c   Rasooli, Rokhsana ^a,b   Pourgholi, Leyla ^b   Nakhaeipour, Fatemeh ^b   Samareh Fekri, Hojjat ^b   Iranpour, Maryam ^e   Mandegary, Ali ^b,d  

^a KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Gene expression; Oxidative stress; Paraquat; Pulmonary fibrosis; Thymoquinone

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CATALASE; HYDROXYPROLINE; SUPEROXIDE DISMUTASE; THYMOQUINONE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; ACTIN; ALPHA-SMOOTH MUSCLE ACTIN, MOUSE; ANTIINFLAMMATORY AGENT; BENZOQUINONE DERIVATIVE; COLLAGEN TYPE 1; COLLAGEN TYPE 4; COLLAGEN TYPE I, ALPHA 1 CHAIN; PARAQUAT; TRANSFORMING GROWTH FACTOR BETA1;

ALPHA SMA GENE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; COLLAGEN 1A1 GENE; COLLAGEN 4A1 GENE; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG DOSE COMPARISON; DRUG MEGADOSE; ENZYME ACTIVITY; FIBROGENESIS; GENE; GENE EXPRESSION REGULATION; LIPID PEROXIDATION; LOW DRUG DOSE; LUNG FIBROSIS; LUNG PARENCHYMA; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROFIBROTIC GENE; TGF BETA1 GENE; ANIMAL; BLACK CUMIN; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION; GENETICS; INBRED MOUSE STRAIN; ISOLATION AND PURIFICATION; LUNG; METABOLISM; ORAL DRUG ADMINISTRATION; PATHOLOGY; PLANT SEED; PULMONARY FIBROSIS;

ACTINS; ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS; BENZOQUINONES; COLLAGEN TYPE I; COLLAGEN TYPE IV; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; GENE EXPRESSION; LUNG; MALE; MICE, INBRED STRAINS; NIGELLA SATIVA; OXIDATIVE STRESS; PARAQUAT; PULMONARY FIBROSIS; SEEDS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84976449021     PISSN: 13826689     EISSN: 18727077     Source Type: Journal    
DOI: 10.1016/j.etap.2016.06.019     Document Type: Article

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