Intravenous versus topical tranexamic acid in primary total hip replacement: A meta-analysis

Medicine (United States)

Volumn 95, Issue 50, 2016, Pages e5573-

  Pei, Zhang ^a   Yuan, Liang ^a   Chen, Pengtao ^a   Yongchao, Fang ^a   He, Jinshan ^a   Jingcheng, Wang ^a  

^a NORTHERN JIANGSU PEOPLE S HOSPITAL   (China)

Author keywords

Intravenous; Meta analysis; Topical; Total hip arthroplasty; Tranexamic acid

Indexed keywords

HEMOGLOBIN; TRANEXAMIC ACID; ANTIFIBRINOLYTIC AGENT;

BLEEDING; DEEP VEIN THROMBOSIS; DRUG EFFICACY; DRUG SAFETY; HUMAN; INCIDENCE; LUNG EMBOLISM; META ANALYSIS; OUTCOME ASSESSMENT; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SYSTEMATIC REVIEW; TOTAL HIP PROSTHESIS; TRANSFUSION; WOUND INFECTION; ADVERSE EFFECTS; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION; COMPARATIVE STUDY; HIP REPLACEMENT; INTRAVENOUS DRUG ADMINISTRATION; PERIOPERATIVE PERIOD; PROCEDURES; PULMONARY EMBOLISM; STATISTICS AND NUMERICAL DATA; SURGICAL WOUND INFECTION; TOPICAL DRUG ADMINISTRATION; VENOUS THROMBOSIS;

ADMINISTRATION, INTRAVENOUS; ADMINISTRATION, TOPICAL; ANTIFIBRINOLYTIC AGENTS; ARTHROPLASTY, REPLACEMENT, HIP; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION; HEMOGLOBINS; HUMANS; PERIOPERATIVE PERIOD; PULMONARY EMBOLISM; SURGICAL WOUND INFECTION; TRANEXAMIC ACID; VENOUS THROMBOSIS;

EID: 85013213798     PISSN: 00257974     EISSN: 15365964     Source Type: Journal    
DOI: 10.1097/MD.0000000000005573     Document Type: Review

References (39)

1. Iorio R, Robb WJ, Healy WL, et al. Orthopedic surgeon workforce and volume assessment for total hip and knee replacement in the United States: preparing for an epidemic. J Bone Joint Surg Am 2008;90:1598-605.
2. Lovald ST, Ong KL, Lau EC, et al. Mortality, cost, and downstream disease of total hip arthroplasty patients in the Medicare population. J Arthroplasty 2014;29:242-6.
3. Kurtz S, Ong K, Lau E, et al. Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J Bone Joint Surg Am 2007;89:780-5.
4. Rosencher N, Kerkkamp HE, Macheras G, et al. Orthopedic Surgery Transfusion Hemoglobin European Overview (OSTHEO) study: blood management in elective knee and hip arthroplasty in Europe. Transfusion 2003;43:459-69.
5. Saleh A, Small T, Chandran Pillai AL, et al. Allogenic blood transfusion following total hip arthroplasty results from the nationwide inpatient sample, 2000 to 2009. J Bone Joint Surg Am 2014;96:e155.
6. Newman ET, Watters TS, Lewis JS, et al. Impact of perioperative allogeneic and autologous blood transfusion on acute wound infection following total knee and total hip arthroplasty. J Bone Joint Surg Am 2014;96:279-84.
7. Vamvakas EC, Blajchman MA. Transfusion-related mortality: the ongoing risks of allogeneic blood transfusion and the available strategies for their prevention. Blood 2009;113:3406-17.
8. Allain JP, Stramer SL, Carneiro-Proietti ABF, et al. Transfusiontransmitted infectious diseases. Biologicals 2009;37:71-7.
9. Myers E, Grady PO, Dolan AM. The influence of preclinical anaemia on outcome following total hip replacement. Arch Orthop Trauma Surg 2004;124:699-701.
10. Eubanks JD. Antifibrinolytics in major orthopaedic surgery. J Am Acad Orthop Sur 2010;18:132-8.
11. Strang CM, Hachenberg T. Current strategies to minimize of blood loss during radical prostatectomy. Anasthesiol Intensivmed Notfallmed Schmerzther 2013;48:494-9. quiz 500-491.
12. Bonis MD, Cavaliere F, Alessandrini F, et al. Topical use of tranexamic acid in coronary artery bypass operations: a double-blind, prospective, randomized, placebo-controlled study. J Thorac Cardiovasc Surg 2000;119:575-80.
13. Ngichabe S, Obura T, Stones W. Intravenous tranexamic acid as an adjunct haemostat to ornipressin during open myomectomy. A randomized double blind placebo controlled trial. Ann Surg Innov Res 2015;9:1-6.
14. Johansson T, Pettersson L, Lisander B. Tranexamic acid in total hip arthroplasty saves blood and money. Acta Orthop 2015;76:314-9.
15. Seyyed Morteza K, Faramarz M, Alireza E, et al. The effect of tranexamic acid on reducing blood loss in cementless total hip arthroplasty under epidural anesthesia. Orthopedics 2010;33:17.
16. Mcconnell JS, Shewale S, Munro NA, et al. Reduction of blood loss in primary hip arthroplasty with tranexamic acid or fibrin spray. Acta Orthopaedica 2011;82:660-3.
17. Alshryda S, Mason J, Vaghela M, et al. Topical (intra-articular) tranexamic acid reduces blood loss and transfusion rates following total knee replacement: a randomized controlled trial (TRANX-K). J Bone Joint Surg Am 2013;95:1961-8.
18. Alshryda S, Sukeik M, Sarda P, et al. A systematic review and metaanalysis of the topical administration of tranexamic acid in total hip and knee replacement. Bone Joint J 2014;96-B:1005-15.
19. Martin JG, Cassatt KB, Kincaid-Cinnamon KA, et al. Topical administration of tranexamic acid in primary total hip and total knee arthroplasty. J Arthroplasty 2014;29:889-94.
20. Yue C, Kang P, Yang P, et al. Topical application of tranexamic acid in primary total hip arthroplasty: a randomized double-blind controlled trial. J Arthroplasty 2014;29:2452-6.
21. Chen S, Wu K, Kong G, et al. The efficacy of topical tranexamic acid in total hip arthroplasty: a meta-analysis. BMC Musculoskelet Disord 2016;17:81.
22. Wind TC, Barfield WR, Moskal JT. The effect of tranexamic acid on transfusion rate in primary total hip arthroplasty. J Arthroplasty 2014;29:387-9.
23. Ueno M, Sonohata M, Fukumori N, et al. Comparison between topical and intravenous administration of tranexamic acid in primary total hip arthroplasty. J Orthop Sci 2015;21:44-7.
24. North WT, Mehran N, Davis JJ, et al. Topical vs intravenous tranexamic acid in primary total hip arthroplasty: a double-blind, randomized controlled trial. J Arthroplasty 2016;31:1022-6.
25. Lu C, Guo H, Hao YQ, et al. A prospective randomized controlled study of tranexamic acid used in different ways to reduce blood loss in total hip arthroplasty. Chin J Bone Joint Surg 2016;9:140-4.
26. Xie JW, Ma J, Yue C, et al. Combined use of intravenous and topical tranexamic acid following cementless total hip arthroplasty: a randomised clinical trial. Hip Int 2016;26:36-42.
27. Zhang L, Wang DR, Zhao GP, et al. Evaluation of curative effect of combined intravenous and topical application of tranexamic acid in total hip arthroplasty. J Pract Med 2015;3358-60.
28. Wei W, Wei B. Comparison of topical and intravenous tranexamic acid on blood loss and transfusion rates in total hip arthroplasty. J Arthroplasty 2014;29:2113-6.
29. Zhu C, Chu XB, Zhang JH. Different methods of tranexamic acid on reducing blood loss during total hip arthroplasty. J Jiangxi Univ TCM 2016;28:47-9.
30. Zhao QB, Ren JD, Zhang XG, et al. Comparison of perioperative blood loss and transfusion rate in primary unilateral total hip arthroplasty by topical, intravenous application or combined application of tranexamic acid. Zhongguo Zuzhi Gongcheng Yanjiu 2016;20:459-64.
31. Benoni G, Björkman DS, Fredin H. Application of pharmacokinetic data from healthy volunteers for the prediction of plasma concentrations of tranexamic acid in surgical patients. Clin Drug Invest 1995;10:280-7.
32. Wong J, Abrishami A, El BH. Topical application of tranexamic acid reduces postoperative blood loss in total knee arthroplasty: a randomized, controlled trial. J Bone Joint Surg Am 2010;92:2503-13.
33. Gilbody J, Dhotar HS, Perruccio AV. Topical tranexamic acid reduces transfusion rates in total hip and knee arthroplasty. J Arthroplasty 2013;29:681-4.
34. Konig G, Hamlin BR, Waters JH. Topical tranexamic acid reduces blood loss and transfusion rates in total hip and total knee arthroplasty. J Arthroplasty 2013;28:1473-6.
35. Hsu CH, Lin PC, Kuo FC, et al. A regime of two intravenous injections of tranexamic acid reduces blood loss in minimally invasive total hip arthroplasty: a prospective randomised double-blind study. Bone Joint J 2015;97-B:905-10.
36. Jaszczyk M, Kozerawski D, Kazimierczak A, et al. Effect of single preoperative dose of tranexamic acid on blood loss and transfusion in hip arthroplasty. Ortop Traumatol Rehabil 2015;17:265-73.
37. Roberts I, Shakur H, Roberts I, et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. West Indian Med J 2010;59:612-24.
38. Maurer SG, Chen AL,Hiebert R, et al. Comparison of outcomes of using spinal versus general anesthesia in total hip arthroplasty. Am J Orthop 2007;36:E101-106.
39. Basques BA, Toy JO, Bohl DD, et al. General compared with spinal anesthesia for total hip arthroplasty. J Bone Joint Surg Am 2015;97: 455-61.