Defective Branched-Chain Amino Acid Catabolism Disrupts Glucose Metabolism and Sensitizes the Heart to Ischemia-Reperfusion Injury

Cell Metabolism

Volumn 25, Issue 2, 2017, Pages 374-385

  Li, Tao ^a,b   Zhang, Zhen ^b   Kolwicz, Stephen C ^b   Abell, Lauren ^b   Roe, Nathan D ^b   Kim, Maengjo ^b   Zhou, Bo ^b   Cao, Yang ^b   Ritterhoff, Julia ^b   Gu, Haiwei ^b   Raftery, Daniel ^b   Sun, Haipeng ^c   Tian, Rong ^b  

^a SICHUAN UNIVERSITY   (China)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

branched chain amino acids; cardiac metabolism; glucose; ischemia reperfusion; mitochondria; N glcNacation; pyruvate dehydrogenase

Indexed keywords

BRANCHED CHAIN AMINO ACID; GLUCOSE TRANSPORTER 1; HEXOSAMINE; N ACETYLGLUCOSAMINE; PYRUVATE DEHYDROGENASE COMPLEX; GLUCOSE; PYRUVIC ACID;

AMINO ACID BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; CARBON NUCLEAR MAGNETIC RESONANCE; CATABOLISM; CONTROLLED STUDY; DISEASE EXACERBATION; DOWN REGULATION; ENERGY TRANSFER; ENZYME ACTIVITY; ENZYME INHIBITION; FATTY ACID OXIDATION; GENE OVEREXPRESSION; GLUCOSE METABOLISM; GLUCOSE OXIDATION; GLUCOSE TRANSPORT; GLUCOSE UTILIZATION; HEART; HEART FUNCTION; HEART MUSCLE METABOLISM; HEART PERFUSION; HEART TISSUE; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION; PROTEIN MODIFICATION; REPERFUSION INJURY; SENSITIZATION; ANIMAL; C57BL MOUSE; CARDIAC MUSCLE; GLYCOSYLATION; HEART FUNCTION TEST; HEART MITOCHONDRION; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY;

ACETYLGLUCOSAMINE; AMINO ACIDS, BRANCHED-CHAIN; ANIMALS; GLUCOSE; GLYCOSYLATION; HEART FUNCTION TESTS; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA, HEART; MYOCARDIUM; PYRUVATE DEHYDROGENASE COMPLEX; PYRUVIC ACID; REPERFUSION INJURY;

EID: 85013191430     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2016.11.005     Document Type: Article

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