Serotonin and Development

Handbook of Behavioral Neuroscience

Volumn 21, Issue C, 2010, Pages 309-323

  Whitaker Azmitia, Patricia M ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

development; fetal; gliogenesis; neonatal; neurogenesis; neuroprotection; ontogeny; serotonin; synaptogenesis

Indexed keywords

EID: 85013214467     PISSN: 15697339     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1569-7339(10)70086-2     Document Type: Chapter

References (198)

1. B. Ahlemeyer H. Beier I. Semkova C. Schaper J. Krieglstein S-100beta protects cultured neurons against glutamate- and staurosporine-induced damage and is involved in the antiapoptotic action of the 5 HT(1A)-receptor agonist, Bay × 3702 Brain Res. 858 2000 121 128
2. A.R. Aitken I. Tork Early development of serotonin-containing neurons and pathways as seen in wholemount preparations of the fetal rat brain J. Comp. Neurol. 274 1988 32 47
3. H.M. Akbari H.K. Kramer P.M. Whitaker-Azmitia L.P. Spear E.C. Azmitia Prenatal cocaine exposure disrupts the development of the serotonergic system Brain Res. 572 1-2 1992 57 63
4. N. Alenina S. Bashammakh M. Bader Specification and differentiation of serotonergic neurons Stem Cell Rev. 2 1 2006 5 10
5. C. Alexandre D. Popa V. Fabre S. Bouali P. Venault K.P. Lesch M. Hamon J. Adrien Early life blockade of 5-hydroxytryptamine 1A receptors normalizes sleep and depression-like behavior in adult knockout mice lacking the serotonin transporter J. Neurosci. 26 20 2006 5554 5564
6. S.E. Alves E. Hoskin S.J. Lee W.G. Brake D. Ferguson V. Luine P.B. Allen P. Greengard B.S. McEwen Serotonin mediates CA1 spine density but is not crucial for ovarian steroid regulation of synaptic plasticity in the adult rat dorsal hippocampus Synapse 45 2002 143 151
7. S.L. Andersen Trajectories of brain development: point of vulnerability or window of opportunity? Neurosci. Biobehav. Rev. 27 2003 3 18
8. G.M. Anderson K. Czarkowski N. Ravski C.N. Epperson Platelet serotonin in newborns and infants: ontogeny, heritability, and effect of in utero exposure to selective serotonin reuptake inhibitors Pediatr. Res. 56 2004 418 422
9. M.S. Ansorge E. Morelli J.A. Gingrich Inhibition of serotonin but not norepinephrine transport during development produces delayed, persistent perturbations of emotional behaviors in mice J. Neurosci. 28 1 2008 199 207
10. A. Attanasio K. Rager D. Gupta Ontogeny of circadian rhythmicity for melatonin, serotonin, and N-acetylserotonin in humans J. Pineal. Res. 3 3 1986 251 256
11. E.C. Azmitia Neuronal instability: implications for Rett's syndrome Brain Dev. 23 Suppl. 1 2001 S1 S10
12. E.C. Azmitia K. Dolan P.M. Whitaker-Azmitia S-100B but not NGF, EGF, insulin or calmodulin is a CNS serotonergic growth factor Brain Res. 516 2 1990 354 356
13. E.C. Azmitia V.J. Rubinstein J.A. Strafaci J.C. Rios P.M. Whitaker-Azmitia 5-HT1A agonist and dexamethasone reversal of para-chloroamphetamine induced loss of MAP-2 and synaptophysin immunoreactivity in adult rat brain Brain Res. 677 2 1995 181 192
14. O. Bar-Peled R. Gross-Isseroff H. Ben-Hur I. Hoskins Y. Groner A. Biegon Fetal human brain exhibits a prenatal peak in the density of serotonin 5-HT1A receptors Neurosci. Lett. 127 2 1991 173 176
15. G.J. Basura P.D. Walker Suppression of serotonin hyperinnervation does not alter the dysregulatory influences of dopamine depletion on striatal neuropeptide gene expression in rodent neonates Neurosci. Lett. 274 1 1999 9 12
16. G.J. Basura P.D. Walker Stimulated serotonin release from hyperinnervated terminals subsequent to neonatal dopamine depletion regulates striatal tachykinin, but not enkephalin gene expression Brain Res. 81 1-2 2000 80 91
17. G.J. Basura A.I. Abbas H. O'Donohue J.M. Lauder B.L. Roth P.D. Walker P.B. Manis Ontogeny of serotonin and serotonin2A receptors in rat auditory cortex Hear Res. 244 1-2 2008 45 50
18. F.M. Benes J.B. Taylor M.C. Cunningham Convergence and plasticity of monoaminergic systems in the medial prefrontal cortex during the postnatal period: implications for the development of psychopathology Cereb. Cortex 10 10 2000 1014 1027
19. G.W. Bielenberg M. Burkhardt 5-hydroxytryptamine1A agonists. A new therapeutic principle for stroke treatment Stroke 21 Suppl. 12 1990 IV161 IV163
20. K.M. Bode-Greuel J. Klisch E. Horváth T. Glaser J. Traber Effects of 5-hydroxytryptamine1A-receptor agonists on hippocampal damage after transient forebrain ischemia in the Mongolian gerbil Stroke 21 Suppl. 12 1990 IV164 IV166
21. A. Bonnin W. Peng W. Hewlett P. Levitt Expression mapping of 5-HT1 serotonin receptor subtypes during fetal and early postnatal mouse forebrain development Neuroscience 141 2 2006 781 794
22. A. Borella M. Bindra P.M. Whitaker-Azmitia Role of the 5-HT1A receptor in development of the neonatal rat brain: preliminary behavioral studies Neuropharmacology 36 4-5 1997 445 450
23. C. Bou-Florés A.-M. Lajard R. Monteau E. De Maeyer I. Seif J. Lanoir G. Hilaire Abnormal phrenic motoneuron activity and morphology in neonatal monoamine oxidase A-deficient transgenic mice: possible role of a serotonin excess J. Neurosci. 20 2000 4646 4656
24. L.S. Brewton L. Haddad E.C. Azmitia Colchicine-induced cytoskeletal collapse and apoptosis in N-18 neuroblastoma cultures is rapidly reversed by applied S-100β Brain Res. 912 2001 9 16
25. J.M. Brezun A. Daszuta Depletion in serotonin decreases neurogenesis in the dentate gyrus and the subventricular zone of adult rats Neuroscience 89 4 1999 999 1002
26. J.M. Brezun A. Daszuta Serotonin may stimulate granule cell proliferation in the adult hippocampus, as observed in rats grafted with foetal raphe neurons Eur. J. Neurosci. 12 1 2000 391 396
27. J. Briscoe L. Sussel P. Serup D. Hartigan-O'Connor T.M. Jessell J.L. Rubenstein J. Ericson Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling Nature 398 6728 1999 622 627
28. G. Brüning O. Liangos Transient expression of the serotonin transporter in the developing mouse thalamocortical system Acta Histochem. 99 1 1997 117 121
29. G. Brüning O. Liangos H.G. Baumgarten Prenatal development of the serotonin transporter in mouse brain Cell Tissue Res. 289 2 1997 211 221
30. T.M. Cabrera-Vera G. Battaglia Prenatal exposure to fluoxetine (Prozac) produces site-specific and age-dependent alterations in brain serotonin transporters in rat progeny: evidence from autoradiographic studies J. Pharmacol. Exp. Ther. 286 3 1998 1474 1481
31. T.M. Cabrera-Vera F. Garcia W. Pinto G. Battaglia Effect of prenatal fluoxetine (Prozac) exposure on brain serotonin neurons in prepubescent and adult male rat offspring J. Pharmacol. Exp. Ther. 280 1 1997 138 145
32. C. Cannizzaro F. Plescia M. Gagliano G. Cannizzaro G. Mantia M. La Barbera G. Provenzano E. Cannizzaro Perinatal exposure to 5-methoxytryptamine, behavioural-stress reactivity and functional response of 5-HT1A receptors in the adolescent rat Behav. Brain Res. 186 1 2008 98 106
33. O. Cases T. Vitalis I. Seif E. De Maeyer C. Sotelo P. Gaspar Lack of barrels in the somatosensory cortex of monoamine oxidase A-deficient mice: role of a serotonin excess during the critical period Neuron 16 2 1996 297 307
34. R.C. Casper B.E. Fleisher J.C. Lee-Ancajas A. Gilles E. Gaylor A. De Battista H.E. Hoyme Follow-up of children of depressed mothers exposed or not exposed to antidepressant drugs during pregnancy J. Pediatr. 142 2003 402 408
35. L. Chen K. Hamaguchi M. Ogawa S. Hamada N. Okado PCPA reduces both monoaminergic afferents and nonmonoaminergic synapses in the cerebral cortex Neurosci. Res. 19 1994 111 115
36. D.C. Chugani O. Muzik R. Rothermel M. Behen P. Chakraborty T. Mangner E.A. da Silva H.T. Chugani Altered serotonin synthesis in the dentatothalamocortical pathway in autistic boys Ann. Neurol. 42 4 1997 666 669
37. D.C. Chugani O. Muzik M. Behen R. Rothermel J.J. Janisse J. Lee H.T. Chugani Developmental changes in brain serotonin synthesis capacity in autistic and nonautistic children Ann. Neurol. 45 3 1999 287 295
38. H.T. Chugani M.E. Phelps J.C. Mazziotta Positron emission tomography study of human brain functional development Ann. Neurol. 22 4 1987 487 497
39. S.P. Cordes Molecular genetics of the early development of hindbrain serotonergic neurons Clin. Genet. 68 6 2005 487 494
40. N. Costes I. Merlet K. Ostrowsky I. Faillenot F. Lavenne L. Zimmer P. Ryvlin D. Le Bars A 18F-MPPF PET normative database of 5-HT1A receptor binding in men and women over aging J. Nucl. Med. 46 12 2005 1980 1989
41. D.S. Cowen L.F. Takase C.A. Fornal B.L. Jacobs Age-dependent decline in hippocampal neurogenesis is not altered by chronic treatment with fluoxetine Brain Res. 1228 2008 14 19
42. B. Czéh M. Simon B. Schmelting C. Hiemke E. Fuchs Astroglial plasticity in the hippocampus is affected by chronic psychosocial stress and concomitant fluoxetine treatment Neuropsychopharmacology 31 8 2006 1616 1626
43. R.J. D'Amato M.E. Blue B.L. Largent D.J. Ledbetter M.E. Molliver S.H. Snyder Ontogeny of the serotonergic projection to rat neocortex: transient expression of a dense innervation to primary sensory areas Proc. Natl. Acad. Sci. USA 84 1987 4322 4326
44. D. Daval A. Verge H. Becerril U. Gozlan J. Spampinato M. Hamon Transient expression of 5-HT1A receptors binding sites in some areas of the rat CNS during postnatal development Intl. J. Dev. Neurosci. 5 1987 171 189
45. E. del Olmo A. Pazos Aminergic receptors during the development of the human brain: the contribution of in vitro imaging techniques J. Chem. Neuroanat. 22 1-2 2001 101 114
46. E. del Olmo A. Díaz M. Guirao-Piñeyro C. del Arco J. Pascual A. Pazos Transient localization of 5-HT1A receptors in human cerebellum during development Neurosci. Lett. 166 2 1994 149 152
47. E. del Olmo J.F. López-Giménez M.T. Vilaró G. Mengod J.M. Palacios A. Pazos Early localization of mRNA coding for 5-HT1A receptors in human brain during development Brain Res. Mol. Brain Res. 60 1 1998 123 126
48. D.R. Deng S. Djalali M. Holtje G. Grosse T. Stroh I. Voigt H. Kusserow F. Theuring G. Ahnert-Hilger H. Hortnagi Embryonic and postnatal development of the serotonergic raphe system and its target regions in 5-HT1A receptor deletion or overexpressing mouse mutants Neuroscience 147 2 2007 338 402
49. T.J. Diefenbach B.D. Sloley J.I. Goldberg Neurite branch development of an identified serotonergic neuron from embryonic Helisoma: evidence for autoregulation by serotonin Dev. Biol. 167 1 1995 282 293
50. R. Donato Intracellular and extracellular roles of S100 proteins Microsc. Res. Tech. 60 6 2003 540 551
51. R. Donato RAGE: a single receptor for several ligands and different cellular responses: the case of certain S100 proteins Curr. Mol. Med. 7 8 2007 711 724
52. M.J. Druse N.F. Tajuddin R.A. Gillespie P. Le The effects of ethanol and the serotonin(1A) agonist ipsapirone on the expression of the serotonin(1A) receptor and several antiapoptotic proteins in fetal rhombencephalic neurons Brain Res. 1092 1 2006 79 86
53. M.J. Druse R.A. Gillespie N.F. Tajuddin M. Rich S100B-mediated protection against the pro-apoptotic effects of ethanol on fetal rhombencephalic neurons Brain Res. 1150 2007 46 54
54. K.M. Faber J.H. Haring Synaptogenesis in the postnatal rat fascia dentata is influenced by 5-HT1A receptor activation Dev. Brain Res. 114 1999 245 252
55. F. Farabollini D.R. Hole C.A. Wilson Behavioral effects in adulthood of serotonin depletion by P-chlorophenylalanine given neonatally to male rats Intl. J. Neurosci. 41 3-4 1988 187 199
56. S.H. Fatemi A.V. Snow J.M. Stary M. Araghi-Niknam T.J. Reutiman S. Lee A.I. Brooks D.A. Pearce Reelin signaling is impaired in autism Biol. Psychiatry 57 7 2005 777 787
57. M.G. Feenstra H. van Galen P.J. Te Riele M.H. Botterblom M. Mirmiran Decreased hypothalamic serotonin levels in adult rats treated neonatally with clomipramine Pharmacol. Biochem. Behav. 55 1996 647 652
58. A. Feria-Velasco A.R. del Angel I. Gonzalez-Burgos Modification of dendritic development Prog. Brain Res. 136 2002 135 143
59. J. Fernandez-Pardal L.A. Hilakivi Effect of low alcohol dose on behavioral despair in rats neonatally treated with antidepressant drugs Alcohol 6 1989 93 95
60. T. Field Violence and touch deprivation in adolescents Adolescence 37 148 2002 735 749
61. T. Field M. Diego M. Hernandez-Reif S. Schanberg C. Kuhn R. Yando D. Bendell Pregnancy anxiety and comorbid depression and anger: effects on the fetus and neonate Depress. Anxiety 17 3 2003 140 151
62. T. Field M. Diego J. Dieter M. Hernandez-Reif S. Schanberg C. Kuhn Prenatal depression effects on the fetus and the newborn Infant Behav. Dev. 27 2004 216 229
63. A.D. Fricker C. Rios L.A. Devi I. Gomes Serotonin receptor activation leads to neurite outgrowth and neuronal survival Brain Res. Mol. Brain Res. 138 2 2005 228 235
64. G. Garcia P. Tagliaferro A. Bortolozzi M.J. Madariaga A. Brusco A.M. Evangelista de Duffard R. Duffard J.P. Saavedra Morphological study of 5-HT neurons and astroglial cells on brain of adult rats perinatal or chronically exposed to 2,4-dichlorophenoxyacetic acid Neurotoxicology 22 6 2001 733 741
65. P. Gaspar O. Cases L. Maroteaux The developmental role of serotonin: news from mouse molecular genetics Nat. Rev. Neurosci. 4 12 2003 1002 1012
66. J.I. Goldberg Serotonin regulation of neurite outgrowth in identified neurons from mature and embryonic Helisoma trivolvis Perspect. Dev. Neurobiol. 5 4 1998 373 387
67. E.M. González L.A. Penedo P. Oliveira-Silva P. Campello-Costa R.C. Guedes C.A. Serfaty Neonatal tryptophan dietary restriction alters development of retinotectal projections in rats Exp. Neurol. 211 2 2008 441 448
68. I. Gonzalez-Burgos A.R. del Angel-Meza G. Barajas-López A. Feria-Velasco Tryptophan restriction causes long-term plastic changes in corticofrontal pyramidal neurons Intl. J. Dev. Neurosci. 14 5 1996 673 679
69. T. Gos K. Becker J. Bock U. Malecki B. Bogerts G. Poeggel K. Braun Early neonatal and postweaning social emotional deprivation interferes with the maturation of serotonergic and tyrosine hydroxylase-immunoreactive afferent fiber systems in the rodent nucleus accumbens, hippocampus and amygdala Neuroscience 140 3 2006 811 821
70. E. Gould Serotonin and hippocampal neurogenesis Neuropsychopharmacology 21 Suppl. 2 1999 46S 51S
71. H. Hansen C. Sanchez E. Meier Neonatal administration of the selective serotonin reuptake inhibitor Lu 10-134-C increases forced swimming-induced immobility of adult rats: a putative animal model of depression? J. Pharm. Exp. Ther. 283 1997 1333 1341
72. H.H. Hansen J.D. Mikkelsen Long-term effects on serotonin transporter mRNA expression of chronic neonatal exposure to a serotonin reuptake inhibitor Eur. J. Pharmacol. 352 1998 307 315
73. S.R. Hansson E. Mezey B.J. Hoffman Serotonin transporter messenger RNA in the developing rat brain: early expression in serotonergic neurons and transient expression in non-serotonergic neurons Neuroscience 83 1998 1185 1201
74. P.G. Haydon D.P. McCobb S.B. Kater The regulation of neurite outgrowth, growth cone motility, and electrical synaptogenesis by serotonin J. Neurobiol. 18 2 1987 197 215
75. J. Hedner K.H. Lundell G.R. Breese R.A. Mueller T. Hedner Developmental variations in CSF monoamine metabolites during childhood Biol. Neonate. 49 4 1986 190 197
76. T. Hendricks N. Francis D. Fyodorov E.S. Deneris The ETS domain factor Pet-1 is an early and precise marker of central serotonin neurons and interacts with a conserved element in serotonergic genes J. Neurosci. 19 23 1999 10348 10356
77. T.J. Hendricks D.V. Fyodorov L.J. Wegman N.B. Lelutiu E.A. Pehek B. Yamamoto J. Silver E.J. Weeber J.D. Sweatt E.S. Deneris Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior Neuron 37 2 2003 233 247
78. L.A. Hilakivi I. Hilakivi Increased adult behavioral ‘despair’ in rats neonatally exposed to desipramine or zimel-dine: an animal model of depression? Pharmacol. Biochem. Behav. 28 1987 367 369
79. S. Himpel J. Bartels K. Zimdars G. Huether L. Adler R.R. Dawirs G.H. Moll Association between body weight of newborn rats and density of serotonin transporters in the frontal cortex at adulthood J. Neural Transm. 113 3 2006 295 302
80. C.F. Hohmann E.M. Walker C.B. Boylan M.E. Blue Neonatal serotonin depletion alters behavioral responses to spatial change and novelty Brain Res. 1139 2007 163 177
81. A. Holmes Q. Lit D.L. Murphy E. Gold J.N. Crawley Abnormal anxiety-related behavior in serotonin transporter null mutant mice: the influence of genetic background Genes Brain Behav. 2 6 2003 365 380
82. G.J. Huang D. Bannerman J. Flint Chronic fluoxetine treatment alters behavior, but not adult hippocampal neurogenesis, in BALB/cJ mice Mol. Psychiatry 13 2 2008 119 121
83. P.R. Huttenlocher C. De Courten L.J. Garey H. Van der Loos Synaptic development in human cerebral cortex Intl. J. Neurol. 16-17 1983 144 154
84. M. Hynes A. Rosenthal Specification of dopaminergic and serotonergic neurons in the vertebrate CNS Curr. Opin. Neurobiol. 9 1 1999 26 36
85. S. Janusonis V. Gluncic P. Rakic Early serotonergic projections to Cajal-Retzius cells: relevance for cortical development J. Neurosci. 24 7 2005 1652 1659
86. D. Kahne A. Tudorica A. Borella L. Shapiro F. Johnstone W. Huang P.M. Whitaker-Azmitia Behavioral and magnetic resonance spectroscopic studies in the rat hyperserotonemic model of autism Physiol. Behav. 75 3 2002 403 410
87. L.I. Khozhai Formation of the astroglia in the mouse neocortex after temporary prenatal blockade of serotonin synthesis Neurosci. Behav. Physiol. 36 3 2006 275 278
88. L.I. Khozhai V.A. Otellin Formation of the neocortex in mice developing in conditions of prenatal serotonin deficiency Neurosci. Behav. Physiol. 36 5 2006 513 517
89. H.C. Kinney L.L. Randall L.A. Sleeper M. Willinger R.A. Belliveau N. Zec L.A. Rava L. Dominici S. Iyasu B. Randall D. Habbe H. Wilson F. Mandell M. McClain T.K. Welty Serotonergic brainstem abnormalities in Northern Plains Indians with the sudden infant death syndrome J. Neuropathol. Exp. Neurol. 62 11 2003 1178 1191
90. H.C. Kinney R.A. Belliveau F.L. Trachtenberg L.A. Rava D.S. Paterson The development of the medullary serotonergic system in early human life Auton. Neurosci. 132 1-2 2007 81 102
91. M. Kondoh T. Shiga N. Okado Regulation of dendrite formation of Purkinje cells by serotonin through serotonin(1A) and serotonin(2A) receptors in culture Neurosci. Res. 48 2004 101 109
92. P.J. Kontur C. Leranth D.E. Redmond Jr. R.H. Roth R.J. Robbins Tyrosine hydroxylase immunoreactivity and monoamine and metabolite levels in cryopreserved human fetal ventral mesencephalon Exp. Neurol. 121 2 1993 172 180
93. J.B. Koprich E.Y. Chen N.M. Kanaan N.G. Campbell J.H. Kordower J.W. Lipton Prenatal 3,4-methylenedioxymethamphetamine (ecstasy) alters exploratory behavior, reduces monoamine metabolism, and increases forebrain tyrosine hydroxylase fiber density of juvenile rats Neurotoxicol. Teratol. 25 5 2003 509 517
94. K. Laine T. Heikkinen U. Ekblad P. Kero Effects of exposure to selective serotonin reuptake inhibitors during pregnancy on serotonergic symptoms in newborns and cord blood monoamine and prolactin concentrations Arch. Gen. Psychiatry 60 7 2003 720 726
95. R.D. Lane N.L. Chiaia K.L. Kesterson R.W. Rhoades R.D. Mooney Boundary-limited serotonergic influences on pattern organization in rat sensory cortex Neurosci. Lett. 395 2 2006 165 169
96. L. Lanfumey R. Mongeau C. Cohen-Salmon M. Hamon Corticosteroid-serotonin interactions in the neurobiological mechanisms of stress-related disorders Neurosci. Biobehav. Rev. 32 6 2008 1174 1184
97. J.M. Lauder Hormonal and humoral influences on brain development Psychoneuroendocrinology 8 2 1983 121 155
98. J.M. Lauder Roles for neurotransmitters in development: possible interaction with drugs during the fetal and neonatal periods Prog. Clin. Biol. Res. 163C 1985 375 380
99. J.M. Lauder Ontogeny of the serotonergic system in the rat: serotonin as a developmental signal Ann. NY Acad. Sci. 600 1990 297 313
100. J.M. Lauder H. Krebs Serotonin as a differentiation signal in early neurogenesis Dev. Neurosci. 1 1 1978 15 30
101. J.M. Lauder J.A. Wallace H. Krebs Roles for serotonin in neuroembryogenesis Adv. Exp. Med. Biol. 133 1981 477 506
102. J.M. Lauder P. Petrusz J.A. Wallace A. Dinome M.B. Wilkie K. McCarthy Combined serotonin immunocytochemistry and 3H-thymidine autoradiography: in vivo and in vitro methods J. Histochem. Cytochem. 30 8 1982 788 793
103. J.H. Lee N.F. Tajuddin M.J. Druse Effects of ethanol and ipsapirone on the expression of genes encoding anti-apoptotic proteins and an antioxidant enzyme in ethanol-treated neurons Brain Res 2008 1 November [Epub ahead of print]
104. B. Lerer Y. Gelfin B. Shapira Neuroendocrine evidence for age-related decline in central serotonergic function Neuropsychopharmacology 21 2 1999 321 322
105. M.L. Leret V. Peinado L.M. Suárez L. Tecedor A. Gamallo J.C. González Role of maternal adrenal glands on the developing serotoninergic and aminoacidergic systems of the postnatal rat brain Intl. J. Dev. Neurosci. 22 2 2004 87 93
106. C. Levallois M.C. Calvet D. Petite Immunocytochemical demonstration of monoamine-containing cells in human fetal brain stem dissociated cultures Dev. Brain Res. 75 1 1993 141 145
107. H.G. Lidov M.E. Molliver An immunohistochemical study of serotonin neuron development in the rat: ascending pathways and terminal fields Brain Res. Bull. 8 4 1982 389 430
108. V. Lieske C.A. Bennett-Clarke R.W. Rhoades Effects of serotonin on neurite outgrowth from thalamic neurons in vitro. Neuroscience 90 3 1999 967 974
109. A. Lira M. Zhou N. Castanon M.S. Ansorge J.A. Gordon J.H. Francis M. Bradley-Moore J. Lira M.D. Underwood V. Arango H.F. Kung M.A. Hofer R. Hen J.A. Gingrich Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient mice Biol. Psychiatry 54 10 2003 960 971
110. B. Lotto L. Upton D.J. Price P. Gaspar Serotonin receptor activation enhances neurite outgrowth of thalamic neurones in rodents Neurosci. Lett. 269 1999 87 90
111. D. Maciag L. Williams D. Coppinger I.A. Paul Neonatal citalopram exposure produces lasting changes in behavior which are reversed by adult imipramine treatment Eur. J. Pharmacol. 532 3 2006 265 269
112. L. Madhavan W.J. Freed V. Anantharam A.G. Kanthasamy 5-hydroxytryptamine1A receptor activation protects against N-methyl-Daspartate-induced apoptotic cell death in striatal and mesencephalic cultures J. Pharmacol. Exp. Ther. 304 2003 913 923
113. I. Makkonen R. Riikonen H. Kokki M.M. Airaksinen J.T. Kuikka Serotonin and dopamine transporter binding in children with autism determined by SPECT Dev. Med. Child Neurol. 50 8 2008 593 597
114. H. Manev T. Uz R. Manev Glia as a putative target for antidepressant treatments J. Affect Disord. 75 1 2003 59 64
115. A.B. Marcussen P. Flagstad P.E. Kristjansen F.F. Johansen U. Englund Increase in neurogenesis and behavioural benefit after chronic fluoxetine treatment in Wistar rats Acta Neurol. Scand. 117 2 2008 94 100
116. M. Matsukawa M. Ogawa K. Nakadate T. Maeshima Y. Ichitani N. Kawai N. Okado Serotonin and acetylcholine are crucial to maintain hippocampal synapses and memory acquisition in rats Neurosci. Lett. 230 1997 13 16
117. K. Matthews J.W. Dalley C. Matthews T.H. Tsai T.W. Robbins Periodic maternal separation of neonatal rats produces region- and gender-specific effects on biogenic amine content in postmortem adult brain Synapse 40 1 2001 1 10
118. C. Mazer J. Muneyyirci K. Taheny N. Raio A. Borella P.M. Whitaker-Azmitia Serotonin depletion during synaptogenesis leads to decreased synaptic density and learning deficits in the adult rat: a possible model of neurodevelopmental disorders with cognitive deficits Brain Res. 760 1-2 1997 68 73
119. B.S. McEwen Early life influences on life-long patterns of behavior and health Ment. Retard. Dev. Disabil. Res. Rev. 9 3 2003 149 154
120. I. McNamara A. Borella L. Bialowas P.M. Whitaker-Azmitia Further studies in the developmental hyperserotonemia model (DHS) of autism: social, behavioral and peptide changes Brain Res. 1189 2008 204 213
121. S.D. Mendelson B.S. McEwen Autoradiographic analyses of the effects of restraint-induced stress on 5-HT1A, 5-HT1C and 5-HT2 receptors in the dorsal hippocampus of male and female rats Neuroendocrinology 54 1991 454 461
122. J.P. Mostert M.W. Koch M. Heerings D.J. Heersema J. De Keyser Therapeutic potential of fluoxetine in neurological disorders CNS Neurosci. Ther. 14 2 2008 153 164
123. K. Muneoka M. Mikuni T. Ogawa K. Kitera K. Kamei M. Takigawa K. Takahashi Prenatal dexamethasone exposure alters brain monoamine metabolism and adrenocortical response in rat offspring Am. J. Physiol. 273 5 Pt 2 1997 R1669 R1675
124. N. Nakata H. Suda J. Izumi Y. Tanaka Y. Ikeda H. Kato Y. Itoyama K. Kogure Role of hippocampal serotonergic neurons in ischemic neuronal death Behav. Brain Res. 83 1-2 1997 217 220
125. N. Narboux-Neme L.M. Pavone L. Avallone X. Zhuang P. Gaspar Serotonin transporter transgenic (SERT(cre)) mouse line reveals developmental targets of serotonin specific reuptake inhibitors (SSRIs) Neuropharmacology 55 6 2008 994 1005
126. S. Navailles P.R. Hof C. Schmauss Antidepressant drug-induced stimulation of mouse hippocampal neurogenesis is age-dependent and altered by early life stress J. Comp. Neurol. 509 4 2008 372 381
127. M. Nishi P.M. Whitaker-Azmitia E.C. Azmitia Enhanced synaptophysin immunoreactivity in rat hippocampal culture by 5-HT 1A agonist, S100b, and corticosteroid receptor agonists Synapse 23 1 1996 1 9
128. H. Nordeng R. Lindemann K.V. Perminov A. Reikvam Neonatal withdrawal syndrome after in utero exposure to selective serotonin reuptake inhibitors Acta Paediatr. 90 3 2001 288 291
129. T.F. Oberlander S. Misri C.E. Fitzgerald X. Kostaras D. Rurak W. Riggs Pharmacologic factors associated with transient neonatal symptoms following prenatal psychotropic medication exposure J. Clin. Psychiatry 65 2 2004 230 237
130. T.F. Oberlander W. Warburton S. Misri J. Aghajanian C. Hertzman Neonatal outcomes after prenatal exposure to selective serotonin reuptake inhibitor antidepressants and maternal depression using population-based linked health data Arch. Gen. Psychiatry 63 8 2006 898 906
131. T.F. Oberlander R. Grunau L. Mayes W. Riggs D. Rurak M. Papsdorf S. Misri J. Weinberg Hypothalamic-pituitary-adrenal (HPA) axis function in 3-month old infants with prenatal selective serotonin reuptake inhibitor (SSRI) antidepressant exposure Early Hum. Dev. 84 10 2008 689 697
132. B.J. Oosterink S.M. Korte C. Nyakas J. Korf P.G. Luiten Neuroprotection against N-methyl-D-aspartate-induced excitotoxicity in rat magnocellular nucleus basalis by the 5-HT1A receptor agonist 8-OH-DPAT Eur. J. Pharmacol. 358 1998 147 152
133. K.C. O'Reilly S. Trent S.J. Bailey M.A. Lane 13-cis-Retinoic acid alters intracellular serotonin, increases 5-HT1A receptor, and serotonin reuptake transporter levels in vitro. Exp. Biol. Med. 232 9 2007 1195 1203
134. T.D. Patel F.C. Zhou Ontogeny of 5-HT1A receptor expression in the developing hippocampus Dev. Brain Res. 157 1 2005 42 57
135. D.S. Paterson R.A. Belliveau F. Trachtenberg H.C. Kinney Differential development of 5-HT receptor and the serotonin transporter binding in the human infant medulla J. Comp. Neurol. 472 2 2004 221 231
136. A.M. Persico A. Baldi M.L. Dell'Acqua R. Moessner D.L. Murphy K.P. Lesch F. Keller Reduced programmed cell death in brains of serotonin transporter knockout mice Neuroreport 14 2003 341 344
137. D.A. Peters Prenatal stress: effect on development of rat brain serotonergic neurons Pharmacol. Biochem. Behav. 24 5 1986 1377 1382
138. D. Popa C. Léna C. Alexandre J. Adrien Lasting syndrome of depression produced by reduction in serotonin uptake during postnatal development: evidence from sleep, stress, and behavior J. Neurosci. 28 14 2008 3546 3554
139. L.C. Porto F.L. Sardinha M.M. Telles R.B. Guimarães K.T. Albuquerque I.S. Andrade L.M. Oyama C.M. Nascimento O.F. Santos E.B. Ribeiro Impairment of the serotonergic control of feeding in adult female rats exposed to intra-uterine malnutrition Br JNutr 2008 [Epub ahead of print]
140. C.C. Quattrocchi F. Wannenes A.M. Persico S.A. Ciafré G. D'Arcangelo M.G. Farace F.J. Keller Reelin is a serine protease of the extracellular matrix Biol. Chem. 277 13 2002 11616
141. A.J. Ramos P. Tagliaferro E.M. Lopez J. Pecci Saavedra A. Brusco Neuroglial interactions in a model of para-chlorophenylalanine-induced serotonin depletion Brain Res. 883 2000 1 14
142. A.J. Ramos M.D. Rubio C. Defagot L. Hischberg M.J. Villar A. Brusco The 5HT1A receptor agonist, 8-OH-DPAT, protects neurons and reduces astroglial reaction after ischemic damage caused by cortical devascularization Brain Res. 1030 2 2004 201 220
143. O. Riccio G. Potter C. Walzer P. Vallet G. Szabó L. Vutskits J.Z. Kiss A.G. Dayer Excess of serotonin affects embryonic interneuron migration through activation of the serotonin receptor 6 Mol Psychiatry 2008 [Epub ahead of print]
144. R.S. Riikonen P. Nokelainen K. Valkonen A.I. Kolehmainen K.I. Kumpulainen M. Kônônen R.L. Vanninen J.T. Kuikka Deep serotonergic and dopaminergic structures in fetal alcoholic syndrome: a study with nor-beta-CIT-single-photon emission computed tomography and magnetic resonance imaging volumetry Biol. Psychiatry 57 12 2005 1565 1572
145. M. Rothermundt M. Peters J.H. Prehn V. Arolt S100B in brain damage and neurodegeneration Microsc. Res. Tech. 60 6 2003 614 632
146. P. Rumajogee D. Vergé N. Hanoun M.J. Brisorgueil R. Hen K.P. Lesch M. Hamon M.C. Miquel Adaption of the serotoninergic neuronal phenotype in the absence of 5-HT autoreceptors or the 5-HT transporter: involvement of BDNF and cAMP Eur. J. Neurosci. 19 4 2004 937 944
147. N. Salichon P. Gaspar A.L. Upton S. Picaud N. Hanoun M. Hamon E. De Maeyer D.L. Murphy R. Mössner K.P. Lesh R. Hen I. Seif Excessive activation of serotonin (5-HT) 1B receptors disrupts the formation of sensory maps in monoamine oxidase A and 5-HT transporter knockout mice J. Neurosci. 21 2001 884 896
148. L. Santarelli M. Saxe C. Gross A. Surget F. Battaglia S. Dulawa N. Weisstaub J. Lee R. Duman O. Arancio C. Belzung R. Hen Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants Science 301 5634 2003 805 809
149. E.J. Sanz C. De-las-Cuevas A. Kiuru A. Bate R. Edwards Selective serotonin reuptake inhibitors in pregnant women and neonatal withdrawal syndrome: a database analysis Lancet 365 9458 2005 482 487
150. Y. Sari F.C. Zhou Prenatal alcohol exposure causes long-term serotonin neuron deficit in mice Alcohol. Clin. Exp. Res. 28 2004 941 948
151. C.A. Serfaty P. Oliveira-Silva A.D. Faria Melibeu P. Campello-Costa Nutritional Tryptophan Restriction and the Role of Serotonin in Development and Plasticity of Central Visual Connections Neuroimmunomodulation 15 3 2008 170 175
152. Y.I. Sheline M.A. Mintun S.M. Moerlein A.Z. Snyder Greater loss of 5-HT(2A) receptors in midlife than in late life Am. J. Psychiatry 159 3 2002 430 435
153. A. Shemer P.M. Whitaker-Azmitia E.C. Azmitia Effects of prenatal 5-methoxytryptamine and parachlorophenylalanine on serotonergic uptake and behavior in the neonatal rat Pharmacol. Biochem. Behav. 30 4 1988 847 851
154. A.V. Shemer E.C. Azmitia P.M. Whitaker-Azmitia Dose-related effects of prenatal 5-methoxytryptamine (5-MT) on development of serotonin terminal density and behavior Dev. Brain Res. 59 1991 59 65
155. W.Z. Shen Z.B. Luo D.R. Zheng D.T. Yew Immunohistochemical studies on the development of 5-HT (serotonin) neurons in the nuclei of the reticular formations of human fetuses Pediatr. Neurosci. 15 6 1989 291 295
156. M. Shiraishi Y. Takizawa S. Ide T. Obonai Y. Goto M. Itoh Brainstem monoamine pathology of neonatal hypoxic-ischemic brain damage: a model of acute stage of neonatal asphyxia Brain Res. 1213 2008 120 126
157. R.L. Sidman P. Rakic Neuronal migration, with special reference to developing human brain: a review Brain Res. 62 1 1973 1 35
158. E. Strackx D.L. van den Hove H.P. Steinbusch J. Prickaerts J.S. Vles C.E. Blanco H.W. Steinbusch A.W. Gavilanes Fetal asphyxia leads to a decrease in dorsal raphe serotonergic neurons Dev. Neurosci. 30 2008 358 366
159. E. Sundstrom S. Kolare F. Souverbie E.B. Samuelsson H. Pschera N.O. Lunell A. Seiger Neurochemical differentiation of human bulbospinal monoaminergic neurons during the first trimester Dev. Brain Res. 75 1 1993 1 12
160. N.F. Tajuddin L.A. Orrico J.L. Eriksen M.J. Druse Effects of ethanol and ipsapirone on the development of midline raphe glial cells and astrocytes Alcohol 29 3 2003 157 164
161. H. Takahashi S. Nakashima E. Ohama S. Takeda F. Ikuta Distribution of serotonin-containing cell bodies in the brainstem of the human fetus determined with immunohistochemistry using antiserotonin serum Brain Dev. 8 4 1986 355 365
162. J. Tauscher N.P. Verhoeff B.K. Christensen D. Hussey J.H. Meyer A. Kecojevic M. Javanmard S. Kasper S. Kapur Serotonin 5-HT1A receptor binding potential declines with age as measured by [11C]WAY-100635 and PET Neuropsychopharmacology 24 5 2001 522 530
163. A.M. Thompson Serotonin immunoreactivity in auditory brainstem neurons of the postnatal monoamine oxidase-A knockout mouse Brain Res. 1228 2008 58 67
164. G. Toth M. Fekete 5-Hydroxyindole acetic excretion in newborns, infants and children Acta Paediatr. Hung. 27 3 1986 221 226
165. A.C. Tramontina F. Tramontina L.D. Bobermin C. Zanotto D.F. Souza M.C. Leite P. Nardin C. Gottfried C.A. Gonçalves Secretion of S100B, an astrocyte-derived neurotrophic protein, is stimulated by fluoxetine via a mechanism independent of serotonin Prog. Neuropsychopharmacol. Biol. Psychiatry 32 6 2008 1580 1583
166. M. Tsuchioka M. Takebayashi K. Hisaoka N. Maeda Y. Nakata Serotonin (5-HT) induces glial cell line-derived neurotrophic factor (GDNF) mRNA expression via the transactivation of fibroblast growth factor receptor 2 (FGFR2) in rat C6 glioma cells J. Neurochem. 106 1 2008 244 257
167. D.L. Van den Hove J.M. Lauder A. Scheepens J. Prickaerts C.E. Blanco H.W. Steinbusch Prenatal stress in the rat alters 5-HT1A receptor binding in the ventral hippocampus Brain Res. 1090 1 2006 29 34
168. D.L. Van den Hove H.W. Steinbusch M. Bruschettini D. Gazzolo R. Frulio A. Scheepens J. Prickaerts C.E. Blanco Prenatal stress reduces S100B in the neonatal rat hippocampus Neuroreport 17 10 2006 1077 1080
169. L.A. Vataeva V.S. Kudrin E.A. Vershinina V.M. Mosin E.I. Tiul'kova V.A. Otellin Behavioral alteration in the adult rats prenatally exposed to para-chlorophenylalanine Brain Res. 1169 2007 9 16
170. A.H. Veenema A. Blume D. Niederle B. Buwalda I.D. Neumann Effects of early life stress on adult male aggression and hypothalamic vasopressin and serotonin Eur. J. Neurosci. 24 6 2006 1711 1720
171. J. Velazquez-Moctezuma O.D. Ruiz Neonatal treatment with clomipramine increased immobility in forced swim test: an attribute of animal models of depression Pharm. Biochem. Behav. 42 1992 737 739
172. C. Verney C. Lebrand P. Gaspar Changing distribution of monoaminergic markers in the developing human cerebral cortex with special emphasis on the serotonin transporter Anat. Rec. 267 2 2002 87 93
173. M. Vijayakumar B.L. Meti Alterations in the levels of monoamines in discrete brain regions of clomipramine-induced animal model of endogenous depression Neurochem. Res. 24 3 1999 345 349
174. T. Vitalis O. Cases S. Passemard J. Callebert J.G. Parnavelas Embryonic depletion of serotonin affects cortical development Eur. J. Neurosci. 26 2 2007 331 344
175. G. Vogel D. Neill M. Hagler D. Kors A new animal model of endogenous depression: a summary of present findings Neurosci. Biobehav. Rev. 14 1990 85 91
176. M.S. Wai C. Shi W.H. Kwong L. Zhang W.P. Lam D.T. Yew Development of the human insular cortex: differentiation, proliferation, cell death, and appearance of 5HT-2A receptors Histochem. Cell Biol. 130 2008 1199 1204
177. J.A. Wallace J.M. Lauder Development of the serotonergic system in the rat embryo: an immunocytochemical study Brain Res. Bull. 10 4 1983 459 479
178. B.P. Wann T.M. Bah S. Kaloustian M. Boucher A.M. Dufort N. Le Marec R. Godbout G. Rousseau Behavioural signs of depression and apoptosis in the limbic system following myocardial infarction: effects of sertraline J. Psychopharmacol. 2008 [Epub ahead of print]
179. P. Whitaker-Azmitia F. Zhou J. Hobin A. Borella Isolation-rearing of rats produces deficits as adults in the serotonergic innervation of hippocampus Peptides 21 11 2000 1755 1759
180. P.M. Whitaker J.J. Warsh Specific binding of radiolabelled antidepressants to brain astroglial cells Adv. Biochem. Psychopharmacol. 37 1983 477 485
181. P.M. Whitaker-Azmitia Behavioral and cellular consequences of increasing serotonergic activity during brain development: a role in autism? Intl. J. Dev. Neurosci. 23 1 2005 75 83
182. P.M. Whitaker-Azmitia E.C. Azmitia Auto-regulation of fetal serotonergic neuronal development: Role of high affinity serotonin receptors Neurosci. Lett. 67 1986 307 312
183. P.M. Whitaker-Azmitia E.C. Azmitia [3H]5-hydroxytryptamine binding to brain astroglial cells: differences between intact and homogenized preparations and mature and immature cultures J. Neurochem. 46 4 1986 1186 1189
184. P.M. Whitaker-Azmitia E.C. Azmitia Astroglial 5-HT1A receptors and S-100 beta in development and plasticity Perspect. Dev. Neurobiol. 2 3 1994 233 238
185. P.M. Whitaker-Azmitia J.M. Lauder A. Shemmer E.C. Azmitia Postnatal changes in serotonin receptors following prenatal alterations in serotonin levels: further evidence for functional fetal serotonin receptors Brain Res. 430 2 1987 285 289
186. P.M. Whitaker-Azmitia R. Murphy E.C. Azmitia Stimulation of astroglial 5-HT1A receptors releases the serotonergic growth factor, protein S-100, and alters astroglial morphology Brain Res. 528 1 1990 155 158
187. P.M. Whitaker-Azmitia D. Quartermain A.V. Shemer Prenatal treatment with a selective D1 receptor agonist (SKF 38393) alters adult [3H]paroxetine binding and dopamine and serotonin behavioral sensitivity Brain Res. 57 2 1990 181 185
188. P.M. Whitaker-Azmitia X. Zhang C. Clarke Effects of gestational exposure to monoamine oxidase inhibitors in rats: preliminary behavioral and neurochemical studies Neuropsychopharmacology 11 2 1994 125 132
189. P.M. Whitaker-Azmitia A. Borella N. Raio Serotonin depletion in the adult rat causes loss of the dendritic marker MAP-2. A new animal model of schizophrenia? Neuropsychopharmacology 12 3 1995 269 272
190. C.C. Wilson K.M. Faber J.H. Haring Serotonin regulates synaptic connections in the dentate molecular layer of adult rats via 5-HT1A receptors: evidence for a glial mechanism Brain Res. 782 1-2 1998 235 239
191. C. Winter T.J. Reutiman T.D. Folsom R. Sohr R.J. Wolf G. Juckel S.H. Fatemi Dopamine and serotonin levels following prenatal viral infection in mouse -implications for psychiatric disorders such as schizophrenia and autism Eur. Neuropsychopharmacol. 18 10 2008 712 716
192. M. Yamamoto T. Suhara Y. Okubo T. Ichimiya Y. Sudo M. Inoue A. Takano F. Yasuno K. Yoshikawa S. Tanada Age-related decline of serotonin transporters in living human brain of healthy males Life Sci. 71 7 2002 751 757
193. W. Ye K. Shimamura J.L. Rubenstein M.A. Hynes A. Rosenthal FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate Cell 93 5 1998 755 766
194. N. Zec J.J. Filiano A. Panigrahy W.F. White H.C. Kinney Developmental changes in [3H]lysergic acid diethylamide ([3H]LSD) binding to serotonin receptors in the human brainstem J. Neuropathol. Exp. Neurol. 55 1 1996 114 126
195. P.S. Zeskind L.E. Stephens Maternal selective serotonin reuptake inhibitor use during pregnancy and newborn neurobehavior Pediatrics 113 2 2004 368 375
196. F.C. Zhou Y. Sari J.K. Zhang Expression of serotonin transporter protein in developing rat brain Dev. Brain Res. 119 1 2000 33 45
197. F.C. Zhou Y. Sari T.A. Powrozek Fetal alcohol exposure reduces serotonin innervation and compromises development of the forebrain along the serotonergic pathway Alcohol. Clin. Exp. Res. 29 1 2005 141 149
198. F.C. Zhou Y. Fang C. Goodlett Peptidergic agonists of activity-dependent neurotrophic factor protect against prenatal alcohol-induced neural tube defects and serotonin neuron loss Alcohol. Clin. Exp. Res. 32 8 2008 1361 1371