Fetal asphyxia leads to a decrease in dorsal raphe serotonergic neurons

Developmental Neuroscience

Volumn 30, Issue 5, 2008, Pages 358-366

  Strackx, Eveline ^a,b   Van Den Hove, Daniël L A ^a   Steinbusch, Hellen P ^a   Prickaerts, Jos ^a   Vles, Johan S H ^b   Blanco, Carlos E ^b   Steinbusch, Harry W M ^a   Gavilanes, A W Danilo ^b  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

5 Hydroxytryptamine serotonin; Anxiety; Dorsal raphe nucleus; Fetal asphyxia; Rat brain, aging

Indexed keywords

SEROTONIN;

ADOLESCENT; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; BRAIN DEVELOPMENT; CONTROLLED STUDY; DORSAL RAPHE NUCLEUS; EMBRYO; FETUS; FETUS HYPOXIA; IMMUNOHISTOCHEMISTRY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONINERGIC NERVE CELL;

AGING; ANIMALS; ANXIETY; BEHAVIOR, ANIMAL; FEMALE; FETAL HYPOXIA; MALE; NEURONS; RAPHE NUCLEI; RATS; RATS, INBRED LEW; SEROTONIN;

EID: 52949119171     PISSN: 03785866     EISSN: None     Source Type: Journal    
DOI: 10.1159/000155218     Document Type: Article

References (52)

1. Lawn JE, Cousens S, Zupan J: 4 million neonatal deaths: when? where? why? Lancet 2005;365:891-900.
2. Low JA: Reflections on the occurrence and significance of antepartum fetal asphyxia. Best Pract Res Clin Obstet Gynaecol 2004;18:375-382.
3. Pierrat V, Haouari N, Liska A, Thomas D, Subtil D, Truffert P: Prevalence, causes, and outcome at 2 years of age of newborn encephalopathy: population based study. Arch Dis Child Fetal Neonatal Ed 2005;90:F257-F261.
4. Rees S, Inder T: Fetal and neonatal origins of altered brain development. Early Hum Dev 2005;81:753-761.
5. Salhab WA, Perlman JM: Severe fetal acidemia and subsequent neonatal encephalopathy in the larger premature infant. Pediatr Neurol 2005;32:25-29.
6. Barnett A, Mercuri E, Rutherford M, Haataja L, Frisone MF, Henderson S, Cowan F, Dubowitz L: Neurological and perceptualmotor outcome at 5-6 years of age in children with neonatal encephalopathy: relationship with neonatal brain MRI. Neuropediatrics 2002;33:242-248.
7. Cannon M, Jones PB, Murray RM: Obstetric complications and schizophrenia: historical and meta-analytic review. Am J Psychiatry 2002;159:1080-1092.
8. Hultman CM, Sparen P, Cnattingius S: Perinatal risk factors for infantile autism. Epidemiology 2002;13:417-423.
9. Loidl CF, Gavilanes AW, Van Dijk EH, Vreuls W, Blokland A, Vles JS, Steinbusch HW, Blanco CE: Effects of hypothermia and gender on survival and behavior after perinatal asphyxia in rats. Physiol Behav 2000;68:263-269.
10. Hoeger H, Engelmann M, Bernert G, Seidl R, Bubna-Littitz H, Mosgoeller W, Lubec B, Lubec G: Long term neurological and behavioral effects of graded perinatal asphyxia in the rat. Life Sci 2000;66:947-962.
11. Boksa P, Krishnamurthy A, Brooks W: Effects of a period of asphyxia during birth on spatial learning in the rat. Pediatr Res 1995;37:489-496.
12. Van de Berg WD, Blokland A, Cuello AC, Schmitz C, Vreuls W, Steinbusch HW, Blanco CE: Perinatal asphyxia results in changes in presynaptic bouton number in striatum and cerebral cortex - a stereological and behavioral analysis. J Chem Neuroanat 2000;20:71-82.
13. Weitzdoerfer R, Gerstl N, Hoeger H, Mosgoeller W, Dreher W, Engidawork E, Overgaard-Larsen J, Lubec B: Long-term sequelae of perinatal asphyxia in the aging rat. Cell Mol Life Sci 2002;59:519-526.
14. Weitzdoerfer R, Gerstl N, Pollak D, Hoeger H, Dreher W, Lubec G: Long-term influence of perinatal asphyxia on the social behavior in aging rats. Gerontology 2004;50:200-205.
15. Cai Z, Xiao F, Lee B, Paul IA, Rhodes PG: Prenatal hypoxia-ischemia alters expression and activity of nitric oxide synthase in the young rat brain and causes learning deficits. Brain Res Bull 1999;49:359-365.
16. Strackx E, Van den Hove DL, Steinbusch HP, Steinbusch HW, Vles JS, Blanco CE, Gavilanes AW: A combined behavioral and morphological study on the effects of fetal asphyxia on the nigrostriatal dopaminergic system in adult rats. Exp Neurol 2008;211:413-422.
17. Ressler KJ, Nemeroff CB: Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders. Depress Anxiety 2000;12(suppl 1):2-19.
18. Stockmeier CA: Involvement of serotonin in depression: evidence from postmortem and imaging studies of serotonin receptors and the serotonin transporter. J Psychiatr Res 2003;37:357-373.
19. Arango V, Underwood MD, Mann JJ: Serotonin brain circuits involved in major depression and suicide. Prog Brain Res 2002;136:443-453.
20. Graeff FG, Guimaraes FS, De Andrade TG, Deakin JF: Role of 5-HT in stress, anxiety, and depression. Pharmacol Biochem Behav 1996;54:129-141.
21. Whitaker-Azmitia PM: Serotonin and brain development: role in human developmental diseases. Brain Res Bull 2001;56:479-485.
22. Di Pino GD, Moessner R, Lesch KP, Lauder JM, Persico AM: Roles for serotonin in neurodevelopment: more than just neural transmission. Curr Neuropharmacol 2004;2:403-417.
23. Michelsen KA, Schmitz C, Steinbusch HW: The dorsal raphe nucleus - from silver stainings to a role in depression. Brain Res Rev 2007;55:329-342.
24. El-Khodor BF, Boksa P: Differential vulnerability of male versus female rats to long-term effects of birth insult on brain catecholamine levels. Exp Neurol 2003;182:208-219.
25. Zhang YQ, Shi J, Rajakumar G, Day AL, Simpkins JW: Effects of gender and estradiol treatment on focal brain ischemia. Brain Res 1998;784:321-324.
26. Lieben CK, van Oorsouw K, Deutz NE, Blokland A: Acute tryptophan depletion induced by a gelatin-based mixture impairs object memory but not affective behavior and spatial learning in the rat. Behav Brain Res 2004;151:53-64.
27. Paxinos G, Watson C: The Rat Brain in Stereotaxic Coordinates. San Diego, Academic Press, 1986.
28. Schmitz C, Hof PR: Design-based stereology in neuroscience. Neuroscience 2005;130:813-831.
29. De Haan HH, Gunn AJ, Gluckman PD: Experiments in perinatal brain injury: what have we learnt? Prenat Neonat Med 1996;1:16-25.
30. Bennet L, Roelfsema V, Pathipati P, Quaedackers JS, Gunn AJ: Relationship between evolving epileptiform activity and delayed loss of mitochondrial activity after asphyxia measured by near-infrared spectroscopy in preterm fetal sheep. J Physiol 2006;572:141-154.
31. Aitken AR, Tork I: Early development of serotonin-containing neurons and pathways as seen in wholemount preparations of the fetal rat brain. J Comp Neurol 1988;274:32-47.
32. Lidov HG, Molliver ME: An immunohistochemical study of serotonin neuron development in the rat: ascending pathways and terminal fields. Brain Res Bull 1982;8:389-430.
33. Rubenstein JL: Development of serotonergic neurons and their projections. Biol Psychiatry 1998;44:145-150.
34. Wallace JA, Lauder JM: Development of the serotonergic system in the rat embryo: an immunocytochemical study. Brain Res Bull 1983;10:459-479.
35. Flood DG, Coleman PD: Neuron numbers and sizes in aging brain: comparisons of human, monkey, and rodent data. Neurobiol Aging 1988;9:453-463.
36. Henderson G, Tomlinson BE, Gibson PH: Cell counts in human cerebral cortex in normal adults throughout life using an image analysing computer. J Neurol Sci 1980;46:113-136.
37. Brizzee KR, Ordy JM: Age pigments, cell loss and hippocampal function. Mech Ageing Dev 1979;9:143-162.
38. Mani RB, Lohr JB, Jeste DV: Hippocampal pyramidal cells and aging in the human: a quantitative study of neuronal loss in sectors CA1 to CA4. Exp Neurol 1986;94:29-40.
39. Sapolsky RM, Krey LC, McEwen BS: Prolonged glucocorticoid exposure reduces hippocampal neuron number: implications for aging. J Neurosci 1985;5:1222-1227.
40. Esiri MM: Ageing and the brain. J Pathol 2007;211:181-187.
41. Morrison JH, Hof PR: Selective vulnerability of corticocortical and hippocampal circuits in aging and Alzheimer's disease. Prog Brain Res 2002;136:467-486.
42. Eysel UT, Wolfhard U: The effects of partial retinal lesions on activity and size of cells in the dorsal lateral geniculate nucleus. J Comp Neurol 1984;229:301-309.
43. Kiernan JA, Hudson AJ: Changes in sizes of cortical and lower motor neurons in amyotrophic lateral sclerosis. Brain 1991;114:843-853.
44. Mountjoy CQ, Roth M, Evans NJ, Evans HM: Cortical neuronal counts in normal elderly controls and demented patients. Neurobiol Aging 1983;4:1-11.
45. Nyakas C, Buwalda B, Kramers RJ, Traber J, Luiten PG: Postnatal development of hippocampal and neocortical cholinergic and serotonergic innervation in rat: effects of nitrite-induced prenatal hypoxia and nimodipine treatment. Neuroscience 1994;59:541-559.
46. van Luijtelaar MG, Tonnaer JA, Steinbusch HW: Aging of the serotonergic system in the rat forebrain: an immunocytochemical and neurochemical study. Neurobiol Aging 1992;13:201-215.
47. Rudin M, Ben-Abraham R, Gazit V, Tendler Y, Tashlykov V, Katz Y: Single-dose ketamine administration induces apoptosis in neonatal mouse brain. J Basic Clin Physiol Pharmacol 2005;16:231-243.
48. Young C, Jevtovic-Todorovic V, Qin YQ, Tenkova T, Wang H, Labruyere J, Olney JW: Potential of ketamine and midazolam, individually or in combination, to induce apoptotic neurodegeneration in the infant mouse brain. Br J Pharmacol 2005;146:189-197.
49. Graeff FG, Viana MB, Mora PO: Dual role of 5-HT in defense and anxiety. Neurosci Biobehav Rev 1997;21:791-799.
50. Boguszewski P, Zagrodzka J: Emotional changes related to age in rats - a behavioral analysis. Behav Brain Res 2002;133:323-332.
51. Indredavik MS, Vik T, Heyerdahl S, Kulseng S, Fayers P, Brubakk AM: Psychiatric symptoms and disorders in adolescents with low birth weight. Arch Dis Child Fetal Neonatal Ed 2004;89:F445-F450.
52. Meltzer CC, Smith G, DeKosky ST, Pollock BG, Mathis CA, Moore RY, Kupfer DJ, Reynolds CF 3rd: Serotonin in aging, late-life depression, and Alzheimer's disease: the emerging role of functional imaging. Neuropsychopharmacology 1998;18:407-430.