A regime of two intravenous injections of tranexamic acid reduces blood loss in minimally invasive total hip arthroplasty: A prospective randomised double-blind study

Bone and Joint Journal

Volumn 97-B, Issue 7, 2015, Pages 905-910

  Hsu, C H ^a   Lin, P C ^a   Kuo, F C ^a   Wang, J W ^a  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; PLACEBO; TRANEXAMIC ACID; ANTIFIBRINOLYTIC AGENT;

ADOLESCENT; ADULT; AGED; ARTICLE; BLOOD CONSERVATION; COMPARATIVE STUDY; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ERYTHROCYTE TRANSFUSION; FEMALE; HEMOGLOBIN BLOOD LEVEL; HIP DISLOCATION; HUMAN; LENGTH OF STAY; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; MINIMALLY INVASIVE SURGERY; OPERATIVE BLOOD LOSS; PERIPROSTHETIC FRACTURE; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TOTAL HIP PROSTHESIS; VENOUS THROMBOEMBOLISM; WOUND COMPLICATION; BLOOD LOSS, SURGICAL; HIP ARTHROPLASTY; INTRAVENOUS DRUG ADMINISTRATION; MIDDLE AGED; PROCEDURES; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ANTIFIBRINOLYTIC AGENTS; ARTHROPLASTY, REPLACEMENT, HIP; BLOOD LOSS, SURGICAL; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INJECTIONS, INTRAVENOUS; MALE; MIDDLE AGED; MINIMALLY INVASIVE SURGICAL PROCEDURES; PROSPECTIVE STUDIES; TRANEXAMIC ACID; YOUNG ADULT;

EID: 84937565894     PISSN: 20494394     EISSN: 20494408     Source Type: Journal    
DOI: 10.1302/0301-620X.97B7.35029     Document Type: Article

References (39)

1. McSwiney MM, O'Farrell D, Joshi GP, McCarroll SM. Blood transfusion in total hip arthroplasty: guidelines to eliminate overtransfusion. Can J Anaesth 1993;40:222-226.
2. Callaghan JJ, O'Rourke MR, Liu SS. Blood management: issues and options. J Arthroplasty 2005;20(suppl 2):51-54.
3. Kubota R, Nozawa M, Matsuda K, et al. Combined preoperative autologous blood donation and intra-operative cell salvage for hip surgery. J Orthop Surg (Hong Kong) 2009;17:288-290.
4. Smith LK, Williams DH, Langkamer VG. Post-operative blood salvage with autologous retransfusion in primary total hip replacement. J Bone Joint Surg [Br] 2007;89-B:1092-1097.
5. Salido JA, Marín LA, Gómez LA, Zorrilla P, Martínez C. Preoperative hemoglobin levels and the need for transfusion after prosthetic hip and knee surgery: analysis of predictive factors. J Bone Joint Surg [Am] 2002;84-A:216-220.
6. Lemaire R. Strategies for blood management in orthopaedic and trauma surgery. J Bone Joint Surg [Br] 2008;90-B:1128-1136.
7. Salo M. Immunosuppressive effects of blood transfusion in anesthesia and surgery. Acta Anaesthesiol Scand 1988;32(suppl 89):26-34.
8. Murphy P, Heal JM, Blumberg N. Infection or suspected infection after hip replacement surgery with autologous or homologous blood transfusions. Transfusion 1991;31:212-217.
9. Kendall SJH, Weir J, Aspinall R, Henderson D, Rosson J. Erythrocyte transfusion causes immunosuppression after total hip replacement. Clin Orthop Relat Res 2000;381:145-155.
10. Shore-Lesserson L, Reich DL, Vela-Cantos F, Ammar T, Ergin MA. Tranexamic acid reduces transfusions and mediastinal drainage in repeat cardiac surgery. Anesth Analg 1996;83:18-26.
11. Hiippala S, Strid L, Wennerstrand M, et al. Tranexamic acid (Cyklokapron) reduces perioperative blood loss associated with total knee arthroplasty. Br J Anaesth 1995;74:534-537.
12. Benoni G, Fredin H. Fibrinolytic inhibition with tranexamic acid reduces blood loss and blood transfusion after knee arthroplasty: a prospective, randomised, doubleblind study of 86 patients. J Bone Joint Surg [Br] 1996;78-B:434-440.
13. Benoni G, Lethagen S, Nilsson P, Fredin H. Tranexamic acid, given at the end of the operation, does not reduce postoperative blood loss in hip arthroplasty. Acta Orthop Scand 2000;71:250-254.
14. Benoni G, Fredin H, Knebel R, Nilsson P. Blood conservation with tranexamic acid in total hip arthroplasty: a randomized, double-blind study in 40 primary operations. Acta Orthop Scand 2001;72:442-448.
15. Ekbäck G, Axelsson K, Ryttberg L, et al. Tranexamic acid reduces blood loss in total hip replacement surgery. Anesth Analg 2000;91:1124-1130.
16. Johansson T, Pettersson LG, Lisander B. Tranexamic acid in total hip arthroplasty saves blood and money: a randomized, double-blind study in 100 patients. Acta Orthop 2005;76:314-319.
17. Hynes MC, Calder P, Rosenfeld P, Scott G. The use of tranexamic acid to reduce blood loss during total hip arthroplasty: an observational study. Ann R Coll Surg Engl 2005;87:99-101.
18. Irwin A, Khan SK, Jameson SS, et al. Oral versus intravenous tranexamic acid in enhanced-recovery primary total hip and knee replacement: results of 3000 procedures. Bone Joint J 2013;95-B:1556-1561.
19. Lemay E, Guay J, Côté C, Roy A. Tranexamic acid reduces the need for allogenic red blood cell transfusions in patients undergoing total hip replacement. Can J Anaesth 2004;51:31-37.
20. Garneti N, Field J. Bone bleeding during total hip arthroplasty after administration of tranexamic acid. J Arthroplasty 2004;19:488-492.
21. Rajesparan K, Biant LC, Ahmad M, Field RE. The effect of an intravenous bolus of tranexamic acid on blood loss in total hip replacement. J Bone Joint Surg [Br] 2009;91-B:776-783.
22. Benoni G, Bjorkman S, Fredin H. Application of pharmacokinetic data from healthy volunteers for the prediction of plasma concentrations of tranexamic acid in surgical patients. Clin Drug Investig 1995;10:280-287.
23. Alshryda S, Sukeik M, Sarda P, et al. A systematic review and meta-analysis of the topical administration of tranexamic acid in total hip and knee replacement. Bone Joint J 2014;96-B:1005-1015.
24. Dorr LD, Maheshwari AV, Long WT, Wan Z, Sirianni LE. Early pain relief and function after posterior minimally invasive and conventional total hip arthroplasty. A prospective, randomized, blinded study. J Bone Joint Surg [Am] 2007;89-A:1153-1160.
25. Chimento GF, Pavone V, Sharrock N, et al. Minimally invasive total hip arthroplasty: a prospective randomized study. J Arthroplasty 2005;20:139-144.
26. Nakamura S, Matsuda K, Arai N, Wakimoto N, Matsushita T. Mini-incision posterior approach for total hip arthroplasty. Int Orthop 2004;28:214-217.
27. Hourlier H, Fennema P, Liné B. A novel blood-saving plan for less-invasive primary total hip replacement. Orthopedics 2008;31(suppl 2).
28. Owens WD, Felts JA, Spitznagel EL Jr. ASA physical status classification: a study of consistency of ratings. Anesthesiology 1978;49:239-243.
29. Wang CJ, Wang JW, Weng LH, et al. Prevention of deep-vein thrombosis after total knee arthroplasty in Asian patients. Comparison of low-molecular-weight heparin and indomethacin. J Bone Joint Surg [Am] 2004;86-A:136-140.
30. Nadler SB, Hidalgo JH, Bloch T. Prediction of blood volume in normal human adults. Surgery 1962;51:224-232.
31. Wells PS, Anderson DR, Bormanis J, et al. Value of assessment of pretest probability of deep-vein thrombosis in clinical management. Lancet 1997;350:1795-1798.
32. Husted H, Blønd L, Sonne-Holm S, et al. Tranexamic acid reduces blood loss and blood transfusions in primary total hip arthroplasty: a prospective randomized doubleblind study in 40 patients. Acta Orthop Scand 2003;74:665-669.
33. Ido K, Neo M, Asada Y, et al. Reduction of blood loss using tranexamic acid in total knee and hip arthroplasties. Arch Orthop Trauma Surg 2000;120:518-520.
34. Claeys MA, Vermeersch N, Haentjens P. Reduction of blood loss with tranexamic acid in primary total hip replacement surgery. Acta Chir Belg 2007;107:397-401.
35. Niskanen RO, Korkala OL. Tranexamic acid reduces blood loss in cemented hip arthroplasty: a randomized, double-blind study of 39 patients with osteoarthritis. Acta Orthop 2005;76:829-832.
36. Lin PC, Hsu CH, Chen WS, Wang JW. Does tranexamic acid save blood in minimally invasive total knee arthroplasty? Clin Orthop Relat Res 2011;469:1995-2002.
37. Yamasaki S, Masuhara K, Fuji T. Tranexamic acid reduces blood loss after cementless total hip arthroplasty-prospective randomized study in 40 cases. Int Orthop 2004;28:69-73.
38. DiGioia AM III, Plakseychuk AY, Levison TJ, Jaramaz B. Mini-incision technique for total hip arthroplasty with navigation. J Arthroplasty 2003;18:123-128.
39. Sukeik M, Alshryda S, Haddad FS, Mason JM. Systematic review and metaanalysis of the use of tranexamic acid in total hip replacement. J Bone Joint Surg [Br] 2011;93-B:39-46.