Topical application of tranexamic acid in primary total hip arthroplasty: A randomized double-blind controlled trial

Journal of Arthroplasty

Volumn 29, Issue 12, 2014, Pages 2452-2456

  Yue, Chen ^a   Kang, Pengde ^a   Yang, Peiqing ^a   Xie, Jinwei ^a   Pei, Fuxing ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Blood loss; DVT; THA; Topical; Tranexamic acid; Transfusions

Indexed keywords

HEMOGLOBIN; LOW MOLECULAR WEIGHT HEPARIN; PLACEBO; TRANEXAMIC ACID; ANTIFIBRINOLYTIC AGENT;

ACETABULUM; ADULT; ARTICLE; BLOOD TRANSFUSION; BLOOD VOLUME; BONE NECROSIS; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG MEGADOSE; DRUG SAFETY; ECHOGRAPHY; ERYTHROCYTE; ERYTHROCYTE TRANSFUSION; FEMALE; FEMUR HEAD; FEMUR HEAD NECROSIS; FOLLOW UP; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; HIP OSTEOARTHRITIS; HUMAN; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; OPERATIVE BLOOD LOSS; OUTCOME ASSESSMENT; POSTOPERATIVE COMPLICATION; POSTOPERATIVE HEMORRHAGE; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; RISK REDUCTION; THROMBOSIS PREVENTION; TOTAL HIP PROSTHESIS; TREATMENT OUTCOME; ADVERSE EFFECTS; AGED; HIP ARTHROPLASTY; MIDDLE AGED; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; AGED; ANTIFIBRINOLYTIC AGENTS; ARTHROPLASTY, REPLACEMENT, HIP; BLOOD TRANSFUSION; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; POSTOPERATIVE HEMORRHAGE; TRANEXAMIC ACID;

EID: 84912528650     PISSN: 08835403     EISSN: 15328406     Source Type: Journal    
DOI: 10.1016/j.arth.2014.03.032     Document Type: Article

References (31)

1. Bierbaum B.E., Callaghan J.J., Galante J.O., et al. An analysis of blood management in patients having a total hip or knee arthroplasty. J Bone Joint Surg Am 1999, 81(1):2.
2. Kumar A. Perioperative management of anemia: limits of blood transfusion and alternatives to it. Cleve Clin J Med 2009, 76(4):112.
3. Cardone D., Klein A.A. Perioperative blood conservation. Eur J Anaesthesiol 2009, 26:722.
4. Lemaire R. Strategies for blood management in orthopaedic and trauma surgery [J]. J Bone Joint Surg (Br) 2008, 90:1128.
5. Claeys M.A., Vermeersch N., Haentjens P. Reduction of Blood Loss with Tranexamic Acid in Primary Total Hip Replacement Surgery. Acta Chir Belg 2007, 107:397.
6. Hoylaerts M., Lijnen H.R., Collen D. Studies on the mechanism of the antifibrinolytic action of tranexamic acid. Biochim Biophys Acta 1981, 673(1):75.
7. Singh J., Ballal M.S., Mitchell P., et al. Effects of tranexamic acid on blood loss during total hip arthroplasty. J Orthop Surg 2010, 18(3):282.
8. Dahl O.E. The role of the pulmonary circulation in the regulation of coagulation and fibrinolysis in relation to major surgery. J Cardiothorac Vasc Anesth 1997, 11:322.
9. Reid R.W., Zimmerman A.A., Laussen P.C., et al. The efficacy of tranexamic acid versus placebo in decreasing blood loss in pediatric patients undergoing repeat cardiac surgery. Anesth Analg 1997, 84:990.
10. Sukeik M., Alshryda S., Haddad F.S., et al. Systematic review and meta-analysis of the use of tranexamic acid in total hip replacement. J Bone Joint Surg 2011, 21:869.
11. Benoni G., Fredin H., Knebel R., et al. Blood conservation with tranexamic acid in total hip arthroplasty: a randomized, double-blind study in 40 primary operations. Acta Orthop Scand 2001, 72:442.
12. Husted H., Blønd L., Sonne-Holm S., et al. Tranexamic acid reduces blood loss and blood transfusions in primary total hip arthroplasty: a prospective randomized double-blind study in 40 patients. Acta Orthop Scand 2003, 74:665.
13. Lemay E., Guay J., CÔté C., et al. Tranexamic acid reduces the need for allogenic red blood cell transfusions in patients undergoing total hip replacement. Can J Anaesth 2004, 51:31.
14. Johansson T., Pettersson L.G., Lisander B. Tranexamic acid in total hip arthroplasty saves blood and money: a randomized, double-blind study in 100 patients. Acta Orthop 2005, 76:314.
15. Yamasaki S., Masuhara K., Fuji T. Tranexamic acid reduces blood loss after cementless total hip arthroplasty-prospective randomized study in 40 cases. Int Orthop 2004, 28:69.
16. Ido K., Neo M., Asada Y., et al. Reduction of blood loss using tranexamic acid in total knee and hip arthroplasties. Arch Orthop Trauma Surg 2000, 120:518.
17. Alshryda S., Mason J., Sarda P., et al. Topical (Intra-Articular) Tranexamic Acid Reduces Blood Loss and Transfusion Rates Following Total Hip Replacement A Randomized Controlled Trial (TRANX-H). J Bone Joint Surg Am 2013, 95:1969.
18. Wind T.C., Barfield W.R., Moskal J.T. The Effect of Tranexamic Acid on Transfusion Rate in Primary Total Hip Arthroplasty. J Arthroplasty 2014, 29(2):387-389.
19. Martin J.G., Cassatt K.B., Kincaid-Cinnamon K.A., et al. Topical Administration of Tranexamic Acid in Primary Total Hip and Total Knee Arthroplasty. J Arthroplasty 2013, 10.1016/j.arth.2013.10.005.
20. Konig G., Hamlin B.R., Waters J.H. Topical Tranexamic Acid Reduces Blood Loss and Transfusion Rates in Total Hip and Total Knee Arthroplasty. J Arthroplasty 2013, 28:1473.
21. Gross J.B. Estimating allowable blood loss: corrected for dilution. Anaesthesiology 1983, 58:277.
22. Liu X., Zhang X., Chen Y., et al. Hidden Blood Loss After Total Hip Arthroplasty. J Arthroplasty 2011, 26(7):1100-1105.e.1.
23. Nadler S.B., Hidalgo J.U., Bloch T. Prediction of blood volume in normal human adults. Surgery 1962, 51:224.
24. Panteli M., Papakostidis C., Dahabreh Z., et al. Topical tranexamic acid in total knee replacement: A systematic review and meta-analysis. Knee 2013, 20:300.
25. Sehat K.R., Evans R.L., Newman J.H. Hidden blood loss following hip and knee arthroplasty. J Bone Joint Surg (Br) 2004, 86-B:561.
26. Eipe N.P., Ponniah M. Perioperative blood loss assessment-how accurate?. Indian J Anaesth 2006, 50(1):35.
27. Urguhart D.M., Hanna F.S., Brennan S.L., et al. Incidence and risk factors for deep surgical site infection after primary total hip arthroplasty: a systemic review. J Arthroplasty 2010, 25(8):1216.
28. Zhou X.D., Tao L.J., Li J., et al. Do we really need tranexamic acid in total hip arthroplasty? A meta-analysis of nineteen randomized controlled trials. Arch Orthop Trauma Surg 2013, 133:1017.
29. Barnes C.L., Nelson C.L., Nix M.L., et al. Duplex scanning versus venography as a screening examination in total hip arthroplasty patients. Clin Orthop Relat Res 1991, (271):180.
30. Grady-Benson J.C., Oishi C.S., Hanson P.B., et al. Routine postoperative duplex ultrosonography screening and monitoring for the detection of deep vein thrombosis. Clin Orthop Relat Res 1994, 307:130.
31. Tremaine D.M., Choroszy C.J., Menking S.A. Deep vein thrombosis in the total hip arthroplasty patient after hospital discharge. J Vase Tech 1992, 16:23.