Combined use of intravenous and topical tranexamic acid following cementless total hip arthroplasty: A randomised clinical trial

HIP International

Volumn 26, Issue 1, 2016, Pages 36-42

  Xie, Jinwei ^a   Ma, Jun ^a   Yue, Chen ^a   Kang, Pengde ^a   Pei, Fuxing ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Blood loss; Combined treatment; Total hip arthroplasty; Tranexamic acid; Transfusion

Indexed keywords

ENOXAPARIN; HEMOGLOBIN; RIVAROXABAN; TRANEXAMIC ACID; ANTIFIBRINOLYTIC AGENT;

ADULT; ARTICLE; BLOOD TRANSFUSION; BONE NECROSIS; CEMENTLESS PROSTHESIS; COMPARATIVE EFFECTIVENESS; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DOPPLER FLOWMETRY; DRUG EFFICACY; DRUG SAFETY; FEMALE; HEMATOCRIT; HIP OSTEOARTHRITIS; HUMAN; INTERNATIONAL NORMALIZED RATIO; LENGTH OF STAY; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; OPERATION DURATION; OPERATIVE BLOOD LOSS; PARTIAL THROMBOPLASTIN TIME; POSTOPERATIVE COMPLICATION; PROSPECTIVE STUDY; PROTHROMBIN TIME; RANDOMIZED CONTROLLED TRIAL; SURGICAL INFECTION; THROMBOCYTE COUNT; TOTAL HIP PROSTHESIS; TREATMENT OUTCOME; ULTRASOUND; ADVERSE EFFECTS; AGED; BLOOD LOSS, SURGICAL; CEMENTATION; COMBINATION DRUG THERAPY; FEMUR HEAD NECROSIS; HIP REPLACEMENT; INCIDENCE; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; MIDDLE AGED; OSTEOARTHRITIS, HIP; PROCEDURES; PULMONARY EMBOLISM; TOPICAL DRUG ADMINISTRATION; VENOUS THROMBOSIS;

ADMINISTRATION, TOPICAL; AGED; ANTIFIBRINOLYTIC AGENTS; ARTHROPLASTY, REPLACEMENT, HIP; BLOOD LOSS, SURGICAL; CEMENTATION; DRUG THERAPY, COMBINATION; FEMALE; FEMUR HEAD NECROSIS; HEMOGLOBINS; HUMANS; INCIDENCE; INJECTIONS, INTRAVENOUS; MALE; MIDDLE AGED; OSTEOARTHRITIS, HIP; PROSPECTIVE STUDIES; PULMONARY EMBOLISM; TRANEXAMIC ACID; TREATMENT OUTCOME; VENOUS THROMBOSIS;

EID: 84957869483     PISSN: 11207000     EISSN: None     Source Type: Journal    
DOI: 10.5301/hipint.5000291     Document Type: Article

References (31)

1. Bierbaum BE, Callaghan JJ, Galante JO, Rubash HE, Tooms RE, Welch RB. An analysis of blood management in patients having a total hip or knee arthroplasty. J Bone Joint Surg Am. 1999; 81(1):2-10.
2. Vamvakas EC, Blajchman MA. Transfusion-related mortality: the ongoing risks of allogeneic blood transfusion and the available strategies for their prevention. Blood. 2009;113(15): 3406-3417.
3. Allain JP, Stramer SL, Carneiro-Proietti AB, et al. Transfusiontransmitted infectious diseases. Biologicals. 2009;37(2):71-77.
4. Hill GE, Frawley WH, Griffith KE, Forestner JE, Minei JP. Allogeneic blood transfusion increases the risk of postoperative bacterial infection: a meta-analysis. J Trauma. 2003;54(5):908-914.
5. Newman ET, Watters TS, Lewis JS, et al. Impact of perioperative allogeneic and autologous blood transfusion on acute wound infection following total knee and total hip arthroplasty. J Bone Joint Surg Am. 2014;96(4):279-284.
6. Liu X, Zhang X, Chen Y, Wang Q, Jiang Y, Zeng B. Hidden blood loss after total hip arthroplasty. J Arthroplasty. 2011;26(7):1100-5.e1.
7. Camarasa MA, Ollé G, Serra-Prat M, et al. Efficacy of aminocaproic, tranexamic acids in the control of bleeding during total knee replacement: a randomized clinical trial. Br J Anaesth. 2006;96(5):576-582.
8. McConnell JS, Shewale S, Munro NA, Shah K, Deakin AH, Kinninmonth AW. Reduction of blood loss in primary hip arthroplasty with tranexamic acid or fibrin spray. Acta Orthop. 2011;82(6):660-663.
9. Johansson T, Pettersson LG, Lisander B. Tranexamic acid in total hip arthroplasty saves blood and money: a randomized, doubleblind study in 100 patients. Acta Orthop. 2005;76(3):314-319.
10. Claeys MA, Vermeersch N, Haentjens P. Reduction of blood loss with tranexamic acid in primary total hip replacement surgery. Acta Chir Belg. 2007;107(4):397-401.
11. Kazemi SM, Mosaffa F, Eajazi A, et al. The effect of tranexamic acid on reducing blood loss in cementless total hip arthroplasty under epidural anesthesia. Orthopedics. 2010;33(1):17-22.
12. Yue C, Kang P, Yang P, Xie J, Pei F. Topical application of tranexamic acid in primary total hip arthroplasty: a randomized doubleblind controlled trial. J Arthroplasty. 2014;29(12):2452-2456.
13. Alshryda S, Mason J, Sarda P, et al. Topical (intra-articular) tranexamic acid reduces blood loss and transfusion rates following total hip replacement: a randomized controlled trial (TRANX-H). J Bone Joint Surg Am. 2013;95(21):1969-1974.
14. Martin JG, Cassatt KB, Kincaid-Cinnamon KA, Westendorf DS, Garton AS, Lemke JH. Topical administration of tranexamic acid in primary total hip and total knee arthroplasty. J Arthroplasty. 2014;29(5):889-894.
15. Alshryda S, Sukeik M, Sarda P, Blenkinsopp J, Haddad FS, Mason JM. A systematic review and meta-analysis of the topical administration of tranexamic acid in total hip and knee replacement. Bone Joint J. 2014;96(8):1005-1015.
16. Sukeik M, Alshryda S, Haddad FS, Mason JM. Systematic review and meta-analysis of the use of tranexamic acid in total hip replacement. J Bone Joint Surg Br. 2011;93(1):39-46.
17. Wong J, Abrishami A, El Beheiry H, et al. Topical application of tranexamic acid reduces postoperative blood loss in total knee arthroplasty: a randomized, controlled trial. J Bone Joint Surg Am. 2010;92(15):2503-2513.
18. Karaaslan F, Karaoğlu S, Mermerkaya MU, Baktir A. Reducing blood loss in simultaneous bilateral total knee arthroplasty: combined intravenous-intra-articular tranexamic acid administration. A prospective randomized controlled trial. Knee. 2015; 22(2):131-135.
19. Huang Z, Ma J, Shen B, Pei F. Combination of intravenous and topical application of tranexamic acid in primary total knee arthroplasty: a prospective randomized controlled trial. J Arthroplasty. 2014;29(12):2342-2346.
20. Lin SY, Chen CH, Fu YC, Huang PJ, Chang JK, Huang HT. The efficacy of combined use of intraarticular and intravenous tranexamic Acid on reducing blood loss and transfusion rate in total knee arthroplasty. J Arthroplasty. 2015;30(5): 776-780.
21. Benoni G, Björkman S, Fredin H. Application of pharmacokinetic data from healthy volunteers for the prediction of plasma concentrations of tranexamic acid ın surgical patients. Clin Drug Investig. 1995;10(5):280-287.
22. Krohn CD, Sørensen R, Lange JE, Riise R, Bjørnsen S, Brosstad F. Tranexamic acid given into the wound reduces postoperative blood loss by half in major orthopaedic surgery. Eur J Surg Suppl. 2003;588(588):57-61.
23. Ahlberg A, Eriksson O, Kjellman H. Diffusion of tranexamic acid to the joint. Acta Orthop Scand. 1976;47(5):486-488.
24. Blanié A, Bellamy L, Rhayem Y, et al. Duration of postoperative fibrinolysis after total hip or knee replacement: a laboratory follow-up study. Thromb Res. 2013;131(1):e6-e11.
25. Reikerås O, Clementsen T. Time course of thrombosis and fibrinolysis in total knee arthroplasty with tourniquet application. Local versus systemic activations. J Thromb Thrombolysis. 2009;28(4):425-428.
26. Rajesparan K, Biant LC, Ahmad M, Field RE. The effect of an intravenous bolus of tranexamic acid on blood loss in total hip replacement. J Bone Joint Surg Br. 2009;91(6):776-783.
27. Wei W, Wei B. Comparison of topical and intravenous tranexamic acid on blood loss and transfusion rates in total hip arthroplasty. J Arthroplasty. 2014;29(11):2113-2116.
28. Zufferey PJ, Miquet M, Quenet S, et al. Tranexamic acid in hip-fracture surgery (THIF) study. Tranexamic acid in hip fracture surgery: a randomized controlled trial. Br J Anaesth. 2010; 104(1):23-30.
29. Duncan CM, Gillette BP, Jacob AK, Sierra RJ, Sanchez-Sotelo J, Smith HM. Venous thromboembolism and mortality associated with tranexamic acid use during total hip and knee arthroplasty. J Arthroplasty. 2015;30(2):272-276.
30. Poeran J, Rasul R, Suzuki S, et al. Tranexamic acid use and postoperative outcomes in patients undergoing total hip or knee arthroplasty in the United States: retrospective analysis of effectiveness and safety. BMJ. 2014;349:g4829.
31. Parvizi J, Mui A, Purtill JJ, Sharkey PF, Hozack WJ, Rothman RH. Total joint arthroplasty: When do fatal or near-fatal complications occur? J Bone Joint Surg Am. 2007;89(1):27-32.